{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:50:14Z","timestamp":1788922214047,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pancreatology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.pan.2024.12.014","type":"journal-article","created":{"date-parts":[[2024,12,29]],"date-time":"2024-12-29T06:46:51Z","timestamp":1735454811000},"page":"12-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["No definite associations between opioid doses and severity of acute pancreatitis \u2013 Results from a multicentre international prospective study"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8373-1487","authenticated-orcid":false,"given":"Cecilie Siggaard","family":"Knoph","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2872-0977","authenticated-orcid":false,"given":"Nejo","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6979-7818","authenticated-orcid":false,"given":"James","family":"Lucocq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3916-3168","authenticated-orcid":false,"given":"S\u00f8ren Schou","family":"Olesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6929-4276","authenticated-orcid":false,"given":"Jahnvi","family":"Dhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9277-5086","authenticated-orcid":false,"given":"Jayanta","family":"Samanta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4255-6651","authenticated-orcid":false,"given":"Rupjyoti","family":"Talukdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Capurso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6515-7960","authenticated-orcid":false,"given":"Paoletta","family":"Preatoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2412-9541","authenticated-orcid":false,"family":"Enrique de-Madaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7078-9893","authenticated-orcid":false,"given":"Dhiraj","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5995-5432","authenticated-orcid":false,"given":"John","family":"Windsor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7465-964X","authenticated-orcid":false,"given":"Asbj\u00f8rn Mohr","family":"Drewes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manu","family":"Nayar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3099-2197","authenticated-orcid":false,"family":"Sanjay Pandanaboyana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.pan.2024.12.014_bib1","first-page":"1251","article-title":"Acute pancreatitis: diagnosis and treatment","volume":"82","author":"Szatmary","year":"2022"},{"issue":"3","key":"10.1016\/j.pan.2024.12.014_bib2","first-page":"610","article-title":"The characteristics and prognostic role of acute abdominal on-admission pain in acute pancreatitis: a prospective cohort analysis of 1432 cases","volume":"26","author":"F\u00f6ldi","year":"2022"},{"issue":"4","key":"10.1016\/j.pan.2024.12.014_bib3","first-page":"878","article-title":"Analgesia in the initial management of acute pancreatitis: a systematic review and meta-analysis of randomised controlled trials","volume":"46","author":"Thavanesan","year":"2022"},{"issue":"3","key":"10.1016\/j.pan.2024.12.014_bib4","first-page":"419","article-title":"American College of gastroenterology guidelines: management of acute pancreatitis","volume":"119","author":"Tenner","year":"2024"},{"issue":"1","key":"10.1016\/j.pan.2024.12.014_bib5","article-title":"Pain management in acute pancreatitis: a systematic review and meta-analysis of randomised controlled trials","volume":"8","author":"Cai","year":"2021"},{"issue":"5","key":"10.1016\/j.pan.2024.12.014_bib6","first-page":"487","article-title":"Update on pain management in acute pancreatitis","volume":"38","author":"Pandanaboyana","year":"2022"},{"issue":"7","key":"10.1016\/j.pan.2024.12.014_bib7","first-page":"902","article-title":"Treatment of acute abdominal pain in the emergency room: a systematic review of the literature","volume":"18","author":"Falch","year":"2014"},{"issue":"3","key":"10.1016\/j.pan.2024.12.014_bib8","first-page":"326","article-title":"Opioid analgesia and severity of acute pancreatitis: an international multicentre cohort study on pain management in acute pancreatitis","volume":"12","author":"Pandanaboyana","year":"2024"},{"issue":"4","key":"10.1016\/j.pan.2024.12.014_bib9","first-page":"1362","article-title":"Morphologic severity of acute pancreatitis on imaging is independently associated with opioid dose requirements in hospitalized patients","volume":"67","author":"Ashok","year":"2022"},{"issue":"1","key":"10.1016\/j.pan.2024.12.014_bib10","first-page":"102","article-title":"Classification of acute pancreatitis - 2012: revision of the Atlanta classification and definitions by international consensus","volume":"62","author":"Banks","year":"2013"},{"key":"10.1016\/j.pan.2024.12.014_bib11","series-title":"Global trends in opioid use for pain management in acute pancreatitis: a multicentre prospective observational study","author":"Knoph","year":"2024"},{"issue":"5","key":"10.1016\/j.pan.2024.12.014_bib12","first-page":"373","article-title":"A\u00a0new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"Charlson","year":"1987"},{"issue":"1","key":"10.1016\/j.pan.2024.12.014_bib13","first-page":"1","article-title":"Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD