{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:39:06Z","timestamp":1792899546265,"version":"4.5.0"},"reference-count":118,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"am","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pancreatology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.pan.2022.07.011","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T21:33:17Z","timestamp":1659475997000},"page":"838-845","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Calcium, mitochondria and the initiation of acute pancreatitis"],"prefix":"10.1016","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0818-6017","authenticated-orcid":false,"given":"Stephen J.","family":"Pandol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta A.","family":"Gottlieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pan.2022.07.011_bib1","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1053\/j.gastro.2018.11.082","article-title":"Acute pancreatitis: a multifaceted set of organelle and cellular interactions","volume":"156","author":"Habtezion","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2022.07.011_bib2","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1053\/j.gastro.2017.08.071","article-title":"Autophagy, inflammation, and immune dysfunction in the pathogenesis of pancreatitis","volume":"153","author":"Gukovskaya","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2022.07.011_bib4","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/MPA.0000000000001298","article-title":"Recent insights into the pathogenic mechanism of pancreatitis: role of acinar cell organelle disorders","volume":"48","author":"Gukovskaya","year":"2019","journal-title":"Pancreas"},{"key":"10.1016\/j.pan.2022.07.011_bib5","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1053\/j.gastro.2007.01.055","article-title":"Acute pancreatitis: bench to the bedside","volume":"132","author":"Pandol","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2022.07.011_bib6","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1053\/j.gastro.2012.08.002","article-title":"Burden of gastrointestinal disease in the United States: 2012 update","volume":"143","author":"Peery","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2022.07.011_bib7","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1056\/NEJMra1505202","article-title":"Acute pancreatitis","volume":"375","author":"Forsmark","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.pan.2022.07.011_bib8","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1001\/archinternmed.2009.125","article-title":"Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronic pancreatitis","volume":"169","author":"Yadav","year":"2009","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.pan.2022.07.011_bib9","doi-asserted-by":"crossref","first-page":"173","DOI":"10.35946\/arcr.v38.2.03","article-title":"Uniting epidemiology and experimental disease models for alcohol-related pancreatic disease","volume":"38","author":"Setiawan","year":"2017","journal-title":"Alcohol Res"},{"key":"10.1016\/j.pan.2022.07.011_bib10","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1053\/j.gastro.2017.08.036","article-title":"The combination of alcohol and cigarette smoke induces endoplasmic reticulum stress and cell death in pancreatic acinar cells","volume":"153","author":"Lugea","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2022.07.011_bib11","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1001\/jama.2020.20317","article-title":"Acute pancreatitis: a review","volume":"325","author":"Mederos","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.pan.2022.07.011_bib12","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1136\/gutjnl-2019-318241","article-title":"Duration of organ failure impacts mortality in acute pancreatitis","volume":"69","author":"Shi","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.pan.2022.07.011_bib13","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1097\/MPA.0000000000000776","article-title":"A\u00a0study on the etiology, severity, and mortality of 3260 patients with acute pancreatitis according to the revised atlanta classification in jiangxi, China over an 8-year period","volume":"46","author":"Zhu","year":"2017","journal-title":"Pancreas"},{"key":"10.1016\/j.pan.2022.07.011_bib14","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12876-018-0821-z","article-title":"Significantly different clinical features between hypertriglyceridemia and biliary acute pancreatitis: a retrospective study of 730 patients from a tertiary center","volume":"18","author":"Li","year":"2018","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.pan.2022.07.011_bib15","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1053\/j.gastro.2013.01.068","article-title":"The epidemiology of pancreatitis and pancreatic cancer","volume":"144","author":"Yadav","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2022.07.011_bib16","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1097\/MPA.0000000000001335","article-title":"Animal models: challenges and opportunities to determine optimal experimental models of pancreatitis and pancreatic