{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:37:55Z","timestamp":1787920675239,"version":"build-2784847793"},"reference-count":77,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T00:00:00Z","timestamp":1746921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pancreatology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.pan.2025.05.003","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T23:30:58Z","timestamp":1746919858000},"page":"516-527","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Chronic pancreatitis and extra pancreatic cancers- A systematic review and meta analysis"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9382-5030","authenticated-orcid":false,"given":"Shauntelle","family":"Quammie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6794-6621","authenticated-orcid":false,"given":"Colin John","family":"Crooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7326-0917","authenticated-orcid":false,"given":"Abdulsalam","family":"Aliyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guruprasad P.","family":"Aithal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aloysious D.","family":"Aravinthan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"24","key":"10.1016\/j.pan.2025.05.003_bib1","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1001\/jama.2019.19411","article-title":"Diagnosis and management of chronic pancreatitis: a review","volume":"322","author":"Singh","year":"2019","journal-title":"JAMA"},{"issue":"30","key":"10.1016\/j.pan.2025.05.003_bib2","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.3748\/wjg.v29.i30.4671","article-title":"Incidence, prevalence, and comorbidities of chronic pancreatitis: a 7-year population-based study","volume":"29","author":"Cai","year":"2023","journal-title":"World J Gastroenterol"},{"issue":"6","key":"10.1016\/j.pan.2025.05.003_bib3","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.pan.2014.08.008","article-title":"The seventh nationwide epidemiological survey for chronic pancreatitis in Japan: clinical significance of smoking habit in Japanese patients","volume":"14","author":"Hirota","year":"2014","journal-title":"Pancreatology"},{"issue":"12","key":"10.1016\/j.pan.2025.05.003_bib4","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1038\/ajg.2011.328","article-title":"Incidence, prevalence, and survival of chronic pancreatitis: a population-based study","volume":"106","author":"Yadav","year":"2011","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"10.1016\/j.pan.2025.05.003_bib5","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1177\/2050640620966513","article-title":"Time trends in incidence and prevalence of chronic pancreatitis: a 25-year population-based nationwide study","volume":"9","author":"Olesen","year":"2021","journal-title":"United European Gastroenterol J"},{"issue":"1","key":"10.1016\/j.pan.2025.05.003_bib6","doi-asserted-by":"crossref","DOI":"10.14309\/ctg.0000000000000455","article-title":"Acute and chronic pancreatitis disease prevalence, classification, and comorbidities: a cohort study of the UK BioBank","volume":"13","author":"Spagnolo","year":"2022","journal-title":"Clin Transl Gastroenterol"},{"issue":"3","key":"10.1016\/j.pan.2025.05.003_bib7","doi-asserted-by":"crossref","DOI":"10.14309\/ctg.0000000000000463","article-title":"Chronic pancreatitis is a risk factor for pancreatic cancer, and incidence increases with duration of disease: a systematic review and meta-analysis","volume":"13","author":"Gandhi","year":"2022","journal-title":"Clin Transl Gastroenterol"},{"issue":"9","key":"10.1016\/j.pan.2025.05.003_bib8","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/ajg.2017.218","article-title":"Chronic pancreatitis and pancreatic cancer risk: a systematic review and meta-analysis","volume":"112","author":"Kirkegard","year":"2017","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"10.1016\/j.pan.2025.05.003_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15030761","article-title":"Pancreatic cancer in chronic pancreatitis: pathogenesis and diagnostic approach","volume":"15","author":"Le Cosquer","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"3","key":"10.1016\/j.pan.2025.05.003_bib10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF02784947","article-title":"Chronic pancreatitis and extrapancreatic cancer: a retrospective study among 181 patients with chronic pancreatitis","volume":"18","author":"Hansen","year":"1995","journal-title":"Int J Pancreatol"},{"issue":"4","key":"10.1016\/j.pan.2025.05.003_bib11","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3109\/00365528009181490","article-title":"High incidence of extrapancreatic carcinoma in chronic pancreatitis","volume":"15","author":"Ammann","year":"1980","journal-title":"Scand J Gastroenterol"},{"issue":"1","key":"10.1016\/j.pan.2025.05.003_bib12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s10654-022-00945-7","article-title":"Smoking as the most important risk factor for chronic pancreatitis in the general