{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T13:28:29Z","timestamp":1789219709324,"version":"build-2803163510"},"reference-count":60,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273018"],"award-info":[{"award-number":["82273018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272685"],"award-info":[{"award-number":["82272685"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["2018HXFH015"],"award-info":[{"award-number":["2018HXFH015"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2023YFS0128"],"award-info":[{"award-number":["2023YFS0128"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2021YFS0108"],"award-info":[{"award-number":["2021YFS0108"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pancreatology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.pan.2025.12.012","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T05:43:17Z","timestamp":1766122997000},"page":"246-258","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evolution of the Spatial transcriptomic landscape during the progression of high-grade pancreatic intraductal papillary mucinous neoplasms to invasive cancer"],"prefix":"10.1016","volume":"26","author":[{"given":"Sirui","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiangxing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengling","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqiang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiafei","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingwei","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panpan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xie","family":"Dan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.pan.2025.12.012_bib1","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.4708","article-title":"Estimated projection of US cancer incidence and death to 2040","volume":"4","author":"Rahib","year":"2021","journal-title":"JAMA Netw Open"},{"issue":"12","key":"10.1016\/j.pan.2025.12.012_bib2","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1097\/PAS.0000000000000533","article-title":"A revised classification system and recommendations from the Baltimore consensus meeting for neoplastic precursor lesions in the pancreas","volume":"39","author":"Basturk","year":"2015","journal-title":"Am J Surg Pathol"},{"issue":"92","key":"10.1016\/j.pan.2025.12.012_bib3","doi-asserted-by":"crossref","first-page":"92ra66","DOI":"10.1126\/scitranslmed.3002543","article-title":"Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development","volume":"3","author":"Wu","year":"2011","journal-title":"Sci Transl Med"},{"issue":"3","key":"10.1016\/j.pan.2025.12.012_bib4","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/00006676-200404000-00013","article-title":"Intraductal papillary mucinous neoplasm of the pancreas: diagnosis and treatment","volume":"28","author":"Tanaka","year":"2004","journal-title":"Pancreas"},{"issue":"161","key":"10.1016\/j.pan.2025.12.012_bib5","article-title":"Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas","volume":"1","author":"Furukawa","year":"2011","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.pan.2025.12.012_bib6","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1053\/j.gastro.2019.06.001","article-title":"Intraductal papillary mucinous neoplasms arise from multiple independent clones, each with distinct mutations","volume":"157","author":"Fischer","year":"2019","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.pan.2025.12.012_bib7","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1158\/1078-0432.CCR-18-1955","article-title":"Single-cell transcriptomics of pancreatic cancer precursors demonstrates epithelial and microenvironmental heterogeneity as an early event in neoplastic progression","volume":"25","author":"Bernard","year":"2019","journal-title":"Clin Cancer Res"},{"issue":"11","key":"10.1016\/j.pan.2025.12.012_bib8","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/s41587-020-0734-6","article-title":"10x genomics sequences in situ","volume":"38","year":"2020","journal-title":"Nat Biotechnol"},{"issue":"28","key":"10.1016\/j.pan.2025.12.012_bib9","article-title":"Single-cell and spatial dissection of precancerous lesions underlying the initiation process of oral squamous cell carcinoma","volume":"9","author":"Sun","year":"2023","journal-title":"Cell Discov"},{"issue":"1095","key":"10.1016\/j.pan.2025.12.012_bib10","article-title":"Spatial transcriptomics reveals gene expression characteristics in invasive micropapillary carcinoma of the breast","volume":"12","author":"Lv","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.pan.2025.12.012_bib11","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/his.13975","article-title":"Board WHOCoTE: the 2019 WHO classification of tumours of the digestive system","volume":"76","author":"Nagtegaal","year":"2020","journal-title":"Histopathology"},{"key":"10.1016\/j.pan.2025.12.012_bib12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nature16965","article-title":"Genomic