cancer","volume":"48","author":"Saloman","year":"2019","journal-title":"Pancreas"},{"key":"10.1016\/j.pan.2022.07.011_bib17","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1172\/JCI130172","article-title":"Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H","volume":"130","author":"Gui","year":"2020","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.pan.2022.07.011_bib18","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1016\/j.ajpath.2017.08.017","article-title":"Human pancreatic acinar cells: proteomic characterization, physiologic responses, and organellar disorders in ex\u00a0vivo pancreatitis","volume":"187","author":"Lugea","year":"2017","journal-title":"Am J Pathol"},{"key":"10.1016\/j.pan.2022.07.011_bib19","series-title":"The exorcine pancreas","author":"SJ","year":"2010"},{"key":"10.1016\/j.pan.2022.07.011_bib20","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/MOG.0000000000000301","article-title":"New insights into the pathways initiating and driving pancreatitis","volume":"32","author":"Gukovskaya","year":"2016","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.pan.2022.07.011_bib21","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1053\/j.gastro.2014.11.002","article-title":"Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis","volume":"148","author":"Mal\u00e9th","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2022.07.011_bib22","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1136\/gut.2010.218461","article-title":"The acinar-ductal tango in the pathogenesis of acute pancreatitis","volume":"60","author":"Hegyi","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.pan.2022.07.011_bib23","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1152\/physrev.00003.2021","article-title":"The roles of calcium and ATP in the physiology and pathology of the exocrine pancreas","volume":"101","author":"Petersen","year":"2021","journal-title":"Physiol Rev"},{"key":"10.1016\/j.pan.2022.07.011_bib24","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/306067a0","article-title":"Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate","volume":"306","author":"Streb","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.pan.2022.07.011_bib25","doi-asserted-by":"crossref","first-page":"10081","DOI":"10.1016\/S0021-9258(17)39215-3","article-title":"Role of free cytosolic calcium in secretagogue-stimulated amylase release from dispersed acini from Guinea pig pancreas","volume":"260","author":"Pandol","year":"1985","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.pan.2022.07.011_bib26","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/j.2040-4603.2019.tb00073.x","article-title":"Cholecystokinin (CCK) regulation of pancreatic acinar cells: physiological actions and signal transduction mechanisms","volume":"9","author":"Williams","year":"2019","journal-title":"Compr Physiol"},{"key":"10.1016\/j.pan.2022.07.011_bib27","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1146\/annurev.physiol.70.113006.100618","article-title":"Polarized calcium signaling in exocrine gland cells","volume":"70","author":"Petersen","year":"2008","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.pan.2022.07.011_bib28","doi-asserted-by":"crossref","first-page":"5729","DOI":"10.1093\/emboj\/19.21.5729","article-title":"The endoplasmic reticulum as one continuous Ca(2+) pool: visualization of rapid Ca(2+) movements and equilibration","volume":"19","author":"Park","year":"2000","journal-title":"EMBO J"},{"key":"10.1016\/j.pan.2022.07.011_bib29","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1016\/S0021-9258(17)37597-X","article-title":"Localization of the type 3 inositol 1,4,5-trisphosphate receptor in the Ca2+ wave trigger zone of pancreatic acinar cells","volume":"269","author":"Nathanson","year":"1994","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.pan.2022.07.011_bib30","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1053\/gast.2002.30982","article-title":"Ca2+ waves require sequential activation of inositol trisphosphate receptors and ryanodine receptors in pancreatic acini","volume":"122","author":"Leite","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2022.07.011_bib31","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/0143-4160(95)90052-7","article-title":"Isolation of subcellular agonist-sensitive calcium stores from the pancreatic acinar cell","volume":"18","author":"Pandol","year":"1995","journal-title":"Cell Calcium"},{"key":"10.1016\/j.pan.2022.07.011_bib32","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1042\/bj3510265","article-title":"Multiple isoforms of the ryanodine receptor are expressed in rat pancreatic acinar cells","volume":"351","author":"Fitzsimmons","year":"2000","journal-title":"Biochem J"},{"key":"10.1016\/j.pan.2022.07.011_bib33","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1053\/j.gastro.2010.01.037","article-title":"Dynamic changes in cytosolic and mitochondrial ATP levels in pancreatic acinar cells","volume":"138","author":"Voronina","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2022.07.011_bib34","doi-asserted-by":"crossref","first-page":"16963","DOI":"10.1016\/S0021-9258(18)45478-6","article-title":"The agonist-sensitive calcium pool in the pancreatic acinar cell. Activation of plasma membrane Ca2+ influx