population","volume":"38","author":"Hansen","year":"2023","journal-title":"Eur J Epidemiol"},{"issue":"2","key":"10.1016\/j.pan.2025.05.003_bib13","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1097\/00006676-200308000-00008","article-title":"Pancreatic stellate cell activation by ethanol and acetaldehyde: is it mediated by the mitogen-activated protein kinase signaling pathway?","volume":"27","author":"McCarroll","year":"2003","journal-title":"Pancreas"},{"issue":"4","key":"10.1016\/j.pan.2025.05.003_bib14","first-page":"183","article-title":"Proinflammatory cytokines: an insight into pancreatic oncogenesis","volume":"69","author":"Miron","year":"2010","journal-title":"Roum Arch Microbiol Immunol"},{"issue":"9\u201310","key":"10.1016\/j.pan.2025.05.003_bib15","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/prca.201200051","article-title":"Serum proteome profiling of pancreatitis using recombinant antibody microarrays reveals disease-associated biomarker signatures","volume":"6","author":"Sandstrom","year":"2012","journal-title":"Proteonomics Clin Appl"},{"issue":"2","key":"10.1016\/j.pan.2025.05.003_bib16","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.gene.2014.02.014","article-title":"A single-nucleotide polymorphism in tumor necrosis factor-alpha (-308 G\/A) as a biomarker in chronic pancreatitis","volume":"539","author":"Sri Manjari","year":"2014","journal-title":"Gene"},{"issue":"2","key":"10.1016\/j.pan.2025.05.003_bib17","doi-asserted-by":"crossref","first-page":"190","DOI":"10.5114\/ceji.2018.76273","article-title":"Scientific reports concerning the impact of interleukin 4, interleukin 10 and transforming growth factor beta on cancer cells","volume":"44","author":"Kwasniak","year":"2019","journal-title":"Cent Eur J Immunol"},{"issue":"6","key":"10.1016\/j.pan.2025.05.003_bib18","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1002\/cam4.330","article-title":"Interleukin-4 receptor alpha overexpression in human bladder cancer correlates with the pathological grade and stage of the disease","volume":"3","author":"Joshi","year":"2014","journal-title":"Cancer Med"},{"issue":"7","key":"10.1016\/j.pan.2025.05.003_bib19","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1158\/0008-5472.CAN-04-3592","article-title":"Aberrant Stat3 signaling by interleukin-4 in malignant glioma cells: involvement of IL-13Ralpha2","volume":"65","author":"Rahaman","year":"2005","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.pan.2025.05.003_bib20","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/(SICI)1097-0215(19970117)70:2<230::AID-IJC15>3.0.CO;2-M","article-title":"Human ovarian-carcinoma cell lines express IL-4 and IL-13 receptors: comparison between IL-4- and IL-13-induced signal transduction","volume":"70","author":"Murata","year":"1997","journal-title":"Int J Cancer"},{"issue":"11","key":"10.1016\/j.pan.2025.05.003_bib21","first-page":"3503","article-title":"Interleukin 4 receptor on human lung cancer: a molecular target for cytotoxin therapy","volume":"8","author":"Kawakami","year":"2002","journal-title":"Clin Cancer Res"},{"issue":"5","key":"10.1016\/j.pan.2025.05.003_bib22","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.bbamcr.2015.02.020","article-title":"IL4 receptor alpha mediates enhanced glucose and glutamine metabolism to support breast cancer growth","volume":"1853","author":"Venmar","year":"2015","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"10.1016\/j.pan.2025.05.003_bib23","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1093\/carcin\/bgq044","article-title":"Epithelial interleukin-4 receptor expression promotes colon tumor growth","volume":"31","author":"Koller","year":"2010","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.pan.2025.05.003_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.760971","article-title":"IL-6\/STAT3 is a promising therapeutic target for hepatocellular carcinoma","volume":"11","author":"Xu","year":"2021","journal-title":"Front Oncol"},{"issue":"3","key":"10.1016\/j.pan.2025.05.003_bib25","doi-asserted-by":"crossref","first-page":"201","DOI":"10.21037\/hbsn.2016.03.02","article-title":"STAT3 is a key transcriptional regulator of cancer stem cell marker CD133 in HCC","volume":"5","author":"Ghoshal","year":"2016","journal-title":"Hepatobiliary Surg Nutr"},{"issue":"9","key":"10.1016\/j.pan.2025.05.003_bib26","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.cellsig.2016.06.009","article-title":"IL-6\/STAT3 axis initiated CAFs via up-regulating TIMP-1 which was attenuated by acetylation of STAT3 induced by PCAF in HCC microenvironment","volume":"28","author":"Zheng","year":"2016","journal-title":"Cell Signal"},{"issue":"11","key":"10.1016\/j.pan.2025.05.003_bib27","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1038\/bjc.2012.177","article-title":"Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis","volume":"106","author":"Lee","year":"2012","journal-title":"Br J Cancer"},{"issue":"10","key":"10.1016\/j.pan.2025.05.003_bib28","doi-asserted-by":"crossref","first-page":"3694","DOI":"10.1158\/0008-5472.CAN-03-3264","article-title":"Alteration