{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T16:44:01Z","timestamp":1773938641568,"version":"3.50.1"},"reference-count":21,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2023KY1212"],"award-info":[{"award-number":["2023KY1212"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LBY23H200001"],"award-info":[{"award-number":["LBY23H200001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pancreatology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.pan.2025.11.016","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T16:12:10Z","timestamp":1763827930000},"page":"103-113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["FBXO22-mediated ubiquitination of KLF10 promoting pancreatic cancer proliferation and invasion"],"prefix":"10.1016","volume":"26","author":[{"given":"Xiaorong","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7550-7342","authenticated-orcid":false,"given":"Xuesong","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanmin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzhe","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenfen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoguang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.pan.2025.11.016_bib1","first-page":"7","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J Clin"},{"issue":"3","key":"10.1016\/j.pan.2025.11.016_bib2","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"issue":"2","key":"10.1016\/j.pan.2025.11.016_bib3","first-page":"115","article-title":"Cancer statistics in China, 2015","volume":"66","author":"Chen","year":"2016","journal-title":"CA Cancer J Clin"},{"issue":"7","key":"10.1016\/j.pan.2025.11.016_bib4","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1097\/CM9.0000000000001474","article-title":"Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020","volume":"134","author":"Cao","year":"2021","journal-title":"Chin Med J (Engl)"},{"issue":"11","key":"10.1016\/j.pan.2025.11.016_bib5","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1038\/nm.3739","article-title":"Ubiquitination in disease pathogenesis and treatment","volume":"20","author":"Popovic","year":"2014","journal-title":"Nat Med"},{"issue":"9","key":"10.1016\/j.pan.2025.11.016_bib6","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.7150\/thno.42735","article-title":"F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects","volume":"10","author":"Tekcham","year":"2020","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.pan.2025.11.016_bib7","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nrm3582","article-title":"Mechanisms and function of substrate recruitment by F-box proteins","volume":"14","author":"Skaar","year":"2013","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"10.1016\/j.pan.2025.11.016_bib8","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12935-021-01833-y","article-title":"Systematic analysis of the expression and prognosis relevance of FBXO family reveals the significance of FBXO1 in human breast cancer","volume":"21","author":"Liu","year":"2021","journal-title":"Cancer Cell Int"},{"issue":"26","key":"10.1016\/j.pan.2025.11.016_bib9","doi-asserted-by":"crossref","first-page":"22767","DOI":"10.18632\/oncotarget.4082","article-title":"F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression","volume":"6","author":"Tian","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.pan.2025.11.016_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10574","article-title":"SCF(Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence","volume":"7","author":"Johmura","year":"2016","journal-title":"Nat Commun"},{"issue":"8","key":"10.1016\/j.pan.2025.11.016_bib11","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1111\/cas.14534","article-title":"FBXO22, an epigenetic multiplayer coordinating senescence, hormone signaling, and metastasis","volume":"111","author":"Johmura","year":"2020","journal-title":"Cancer Sci"},{"issue":"26","key":"10.1016\/j.pan.2025.11.016_bib12","doi-asserted-by":"crossref","first-page":"22767","DOI":"10.18632\/oncotarget.4082","article-title":"F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression","volume":"6","author":"Tian","year":"2015","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.pan.2025.11.016_bib13","doi-asserted-by":"crossref","first-page":"647","DOI":"10.7150\/ijbs.31293","article-title":"FBXO22 suppresses metastasis in human renal cell carcinoma via inhibiting MMP-9-Mediated migration and invasion and VEGF-mediated angiogenesis","volume":"15","author":"Guo","year":"2019","journal-title":"Int J Biol Sci"},{"issue":"2","key":"10.1016\/j.pan.2025.11.016_bib14","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.cell.2019.06.003","article-title":"Nrf2 activation promotes lung cancer metastasis by inhibiting the degradation of Bach1","volume":"178","author":"Lignitto","year":"2019","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.pan.2025.11.016_bib15","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41419-019-1732-9","article-title":"FBXO22 mediates polyubiquitination and inactivation of LKB1 to promote lung cancer cell growth","volume":"10","author":"Zhu","year":"2019","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.pan.2025.11.016_bib16","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1038\/s41467-020-15578-1","article-title":"FBXO22 degrades nuclear PTEN to promote tumorigenesis","volume":"11","author":"Ge","year":"2020","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.pan.2025.11.016_bib17","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12967-023-04666-7","article-title":"Klf10 is involved in extracellular matrix calcification of chondrocytes alleviating chondrocyte senescence","volume":"22","author":"Peng","year":"2024","journal-title":"J Transl Med"},{"issue":"2","key":"10.1016\/j.pan.2025.11.016_bib18","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.ajpath.2012.04.025","article-title":"Kr\u00fcppel-like factor 10 expression as a prognostic indicator for pancreatic adenocarcinoma","volume":"181","author":"Chang","year":"2012","journal-title":"Am J Pathol"},{"issue":"3","key":"10.1016\/j.pan.2025.11.016_bib19","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.gendis.2022.06.005","article-title":"Kr\u00fcppel-like factor 10 (KLF10) as a critical signaling mediator: versatile functions in physiological and pathophysiological processes","volume":"10","author":"Luo","year":"2022","journal-title":"Genes Dis"},{"issue":"10242","key":"10.1016\/j.pan.2025.11.016_bib20","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1016\/S0140-6736(20)30974-0","article-title":"Pancreatic cancer","volume":"395","author":"Mizrahi","year":"2020","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.pan.2025.11.016_bib21","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/s41419-022-05248-z","article-title":"Fbxo22 promotes cervical cancer progression via targeting p57Kip2 for ubiquitination and degradation","volume":"13","author":"Lin","year":"2022","journal-title":"Cell Death Dis"}],"container-title":["Pancreatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390325006891?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390325006891?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T15:19:00Z","timestamp":1773933540000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1424390325006891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S1424390325006891"],"URL":"https:\/\/doi.org\/10.1016\/j.pan.2025.11.016","relation":{},"ISSN":["1424-3903"],"issn-type":[{"value":"1424-3903","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FBXO22-mediated ubiquitination of KLF10 promoting pancreatic cancer proliferation and invasion","name":"articletitle","label":"Article Title"},{"value":"Pancreatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pan.2025.11.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of IAP and EPC.","name":"copyright","label":"Copyright"}]}}