analyses identify molecular subtypes of pancreatic cancer","volume":"531","author":"Bailey","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.pan.2025.12.012_bib13","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1038\/ng.3398","article-title":"Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma","volume":"47","author":"Moffitt","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.pan.2025.12.012_bib14","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/nm.2344","article-title":"Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy","volume":"17","author":"Collisson","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.pan.2025.12.012_bib15","doi-asserted-by":"crossref","first-page":"5826","DOI":"10.1038\/s41467-021-26059-4","article-title":"Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy","volume":"12","author":"Krieger","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.pan.2025.12.012_bib16","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41575-019-0109-y","article-title":"Molecular subtypes of pancreatic cancer","volume":"16","author":"Collisson","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.pan.2025.12.012_bib17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrclinonc.2017.166","article-title":"Tumour heterogeneity and resistance to cancer therapies","volume":"15","author":"Dagogo-Jack","year":"2018","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.pan.2025.12.012_bib18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41573-018-0004-1","article-title":"Turning foes to friends: targeting cancer-associated fibroblasts","volume":"18","author":"Chen","year":"2019","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.pan.2025.12.012_bib19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.immuni.2019.12.018","article-title":"Tumor immunology and tumor evolution: intertwined histories","volume":"52","author":"Galon","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.pan.2025.12.012_bib20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/imm.12888","article-title":"Human dendritic cell subsets: an update","volume":"154","author":"Collin","year":"2018","journal-title":"Immunology"},{"key":"10.1016\/j.pan.2025.12.012_bib21","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1016\/j.apsb.2020.04.004","article-title":"The role of tumor-associated macrophages (TAMs) in tumor progression and relevant advance in targeted therapy","volume":"10","author":"Yang","year":"2020","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.pan.2025.12.012_bib22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10456-013-9381-6","article-title":"Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo","volume":"17","author":"Jetten","year":"2014","journal-title":"Angiogenesis"},{"key":"10.1016\/j.pan.2025.12.012_bib23","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1158\/0008-5472.CAN-15-1737","article-title":"A breakthrough: macrophage-directed cancer immunotherapy","volume":"76","author":"Mills","year":"2016","journal-title":"Cancer Res"},{"key":"10.1016\/j.pan.2025.12.012_bib24","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3389\/fimmu.2019.00168","article-title":"Cold tumors: a therapeutic challenge for immunotherapy","volume":"10","author":"Bonaventura","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.pan.2025.12.012_bib25","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.pan.2025.12.012_bib26","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.hpb.2015.10.010","article-title":"Intraductal papillary mucinous neoplasm (IPMN) with high-grade dysplasia is a risk factor for the subsequent development of pancreatic ductal adenocarcinoma","volume":"18","author":"Rezaee","year":"2016","journal-title":"HPB (Oxford)"},{"issue":"1","key":"10.1016\/j.pan.2025.12.012_bib27","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cgh.2023.03.035","article-title":"Intraductal papillary mucinous neoplasms in high-risk individuals: incidence, growth rate, and malignancy risk","volume":"22","author":"Overbeek","year":"2024","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"8","key":"10.1016\/j.pan.2025.12.012_bib28","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.ejim.2015.07.016","article-title":"Malignant transformation and overall survival of morphological subtypes of intraductal papillary mucinous neoplasms of the pancreas: a network meta-analysis","volume":"26","author":"Qi","year":"2015","journal-title":"Eur J Intern Med Oct"},{"key":"10.1016\/j.pan.2025.12.012_bib29","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.cell.2012.03.003","article-title":"MYC on the path to cancer","volume":"149","author":"Dang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.pan.2025.12.012_bib30","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.it.2017.01.002","article-title":"MYC: master regulator of immune privilege","volume":"38","author":"Casey","year":"2017","journal-title":"Trends