mechanism","volume":"262","author":"Pandol","year":"1987","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.pan.2022.07.011_bib35","first-page":"G221","article-title":"Agonist-sensitive calcium pool in the pancreatic acinar cell. I. Permeability properties","volume":"255","author":"Muallem","year":"1988","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pan.2022.07.011_bib36","first-page":"G229","article-title":"Agonist-sensitive calcium pool in the pancreatic acinar cell. II. Characterization of reloading","volume":"255","author":"Muallem","year":"1988","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pan.2022.07.011_bib37","doi-asserted-by":"crossref","first-page":"27327","DOI":"10.1074\/jbc.M311698200","article-title":"Effects of secretagogues and bile acids on mitochondrial membrane potential of pancreatic acinar cells: comparison of different modes of evaluating DeltaPsim","volume":"279","author":"Voronina","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.pan.2022.07.011_bib38","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/MPA.0b013e3181675010","article-title":"Pancreatitis and calcium signalling: report of an international workshop","volume":"36","author":"Sutton","year":"2008","journal-title":"Pancreas"},{"key":"10.1016\/j.pan.2022.07.011_bib39","doi-asserted-by":"crossref","first-page":"13186","DOI":"10.1073\/pnas.1300910110","article-title":"Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy","volume":"110","author":"Gerasimenko","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pan.2022.07.011_bib40","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1113\/jphysiol.2013.261784","article-title":"The role of Ca2+ in the pathophysiology of pancreatitis","volume":"592","author":"Gerasimenko","year":"2014","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.pan.2022.07.011_bib41","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1053\/j.gastro.2009.07.042","article-title":"Deletion of TRPC3 in mice reduces store-operated Ca2+ influx and the severity of acute pancreatitis","volume":"137","author":"Kim","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2022.07.011_bib42","doi-asserted-by":"crossref","first-page":"10738","DOI":"10.1073\/pnas.0403431101","article-title":"Ethanol toxicity in pancreatic acinar cells: mediation by nonoxidative fatty acid metabolites","volume":"101","author":"Criddle","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pan.2022.07.011_bib43","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1159\/000108960","article-title":"The pancreas misled: signals to pancreatitis","volume":"7","author":"Criddle","year":"2007","journal-title":"Pancreatology"},{"key":"10.1016\/j.pan.2022.07.011_bib44","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ceca.2007.11.013","article-title":"Mitochondrial injury in pancreatitis","volume":"44","author":"Mukherjee","year":"2008","journal-title":"Cell Calcium"},{"key":"10.1016\/j.pan.2022.07.011_bib45","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1089\/ars.2011.4068","article-title":"Organellar dysfunction in the pathogenesis of pancreatitis","volume":"15","author":"Gukovsky","year":"2011","journal-title":"Antioxidants Redox Signal"},{"key":"10.1016\/j.pan.2022.07.011_bib46","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1053\/j.gastro.2011.04.025","article-title":"Which way to die: the regulation of acinar cell death in pancreatitis by mitochondria, calcium, and reactive oxygen species","volume":"140","author":"Gukovskaya","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2022.07.011_bib47","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1053\/j.gastro.2012.10.037","article-title":"Effects of oxidative alcohol metabolism on the mitochondrial permeability transition pore and necrosis in a mouse model of alcoholic pancreatitis","volume":"144","author":"Shalbueva","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2022.07.011_bib48","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1053\/j.gastro.2015.04.015","article-title":"Inhibitors of ORAI1 prevent cytosolic calcium-associated injury of human pancreatic acinar cells and acute pancreatitis in 3 mouse models","volume":"149","author":"Wen","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2022.07.011_bib49","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1113\/JP277856","article-title":"The Orai Ca(2+) channel inhibitor CM4620 targets both parenchymal and immune cells to reduce inflammation in experimental acute pancreatitis","volume":"597","author":"Waldron","year":"2019","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.pan.2022.07.011_bib50","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/nature04147","article-title":"STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane","volume":"437","author":"Zhang","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.pan.2022.07.011_bib51","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1083\/jcb.200502019","article-title":"STIM1, an essential and conserved component of store-operated Ca2+ channel function","volume":"169","author":"Roos","year":"2005","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.pan.2022.07.011_bib52","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ceca.2007.03.002","article-title":"Molecular basis of the CRAC