of gene expression in normal-appearing colon mucosa of APC(min) mice and human cancer patients","volume":"64","author":"Chen","year":"2004","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.pan.2025.05.003_bib29","first-page":"30","article-title":"A survey on the role of interleukin-10 in breast cancer: a narrative","volume":"7","author":"Sheikhpour","year":"2018","journal-title":"Rep Biochem Mol Biol"},{"issue":"1","key":"10.1016\/j.pan.2025.05.003_bib30","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2478\/v10035-011-0004-x","article-title":"Association of -1112 c\/t promoter region polymorphism of the interleukin 13 gene with occurrence of colorectal cancer","volume":"83","author":"Walczak","year":"2011","journal-title":"Pol Przegl Chir"},{"issue":"6","key":"10.1016\/j.pan.2025.05.003_bib31","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1158\/1055-9965.EPI-06-0042","article-title":"Inflammation-related gene polymorphisms and colorectal adenoma","volume":"15","author":"Gunter","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"7","key":"10.1016\/j.pan.2025.05.003_bib32","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1093\/carcin\/bgp122","article-title":"A specific interleukin-1B haplotype correlates with high levels of IL1B mRNA in the lung and increased risk of non-small cell lung cancer","volume":"30","author":"Landvik","year":"2009","journal-title":"Carcinogenesis"},{"issue":"11","key":"10.1016\/j.pan.2025.05.003_bib33","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1172\/JCI23298","article-title":"Infiltration of COX-2-expressing macrophages is a prerequisite for IL-1 beta-induced neovascularization and tumor growth","volume":"115","author":"Nakao","year":"2005","journal-title":"J Clin Investig"},{"issue":"6","key":"10.1016\/j.pan.2025.05.003_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15061841","article-title":"Tumour necrosis factor alpha (TNF-alpha) and oral squamous cell carcinoma","volume":"15","author":"Brierly","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"5","key":"10.1016\/j.pan.2025.05.003_bib35","doi-asserted-by":"crossref","first-page":"323","DOI":"10.4062\/biomolther.2013.072","article-title":"Targeting the transforming growth factor-beta signaling in cancer therapy","volume":"21","author":"Sheen","year":"2013","journal-title":"Biomol Ther (Seoul)"},{"key":"10.1016\/j.pan.2025.05.003_bib36","article-title":"Regulation of TGF-beta signal transduction","volume":"2014","author":"Zhao","year":"2014","journal-title":"Sci Tech Rep"},{"issue":"1","key":"10.1016\/j.pan.2025.05.003_bib37","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00441-017-2633-9","article-title":"Role of TGF-beta in metastatic colon cancer: it is finally time for targeted therapy","volume":"370","author":"Villalba","year":"2017","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.pan.2025.05.003_bib38","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"Br Med J"},{"issue":"15","key":"10.1016\/j.pan.2025.05.003_bib39","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of Observational Studies in Epidemiology (MOOSE) group","volume":"283","author":"Stroup","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.pan.2025.05.003_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v036.i03","article-title":"Conducting meta-analyses in {R} with the {metafor} package","volume":"36","author":"Viechtbauer","year":"2010","journal-title":"J Stat Software"},{"issue":"4","key":"10.1016\/j.pan.2025.05.003_bib41","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1053\/j.gastro.2013.12.033","article-title":"Mortality, cancer, and comorbidities associated with chronic pancreatitis: a Danish nationwide matched-cohort study","volume":"146","author":"Bang","year":"2014","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.pan.2025.05.003_bib42","doi-asserted-by":"crossref","first-page":"213","DOI":"10.21037\/atm.2020.01.40","article-title":"Risk of head and neck cancer after chronic pancreatitis","volume":"8","author":"Chen","year":"2020","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.pan.2025.05.003_bib43","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.14309\/01.ajg.0000698072.57675.f5","article-title":"S0047 chronic pancreatitis as a possible risk factor for colorectal cancer: a large population data analysis","volume":"115","author":"Dahabra","year":"2020","journal-title":"Official J. American College of Gastroenterology | ACG"},{"issue":"5","key":"10.1016\/j.pan.2025.05.003_bib44","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/MEG.0b013e3282f4489f","article-title":"Liver cirrhosis, other liver diseases, pancreatitis and subsequent cancer: record linkage study","volume":"20","author":"Goldacre","year":"2008","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.pan.2025.05.003_bib45","doi-asserted-by":"crossref","first-page":"5545","DOI":"10.1038\/s41598-022-09426-z","article-title":"Chronic pancreatitis and cancer risk in a matched cohort