Immunol"},{"key":"10.1016\/j.pan.2025.12.012_bib31","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a014381","article-title":"Roles for MYC in the establishment and maintenance of pluripotency","volume":"3","author":"Chappell","year":"2013","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.pan.2025.12.012_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23092191","article-title":"ELF3, ELF5, EHF and SPDEF transcription factors in tissue homeostasis and cancer","volume":"23","author":"Luk","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.pan.2025.12.012_bib33","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41420-023-01416-y","article-title":"KLF4 transcription factor in tumorigenesis","volume":"9","author":"He","year":"2023","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.pan.2025.12.012_bib34","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ccell.2016.02.005","article-title":"KLF4 is essential for induction of cellular identity change and acinar-to-ductal reprogramming during early pancreatic carcinogenesis","volume":"29","author":"Wei","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.pan.2025.12.012_bib35","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1158\/0008-5472.CAN-04-1413","article-title":"Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of hedgehog signaling on pancreatic ductal epithelial cells","volume":"65","author":"Prasad","year":"2005","journal-title":"Cancer Res"},{"issue":"81","key":"10.1016\/j.pan.2025.12.012_bib36","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1158\/0008-5472.CAN-20-1293","article-title":"Secretory mucin 5AC promotes neoplastic progression by augmenting KLF4-Mediated pancreatic cancer cell stemness","volume":"1","author":"Ganguly","year":"2021","journal-title":"Cancer Res"},{"issue":"12","key":"10.1016\/j.pan.2025.12.012_bib37","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1080\/14728222.2021.2015321","article-title":"Glycometabolic rearrangements\u2013aerobic glycolysis in pancreatic ductal adenocarcinoma (PDAC): roles, regulatory networks, and therapeutic potential","volume":"25","author":"Zhang","year":"2021","journal-title":"Expert Opin Ther Targets"},{"issue":"1","key":"10.1016\/j.pan.2025.12.012_bib38","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3390\/cancers15010062","article-title":"The effect of oxidative phosphorylation on cancer drug resistance","volume":"15","author":"Zhao","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.pan.2025.12.012_bib39","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.4049\/jimmunol.1003613","article-title":"Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets","volume":"186","author":"Michalek","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.pan.2025.12.012_bib40","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41568-021-00418-1","article-title":"Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data","volume":"22","author":"Connor","year":"2022","journal-title":"Nat Rev Cancer"},{"issue":"7922","key":"10.1016\/j.pan.2025.12.012_bib41","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/s41586-022-05023-2","article-title":"Spatially resolved clonal copy number alterations in benign and malignant tissue","volume":"608","author":"Erickson","year":"2022","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.pan.2025.12.012_bib42","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1136\/gutjnl-2021-326550","article-title":"Molecular heterogeneity and commonalities in pancreatic cancer precursors with gastric and intestinal phenotype","volume":"72","author":"Liffers","year":"2023","journal-title":"Gut"},{"key":"10.1016\/j.pan.2025.12.012_bib43","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nrc3261","article-title":"Intra-tumour heterogeneity: a looking glass for cancer?","volume":"12","author":"Marusyk","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.pan.2025.12.012_bib44","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1136\/gut.2010.226092","article-title":"Stromal biology and therapy in pancreatic cancer","volume":"60","author":"Neesse","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.pan.2025.12.012_bib45","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1097\/MOG.0b013e328363affe","article-title":"Deciphering the role of stroma in pancreatic cancer","volume":"29","author":"Waghray","year":"2013","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.pan.2025.12.012_bib46","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1158\/2159-8290.CD-19-0094","article-title":"Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts","volume":"9","author":"Elyada","year":"2019","journal-title":"Cancer Discov"},{"key":"10.1016\/j.pan.2025.12.012_bib47","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1084\/jem.20162024","article-title":"Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer","volume":"214","author":"Ohlund","year":"2017","journal-title":"J Exp