{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:16:59Z","timestamp":1792109819640,"version":"4.4.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T00:00:00Z","timestamp":1640736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pancreatology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.pan.2021.12.008","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T21:15:38Z","timestamp":1640121338000},"page":"235-243","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Therapeutic anticoagulation for splanchnic vein thrombosis in acute pancreatitis: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6728-949X","authenticated-orcid":false,"given":"Noor J.","family":"Sissingh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2438-4665","authenticated-orcid":false,"given":"Jesse V.","family":"Groen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2770-5655","authenticated-orcid":false,"given":"Dylan","family":"Koole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederikus A.","family":"Klok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bas","family":"Boekestijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L.","family":"Bollen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hjalmar C.","family":"van Santvoort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5591-0499","authenticated-orcid":false,"given":"Robert C.","family":"Verdonk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4513-5737","authenticated-orcid":false,"given":"Bert A.","family":"Bonsing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casper H.J.","family":"van Eijck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanin E.","family":"van Hooft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Sven D.","family":"Mieog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.pan.2021.12.008_bib1","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1111\/j.1445-2197.2005.03607.x","article-title":"Vascular complications of pancreatitis","volume":"75","author":"Mendelson","year":"2005","journal-title":"ANZ J Surg"},{"issue":"12","key":"10.1016\/j.pan.2021.12.008_bib2","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1111\/j.1477-2574.2011.00392.x","article-title":"Splanchnic vein thrombosis in severe acute pancreatitis: a 2-year, single-institution experience","volume":"13","author":"Gonzelez","year":"2011","journal-title":"HPB"},{"issue":"6","key":"10.1016\/j.pan.2021.12.008_bib3","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1097\/MPA.0b013e318287cd3d","article-title":"Splanchnic venous thrombosis and pancreatitis","volume":"42","author":"Nadkarni","year":"2013","journal-title":"Pancreas"},{"issue":"12","key":"10.1016\/j.pan.2021.12.008_bib4","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1477-2574.2011.00411.x","article-title":"Splanchnic vein thrombosis complicating severe acute pancreatitis","volume":"13","author":"Besselink","year":"2011","journal-title":"HPB"},{"key":"10.1016\/j.pan.2021.12.008_bib5","doi-asserted-by":"crossref","first-page":"449","DOI":"10.2147\/VHRM.S197732","article-title":"Splanchnic vein thrombosis: current perspectives","volume":"15","author":"Valeriani","year":"2019","journal-title":"Vasc Health Risk Manag"},{"issue":"3","key":"10.1016\/j.pan.2021.12.008_bib6","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/jth.12121","article-title":"Anticoagulant therapy in patients with non-cirrhotic portal vein thrombosis: effect on new thrombotic events and gastrointestinal bleeding","volume":"11","author":"Spaander","year":"2013","journal-title":"J\u00a0Thromb Haemostasis"},{"issue":"4","key":"10.1016\/j.pan.2021.12.008_bib7","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1053\/j.gastro.2011.06.073","article-title":"A\u00a0conservative and minimally invasive approach to necrotizing pancreatitis improves outcome","volume":"141","author":"van Santvoort","year":"2011","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.pan.2021.12.008_bib8","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.chest.2015.11.026","article-title":"Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report","volume":"149","author":"Kearon","year":"2016","journal-title":"Chest"},{"issue":"3","key":"10.1016\/j.pan.2021.12.008_bib9","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.jhep.2015.05.022","article-title":"Expanding consensus in portal hypertension: report of the Baveno VI Consensus Workshop: stratifying risk and individualizing care for portal hypertension","volume":"63","author":"de Franchis","year":"2015","journal-title":"J\u00a0Hepatol"},{"issue":"1","key":"10.1016\/j.pan.2021.12.008_bib10","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jhep.2015.07.040","article-title":"Electronic address eee. EASL clinical practice guidelines: vascular diseases of the liver","volume":"64","year":"2016","journal-title":"J\u00a0Hepatol"},{"issue":"1","key":"10.1016\/j.pan.2021.12.008_bib11","doi-asserted-by":"crossref","first-page":"18","DOI":"10.14309\/ajg.0000000000000486","article-title":"ACG clinical guideline: disorders of the hepatic and mesenteric circulation","volume":"115","author":"Simonetto","year":"2020","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"10.1016\/j.pan.2021.12.008_bib12","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1538-7836.2011.04565.x","article-title":"Incidental