{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:00:55Z","timestamp":1792036855667,"version":"4.4.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006487","name":"Ag\u00eancia Nacional do Petr\u00f3leo, G\u00e1s Natural e Biocombust\u00edveis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006487","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pancreatology"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.pan.2023.01.008","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T11:23:17Z","timestamp":1674040997000},"page":"163-170","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["The incidence of new mental health disorders after acute pancreatitis: A large, propensity-matched, observational study"],"prefix":"10.1016","volume":"23","author":[{"given":"Komal","family":"Khoja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5379-9299","authenticated-orcid":false,"given":"Omar","family":"Sadiq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9479-1485","authenticated-orcid":false,"given":"Phillip R.","family":"Chisholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0460-5595","authenticated-orcid":false,"given":"Kulwinder S.","family":"Dua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srivats","family":"Madhavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0306-8364","authenticated-orcid":false,"given":"Zachary L.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pan.2023.01.008_bib1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S2468-1253(16)30004-8","article-title":"Global incidence and mortality of pancreatic diseases: a systematic review, meta-analysis, and meta-regression of population-based cohort studies","volume":"1","author":"Xiao","year":"2016","journal-title":"Lancet Gastroentrol Hepatol"},{"key":"10.1016\/j.pan.2023.01.008_bib2","doi-asserted-by":"crossref","first-page":"17196","DOI":"10.3748\/wjg.v20.i45.17196","article-title":"Relationship between the exocrine and endocrine pancreas after acute pancreatitis","volume":"20","author":"Das","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.pan.2023.01.008_bib3","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.dld.2018.11.001","article-title":"Frequency and risk factors for liver disease following pancreatitis: a population-based cohort study","volume":"51","author":"Chand","year":"2019","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.pan.2023.01.008_bib4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41575-018-0087-5","article-title":"Global epidemiology and holistic prevention of pancreatitis","volume":"16","author":"Petrov","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.pan.2023.01.008_bib5","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/S0140-6736(18)31612-X","article-title":"The Lancet Commission on global mental health and sustainable development","volume":"392","author":"Patel","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.pan.2023.01.008_bib6","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/MPA.0000000000001746","article-title":"Increasing prevalence of anxiety and depression disorders after diagnosis of chronic pancreatitis: a 5-year population-based study","volume":"50","author":"Alkhayyat","year":"2021","journal-title":"Pancreas"},{"key":"10.1016\/j.pan.2023.01.008_bib7","first-page":"115","article-title":"Psychiatric comorbidity in patients with chronic pancreatitis associates with pain and reduced quality of life","author":"Phillips","year":"2020","journal-title":"Offc J Am College Gastroentrol ACG"},{"key":"10.1016\/j.pan.2023.01.008_bib8","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.cgh.2011.04.024","article-title":"Quality of life improves for pediatric patients after total pancreatectomy and islet autotransplant for chronic pancreatitis","volume":"9","author":"Bellin","year":"2011","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.pan.2023.01.008_bib9","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1007\/s00535-020-01703-w","article-title":"Constant-severe pain in chronic pancreatitis is associated with genetic loci for major depression in the NAPS2 cohort","volume":"55","author":"Dunbar","year":"2020","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1016\/j.pan.2023.01.008_bib10","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.14309\/ajg.0000000000001366","article-title":"Pain experience in pancreatitis: strong association of genetic risk loci for anxiety and PTSD in patients with severe, constant, and constant-severe pain","volume":"116","author":"Dunbar","year":"2021","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.pan.2023.01.008_bib11","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.14309\/ajg.0000000000001491","article-title":"Psychiatric disease susceptibility and pain in chronic pancreatitis: association or causation?","volume":"116","author":"Faghih","year":"2021","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.pan.2023.01.008_bib12","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1136\/gut.2010.213835","article-title":"Type of pain, pain-associated complications, quality of life, disability and resource utilisation in chronic pancreatitis: a prospective cohort study","volume":"60","author":"Mullady","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.pan.2023.01.008_bib13","first-page":"262","article-title":"Predictors, rates, and trends of opioid use disorder among patients hospitalized with chronic pancreatitis","volume":"34","author":"Adejumo","year":"2021","journal-title":"Ann Gastroenterol"},{"issue":"2","key":"10.1016\/j.pan.2023.01.008_bib14","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1093\/ajhp\/zxab363","article-title":"Opioid-related emergency department