Statement","volume":"13","author":"Collins","year":"2015"},{"issue":"7","key":"10.1016\/j.pan.2024.12.014_bib14","first-page":"CD009179","article-title":"Opioids for acute pancreatitis pain","volume":"2013","author":"Basurto","year":"2013"},{"issue":"4","key":"10.1016\/j.pan.2024.12.014_bib15","first-page":"281","article-title":"The efficacy and safety of using opioids in acute pancreatitis: an update on systematic review and meta-analysis","volume":"77","author":"Almulhim","year":"2023"},{"issue":"3","key":"10.1016\/j.pan.2024.12.014_bib16","first-page":"201","article-title":"Parenteral analgesics for pain relief in acute pancreatitis","volume":"13","author":"Meng","year":"2013","journal-title":"a systematic review"},{"issue":"12","key":"10.1016\/j.pan.2024.12.014_bib17","first-page":"2582","article-title":"Controversies in the management of acute pancreatitis: an update","volume":"11","author":"Manrai","year":"2023"},{"key":"10.1016\/j.pan.2024.12.014_bib18","series-title":"No effect of methylnaltrexone on acute pancreatitis severity: a multicenter randomized controlled trial","first-page":"1","author":"Knoph","year":"2024"},{"issue":"4","key":"10.1016\/j.pan.2024.12.014_bib19","first-page":"600","article-title":"Morphine worsens the severity and prevents pancreatic regeneration in mouse models of acute pancreatitis","volume":"67","author":"Barlass","year":"2018"},{"key":"10.1016\/j.pan.2024.12.014_bib20","series-title":"Buprenorphine affects the initiation and severity of interleukin induced acute pancreatitis in mice","author":"Jahangir","year":"2024"},{"issue":"6","key":"10.1016\/j.pan.2024.12.014_bib21","first-page":"801","article-title":"Prescription opioids induce gut dysbiosis and exacerbate colitis in a murine model of inflammatory bowel disease","volume":"14","author":"Sharma","year":"2020"},{"issue":"4","key":"10.1016\/j.pan.2024.12.014_bib22","first-page":"276","article-title":"The effectiveness and risks of long-term opioid therapy for chronic pain: a systematic review for a National Institutes of Health Pathways to Prevention Workshop","volume":"162","author":"Chou","year":"2015"},{"issue":"5","key":"10.1016\/j.pan.2024.12.014_bib23","first-page":"895","article-title":"Opioid use among patients with inflammatory bowel disease: a systematic review and meta-analysis","volume":"19","author":"Niccum","year":"2021"},{"issue":"3","key":"10.1016\/j.pan.2024.12.014_bib24","first-page":"297","article-title":"Association of prescribed opioids with increased risk of community-acquired pneumonia among patients with and without HIV","volume":"179","author":"Edelman","year":"2019"},{"key":"10.1016\/j.pan.2024.12.014_bib25","first-page":"2914","article-title":"Do all opioid drugs share the same immunomodulatory properties?","volume":"10","author":"Franchi","year":"2019","journal-title":"A\u00a0Review From Animal and Human Studies"},{"issue":"5","key":"10.1016\/j.pan.2024.12.014_bib26","first-page":"813","article-title":"Pentazocine, a kappa-opioid agonist, is better than diclofenac for analgesia in acute pancreatitis: a randomized","volume":"114","author":"Mahapatra","year":"2019","journal-title":"Controlled Trial"},{"key":"10.1016\/j.pan.2024.12.014_bib27","series-title":"Buprenorphine versus diclofenac for pain relief in acute pancreatitis: a double-blinded randomized controlled trial","author":"Saini","year":"2023"},{"issue":"12","key":"10.1016\/j.pan.2024.12.014_bib28","first-page":"1319","article-title":"Buprenorphine or procaine for pain relief in acute pancreatitis","volume":"35","author":"Jakobs","year":"2000","journal-title":"A\u00a0prospective randomized study"},{"issue":"1","key":"10.1016\/j.pan.2024.12.014_bib29","first-page":"5","article-title":"Procaine hydrochloride fails to relieve pain in patients with acute pancreatitis","volume":"69","author":"Kahl","year":"2004"},{"issue":"1","key":"10.1016\/j.pan.2024.12.014_bib30","first-page":"14","article-title":"Opioid-induced immunosuppression","volume":"2","author":"Sacerdote","year":"2008"},{"key":"10.1016\/j.pan.2024.12.014_bib31","series-title":"Complexity of trials on pain management in acute pancreatitis: an ongoing challenge","author":"Kamarajah","year":"2024"}],"container-title":["Pancreatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390324008421?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390324008421?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T22:01:56Z","timestamp":1740607316000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1424390324008421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S1424390324008421"],"URL":"https:\/\/doi.org\/10.1016\/j.pan.2024.12.014","relation":{},"ISSN":["1424-3903"],"issn-type":[{"value":"1424-3903","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"No definite associations between opioid doses and severity of acute pancreatitis \u2013 Results from a multicentre international prospective study","name":"articletitle","label":"Article Title"},{"value":"Pancreatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pan.2024.12.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 IAP and EPC. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}