{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:53:16Z","timestamp":1790869996902,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001332","name":"CSIR","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001332","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology International"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.parint.2010.09.009","type":"journal-article","created":{"date-parts":[[2010,10,23]],"date-time":"2010-10-23T08:29:40Z","timestamp":1287822580000},"page":"97-100","source":"Crossref","is-referenced-by-count":18,"title":["Implication of intracellular glutathione and its related enzymes on resistance of malaria parasites to the antimalarial drug arteether"],"prefix":"10.1016","volume":"60","author":[{"given":"Ramesh","family":"Chandra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.M.","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.K.","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.K.","family":"Puri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1\u20132 Suppl","key":"10.1016\/j.parint.2010.09.009_bb0005","article-title":"The intolerable burden of malaria: a new look at the numbers","volume":"64","author":"Breman","year":"2001","journal-title":"Am J Trop Med Hyg"},{"issue":"4","key":"10.1016\/j.parint.2010.09.009_bb0010","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S1473-3099(02)00239-6","article-title":"Epidemiology of drug-resistant malaria","volume":"2","author":"Wongsrichanalai","year":"2002","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.parint.2010.09.009_bb0015","unstructured":"WHO: the use of ACT in order to \u2018provide effective treatment against malaria and to slow the spread of drug resistance\u2019 in a statement released on 20 February 2002."},{"key":"10.1016\/j.parint.2010.09.009_bb0020","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1016\/S0140-6736(05)67787-2","article-title":"Resistance of Plasmodium falciparum field isolates to in vitro artemether and point mutation of SERCA-type PfATPase6","volume":"366","author":"Jambou","year":"2005","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.parint.2010.09.009_bb0025","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1365-3156.2007.01991.x","article-title":"Plasmodium falciparum from Par\u00e1 state (Brazil) shows satisfactory in vitro response to artemisinin derivatives and absence of the S769N mutation in the SERCA-type PfATPase6","author":"Ferreira","year":"2008","journal-title":"Trop Med Int Health"},{"issue":"5","key":"10.1016\/j.parint.2010.09.009_bb0030","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMoa0808859","article-title":"Artemisinin resistance in Plasmodium falciparum malaria","author":"Dondorp","year":"2009","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.parint.2010.09.009_bb0035","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0035-9203(86)90351-2","article-title":"Qinghaosu resistance in rodent malaria","volume":"80","author":"Chawira","year":"1986","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"4","key":"10.1016\/j.parint.2010.09.009_bb0040","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1080\/00034989958320","article-title":"The chemotherapy of rodent malaria. LVI. Studies on the development of resistance to natural and synthetic endoperoxides","volume":"93","author":"Peters","year":"1999","journal-title":"Ann Trop Med Parasitol"},{"issue":"2","key":"10.1016\/j.parint.2010.09.009_bb0045","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1128\/AAC.50.2.480-489.2006","article-title":"Malaria parasites can develop stable resistance to artemisinin but lack mutations in candidate genes atp6 (encoding the sarcoplasmic and endoplasmic reticulum Ca2+ ATPase), tctp, mdr1, and cg10","volume":"50","author":"Afonso","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"10.1016\/j.parint.2010.09.009_bb0050","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1128\/AAC.44.2.344-347.2000","article-title":"Mechanisms of artemisinin resistance in the rodent malaria pathogen Plasmodium yoelii","volume":"44","author":"Walker","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"10.1016\/j.parint.2010.09.009_bb0055","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1645\/GE-3225","article-title":"Plasmodium yoelii: identification and partial characterization of an MDR1 gene in an artemisinin-resistant line","volume":"90","author":"Ferrer-Rodriguez","year":"2004","journal-title":"J Parasitol"},{"issue":"14","key":"10.1016\/j.parint.2010.09.009_bb0060","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.ijpara.2006.07.011","article-title":"Current perspectives on the mechanism of action of artemisinins","volume":"36","author":"Golenser","year":"2006","journal-title":"Int J Parasitol"},{"issue":"4\u20135","key":"10.1016\/j.parint.2010.09.009_bb0065","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.drup.2004.07.001","article-title":"Artemisinins: mechanisms of action and potential for resistance","volume":"7","author":"Krishna","year":"2004","journal-title":"Drug Resist Updat"},{"issue":"6951","key":"10.1016\/j.parint.2010.09.009_bb0070","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/nature01813","article-title":"Artemisinins target the SERCA of Plasmodium falciparum","volume":"424","author":"Eckstein-Ludwig","year":"2003","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.parint.2010.09.009_bb0075","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0166-6851(99)00153-X","article-title":"Gametocyte-dominant expression of a novel P-type ATPase in Plasmodium yoelii","volume":"104","author":"Kimura","year":"1999","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.parint.2010.09.009_bb0080","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1089\/ars.2005.7.1302","article-title":"Reactive oxygen species as mediators of calcium signaling by angiotensin II: implications in vascular physiology and pathophysiology","volume":"7","author":"Touyz","year":"2005","journal-title":"Antioxid Redox Signal"},{"issue":"2","key":"10.1016\/j.parint.2010.09.009_bb0085","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.exppara.2006.02.017","article-title":"Plasmodium vinckei: selection of a strain exhibiting stable resistance to arteether","volume":"114","author":"Puri","year":"2006","journal-title":"Exp Parasitol"},{"issue":"4","key":"10.1016\/j.parint.2010.09.009_bb0090","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0169-4758(97)01211-8","article-title":"Peroxidoxins: a new antioxidant family","volume":"14","author":"McGonigle","year":"1998","journal-title":"Parasitol Today"},{"issue":"1","key":"10.1016\/j.parint.2010.09.009_bb0095","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/0035-9203(72)90005-3","article-title":"Use of CF 12 columns for preparations of DNA from rodent malarias","volume":"66","author":"Baggaley","year":"1972","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"Suppl 1","key":"10.1016\/j.parint.2010.09.009_bb0100","first-page":"75","article-title":"In vitro production and partial purification of Plasmodium falciparum antigen","volume":"57","author":"Siddiqui","year":"1979","journal-title":"Bull World Health Organ"},{"issue":"1","key":"10.1016\/j.parint.2010.09.009_bb0105","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0003-2697(76)90323-7","article-title":"Enzymatic assay for glutathione","volume":"74","author":"Brehe","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1016\/j.parint.2010.09.009_bb0110","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0006-291X(72)80218-3","article-title":"The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen","volume":"46","author":"Nishikami","year":"1972","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.parint.2010.09.009_bb0115","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/S0076-6879(55)02291-X","article-title":"Glutathione reductase (liver and yeast)","volume":"2","author":"Racker","year":"1955","journal-title":"Meth Enzymol"},{"key":"10.1016\/j.parint.2010.09.009_bb0120","first-page":"499","article-title":"The mechanism of the heterocyclic fermentation: a new rout of ethanol fermentation","volume":"6","author":"Moss","year":"1951","journal-title":"J Bacterial"},{"key":"10.1016\/j.parint.2010.09.009_bb0125","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1021\/bi00606a028","article-title":"Identification of the catalytic site of rat liver glutathione peroxidase as selenocysteine","volume":"17","author":"Forstrom","year":"1978","journal-title":"Biochemistry"},{"key":"10.1016\/j.parint.2010.09.009_bb0130","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferases. The first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J Biol Chem"},{"key":"10.1016\/j.parint.2010.09.009_bb0135","first-page":"130","article-title":"A modified spectrphotometric assay of superoxide dismutase","volume":"21","author":"Kakkar","year":"1984","journal-title":"Indian J Biochem Biophys"},{"issue":"4","key":"10.1016\/j.parint.2010.09.009_bb0140","first-page":"744","article-title":"Effect of dihydroartemisinin on the antioxidant capacity of P. falciparum-infected erythrocytes","volume":"34","author":"Ittarat","year":"2003","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"10.1016\/j.parint.2010.09.009_bb0145","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1039\/b006906j","article-title":"A possible antimalarial action mode of quighaosu (artemisinin) series compounds. Alkylation of reduced glutathione by C-centered primary radicals produced from antimalarial compound qinghaosu and 12-(2,4-dimethoxyphenyl)-12-deoxoqinghaosu","author":"Wang","year":"2000","journal-title":"Chem Commun"},{"issue":"Pt 3","key":"10.1016\/j.parint.2010.09.009_bb0150","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1042\/bj20020962","article-title":"Regulation of intracellular glutathione levels in erythrocytes infected with chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum","volume":"368","author":"Meierjohann","year":"2002","journal-title":"Biochem J"},{"issue":"1","key":"10.1016\/j.parint.2010.09.009_bb0155","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1006\/expr.1995.1099","article-title":"Plasmodium berghei: implication of intracellular glutathione and its related enzyme in chloroquine resistance in vivo","volume":"81","author":"Dubois","year":"1995","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.parint.2010.09.009_bb0160","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.exppara.2009.06.008","article-title":"Antiretroviral protease inhibitors potentiate chloroquine antimalarial activity in malaria parasites by regulating intracellular glutathione metabolism","volume":"123","author":"He","year":"2009","journal-title":"Exp Parasitol"},{"issue":"42","key":"10.1016\/j.parint.2010.09.009_bb0165","doi-asserted-by":"crossref","first-page":"24876","DOI":"10.1074\/jbc.270.42.24876","article-title":"Heme degradation in the presence of glutathione. A proposed mechanism to account for the high levels of non-heme iron found in the membranes of hemoglobinopathic red blood cells","volume":"270","author":"Atamna","year":"1995","journal-title":"J Biol Chem"},{"issue":"10","key":"10.1016\/j.parint.2010.09.009_bb0170","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/S0006-2952(98)00184-1","article-title":"Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action","volume":"56","author":"Ginsburg","year":"1998","journal-title":"Biochem Pharmacol"},{"issue":"23","key":"10.1016\/j.parint.2010.09.009_bb0175","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3109\/10409238809088226","article-title":"Glutathione transferases \u2014 structure and catalytic activity","author":"Mannervik","year":"1988","journal-title":"CRC Crit Rev Biochem"},{"key":"10.1016\/j.parint.2010.09.009_bb0180","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1046\/j.1365-3156.1999.00387.x","article-title":"Glutathione-S transferase activity in malarial parasites","volume":"4","author":"Srivastava","year":"1999","journal-title":"Trop Med Int Health"},{"issue":"401","key":"10.1016\/j.parint.2010.09.009_bb0185","first-page":"240","article-title":"Glutathione S-transferase from malarial parasites \u2014 structural and functional aspects","author":"Deponte","year":"2005","journal-title":"Meth Enzymol"}],"container-title":["Parasitology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383576910001510?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383576910001510?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T15:10:58Z","timestamp":1636729858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1383576910001510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S1383576910001510"],"URL":"https:\/\/doi.org\/10.1016\/j.parint.2010.09.009","relation":{},"ISSN":["1383-5769"],"issn-type":[{"value":"1383-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}