visits and hospitalizations among patients with chronic gastrointestinal symptoms and disorders dually enrolled in the Department of Veterans Affairs and Medicare Part D","volume":"79","author":"Balbale","year":"2021","journal-title":"Am J Health Syst Pharm"},{"key":"10.1016\/j.pan.2023.01.008_bib15","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/milmed\/usab095","article-title":"Characteristics of opioid prescriptions to veterans with chronic gastrointestinal symptoms and disorders dually enrolled in the department of veterans affairs and medicare Part D","volume":"186","author":"Balbale","year":"2021","journal-title":"Mil Med"},{"key":"10.1016\/j.pan.2023.01.008_bib16","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1097\/MPA.0000000000001430","article-title":"Rising prevalence of opioid use disorder and predictors for opioid use disorder among hospitalized patients with chronic pancreatitis","volume":"48","author":"Bilal","year":"2019","journal-title":"Pancreas"},{"key":"10.1016\/j.pan.2023.01.008_bib17","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pan.2019.11.004","article-title":"Opioid use disorder in admissions for acute exacerbations of chronic pancreatitis and 30-day readmission risk: a nationwide matched analysis","volume":"20","author":"Charilaou","year":"2020","journal-title":"Pancreatology"},{"key":"10.1016\/j.pan.2023.01.008_bib18","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/MPG.0000000000002502","article-title":"Factors associated with frequent opioid use in children with acute recurrent and chronic pancreatitis","volume":"70","author":"Perito","year":"2020","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.pan.2023.01.008_bib19","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S2215-0366(21)00084-5","article-title":"6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records","volume":"8","author":"Taquet","year":"2021","journal-title":"Lancet Psychiatr"},{"key":"10.1016\/j.pan.2023.01.008_bib20","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S2215-0366(20)30462-4","article-title":"Bidirectional associations between COVID-19 and psychiatric disorder: retrospective cohort studies of 62 354 COVID-19 cases in the USA","volume":"8","author":"Taquet","year":"2021","journal-title":"Lancet Psychiatr"},{"key":"10.1016\/j.pan.2023.01.008_bib21","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1053\/j.gastro.2021.09.043","article-title":"Global incidence of acute pancreatitis is increasing over time: a systematic review and meta-analysis","volume":"162","author":"Iannuzzi","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2023.01.008_bib22","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/S0140-6736(21)02143-7","article-title":"Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic","volume":"398","author":"Santomauro","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.pan.2023.01.008_bib23","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1080\/03007995.2018.1560748","article-title":"Frequency and risk factors for mental disorders following pancreatitis: a nationwide cohort study","volume":"35","author":"Cho","year":"2019","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.pan.2023.01.008_bib24","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/apt.15068","article-title":"Depression in cirrhosis - a prospective evaluation of the prevalence, predictors and development of a screening nomogram","volume":"49","author":"Buganza-Torio","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.pan.2023.01.008_bib25","first-page":"466","article-title":"Inflammatory bowel disease and patients with mental disorders: what do we know?","volume":"13","author":"Fousekis","year":"2021","journal-title":"J\u00a0Clin Med Res"},{"key":"10.1016\/j.pan.2023.01.008_bib26","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/apt.14840","article-title":"Systematic review with meta-analysis: online psychological interventions for mental and physical health outcomes in gastrointestinal disorders including irritable bowel syndrome and inflammatory bowel disease","volume":"48","author":"Hanlon","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.pan.2023.01.008_bib27","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.cgh.2020.08.045","article-title":"Depression and anxiety are common among patients with cirrhosis","volume":"20","author":"Hernaez","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.pan.2023.01.008_bib28","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/apt.12925","article-title":"Review article: depression and the use of antidepressants in patients with chronic liver disease or liver transplantation","volume":"40","author":"Mullish","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.pan.2023.01.008_bib29","first-page":"197","article-title":"Prevalence of mental health disorders in inflammatory bowel disease: an Australian outpatient cohort","volume":"8","author":"Tribbick","year":"2015","journal-title":"Clin Exp Gastroenterol"},{"key":"10.1016\/j.pan.2023.01.008_bib30","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/MPG.0000000000001947","article-title":"Mental health service needs in children and adolescents with inflammatory bowel disease and other chronic gastrointestinal disorders","volume":"67","author":"Wong","year":"2018","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.pan.2023.01.008_bib31","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.cgh.2015.12.040","article-title":"Risk of recurrent pancreatitis and progression to chronic pancreatitis after a first episode of acute pancreatitis","volume":"14","author":"Ahmed