{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:31:26Z","timestamp":1788478286152,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pancreatology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.pan.2023.07.008","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T11:53:26Z","timestamp":1690804406000},"page":"663-673","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Dynamics of intestinal and intratumoral microbiome signatures in genetically engineered mice and human pancreatic ductal adenocarcinoma"],"prefix":"10.1016","volume":"23","author":[{"given":"Nina","family":"Pfisterer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Ammer-Herrmenau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3849-044X","authenticated-orcid":false,"given":"Kai","family":"Antweiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8443-601X","authenticated-orcid":false,"given":"Stefan","family":"K\u00fcffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Ellenrieder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albrecht","family":"Neesse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pan.2023.07.008_bib1","first-page":"7","article-title":"Cancer statistics, 2021","volume":"71","author":"Siegel","year":"2021","journal-title":"CA A Cancer J Clin"},{"key":"10.1016\/j.pan.2023.07.008_bib2","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1158\/0008-5472.CAN-14-0155","article-title":"Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States","volume":"74","author":"Rahib","year":"2014","journal-title":"Cancer Res"},{"key":"10.1016\/j.pan.2023.07.008_bib3","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1136\/gutjnl-2015-309304","article-title":"Stromal biology and therapy in pancreatic cancer: a changing paradigm","volume":"64","author":"Neesse","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.pan.2023.07.008_bib4","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.jcmgh.2021.01.008","article-title":"Pharmacologic normalization of pancreatic cancer-associated fibroblast secretome impairs prometastatic cross-talk with macrophages","volume":"11","author":"Samain","year":"2021","journal-title":"Cellular and Molecular Gastroenterology and Hepatology"},{"key":"10.1016\/j.pan.2023.07.008_bib5","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.ccr.2005.04.023","article-title":"Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice","volume":"7","author":"Hingorani","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.pan.2023.07.008_bib6","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1242\/dmm.021055","article-title":"GEMMs as preclinical models for testing pancreatic cancer therapies","volume":"8","author":"Gopinathan","year":"2015","journal-title":"Disease Models & Mechanisms"},{"key":"10.1016\/j.pan.2023.07.008_bib7","doi-asserted-by":"crossref","DOI":"10.1002\/cpph.2","article-title":"Genetically engineered mouse models of pancreatic cancer: the KPC model (LSL-kras G12D\/+ ;LSL-Trp53 R172H\/+ ;Pdx-1-Cre), its variants, and their application in immuno-oncology drug discovery","volume":"73","author":"Lee","year":"2016","journal-title":"CP Pharmacology"},{"key":"10.1016\/j.pan.2023.07.008_bib8","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1097\/PPO.0b013e31827ab4c4","article-title":"Genetically engineered mouse models of pancreatic cancer","volume":"18","author":"Westphalen","year":"2012","journal-title":"Cancer J"},{"key":"10.1016\/j.pan.2023.07.008_bib9","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3390\/cells9010058","article-title":"Stromal features of the primary tumor are not prognostic in genetically engineered mice of pancreatic cancer","volume":"9","author":"Hasselluhn","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.pan.2023.07.008_bib10","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00262-022-03237-x","article-title":"Personalized tumor vaccine for pancreatic cancer","volume":"72","author":"Orr","year":"2023","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.pan.2023.07.008_bib11","article-title":"Combination cancer immunotherapy targeting TNFR2 and PD-1\/PD-L1 signaling reduces immunosuppressive effects in the microenvironment of pancreatic tumors","volume":"10","author":"Zhang","year":"2022","journal-title":"J\u00a0Immunother Cancer"},{"key":"10.1016\/j.pan.2023.07.008_bib12","first-page":"2201","article-title":"Prediction of therapeutic outcome and survival in a transgenic mouse model of pancreatic ductal adenocarcinoma treated with dendritic cell vaccination or cdk inhibitor using mri texture: a feasibility study","volume":"12","author":"Eresen","year":"2020","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.pan.2023.07.008_bib13","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1097\/MCG.0000000000001092","article-title":"The microbiome and pancreatic cancer: an evidence-based association?","volume":"52","author":"Archibugi","year":"2018","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.pan.2023.07.008_bib14","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1126\/science.aah5043","article-title":"Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine","volume":"357","author":"Geller","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.pan.2023.07.008_bib15","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1158\/2159-8290.CD-17-1134","article-title":"The pancreatic cancer microbiome promotes oncogenesis by induction of innate and adaptive immune suppression","volume":"8","author":"Pushalkar","year":"2018","journal-title":"Cancer Discov"},{"key":"10.1016\/j.pan.2023.07.008_bib16","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.aay9189","article-title":"The human tumor microbiome is composed of tumor type\u2013specific intracellular bacteria","volume":"368","author":"Nejman","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.pan.2023.07.008_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2019.07.008","article-title":"Tumor microbiome diversity and composition influence pancreatic cancer outcomes","volume":"178","author":"Riquelme","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.pan.2023.07.008_bib18","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1136\/gutjnl-2021-324755","article-title":"A\u00a0faecal microbiota signature with high specificity for pancreatic cancer","volume":"71","author":"Kartal","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.pan.2023.07.008_bib19","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1053\/j.gastro.2022.03.054","article-title":"Metagenomic identification of microbial signatures predicting pancreatic cancer from a multinational