channel","volume":"42","author":"Cahalan","year":"2007","journal-title":"Cell Calcium"},{"key":"10.1016\/j.pan.2022.07.011_bib53","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1042\/BST20110639","article-title":"Cellular geography of IP3 receptors, STIM and Orai: a lesson from secretory epithelial cells","volume":"40","author":"Dingsdale","year":"2012","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.pan.2022.07.011_bib54","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1600-0854.2010.01138.x","article-title":"Polarized but differential localization and recruitment of STIM1, Orai1 and TRPC channels in secretory cells","volume":"12","author":"Hong","year":"2011","journal-title":"Traffic"},{"key":"10.1016\/j.pan.2022.07.011_bib55","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1038\/ncb3245","article-title":"STIMATE reveals a STIM1 transitional state","volume":"17","author":"Hooper","year":"2015","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.pan.2022.07.011_bib56","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1038\/s41467-018-04194-9","article-title":"Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis","volume":"9","author":"Romac","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.pan.2022.07.011_bib57","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1172\/JCI134111","article-title":"TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation","volume":"130","author":"Swain","year":"2020","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.pan.2022.07.011_bib58","doi-asserted-by":"crossref","first-page":"40154","DOI":"10.1074\/jbc.M606402200","article-title":"Bile acids induce Ca2+ release from both the endoplasmic reticulum and acidic intracellular calcium stores through activation of inositol trisphosphate receptors and ryanodine receptors","volume":"281","author":"Gerasimenko","year":"2006","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.pan.2022.07.011_bib59","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1074\/jbc.M112.428896","article-title":"Bile acids induce pancreatic acinar cell injury and pancreatitis by activating calcineurin","volume":"288","author":"Muili","year":"2013","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.pan.2022.07.011_bib60","doi-asserted-by":"crossref","first-page":"G1423","DOI":"10.1152\/ajpgi.00546.2011","article-title":"Ryanodine receptors contribute to bile acid-induced pathological calcium signaling and pancreatitis in mice","volume":"302","author":"Husain","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.pan.2022.07.011_bib61","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1053\/gast.2002.33617","article-title":"Transporter-mediated bile acid uptake causes Ca2+-dependent cell death in rat pancreatic acinar cells","volume":"122","author":"Kim","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2022.07.011_bib62","doi-asserted-by":"crossref","first-page":"G875","DOI":"10.1152\/ajpgi.00558.2005","article-title":"Phosphatidylinositol 3-kinase facilitates bile acid-induced Ca(2+) responses in pancreatic acinar cells","volume":"292","author":"Fischer","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.pan.2022.07.011_bib63","doi-asserted-by":"crossref","first-page":"462","DOI":"10.4161\/auto.6.4.11553","article-title":"Cyclophilin D is required for mitochondrial removal by autophagy in cardiac cells","volume":"6","author":"Carreira","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.pan.2022.07.011_bib64","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1152\/physrev.00013.2006","article-title":"Mitochondrial membrane permeabilization in cell death","volume":"87","author":"Kroemer","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.pan.2022.07.011_bib65","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ceca.2018.05.003","article-title":"The still uncertain identity of the channel-forming unit(s) of the mitochondrial permeability transition pore","volume":"73","author":"Baines","year":"2018","journal-title":"Cell Calcium"},{"key":"10.1016\/j.pan.2022.07.011_bib66","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1152\/physrev.00001.2015","article-title":"The mitochondrial permeability transition pore: channel formation by F-ATP synthase, integration in signal transduction, and role in pathophysiology","volume":"95","author":"Bernardi","year":"2015","journal-title":"Physiol Rev"},{"key":"10.1016\/j.pan.2022.07.011_bib67","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1136\/gutjnl-2014-308553","article-title":"Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP","volume":"65","author":"Mukherjee","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.pan.2022.07.011_bib68","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1053\/j.gastro.2017.10.012","article-title":"Mitochondrial dysfunction, through impaired autophagy, leads to endoplasmic reticulum stress, deregulated lipid metabolism, and pancreatitis in animal models","volume":"154","author":"Biczo","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2022.07.011_bib69","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1159\/000201283","article-title":"Intracellular Ca2+ dynamics and in\u00a0vitro secretory response in acute pancreatitis induced by a choline-deficient, ethionine-supplemented