study using national claims data in South Korea","volume":"12","author":"Han","year":"2022","journal-title":"Sci Rep"},{"issue":"16","key":"10.1016\/j.pan.2025.05.003_bib46","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1056\/NEJM197304192881603","article-title":"Relations between pancreatic enzyme outputs and malabsorption in severe pancreatic insufficiency","volume":"288","author":"DiMagno","year":"1973","journal-title":"N Engl J Med"},{"issue":"15","key":"10.1016\/j.pan.2025.05.003_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12155102","article-title":"The impact of chronic pancreatitis on the occurrences of human cancers: Real-World data","volume":"12","author":"Hsieh","year":"2023","journal-title":"J Clin Med"},{"issue":"3","key":"10.1016\/j.pan.2025.05.003_bib48","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1159\/000201029","article-title":"Natural course in chronic pancreatitis. Pain, exocrine and endocrine pancreatic insufficiency and prognosis of the disease","volume":"54","author":"Lankisch","year":"1993","journal-title":"Digestion"},{"issue":"7","key":"10.1016\/j.pan.2025.05.003_bib49","doi-asserted-by":"crossref","first-page":"925","DOI":"10.3109\/00365528209181116","article-title":"Chronic pancreatitis in Copenhagen. A retrospective study of 64 consecutive patients","volume":"17","author":"Thorsgaard Pedersen","year":"1982","journal-title":"Scand J Gastroenterol"},{"issue":"11","key":"10.1016\/j.pan.2025.05.003_bib50","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1007\/s11605-008-0620-x","article-title":"Survival rates and cause of death in 174 patients with chronic pancreatitis","volume":"12","author":"Pedrazzoli","year":"2008","journal-title":"J Gastrointest Surg"},{"issue":"2","key":"10.1016\/j.pan.2025.05.003_bib51","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/00004836-198704000-00013","article-title":"Increased incidence of cancer in chronic pancreatitis","volume":"9","author":"Rocca","year":"1987","journal-title":"J Clin Gastroenterol"},{"issue":"5","key":"10.1016\/j.pan.2025.05.003_bib52","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1111\/j.1572-0241.1999.01075.x","article-title":"Incidence of cancer in the course of chronic pancreatitis","volume":"94","author":"Talamini","year":"1999","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"10.1016\/j.pan.2025.05.003_bib53","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/00004836-200302000-00014","article-title":"Chronic pancreatitis. Long-term pain relief with or without surgery, cancer risk, and mortality","volume":"36","author":"Thuluvath","year":"2003","journal-title":"J Clin Gastroenterol"},{"issue":"9","key":"10.1016\/j.pan.2025.05.003_bib54","first-page":"1467","article-title":"Prognosis of chronic pancreatitis: an international multicenter study. International Pancreatitis Study Group","volume":"89","author":"Lowenfels","year":"1994","journal-title":"Am J Gastroenterol"},{"issue":"77","key":"10.1016\/j.pan.2025.05.003_bib55","first-page":"1579","article-title":"The incidence of pancreatic and extrapancreatic cancers in Japanese patients with chronic pancreatitis","volume":"54","author":"Kamisawa","year":"2007","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.pan.2025.05.003_bib56","series-title":"CASP (cohort study)","article-title":"Critical appraisal Skills Programme","year":"2018"},{"issue":"3","key":"10.1016\/j.pan.2025.05.003_bib57","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1080\/00365520310008296","article-title":"Alcohol modulates circulating levels of interleukin-6 and monocyte chemoattractant protein-1 in chronic pancreatitis","volume":"39","author":"Pedersen","year":"2004","journal-title":"Scand J Gastroenterol"},{"issue":"8","key":"10.1016\/j.pan.2025.05.003_bib58","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.cgh.2007.02.039","article-title":"Incidence and predictors of hepatocellular carcinoma in patients with cirrhosis","volume":"5","author":"Ioannou","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"6","key":"10.1016\/j.pan.2025.05.003_bib59","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/s41575-023-00759-2","article-title":"Global epidemiology of cirrhosis - aetiology, trends and predictions","volume":"20","author":"Huang","year":"2023","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"8","key":"10.1016\/j.pan.2025.05.003_bib60","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/S2468-1253(22)00050-4","article-title":"Worldwide prevalence of hepatitis B virus and hepatitis C virus among patients with cirrhosis at country, region, and global levels: a systematic review","volume":"7","author":"Alberts","year":"2022","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"18","key":"10.1016\/j.pan.2025.05.003_bib61","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1001\/jama.2023.5997","article-title":"Diagnosis and management of cirrhosis and its complications: a