Ali","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.pan.2023.01.008_bib32","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1097\/MPA.0b013e318221f569","article-title":"Progression from acute to chronic pancreatitis: prognostic factors, mortality, and natural course","volume":"40","author":"Nojgaard","year":"2011","journal-title":"Pancreas"},{"key":"10.1016\/j.pan.2023.01.008_bib33","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1053\/j.gastro.2015.07.066","article-title":"Frequency of progression from acute to chronic pancreatitis and risk factors: a meta-analysis","volume":"149","author":"Sankaran","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2023.01.008_bib34","doi-asserted-by":"crossref","first-page":"535","DOI":"10.5114\/aoms\/146262","article-title":"Early identification of high-risk patients with recurrent acute pancreatitis progression to chronic pancreatitis","volume":"18","author":"Tao","year":"2022","journal-title":"Arch Med Sci"},{"key":"10.1016\/j.pan.2023.01.008_bib35","first-page":"600","article-title":"Morphine worsens the severity and prevents pancreatic regeneration in mouse models of acute pancreatitis","volume":"67","author":"Barlass","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.pan.2023.01.008_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22147336","article-title":"Tissue regeneration: the dark side of opioids","volume":"22","author":"Berthezene","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.pan.2023.01.008_bib37","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1097\/MEG.0000000000002265","article-title":"Preexisting opioid use disorder is associated with poor outcomes in hospitalized acute pancreatitis patients","volume":"33","author":"Shaikh","year":"2021","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.pan.2023.01.008_bib38","first-page":"69","article-title":"Prognostic signs and the role of operative management in acute pancreatitis","volume":"139","author":"Ranson","year":"1974","journal-title":"Surg Gynecol Obstet"},{"key":"10.1016\/j.pan.2023.01.008_bib39","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1136\/gut.2008.152702","article-title":"The early prediction of mortality in acute pancreatitis: a large population-based study","volume":"57","author":"Wu","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.pan.2023.01.008_bib40","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1053\/j.gastro.2019.01.269","article-title":"Current concepts in severe acute and necrotizing pancreatitis: an evidence-based approach","volume":"156","author":"Trikudanathan","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2023.01.008_bib41","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.pan.2013.07.063","article-title":"IAP\/APA evidence-based guidelines for the management of acute pancreatitis","volume":"13","year":"2013","journal-title":"Pancreatology"},{"key":"10.1016\/j.pan.2023.01.008_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003019","article-title":"Comparison of aggregate and individual participant data approaches to meta-analysis of randomised trials: an observational study","volume":"17","author":"Tierney","year":"2020","journal-title":"PLoS Med"},{"key":"10.1016\/j.pan.2023.01.008_bib43","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.pan.2018.02.012","article-title":"Quality of life comparison between smokers and non-smokers with chronic pancreatitis","volume":"18","author":"Han","year":"2018","journal-title":"Pancreatology"},{"key":"10.1016\/j.pan.2023.01.008_bib44","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/j.pan.2020.10.031","article-title":"Divergent trends in lifetime drinking and smoking between Black and White Americans diagnosed with chronic pancreatitis","volume":"20","author":"Jeon","year":"2020","journal-title":"Pancreatology"},{"key":"10.1016\/j.pan.2023.01.008_bib45","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1136\/gut.2004.039263","article-title":"Cigarette smoking accelerates progression of alcoholic chronic pancreatitis","volume":"54","author":"Maisonneuve","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.pan.2023.01.008_bib46","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1097\/MPA.0000000000001850","article-title":"The association of smoking and alcohol abuse on anxiety and depression in patients with recurrent acute or chronic pancreatitis undergoing total pancreatectomy and islet autotransplantation: a report from the prospective observational study of tpiat cohort","volume":"50","author":"Lara","year":"2021","journal-title":"Pancreas"},{"key":"10.1016\/j.pan.2023.01.008_bib47","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000123119","article-title":"Tobacco smoking and depression--results from the WHO\/ISBRA study","volume":"57","author":"Wiesbeck","year":"2008","journal-title":"Neuropsychobiology"}],"container-title":["Pancreatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390323000339?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390323000339?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T16:18:03Z","timestamp":1761409083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1424390323000339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S1424390323000339"],"URL":"https:\/\/doi.org\/10.1016\/j.pan.2023.01.008","relation":{},"ISSN":["1424-3903"],"issn-type":[{"value":"1424-3903","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The incidence of new mental health disorders after acute pancreatitis: A large, propensity-matched, observational study","name":"articletitle","label":"Article Title"},{"value":"Pancreatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pan.2023.01.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V. on behalf of IAP and EPC.","name":"copyright","label":"Copyright"}]}}