diet in mice","volume":"56","author":"Okada","year":"1995","journal-title":"Digestion"},{"key":"10.1016\/j.pan.2022.07.011_bib70","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1089\/ars.2011.4065","article-title":"The crucial role of early mitochondrial injury in L-lysine-induced acute pancreatitis","volume":"15","author":"Bicz\u00f3","year":"2011","journal-title":"Antioxidants Redox Signal"},{"key":"10.1016\/j.pan.2022.07.011_bib71","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1097\/CCM.0b013e31817d7f5c","article-title":"A\u00a0new severe acute necrotizing pancreatitis model induced by L-ornithine in rats","volume":"36","author":"Rakonczay","year":"2008","journal-title":"Crit Care Med"},{"key":"10.1016\/j.pan.2022.07.011_bib72","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.3389\/fphys.2018.01922","article-title":"Mechanisms of pancreatic injury induced by basic amino acids differ between L-arginine, L-ornithine, and L-histidine","volume":"9","author":"Zhang","year":"2018","journal-title":"Front Physiol"},{"key":"10.1016\/j.pan.2022.07.011_bib73","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1053\/j.gastro.2021.05.048","article-title":"The role of phosphate in alcohol-induced experimental pancreatitis","volume":"161","author":"Farooq","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2022.07.011_bib74","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1053\/j.gastro.2021.11.018","article-title":"Serum phosphate levels and alcohol-induced pancreatitis","volume":"162","author":"Pandol","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2022.07.011_bib75","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1097\/MPA.0000000000001793","article-title":"Auxora for the treatment of patients with acute pancreatitis and accompanying systemic inflammatory response syndrome: clinical development of a calcium release-activated calcium channel inhibitor","volume":"50","author":"Bruen","year":"2021","journal-title":"Pancreas"},{"key":"10.1016\/j.pan.2022.07.011_bib78","article-title":"Simvastatin induces mitophagy and restores cerulein impaired phagosome-lysosome fusion to reduce the severity of acute pancreatitis","volume":"47","author":"Piplani","year":"2018","journal-title":"Pancreas"},{"key":"10.1016\/j.pan.2022.07.011_bib79","article-title":"Simvastatin prevents impaired BNip3-mediated mitophagy and cell death in alcoholic pancreatitis","volume":"49","author":"Thakur","year":"2020","journal-title":"Pancreas"},{"key":"10.1016\/j.pan.2022.07.011_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165987","article-title":"Pancreas-specific deletion of protein kinase D attenuates inflammation, necrosis, and severity of acute pancreatitis","volume":"1867","author":"Yuan","year":"2021","journal-title":"Biochim Biophys Acta, Mol Basis Dis"},{"key":"10.1016\/j.pan.2022.07.011_bib81","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.yjmcc.2015.11.032","article-title":"alpha-MHC MitoTimer mouse: in\u00a0vivo mitochondrial turnover model reveals remarkable mitochondrial heterogeneity in the heart","volume":"90","author":"Stotland","year":"2015","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.pan.2022.07.011_bib82","doi-asserted-by":"crossref","first-page":"3509","DOI":"10.1016\/j.bpj.2008.12.3959","article-title":"Frequency and selectivity of mitochondrial fusion are key to its quality maintenance function","volume":"96","author":"Mouli","year":"2009","journal-title":"Biophys J"},{"key":"10.1016\/j.pan.2022.07.011_bib83","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/sj.emboj.7601963","article-title":"Fission and selective fusion govern mitochondrial segregation and elimination by autophagy","volume":"27","author":"Twig","year":"2008","journal-title":"EMBO J"},{"key":"10.1016\/j.pan.2022.07.011_bib84","doi-asserted-by":"crossref","first-page":"15927","DOI":"10.1073\/pnas.0407043101","article-title":"OPA1 requires mitofusin 1 to promote mitochondrial fusion","volume":"101","author":"Cipolat","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pan.2022.07.011_bib85","doi-asserted-by":"crossref","first-page":"7828","DOI":"10.1074\/jbc.M117.781815","article-title":"Acute acinar pancreatitis blocks vesicle-associated membrane protein 8 (VAMP8)-dependent secretion, resulting in intracellular trypsin accumulation","volume":"292","author":"Messenger","year":"2017","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.pan.2022.07.011_bib86","doi-asserted-by":"crossref","first-page":"G993","DOI":"10.1152\/ajpgi.00122.2012","article-title":"Autophagy and pancreatitis","volume":"303","author":"Gukovskaya","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.pan.2022.07.011_bib87","first-page":"131","article-title":"Dysregulation of mannose-6-phosphate-dependent cholesterol homeostasis in acinar cells mediates pancreatitis","author":"Mareninova","year":"2021","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.pan.2022.07.011_bib88","first-page":"3340","article-title":"Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis","volume":"119","author":"Mareninova","year":"2009","journal-title":"J\u00a0Clin Invest"},{"issue":"Suppl 2","key":"10.1016\/j.pan.2022.07.011_bib89","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1440-1746.2011.07004.x","article-title":"Impaired