{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:25:58Z","timestamp":1791822358251,"version":"4.3.4"},"reference-count":16,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pancreatology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.pan.2025.08.001","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T22:57:07Z","timestamp":1754521027000},"page":"905-911","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association between intra-tumoral microbiome and genetic alterations in intraductal papillary mucinous neoplasms of the pancreas"],"prefix":"10.1016","volume":"25","author":[{"given":"Kosuke","family":"Fukuda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0655-4488","authenticated-orcid":false,"given":"Yuto","family":"Hozaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0747-6462","authenticated-orcid":false,"given":"Hideyuki","family":"Oi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyo","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8048-2203","authenticated-orcid":false,"given":"Tetsuya","family":"Idichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2264-3619","authenticated-orcid":false,"given":"Yota","family":"Kawasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yodai","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5658-7865","authenticated-orcid":false,"given":"Yuichi","family":"Goto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9964-1785","authenticated-orcid":false,"given":"Tsuyoshi","family":"Sugiura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7508-1624","authenticated-orcid":false,"given":"Toshiaki","family":"Akahane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2723-1063","authenticated-orcid":false,"given":"Michiyo","family":"Higashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihide","family":"Tanimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2946-1092","authenticated-orcid":false,"given":"Takao","family":"Ohtsuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pan.2025.08.001_bib1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.pan.2023.12.009","article-title":"International evidence-based Kyoto guidelines for the management of intraductal papillary mucinous neoplasm of the pancreas","volume":"24","author":"Ohtsuka","year":"2024","journal-title":"Pancreatology"},{"key":"10.1016\/j.pan.2025.08.001_bib2","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/MPA.0000000000001047","article-title":"Intraductal papillary mucinous neoplasm of the pancreas as the main focus for early detection of pancreatic adenocarcinoma","volume":"47","author":"Tanaka","year":"2018","journal-title":"Pancreas"},{"key":"10.1016\/j.pan.2025.08.001_bib3","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1007\/s005340200075","article-title":"Advances in research and clinical practice in motor disorders of the sphincter of Oddi","volume":"9","author":"Tanaka","year":"2002","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"10.1016\/j.pan.2025.08.001_bib4","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.surg.2022.10.003","article-title":"Are intratumoral microbiota involved in the progression of intraductal papillary mucinous neoplasms of the pancreas?","volume":"173","author":"Hozaka","year":"2023","journal-title":"Surgery"},{"key":"10.1016\/j.pan.2025.08.001_bib5","doi-asserted-by":"crossref","first-page":"e790","DOI":"10.1097\/MPA.0000000000002373","article-title":"Genetic assessment of IPMN for predicting concomitant pancreatic ductal adenocarcinoma","volume":"53","author":"Oi","year":"2024","journal-title":"Pancreas."},{"key":"10.1016\/j.pan.2025.08.001_bib6","series-title":"WHO classification of tumors: Digestive system","first-page":"295","article-title":"Tumors of the pancreas","author":"Basturk","year":"2019"},{"key":"10.1016\/j.pan.2025.08.001_bib7","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1053\/j.gastro.2018.10.029","article-title":"Pathways of progression from intraductal papillary mucinous neoplasm to pancreatic ductal adenocarcinoma based on molecular features","volume":"156","author":"Omori","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2025.08.001_bib8","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1136\/gutjnl-2023-331012","article-title":"Absence of a microbiome in intraductal papillary mucinous neoplasm","volume":"73","author":"Pust","year":"2024","journal-title":"Gut"},{"key":"10.1016\/j.pan.2025.08.001_bib9","article-title":"Comprehensive assessment of the intrinsic pancreatic microbiome","author":"Eckhoff","year":"2024","journal-title":"Ann Surg"},{"key":"10.1016\/j.pan.2025.08.001_bib10","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/jgh.16437","article-title":"The tumoral microbiome of pancreatic intraductal papillary mucinous neoplasm: a single-center retrospective cohort study","volume":"39","author":"Zou","year":"2024","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.pan.2025.08.001_bib11","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2021.1887680","article-title":"Comparisons of oral, intestinal, and pancreatic bacterial microbiomes in patients with pancreatic cancer and other gastrointestinal diseases","volume":"13","author":"Chung","year":"2021","journal-title":"J Oral Microbiol"},{"key":"10.1016\/j.pan.2025.08.001_bib12","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.cell.2019.07.008","article-title":"Tumor microbiome diversity and composition influence pancreatic cancer outcomes","volume":"178","author":"Riquelme","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.pan.2025.08.001_bib13","doi-asserted-by":"crossref","first-page":"e196","DOI":"10.1016\/j.cgh.2020.11.006","article-title":"Alterations in the duodenal fluid microbiome of patients with pancreatic cancer","volume":"20","author":"Kohi","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.pan.2025.08.001_bib14","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1136\/gutjnl-2020-321217","article-title":"Multiregion whole-exome sequencing of intraductal papillary mucinous neoplasms reveals frequent somatic KLF4 mutations predominantly in low-grade regions","volume":"70","author":"Fujikura","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.pan.2025.08.001_bib15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/SLA.0b013e31828cd008","article-title":"Intraductal papillary mucinous neoplasms of the pancreas with distinct pancreatic ductal adenocarcinomas are frequently of gastric subtype","volume":"258","author":"Ideno","year":"2013","journal-title":"Ann Surg"},{"key":"10.1016\/j.pan.2025.08.001_bib16","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.pan.2024.08.013","article-title":"Prospective multicenter surveillance study of branch-duct intraductal papillary mucinous neoplasm of the pancreas; risk of dual carcinogenesis","volume":"24","author":"Ohtsuka","year":"2024","journal-title":"Pancreatology"}],"container-title":["Pancreatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390325005757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390325005757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:33:39Z","timestamp":1784126019000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1424390325005757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S1424390325005757"],"URL":"https:\/\/doi.org\/10.1016\/j.pan.2025.08.001","relation":{},"ISSN":["1424-3903"],"issn-type":[{"value":"1424-3903","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between intra-tumoral microbiome and genetic alterations in intraductal papillary mucinous neoplasms of the pancreas","name":"articletitle","label":"Article Title"},{"value":"Pancreatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pan.2025.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of IAP and EPC.","name":"copyright","label":"Copyright"}]}}