review","volume":"329","author":"Tapper","year":"2023","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.pan.2025.05.003_bib62","doi-asserted-by":"crossref","first-page":"638","DOI":"10.3748\/wjg.v19.i5.638","article-title":"Alcohol consumption on pancreatic diseases","volume":"19","author":"Herreros-Villanueva","year":"2013","journal-title":"World J Gastroenterol"},{"issue":"11","key":"10.1016\/j.pan.2025.05.003_bib63","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.cgh.2009.06.010","article-title":"Pancreas and liver injury are associated in individuals with increased alcohol consumption","volume":"7","author":"Pace","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.pan.2025.05.003_bib64","first-page":"106","article-title":"Identifying common genes and networks in multi-organ fibrosis","volume":"2012","author":"Wenzke","year":"2012","journal-title":"AMIA Jt Summits Transl Sci Proc"},{"issue":"7","key":"10.1016\/j.pan.2025.05.003_bib65","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1023\/A:1026670911955","article-title":"Alcohol and smoking as risk factors in chronic pancreatitis and pancreatic cancer","volume":"44","author":"Talamini","year":"1999","journal-title":"Dig Dis Sci"},{"issue":"3","key":"10.1016\/j.pan.2025.05.003_bib66","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrgastro.2010.6","article-title":"The role of alcohol and smoking in pancreatitis","volume":"7","author":"Yadav","year":"2010","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.pan.2025.05.003_bib67","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1572-0241.2006.00405.x","article-title":"Chronic pancreatic inflammation induced by environmental tobacco smoke inhalation in rats","volume":"101","author":"Wittel","year":"2006","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"10.1016\/j.pan.2025.05.003_bib68","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"issue":"3","key":"10.1016\/j.pan.2025.05.003_bib69","doi-asserted-by":"crossref","first-page":"220","DOI":"10.21037\/tlcr.2018.05.06","article-title":"The epidemiology of lung cancer","volume":"7","author":"de Groot","year":"2018","journal-title":"Transl Lung Cancer Res"},{"issue":"3","key":"10.1016\/j.pan.2025.05.003_bib70","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"issue":"Suppl 2","key":"10.1016\/j.pan.2025.05.003_bib71","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.lungcan.2004.07.998","article-title":"Tobacco smoking and cancer: a brief review of recent epidemiological evidence","volume":"45","author":"Sasco","year":"2004","journal-title":"Lung Cancer"},{"issue":"6","key":"10.1016\/j.pan.2025.05.003_bib72","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00423-006-0111-z","article-title":"Cigarette smoking: cancer risks, carcinogens, and mechanisms","volume":"391","author":"Hecht","year":"2006","journal-title":"Langenbecks Arch Surg"},{"issue":"1","key":"10.1016\/j.pan.2025.05.003_bib73","article-title":"The molecular mechanisms of tobacco in cancer pathogenesis","volume":"10","author":"Nooshinfar","year":"2017","journal-title":"Int J Cancer Manag"},{"issue":"8","key":"10.1016\/j.pan.2025.05.003_bib74","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nrc2191","article-title":"Molecular mechanisms of alcohol-mediated carcinogenesis","volume":"7","author":"Seitz","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.pan.2025.05.003_bib75","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.redox.2014.08.009","article-title":"The role of reactive oxygen species (ROS) and cytochrome P-450 2E1 in the generation of carcinogenic etheno-DNA adducts","volume":"3","author":"Linhart","year":"2014","journal-title":"Redox Biol"},{"issue":"3","key":"10.1016\/j.pan.2025.05.003_bib76","doi-asserted-by":"crossref","DOI":"10.3390\/biom7030061","article-title":"Alcohol and cancer: mechanisms and therapies","volume":"7","author":"Ratna","year":"2017","journal-title":"Biomolecules"},{"issue":"4","key":"10.1016\/j.pan.2025.05.003_bib77","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/jac5.1591","article-title":"Research and scholarly methods: propensity scores","volume":"5","author":"Medaglio","year":"2022","journal-title":"J Am Coll Clin Pharm"}],"container-title":["Pancreatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390325000882?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390325000882?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T14:58:07Z","timestamp":1751036287000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1424390325000882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":77,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S1424390325000882"],"URL":"https:\/\/doi.org\/10.1016\/j.pan.2025.05.003","relation":{},"ISSN":["1424-3903"],"issn-type":[{"value":"1424-3903","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic pancreatitis and extra pancreatic cancers- A systematic review and meta analysis","name":"articletitle","label":"Article Title"},{"value":"Pancreatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pan.2025.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of IAP and EPC.","name":"copyright","label":"Copyright"}]}}