{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T11:50:17Z","timestamp":1785671417545,"version":"3.56.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004532","name":"Japan International Cooperation Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004532","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003008","name":"Ministry of Higher Education, Egypt","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003008","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Parasitology International"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.parint.2010.02.006","type":"journal-article","created":{"date-parts":[[2010,2,22]],"date-time":"2010-02-22T04:12:20Z","timestamp":1266811940000},"page":"278-282","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Inhibitory effect of terpene nerolidol on the growth of Babesia parasites"],"prefix":"10.1016","volume":"59","author":[{"given":"Mahmoud","family":"AbouLaila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thillaiampalam","family":"Sivakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoaki","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuo","family":"Igarashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.parint.2010.02.006_bib1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1128\/CMR.13.3.451","article-title":"Babesiosis","volume":"13","author":"Homer","year":"2000","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.parint.2010.02.006_bib2","series-title":"Babesiosis of domestic animals and man","first-page":"1","article-title":"Worldwide impact of babesiosis","author":"Kuttler","year":"1988"},{"key":"10.1016\/j.parint.2010.02.006_bib3","first-page":"233","article-title":"Recent advances in the chemotherapy of babesiosis by Asian scientist: toxoplasmosis and babesiosis in Asia","volume":"4","author":"Bork","year":"2005","journal-title":"Asian Parasitol"},{"key":"10.1016\/j.parint.2010.02.006_bib4","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.vetpar.2006.01.048","article-title":"Chemotherapy against babesiosis","volume":"138","author":"Vial","year":"2006","journal-title":"Vet Parasitol"},{"key":"10.1016\/j.parint.2010.02.006_bib5","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/S0020-7519(00)00100-4","article-title":"The plastid in Apicomplexa: what use is it?","volume":"30","author":"Gleeson","year":"2000","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.parint.2010.02.006_bib6","first-page":"1","article-title":"Extrachromosomal DNA in the Apicomplexa","volume":"61","author":"Wilson","year":"1997","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.parint.2010.02.006_bib7","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/37132","article-title":"A plastid organelle as a drug target in apicomplexan parasites","volume":"390","author":"Fichera","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.parint.2010.02.006_bib8","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1111\/j.1365-2958.2006.05343.x","article-title":"The cell biology of secondary endosymbiosis\u2014how parasites build, divide, and segregate the apicoplast","volume":"61","author":"Vaishnava","year":"2006","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.parint.2010.02.006_bib9","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1126\/science.285.5433.1573","article-title":"Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs","volume":"285","author":"Jomaa","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.parint.2010.02.006_bib10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0166-6851(84)90004-5","article-title":"Sterols of Leishmania species: implications for biosynthesis","volume":"10","author":"Goad","year":"1984","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.parint.2010.02.006_bib11","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0166-6851(94)90073-6","article-title":"Detection of ubiquinone in parasitic and free-living protozoa, including species devoid of mitochondria","volume":"65","author":"Ellis","year":"1994","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.parint.2010.02.006_bib12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0166-6851(98)00053-X","article-title":"The effects of protein farnesyltransferase inhibitors on trypanosomatids: inhibition of protein farnesylation and cell growth","volume":"94","author":"Yokoyama","year":"1998","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.parint.2010.02.006_bib13","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1371\/journal.ppat.0030148","article-title":"Genome sequence of Babesia bovis and comparative analysis of apicomplexan hemoprotozoa","volume":"3","author":"Brayton","year":"2007","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.parint.2010.02.006_bib14","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1128\/AAC.49.5.1679-1687.2005","article-title":"Antileishmanial activity of the terpene Nerolidol","volume":"49","author":"Arruda","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.parint.2010.02.006_bib15","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1128\/AAC.48.7.2502-2509.2004","article-title":"Terpenes arrest parasite development and inhibit biosynthesis of isoprenoids in Plasmodium falciparum","volume":"48","author":"Rodrigues Goulart","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.parint.2010.02.006_bib16","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0378-8741(99)00072-0","article-title":"Antimalarial use of volatile oil from leaves of Virola surinamensis (Rol.) Warb. by Waiapi Amazon