{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:51:04Z","timestamp":1789696264372,"version":"4.0.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Parasitology International"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1016\/j.parint.2007.01.004","type":"journal-article","created":{"date-parts":[[2007,1,21]],"date-time":"2007-01-21T07:08:28Z","timestamp":1169363308000},"page":"135-139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["Leishmanicidal activity of a supercritical fluid fraction obtained from Tabernaemontana catharinensis"],"prefix":"10.1016","volume":"56","author":[{"given":"Deivid Costa","family":"Soares","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila G.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria \u00c2ngela A.","family":"Meireles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira Maria","family":"Saraiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.parint.2007.01.004_bib1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1179\/000349803225002499","article-title":"Leishmania\/HIV co-infection: epidemiology in Europe","volume":"97","author":"Desjeux","year":"2003","journal-title":"Ann Trop Med Parasitol"},{"key":"10.1016\/j.parint.2007.01.004_bib2","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.pt.2003.09.008","article-title":"Leishmaniasis \u2014 current chemotherapy and recent advances in the search for novel drugs","volume":"19","author":"Croft","year":"2003","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.parint.2007.01.004_bib3","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/00001432-200310000-00005","article-title":"Current treatment approaches to leishmaniasis","volume":"16","author":"Berman","year":"2003","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.parint.2007.01.004_bib4","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0924-8579(03)00125-0","article-title":"Characterization of Leishmania donovani promastigotites resistant to hexadecylphosphocholine (miltefosine)","volume":"22","author":"Seifert","year":"2003","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.parint.2007.01.004_bib5","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1007\/s00436-002-0768-3","article-title":"Natural products as antiparasitic drugs","volume":"90","author":"Kaiser","year":"2003","journal-title":"Parasitol Res"},{"key":"10.1016\/j.parint.2007.01.004_bib6","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1248\/cpb.40.2075","article-title":"Analgesic components from Bornean medicinal plants, Tabernaemontana pauciflora Blume and Tabernaemontana pandacaqui Poir","volume":"40","author":"Okuyama","year":"1992","journal-title":"Chem Pharm Bull Tokyo"},{"key":"10.1016\/j.parint.2007.01.004_bib7","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3109\/13880209309082955","article-title":"Chemical constituents and pharmacological activities of Peschiera australis","volume":"31","author":"Rates","year":"1993","journal-title":"Int J Pharmacogn"},{"key":"10.1016\/j.parint.2007.01.004_bib8","series-title":"Revision of Tabernaemontana. II. The New World Species and Stemmadenia","first-page":"441","article-title":"Tabernaemontana","author":"Leeuwenberg","year":"1994"},{"key":"10.1016\/j.parint.2007.01.004_bib9","first-page":"334","article-title":"The fatty acid composition of the seed oil of Peschiera australis","volume":"97","author":"Spitzer","year":"1995","journal-title":"Fett (Germany)"},{"key":"10.1016\/j.parint.2007.01.004_bib10","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0021-9673(97)00723-1","article-title":"Gas chromatographic analysis of indole alkaloids from Tabernaemontana hilariana","volume":"788","author":"Cardoso","year":"1997","journal-title":"J Chromatogr A"},{"key":"10.1016\/j.parint.2007.01.004_bib11","series-title":"In ISHS Acta Horticulturae 501: II WOCMAP Congress Medicinal and Aromatic Plants, Part 2: Pharmacognosy, Pharmacology, Phytomedicine, Toxicology [CD-ROM]","first-page":"165","article-title":"Trypanocidal activity from Tabernaemontana catharinensis A. DC","author":"Pereira","year":"1999"},{"key":"10.1016\/j.parint.2007.01.004_bib12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0378-8741(95)01328-8","article-title":"Ervatamia coronaria: chemical constituents and some pharmacological activities","volume":"50","author":"Henriques","year":"1996","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.parint.2007.01.004_bib13","first-page":"267","article-title":"Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe","volume":"20","author":"Rastogi","year":"1998","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.parint.2007.01.004_bib14","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1089\/jmf.2005.8.533","article-title":"Antioxidant and antimycobacterial activities of Tabernaemontana catharinensis extracts obtained by supercritical CO2+cosolvent","volume":"8","author":"Pereira","year":"2005","journal-title":"J Med