study","volume":"163","author":"Nagata","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2023.07.008_bib20","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1128\/aem.56.6.1919-1925.1990","article-title":"Combination of 16S RRNA-targeted oligonucleotide probes with flow cytometry for analyzing mixed microbial populations","volume":"56","author":"Amann","year":"1990","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.pan.2023.07.008_bib21","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1093\/femsre\/fuy040","article-title":"Fluorescence in situ hybridization, a complementary molecular tool for the clinical diagnosis of infectious diseases by intracellular and fastidious bacteria","volume":"43","author":"Prudent","year":"2019","journal-title":"FEMS (Fed Eur Microbiol Soc) Microbiol Rev"},{"key":"10.1016\/j.pan.2023.07.008_bib22","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/cyto.990140205","article-title":"Optimizing fluorescent in situ hybridization with RRNA-targeted oligonucleotide probes for flow cytometric identification of microorganisms","volume":"14","author":"Wallner","year":"1993","journal-title":"Cytometry"},{"key":"10.1016\/j.pan.2023.07.008_bib23","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00750-21","article-title":"Comprehensive wet-bench and bioinformatics workflow for complex microbiota using Oxford Nanopore Technologies","volume":"6","author":"Ammer-Herrmenau","year":"2021","journal-title":"mSystems"},{"key":"10.1016\/j.pan.2023.07.008_bib24","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1093\/biostatistics\/kxy020","article-title":"PERFect: PERmutation filtering test for microbiome data","volume":"20","author":"Smirnova","year":"2019","journal-title":"Biostatistics"},{"key":"10.1016\/j.pan.2023.07.008_bib25","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s40168-018-0605-2","article-title":"Simple statistical identification and removal of contaminant sequences in marker-gene and metagenomics data","volume":"6","author":"Davis","year":"2018","journal-title":"Microbiome"},{"key":"10.1016\/j.pan.2023.07.008_bib26","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol"},{"key":"10.1016\/j.pan.2023.07.008_bib27","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/s41586-020-2881-9","article-title":"Host variables confound gut microbiota studies of human disease","volume":"587","author":"Vujkovic-Cvijin","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.pan.2023.07.008_bib28","doi-asserted-by":"crossref","first-page":"5029","DOI":"10.1038\/s41467-019-13036-1","article-title":"Evaluation of 16S RRNA gene sequencing for species and strain-level microbiome analysis","volume":"10","author":"Johnson","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.pan.2023.07.008_bib29","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/s41586-022-05435-0","article-title":"Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer","volume":"611","author":"Galeano Ni\u00f1o","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.pan.2023.07.008_bib30","first-page":"3","article-title":"Preclinical mouse models for immunotherapeutic and non-immunotherapeutic drug development for pancreatic ductal adenocarcinoma","author":"He","year":"2020","journal-title":"Annals of Pancreatic Cancer"},{"key":"10.1016\/j.pan.2023.07.008_bib31","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.3390\/cancers14164017","article-title":"DWI metrics differentiating benign intraductal papillary mucinous neoplasms from invasive pancreatic cancer: a study in GEM models","volume":"14","author":"Romanello Joaquim","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.pan.2023.07.008_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106841","article-title":"Gender-specific changes of the gut microbiome correlate with tumor development in murine models of pancreatic cancer","volume":"26","author":"Kaune","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.pan.2023.07.008_bib33","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/s11938-018-0197-8","article-title":"Pancreatic cancer and diabetes mellitus","volume":"16","author":"Sharma","year":"2018","journal-title":"Curr Treat Options Gastroenterol"},{"key":"10.1016\/j.pan.2023.07.008_bib34","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3390\/nu9030243","article-title":"Nutritional and metabolic derangements in pancreatic cancer and pancreatic resection","volume":"9","author":"Gilliland","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.pan.2023.07.008_bib35","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s00592-019-01335-4","article-title":"Glucose metabolism during tumorigenesis in the genetic mouse model of pancreatic cancer","volume":"56","author":"Pasquale","year":"2019","journal-title":"Acta Diabetol"},{"key":"10.1016\/j.pan.2023.07.008_bib36","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cmet.2017.02.007","article-title":"Orai1-Mediated antimicrobial secretion from pancreatic acini shapes the gut microbiome and regulates gut innate immunity","volume":"25","author":"Ahuja","year":"2017","journal-title":"Cell Metabol"},{"key":"10.1016\/j.pan.2023.07.008_bib37","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1053\/j.gastro.2018.10.047","article-title":"Impaired exocrine pancreatic function associates with changes in intestinal microbiota composition and diversity","volume":"156","author":"Frost","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2023.07.008_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.devcel.2019.09.018","article-title":"N-WASP control of LPAR1 trafficking establishes response to self-generated LPA gradients to promote pancreatic cancer cell metastasis","volume":"51","author":"Juin","year":"2019","journal-title":"Dev Cell"}],"container-title":["Pancreatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390323016022?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390323016022?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T16:18:41Z","timestamp":1761409121000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1424390323016022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S1424390323016022"],"URL":"https:\/\/doi.org\/10.1016\/j.pan.2023.07.008","relation":{},"ISSN":["1424-3903"],"issn-type":[{"value":"1424-3903","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dynamics of intestinal and intratumoral microbiome signatures in genetically engineered mice and human pancreatic ductal adenocarcinoma","name":"articletitle","label":"Article Title"},{"value":"Pancreatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pan.2023.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V. on behalf of IAP and EPC.","name":"copyright","label":"Copyright"}]}}