autophagy and organellar dysfunction in pancreatitis","volume":"27","author":"Gukovsky","year":"2012","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1016\/j.pan.2022.07.011_bib90","doi-asserted-by":"crossref","first-page":"428","DOI":"10.4161\/auto.6.3.11530","article-title":"Impaired autophagy underlies key pathological responses of acute pancreatitis","volume":"6","author":"Gukovsky","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.pan.2022.07.011_bib91","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1080\/15548627.2019.1596486","article-title":"Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis","volume":"15","author":"Wang","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.pan.2022.07.011_bib92","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1053\/j.gastro.2013.02.007","article-title":"Inflammation, autophagy, and obesity: common features in the pathogenesis of pancreatitis and pancreatic cancer","volume":"144","author":"Gukovsky","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2022.07.011_bib93","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1172\/JCI64498","article-title":"Loss of acinar cell IKK\u03b1 triggers spontaneous pancreatitis in mice","volume":"123","author":"Li","year":"2013","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.pan.2022.07.011_bib94","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.jcmgh.2015.07.006","article-title":"Lysosome associated membrane proteins maintain pancreatic acinar cell homeostasis: LAMP-2 deficient mice develop pancreatitis","volume":"1","author":"Mareninova","year":"2015","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.pan.2022.07.011_bib95","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/MOG.0000000000000301","article-title":"New insights into the pathways initiating and driving pancreatitis","volume":"32","author":"Gukovskaya","year":"2016","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.pan.2022.07.011_bib96","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1080\/15548627.2020.1715047","article-title":"Transgenic expression of GFP-LC3 perturbs autophagy in exocrine pancreas and acute pancreatitis responses in mice","volume":"16","author":"Mareninova","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.pan.2022.07.011_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2019.08.006","article-title":"Simvastatin induces autophagic flux to restore cerulein-impaired phagosome-lysosome fusion in acute pancreatitis","volume":"1865","author":"Piplani","year":"2019","journal-title":"Biochim Biophys Acta, Mol Basis Dis"},{"key":"10.1016\/j.pan.2022.07.011_bib98","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1159\/000151480","article-title":"Autophagy and pancreas disease","volume":"8","author":"Vaccaro","year":"2008","journal-title":"Pancreatology"},{"key":"10.1016\/j.pan.2022.07.011_bib99","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/00006676-200410000-00008","article-title":"Expression of vacuole membrane protein 1 (VMP1) in spontaneous chronic pancreatitis in the WBN\/Kob rat","volume":"29","author":"Jiang","year":"2004","journal-title":"Pancreas"},{"key":"10.1016\/j.pan.2022.07.011_bib100","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/978-1-4939-8873-0_35","article-title":"Measuring autophagy in pancreatitis","volume":"1880","author":"Ropolo","year":"2019","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.pan.2022.07.011_bib101","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.640094","article-title":"Mitochondrial dynamics and VMP1-related selective mitophagy in experimental acute pancreatitis","volume":"9","author":"Vanasco","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.pan.2022.07.011_bib102","doi-asserted-by":"crossref","first-page":"388","DOI":"10.4161\/auto.5656","article-title":"A\u00a0novel mammalian trans-membrane protein reveals an alternative initiation pathway for autophagy","volume":"4","author":"Vaccaro","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.pan.2022.07.011_bib103","doi-asserted-by":"crossref","first-page":"37124","DOI":"10.1074\/jbc.M706956200","article-title":"The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells","volume":"282","author":"Ropolo","year":"2007","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.pan.2022.07.011_bib104","doi-asserted-by":"crossref","first-page":"933","DOI":"10.4161\/auto.24390","article-title":"VMP1 is a new player in the regulation of the autophagy-specific phosphatidylinositol 3-kinase complex activation","volume":"9","author":"Molejon","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.pan.2022.07.011_bib105","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/srep01055","article-title":"The VMP1-Beclin 1 interaction regulates autophagy induction","volume":"3","author":"Molejon","year":"2013","journal-title":"Sci Rep"},{"key":"10.1016\/j.pan.2022.07.011_bib106","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cotox.2017.11.002","article-title":"NF-\u03baB in oxidative stress","volume":"7","author":"Lingappan","year":"2018","journal-title":"Curr Opin