Indians","volume":"67","author":"Lopes","year":"1999","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.parint.2010.02.006_bib17","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1292\/jvms.59.479","article-title":"Improved in vitro cultivation of Babesia caballi","volume":"59","author":"Avarzed","year":"1997","journal-title":"J Vet Med Sci"},{"key":"10.1016\/j.parint.2010.02.006_bib18","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1006\/expr.1998.4331","article-title":"Babesia bigemina: in vitro and in vivo effects of curdlan sulfate on the growth of parasites","volume":"90","author":"Igarashi","year":"1998","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.parint.2010.02.006_bib19","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1017\/S0031182004006821","article-title":"Host serum modifies the drug susceptibility of Babesia bovis in vitro","volume":"130","author":"Bork","year":"2005","journal-title":"Parasitology"},{"key":"10.1016\/j.parint.2010.02.006_bib20","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1128\/AAC.48.1.236-241.2004","article-title":"Growth-inhibitory effect of heparin on Babesia parasites","volume":"48","author":"Bork","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.parint.2010.02.006_bib21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.4269\/ajtmh.2003.68.334","article-title":"Growth inhibitory effect of triclosan on equine and bovine Babesia parasites","volume":"68","author":"Bork","year":"2003","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.parint.2010.02.006_bib22","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/S0020-7519(01)00278-8","article-title":"Characterization of the gene encoding a protective antigen from Babesia microti identified it as the \u03ae subunit of chaperonin-containing T-complex protein 1","volume":"31","author":"Nishisaka","year":"2001","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.parint.2010.02.006_bib23","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1645\/0022-3395(2003)089[0604:CKACAP]2.0.CO;2","article-title":"Clotrimazole, ketoconazole, and clodinafop-propargyl as potent growth inhibitors of equine Babesia parasites during in vitro culture","volume":"89","author":"Bork","year":"2003","journal-title":"J Parasitol"},{"key":"10.1016\/j.parint.2010.02.006_bib24","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1017\/S0031182003003895","article-title":"Clotrimazole, ketoconazole, and clodinafop-propargyl inhibit the in vitro growth of Babesia bigemina and Babesia bovis (Phylum Apicomplexa)","volume":"127","author":"Bork","year":"2003","journal-title":"Parasitology"},{"key":"10.1016\/j.parint.2010.02.006_bib25","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1017\/S0031182006009917","article-title":"Effects of protein kinase inhibitors on the in vitro growth of Babesia bovis","volume":"132","author":"Bork","year":"2006","journal-title":"Parasitology"},{"key":"10.1016\/j.parint.2010.02.006_bib26","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1128\/AAC.47.2.800-803.2003","article-title":"Growth-inhibitory effects of artesunate, pyrimethamine, and pamaquine against Babesia equi and Babesia caballi in in vitro cultures","volume":"47","author":"Nagai","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.parint.2010.02.006_bib27","first-page":"1","article-title":"Cyclin-dependent kinase inhibitors block erythrocyte invasion and intraerythrocytic development of Babesia bovis in vitro","volume":"135","author":"Nakamura","year":"2007","journal-title":"Parasitology"},{"key":"10.1016\/j.parint.2010.02.006_bib28","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1042\/bj3410629","article-title":"Active isoprenoid pathway in the intra-erythrocytic stages of Plasmodium falciparum: presence of dolichols of 11 and 12 isoprene units","volume":"341","author":"Couto","year":"1999","journal-title":"Biochem J"},{"key":"10.1016\/j.parint.2010.02.006_bib29","doi-asserted-by":"crossref","first-page":"19250","DOI":"10.1016\/S0021-9258(18)54990-5","article-title":"The mevalonate pathway in the bloodstream forms of Trypanosoma brucei","volume":"266","author":"L\u00f6w","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/j.parint.2010.02.006_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-291X(84)91058-1","article-title":"Glycoprotein assembly in Leishmania mexicana","volume":"118","author":"Parodi","year":"1984","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.parint.2010.02.006_bib31","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/S1367-5931(97)80054-3","article-title":"Chain elongation in the isoprenoid biosynthetic pathway","volume":"1","author":"Kellogg","year":"1997","journal-title":"Curr Opin Chem Biol"}],"container-title":["Parasitology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383576910000474?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383576910000474?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T10:26:37Z","timestamp":1761301597000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1383576910000474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S1383576910000474"],"URL":"https:\/\/doi.org\/10.1016\/j.parint.2010.02.006","relation":{},"ISSN":["1383-5769"],"issn-type":[{"value":"1383-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibitory effect of terpene nerolidol on the growth of Babesia parasites","name":"articletitle","label":"Article Title"},{"value":"Parasitology International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.parint.2010.02.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}