Food"},{"key":"10.1016\/j.parint.2007.01.004_bib15","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1128\/AAC.45.5.1349-1354.2001","article-title":"Leishmanial activity of an indole alkaloid from Peschiera australis","volume":"45","author":"Delorenzi","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.parint.2007.01.004_bib16","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1128\/AAC.46.7.2111-2115.2002","article-title":"In vitro activities of iboga alkaloid congeners coronaridine and 18-methoxycoronaridine against Leishmania amazonensis","volume":"46","author":"Delorenzi","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.parint.2007.01.004_bib17","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1055\/s-2004-827227","article-title":"Anti-HIV-1 activity of the iboga alkaloid congener 18-methoxycoronaridine","volume":"70","author":"Silva","year":"2004","journal-title":"Planta Med"},{"key":"10.1016\/j.parint.2007.01.004_bib18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0896-8446(03)00112-8","article-title":"Extraction of indole alkaloids from Tabernamontana catharinensis using supercritical CO2+ethanol: an evaluation of the process variables and the raw material origin","volume":"30","author":"Pereira","year":"2004","journal-title":"J Supercrit Fluids"},{"key":"10.1016\/j.parint.2007.01.004_bib19","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1590\/S0100-879X2001000200009","article-title":"Myosin V and iNOS expression is enhanced in J774 murine macrophages treated with IFN-\u03b3","volume":"34","author":"Reis","year":"2001","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.parint.2007.01.004_bib20","doi-asserted-by":"crossref","first-page":"278","DOI":"10.4049\/jimmunol.144.1.278","article-title":"Activated macrophages destroy intracellular Leishmania major amastigotes by an l-arginine-dependent killing mechanism","volume":"144","author":"Green","year":"1990","journal-title":"J Immunol"},{"key":"10.1016\/j.parint.2007.01.004_bib21","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0022-1759(91)90114-U","article-title":"An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT","volume":"142","author":"Roehm","year":"1991","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.parint.2007.01.004_bib22","doi-asserted-by":"crossref","first-page":"4092","DOI":"10.1016\/j.bmc.2005.03.045","article-title":"Indole alkaloids from Tabernaemontana australis (Muell. Arg) Miers that inhibit acetylcholinesterase enzyme","volume":"13","author":"Andrade","year":"2005","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.parint.2007.01.004_bib23","doi-asserted-by":"crossref","first-page":"6006","DOI":"10.1128\/jvi.68.9.6006-6013.1994","article-title":"Cryptic nature of envelope V3 region epitopes protects primary monocytotropic human immunodeficiency virus type 1 from antibody neutralization","volume":"68","author":"Bou-Habib","year":"1994","journal-title":"J Virol"},{"key":"10.1016\/j.parint.2007.01.004_bib24","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.0105-2896.2004.00185.x","article-title":"Re-examination of the immunosuppressive mechanisms mediating non-cure of Leishmania infection in mice","volume":"201","author":"Sacks","year":"2004","journal-title":"Immunol Rev"},{"key":"10.1016\/j.parint.2007.01.004_bib25","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1128\/iai.61.7.2952-2959.1993","article-title":"Immune responses associated with susceptibility of C57BL\/10 mice to Leishmania amazonensis","volume":"61","author":"Afonso","year":"1993","journal-title":"Infect Immun"},{"key":"10.1016\/j.parint.2007.01.004_bib26","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00436-004-1193-6","article-title":"Immune response induced by New World Leishmania species in C57BL\/6 mice","volume":"94","author":"Maioli","year":"2004","journal-title":"Parasitol Res"},{"key":"10.1016\/j.parint.2007.01.004_bib27","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/pca.702","article-title":"Supercritical carbon dioxide extraction of colchicine and related alkaloids from seeds of Colchicum autumnale L","volume":"14","author":"Ellington","year":"2003","journal-title":"Phytochem Anal"}],"container-title":["Parasitology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383576907000074?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383576907000074?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T10:25:38Z","timestamp":1761301538000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1383576907000074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S1383576907000074"],"URL":"https:\/\/doi.org\/10.1016\/j.parint.2007.01.004","relation":{},"ISSN":["1383-5769"],"issn-type":[{"value":"1383-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leishmanicidal activity of a supercritical fluid fraction obtained from Tabernaemontana catharinensis","name":"articletitle","label":"Article Title"},{"value":"Parasitology International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.parint.2007.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}