diagnosis of a deep vein thrombosis in consecutive patients undergoing a computed tomography scan of the abdomen: a retrospective cohort study","volume":"10","author":"Ageno","year":"2012","journal-title":"J\u00a0Thromb Haemostasis"},{"issue":"6","key":"10.1016\/j.pan.2021.12.008_bib13","doi-asserted-by":"crossref","first-page":"e267","DOI":"10.1016\/S2352-3026(16)30020-5","article-title":"Clinical history and antithrombotic treatment of incidentally detected splanchnic vein thrombosis: a multicentre, international prospective registry","volume":"3","author":"Riva","year":"2016","journal-title":"Lancet Haematol"},{"issue":"1","key":"10.1016\/j.pan.2021.12.008_bib14","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/hep.23259","article-title":"Acute portal vein thrombosis unrelated to cirrhosis: a prospective multicenter follow-up study","volume":"51","author":"Plessier","year":"2010","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.pan.2021.12.008_bib15","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1097\/MCG.0b013e3181b3ab44","article-title":"Safety and efficacy of anticoagulation therapy with low molecular weight heparin for portal vein thrombosis in patients with liver cirrhosis","volume":"44","author":"Amitrano","year":"2010","journal-title":"J\u00a0Clin Gastroenterol"},{"issue":"9","key":"10.1016\/j.pan.2021.12.008_bib16","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.1097\/MPA.0000000000001644","article-title":"Anticoagulation versus No anticoagulation for splanchnic venous thrombosis secondary to acute pancreatitis: do we really need to treat the incidental findings?","volume":"49","author":"Hajibandeh","year":"2020","journal-title":"Pancreas"},{"issue":"2","key":"10.1016\/j.pan.2021.12.008_bib17","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.hbpd.2019.12.007","article-title":"Current practice of anticoagulant in the treatment of splanchnic vein thrombosis secondary to acute pancreatitis","volume":"19","author":"Norton","year":"2020","journal-title":"Hepatobiliary Pancreat Dis Int"},{"issue":"7","key":"10.1016\/j.pan.2021.12.008_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"10.1016\/j.pan.2021.12.008_bib19","doi-asserted-by":"crossref","first-page":"i4919","DOI":"10.1136\/bmj.i4919","article-title":"ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions","volume":"355","author":"Sterne","year":"2016","journal-title":"BMJ"},{"issue":"12","key":"10.1016\/j.pan.2021.12.008_bib20","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.jclinepi.2011.03.017","article-title":"GRADE guidelines: 7. Rating the quality of evidence--inconsistency","volume":"64","author":"Guyatt","year":"2011","journal-title":"J\u00a0Clin Epidemiol"},{"issue":"8","key":"10.1016\/j.pan.2021.12.008_bib21","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1097\/MPA.0b013e3182968ff5","article-title":"Splanchnic vein thrombosis in acute pancreatitis: a single-center experience","volume":"42","author":"Harris","year":"2013","journal-title":"Pancreas"},{"issue":"5","key":"10.1016\/j.pan.2021.12.008_bib22","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.cgh.2013.09.068","article-title":"Portosplenomesenteric venous thrombosis in patients with acute pancreatitis is associated with pancreatic necrosis and usually has a benign course","volume":"12","author":"Easler","year":"2014","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"12","key":"10.1016\/j.pan.2021.12.008_bib23","first-page":"734","article-title":"Predictive factors of splanchnic vein thrombosis in acute pancreatitis: a 6-year single-center experience","volume":"16","author":"Toque","year":"2015","journal-title":"J\u00a0Dig Dis"},{"issue":"6","key":"10.1016\/j.pan.2021.12.008_bib24","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1177\/2050640618764049","article-title":"Risk factors and outcomes of infected pancreatic necrosis: retrospective cohort of 148 patients admitted to the ICU for acute pancreatitis","volume":"6","author":"Garret","year":"2018","journal-title":"United European Gastroenterol J"},{"issue":"6","key":"10.1016\/j.pan.2021.12.008_bib25","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s11739-019-02271-5","article-title":"Anticoagulant therapy in the treatment of splanchnic vein thrombosis associated to acute pancreatitis: a 3-year single-centre experience","volume":"15","author":"Pagliari","year":"2020","journal-title":"Intern Emerg Med"},{"issue":"1","key":"10.1016\/j.pan.2021.12.008_bib26","doi-asserted-by":"crossref","first-page":"25","DOI":"10.14740\/gr1223","article-title":"Splanchnic venous thrombosis in acute pancreatitis: does anticoagulation affect outcome?","volume":"13","author":"Junare","year":"2020","journal-title":"Gastroenterol Res"},{"issue":"1","key":"10.1016\/j.pan.2021.12.008_bib27","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/gutjnl-2012-302779","article-title":"Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus","volume":"62","author":"Banks","year":"2013","journal-title":"Gut"},{"issue":"7","key":"10.1016\/j.pan.2021.12.008_bib28","doi-asserted-by":"crossref","first-page":"E990","DOI":"10.1055\/a-1187-1154","article-title":"Endoscopic treatment of variceal upper gastrointestinal bleeding: European society of gastrointestinal endoscopy (ESGE) cascade