Med"},{"key":"10.1016\/j.pan.2025.12.012_bib48","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41571-020-0363-5","article-title":"The tumour microenvironment in pancreatic cancer - clinical challenges and opportunities","volume":"17","author":"Ho","year":"2020","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.pan.2025.12.012_bib49","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.ccr.2012.01.007","article-title":"Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma","volume":"21","author":"Provenzano","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.pan.2025.12.012_bib50","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.ccr.2014.04.005","article-title":"Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival","volume":"25","author":"O\u00f1zdemir","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.pan.2025.12.012_bib51","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.ccr.2014.04.021","article-title":"Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma","volume":"25","author":"Rhim","year":"2014","journal-title":"Cancer Cell"},{"issue":"19","key":"10.1016\/j.pan.2025.12.012_bib52","doi-asserted-by":"crossref","first-page":"4880","DOI":"10.3390\/cancers14194880","article-title":"Multiphasic heterogeneity of fibroblasts in the microenvironment of pancreatic ductal adenocarcinoma: dissection and the sum of the dynamics","volume":"14","author":"Ijichi","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.pan.2025.12.012_bib53","doi-asserted-by":"crossref","first-page":"9518","DOI":"10.1158\/0008-5472.CAN-07-0175","article-title":"Dynamics of the immune reaction to pancreatic cancer from inception to invasion","volume":"67","author":"Clark","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.pan.2025.12.012_bib54","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1158\/1078-0432.CCR-18-1955","article-title":"Single-cell transcriptomics of pancreatic cancer precursors demonstrates epithelial and microenvironmental heterogeneity as an early event in neoplastic progression","volume":"25","author":"Bernard","year":"2019","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.pan.2025.12.012_bib55","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1053\/j.gastro.2010.10.009","article-title":"CXCL17 and ICAM2 are associated with a potential anti-tumor immune response in early intraepithelial stages of human pancreatic carcinogenesis","volume":"140","author":"Hiraoka","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2025.12.012_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102655","article-title":"Recent insights into the biology of pancreatic cancer","volume":"53","author":"Yao","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.pan.2025.12.012_bib57","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.canlet.2020.12.008","article-title":"IGFBP2 promotes tumor progression by inducing alternative polarization of macrophages in pancreatic ductal adenocarcinoma through the STAT3 pathway","volume":"500","author":"Sun","year":"2021","journal-title":"Cancer Lett"},{"issue":"24","key":"10.1016\/j.pan.2025.12.012_bib58","doi-asserted-by":"crossref","first-page":"6113","DOI":"10.1158\/0008-5472.CAN-19-0842","article-title":"Follistatin-like protein 1 inhibits lung cancer metastasis by preventing proteolytic activation of osteopontin","volume":"79","author":"Chiou","year":"2019","journal-title":"Cancer Res"},{"issue":"3","key":"10.1016\/j.pan.2025.12.012_bib59","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41419-018-0391-6","article-title":"The role of osteopontin in the progression of solid organ tumour","volume":"9","author":"Zhao","year":"2018","journal-title":"Cell Death Dis"},{"issue":"10","key":"10.1016\/j.pan.2025.12.012_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/genes13101760","article-title":"Single cell RNA-seq identifies immune-related prognostic model and key signature-SPP1 in pancreatic ductal adenocarcinoma","volume":"13","author":"Chen","year":"2022","journal-title":"Genes"}],"container-title":["Pancreatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390325007203?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390325007203?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T15:18:30Z","timestamp":1773933510000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1424390325007203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1424390325007203"],"URL":"https:\/\/doi.org\/10.1016\/j.pan.2025.12.012","relation":{},"ISSN":["1424-3903"],"issn-type":[{"value":"1424-3903","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evolution of the Spatial transcriptomic landscape during the progression of high-grade pancreatic intraductal papillary mucinous neoplasms to invasive cancer","name":"articletitle","label":"Article Title"},{"value":"Pancreatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pan.2025.12.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V. on behalf of IAP and EPC.","name":"copyright","label":"Copyright"}]}}