{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T14:23:37Z","timestamp":1788013417657,"version":"build-2784847793"},"reference-count":16,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003653","name":"Korea National Institute of Health","doi-asserted-by":"publisher","award":["HI23C1591\/RS-2023-KH140186"],"award-info":[{"award-number":["HI23C1591\/RS-2023-KH140186"]}],"id":[{"id":"10.13039\/501100003653","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pancreatology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.pan.2026.01.079","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:12:22Z","timestamp":1770077542000},"page":"265-271","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic and recurrence implications of subdividing WHO grade 2 pancreatic neuroendocrine tumors at a 10% Ki-67 threshold"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7815-9834","authenticated-orcid":false,"given":"Go-Won","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inhyuck","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Younsoo","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngmin","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Soo","family":"Chae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Sol","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2255-8390","authenticated-orcid":false,"given":"Young Jae","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4827-7805","authenticated-orcid":false,"given":"Wooil","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Young","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Seong","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pan.2026.01.079_bib1","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/oncolo\/oyac049","article-title":"Survival and incidence patterns of pancreatic neuroendocrine tumors over the last 2 decades: a seer database analysis","volume":"27","author":"Sonbol","year":"2022","journal-title":"Oncologist"},{"key":"10.1016\/j.pan.2026.01.079_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15072006","article-title":"Surgical management of pancreatic neuroendocrine tumors","volume":"15","author":"Sulciner","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.pan.2026.01.079_bib3","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.4251\/wjgo.v16.i5.1756","article-title":"Pancreatic neuroendocrine tumors: are tumors smaller than 2 Cm truly indolent?","volume":"16","author":"Hoyos","year":"2024","journal-title":"World J Gastrointest Oncol"},{"key":"10.1016\/j.pan.2026.01.079_bib4","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.gie.2022.07.014","article-title":"Reliability of grading preoperative pancreatic neuroendocrine tumors on eus specimens: a systematic review with meta-analysis of aggregate and individual data","volume":"96","author":"Tacelli","year":"2022","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.pan.2026.01.079_bib5","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/onco.13633","article-title":"Somatostatin analogs for pancreatic neuroendocrine tumors: any benefit when ki-67 is >\/=10","volume":"26","author":"Merola","year":"2021","journal-title":"Oncologist"},{"key":"10.1016\/j.pan.2026.01.079_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13092054","article-title":"Gene expression profiling of pancreas neuroendocrine tumors with different ki67-based grades","volume":"13","author":"Simbolo","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.pan.2026.01.079_bib7","doi-asserted-by":"crossref","first-page":"664","DOI":"10.5858\/arpa.2019-0665-RA","article-title":"What is new in the 2019 world health organization (who) classification of tumors of the digestive system: review of selected updates on neuroendocrine neoplasms, appendiceal tumors, and molecular testing","volume":"145","author":"Assarzadegan","year":"2021","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.pan.2026.01.079_bib8","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00428-007-0452-1","article-title":"Tnm staging of midgut and hindgut (neuro) endocrine tumors: a consensus proposal including a grading system","volume":"451","author":"Rindi","year":"2007","journal-title":"Virchows Arch"},{"key":"10.1016\/j.pan.2026.01.079_bib9","doi-asserted-by":"crossref","DOI":"10.1111\/jne.70003","article-title":"Alternative lengthening of telomeres and ki-67 proliferation index provide complementary information on recurrence risk after resection of pancreatic neuroendocrine tumors","volume":"37","author":"Gudmundsdottir","year":"2025","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.pan.2026.01.079_bib10","doi-asserted-by":"crossref","first-page":"7001","DOI":"10.1245\/s10434-024-15632-y","article-title":"Subgrading of g2 pancreatic neuroendocrine tumors as 2a (ki67 3% to < 10%) versus 2b (10% to <\/= 20%) identifies behaviorally distinct subsets in keeping with the evolving management protocols","volume":"31","author":"Eren","year":"2024","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.pan.2026.01.079_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjsurg.2024.116116","article-title":"Net guidelines for white patients may not fit Asian patients","volume":"240","author":"Irfan","year":"2025","journal-title":"Am J Surg"},{"key":"10.1016\/j.pan.2026.01.079_bib12","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1159\/000511875","article-title":"Risk factors for recurrence in pancreatic neuroendocrine tumor and size as a surrogate in determining the treatment strategy: a Korean nationwide study","volume":"111","author":"Kwon","year":"2021","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.pan.2026.01.079_bib13","doi-asserted-by":"crossref","DOI":"10.1111\/jne.13318","article-title":"European neuroendocrine tumor society 2023 guidance paper for functioning pancreatic neuroendocrine tumour syndromes","volume":"35","author":"Hofland","year":"2023","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.pan.2026.01.079_bib14","series-title":"American cancer society.: ajcc cancer staging manual, Chicago IL, American joint committee on cancer","author":"Amin","year":"2017"},{"key":"10.1016\/j.pan.2026.01.079_bib15","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/jso.27914","article-title":"Incidence and prognostic implications of lymphovascular invasion in node-negative pancreatic neuroendocrine tumors: results from the us neuroendocrine study group","volume":"131","author":"Sahara","year":"2025","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.pan.2026.01.079_bib16","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1007\/s00330-023-10186-1","article-title":"A radiomics-based interpretable model to predict the pathological grade of pancreatic neuroendocrine tumors","volume":"34","author":"Ye","year":"2024","journal-title":"Eur Radiol"}],"container-title":["Pancreatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390326000943?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390326000943?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T23:22:25Z","timestamp":1772493745000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1424390326000943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1424390326000943"],"URL":"https:\/\/doi.org\/10.1016\/j.pan.2026.01.079","relation":{},"ISSN":["1424-3903"],"issn-type":[{"value":"1424-3903","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic and recurrence implications of subdividing WHO grade 2 pancreatic neuroendocrine tumors at a 10% Ki-67 threshold","name":"articletitle","label":"Article Title"},{"value":"Pancreatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pan.2026.01.079","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of IAP and EPC.","name":"copyright","label":"Copyright"}]}}