guideline","volume":"8","author":"Karstensen","year":"2020","journal-title":"Endosc Int Open"},{"issue":"9","key":"10.1016\/j.pan.2021.12.008_bib29","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1182\/blood.2020006827","article-title":"Anticoagulant therapy for splanchnic vein thrombosis: a systematic review and meta-analysis","volume":"137","author":"Valeriani","year":"2021","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.pan.2021.12.008_bib30","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1080\/00365521.2020.1823465","article-title":"Predictors of insufficient recanalization and portal hypertensive complications after treatment of non-cirrhotic, non-malignant portal vein thrombosis - a population-based study","volume":"55","author":"Lemma","year":"2020","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.pan.2021.12.008_bib31","first-page":"112","article-title":"The predictor factors of portal vein thrombosis in pancreatitis patients","author":"Al-Azzawi","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.pan.2021.12.008_bib32","first-page":"112","article-title":"Outcomes of anticoagulation for portal and\/or splenic vein thrombosis in setting of acute pancreatitis","author":"Anderson","year":"2017","journal-title":"Am J Gastroenterol"},{"issue":"9","key":"10.1016\/j.pan.2021.12.008_bib33","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/ncpgasthep0577","article-title":"Nonmalignant portal vein thrombosis in adults","volume":"3","author":"Condat","year":"2006","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.pan.2021.12.008_bib34","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.cgh.2009.09.019","article-title":"Survival and recurrence in patients with splanchnic vein thromboses","volume":"8","author":"Thatipelli","year":"2010","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"10252","key":"10.1016\/j.pan.2021.12.008_bib35","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0140-6736(20)31310-6","article-title":"Acute pancreatitis","volume":"396","author":"Boxhoorn","year":"2020","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.pan.2021.12.008_bib36","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1097\/MPA.0000000000001827","article-title":"Thromboembolic complications in the first year after acute pancreatitis diagnosis","volume":"50","author":"Robbins","year":"2021","journal-title":"Pancreas"},{"issue":"9","key":"10.1016\/j.pan.2021.12.008_bib37","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1001\/jamainternmed.2015.3184","article-title":"Long-term clinical outcomes of splanchnic vein thrombosis: results of an international registry","volume":"175","author":"Ageno","year":"2015","journal-title":"JAMA Intern Med"},{"issue":"25","key":"10.1016\/j.pan.2021.12.008_bib38","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1182\/blood-2014-07-551515","article-title":"How I treat splanchnic vein thrombosis","volume":"124","author":"Ageno","year":"2014","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.pan.2021.12.008_bib39","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1136\/gutjnl-2017-314657","article-title":"Impact of characteristics of organ failure and infected necrosis on mortality in necrotising pancreatitis","volume":"68","author":"Schepers","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.pan.2021.12.008_bib40","doi-asserted-by":"crossref","first-page":"d4002","DOI":"10.1136\/bmj.d4002","article-title":"Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials","volume":"343","author":"Sterne","year":"2011","journal-title":"BMJ"},{"issue":"7568","key":"10.1016\/j.pan.2021.12.008_bib41","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1136\/bmj.333.7568.597","article-title":"The case of the misleading funnel plot","volume":"333","author":"Lau","year":"2006","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.pan.2021.12.008_bib42","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1182\/asheducation-2017.1.237","article-title":"Symptomatic subsegmental pulmonary embolism: to treat or not to treat?","volume":"2017","author":"Carrier","year":"2017","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.pan.2021.12.008_bib43","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.thromres.2019.03.012","article-title":"The problem of under-diagnosis and over-diagnosis of pulmonary embolism","volume":"177","author":"Swan","year":"2019","journal-title":"Thromb Res"}],"container-title":["Pancreatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390321006554?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390321006554?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T16:14:41Z","timestamp":1761408881000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1424390321006554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S1424390321006554"],"URL":"https:\/\/doi.org\/10.1016\/j.pan.2021.12.008","relation":{},"ISSN":["1424-3903"],"issn-type":[{"value":"1424-3903","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic anticoagulation for splanchnic vein thrombosis in acute pancreatitis: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Pancreatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pan.2021.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V. on behalf of IAP and EPC.","name":"copyright","label":"Copyright"}]}}