Toxicol"},{"key":"10.1016\/j.pan.2022.07.011_bib107","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.it.2011.01.005","article-title":"Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation","volume":"32","author":"Krysko","year":"2011","journal-title":"Trends Immunol"},{"key":"10.1016\/j.pan.2022.07.011_bib108","article-title":"Targeting the NLRP3 inflammasome in cardiovascular diseases","volume":"236","author":"Toldo","year":"2021","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.pan.2022.07.011_bib109","first-page":"118","article-title":"Recruitment of pro-IL-1\u03b1 to mitochondrial cardiolipin, via shared LC3 binding domain, inhibits mitophagy and drives maximal NLRP3 activation","author":"Dagvadorj","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pan.2022.07.011_bib110","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202003131","article-title":"Phospholipid ebb and flow makes mitochondria go","volume":"219","author":"Acoba","year":"2020","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.pan.2022.07.011_bib111","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cellimm.2018.12.002","article-title":"Platelet-derived microparticles generated in\u00a0vitro resemble circulating vesicles of patients with rheumatoid arthritis and activate monocytes","volume":"336","author":"Villar-Vesga","year":"2019","journal-title":"Cell Immunol"},{"key":"10.1016\/j.pan.2022.07.011_bib112","doi-asserted-by":"crossref","first-page":"11335","DOI":"10.1016\/S0021-9258(17)44422-X","article-title":"Insertion of fluorescent phosphatidylserine into the plasma membrane of red blood cells. Recognition by autologous macrophages","volume":"258","author":"Tanaka","year":"1983","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.pan.2022.07.011_bib113","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12944-017-0455-0","article-title":"Hypercholesterolemia downregulates autophagy in the rat heart","volume":"16","author":"Giricz","year":"2017","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.pan.2022.07.011_bib114","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167678","article-title":"Bicarbonate increases ischemia-reperfusion damage by inhibiting mitophagy","volume":"11","author":"Queliconi","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.pan.2022.07.011_bib115","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00041.2016","article-title":"Discordant signaling and autophagy response to fasting in hearts of obese mice: implications for ischemia tolerance","volume":"311","author":"Andres","year":"2016","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.pan.2022.07.011_bib116","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0889-8553(21)00513-6","article-title":"Hyperlipidemic pancreatitis","volume":"19","author":"Toskes","year":"1990","journal-title":"Gastroenterol Clin N Am"},{"key":"10.1016\/j.pan.2022.07.011_bib117","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/1752-1947-2-176","article-title":"Cystic fibrosis presenting as recurrent pancreatitis in a young child with a normal sweat test and pancreas divisum: a case report","volume":"2","author":"Conklin","year":"2008","journal-title":"J\u00a0Med Case Rep"},{"key":"10.1016\/j.pan.2022.07.011_bib118","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1097\/MOG.0000000000000386","article-title":"Obesity and pancreatitis","volume":"33","author":"Khatua","year":"2017","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.pan.2022.07.011_bib119","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1136\/gutjnl-2013-306564","article-title":"Simvastatin is associated with reduced risk of acute pancreatitis: findings from a regional integrated healthcare system","volume":"64","author":"Wu","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.pan.2022.07.011_bib120","doi-asserted-by":"crossref","first-page":"7423","DOI":"10.3748\/wjg.v27.i43.7423","article-title":"Idiopathic chronic pancreatitis: beyond antioxidants","volume":"27","author":"Mehta","year":"2021","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.pan.2022.07.011_bib121","doi-asserted-by":"crossref","first-page":"494","DOI":"10.3389\/fmed.2020.00494","article-title":"Simvastatin in the prevention of recurrent pancreatitis: design and rationale of a multicenter triple-blind randomized controlled trial, the SIMBA trial","volume":"7","author":"C\u00e1rdenas-Ja\u00e9n","year":"2020","journal-title":"Front Med (Lausanne)"}],"container-title":["Pancreatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390322004665?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390322004665?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T16:17:59Z","timestamp":1761409079000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1424390322004665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":118,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S1424390322004665"],"URL":"https:\/\/doi.org\/10.1016\/j.pan.2022.07.011","relation":{},"ISSN":["1424-3903"],"issn-type":[{"value":"1424-3903","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Calcium, mitochondria and the initiation of acute pancreatitis","name":"articletitle","label":"Article Title"},{"value":"Pancreatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pan.2022.07.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 IAP and EPC. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}