{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:56:53Z","timestamp":1760043413428},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2007CB513108"],"award-info":[{"award-number":["2007CB513108"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology International"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.parint.2012.05.010","type":"journal-article","created":{"date-parts":[[2012,5,22]],"date-time":"2012-05-22T00:17:26Z","timestamp":1337645846000},"page":"586-593","source":"Crossref","is-referenced-by-count":6,"title":["Identification of Th1 epitopes within molecules from the lung-stage schistosomulum of Schistosoma japonicum by combining prediction analysis of the transcriptome with experimental validation"],"prefix":"10.1016","volume":"61","author":[{"given":"Yan Li","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben Peng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun Xiu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian Mei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao Jiao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin Gang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.parint.2012.05.010_bb0005","first-page":"43","article-title":"Schistosomiasis control in China: the impact of a 10-year World Bank Loan Project (1992\u20132001)","volume":"83","author":"Chen","year":"2005","journal-title":"Bulletin of the World Health Organization"},{"key":"10.1016\/j.parint.2012.05.010_bb0010","doi-asserted-by":"crossref","first-page":"5352","DOI":"10.1128\/IAI.69.9.5352-5362.2001","article-title":"Cellular and humoral immune responses and protection against schistosomes induced by a radiation-attenuated vaccine in chimpanzees","volume":"69","author":"Eberl","year":"2001","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.parint.2012.05.010_bb0015","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1017\/S0031182000001347","article-title":"Immunization of rats against Schistosoma mansoni using irradiated cercariae, lung schistosomula and liver-stage worms","volume":"89","author":"Ford","year":"1984","journal-title":"Parasitology"},{"key":"10.1016\/j.parint.2012.05.010_bb0020","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0035-9203(90)90393-S","article-title":"Immunization of baboons with attenuated schistosomula of Schistosoma haematobium: levels of protection induced by immunization with larvae irradiated with 20 and 60krad","volume":"84","author":"Harrison","year":"1990","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"10.1016\/j.parint.2012.05.010_bb0025","doi-asserted-by":"crossref","first-page":"452","DOI":"10.4269\/ajtmh.1980.29.452","article-title":"Observations on cattle schistosomiasis in the Sudan, a study in comparative medicine. III. Field testing of an irradiated Schistosoma bovis vaccine","volume":"29","author":"Majid","year":"1980","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"10.1016\/j.parint.2012.05.010_bb0030","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1017\/S0031182000076745","article-title":"Immunization of pigs against infection with Schistosoma japonicum using ultraviolet-attenuated cercariae","volume":"106","author":"Shi","year":"1993","journal-title":"Parasitology"},{"key":"10.1016\/j.parint.2012.05.010_bb0035","doi-asserted-by":"crossref","first-page":"4782","DOI":"10.4049\/jimmunol.151.9.4782","article-title":"Protective immunity in baboons vaccinated with a recombinant antigen or radiation-attenuated cercariae of Schistosoma mansoni is antibody-dependent","volume":"151","author":"Soisson","year":"1993","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.parint.2012.05.010_bb0040","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1017\/S0031182000065057","article-title":"Protective immunity to Schistosoma mansoni induced in the olive baboon Papio anubis by the irradiated cercaria vaccine","volume":"112","author":"Yole","year":"1996","journal-title":"Parasitology"},{"key":"10.1016\/j.parint.2012.05.010_bb0045","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.pt.2009.05.011","article-title":"Immune effector mechanisms against schistosomiasis: looking for a chink in the parasite's armour","volume":"25","author":"Wilson","year":"2009","journal-title":"Trends in Parasitology"},{"key":"10.1016\/j.parint.2012.05.010_bb0050","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1128\/CMR.00046-07","article-title":"Current status of vaccines for schistosomiasis","volume":"21","author":"McManus","year":"2008","journal-title":"Clinical Microbiology Reviews"},{"key":"10.1016\/j.parint.2012.05.010_bb0055","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1172\/JCI38330","article-title":"Vaccinology in the genome era","volume":"119","author":"Rinaudo","year":"2009","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.parint.2012.05.010_bb0060","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0169-4758(97)01169-1","article-title":"Vaccination against schistosomiasis: the case for lung-stage antigens","volume":"14","author":"Mountford","year":"1998","journal-title":"Parasitology Today"},{"key":"10.1016\/j.parint.2012.05.010_bb0065","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s00018-005-5578-1","article-title":"Transcriptome profiling of lung schistosomula, in vitro cultured schistosomula and adult Schistosoma japonicum","volume":"63","author":"Chai","year":"2006","journal-title":"Cellular and Molecular Life Sciences"},{"key":"10.1016\/j.parint.2012.05.010_bb0070","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2164-10-128","article-title":"Developmental gene expression profiles of the human pathogen Schistosoma japonicum","volume":"10","author":"Gobert","year":"2009","journal-title":"BMC Genomics"},{"key":"10.1016\/j.parint.2012.05.010_bb0075","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1371\/journal.pntd.0000240","article-title":"Altered patterns of gene expression underlying the enhanced immunogenicity of radiation-attenuated schistosomes","volume":"2","author":"Dillon","year":"2008","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"10.1016\/j.parint.2012.05.010_bb0080","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1186\/1471-2105-9-503","article-title":"ESLpred2 improved method for predicting subcellular localization of eukaryotic proteins","volume":"9","author":"Garg","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.parint.2012.05.010_bb0085","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1093\/nar\/gkg510","article-title":"MHCPred: a server for quantitative prediction of peptide-MHC binding","volume":"31","author":"Guan","year":"2003","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.parint.2012.05.010_bb0090","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s002510050595","article-title":"SYFPEITHI: database for MHC ligands and peptide motifs","volume":"50","author":"Rammensee","year":"1999","journal-title":"Immunogenetics"},{"key":"10.1016\/j.parint.2012.05.010_bb0095","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1093\/bioinformatics\/17.12.1236","article-title":"ProPred: prediction of HLA-DR binding sites","volume":"17","author":"Singh","year":"2001","journal-title":"Bioinformatics"},{"key":"10.1016\/j.parint.2012.05.010_bb0100","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/nar\/gkh354","article-title":"ClusPro: a fully automated algorithm for protein\u2013protein docking","volume":"32","author":"Comeau","year":"2004","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.parint.2012.05.010_bb0105","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1002\/j.1460-2075.1989.tb08588.x","article-title":"Direct binding of a myasthenia gravis related epitope to MHC class II molecules on living murine antigen-presenting cells","volume":"8","author":"Mozes","year":"1989","journal-title":"EMBO Journal"},{"key":"10.1016\/j.parint.2012.05.010_bb0110","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1016\/j.vaccine.2004.10.042","article-title":"Establishment of Schistosoma japonicum calpain-specific mouse T cell hybridomas and identification of a T cell epitope that stimulates IFNgamma production","volume":"23","author":"Osada","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.parint.2012.05.010_bb0115","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1017\/S0031182006001648","article-title":"Biology of the schistosome lung-stage schistosomulum","volume":"134","author":"Gobert","year":"2007","journal-title":"Parasitology"},{"key":"10.1016\/j.parint.2012.05.010_bb0120","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/336778a0","article-title":"A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules","volume":"336","author":"Sinigaglia","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.parint.2012.05.010_bb0125","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1016\/j.vaccine.2010.02.046","article-title":"Promiscuous T-cell epitopes of Plasmodium merozoite surface protein 9 (PvMSP9) induces IFN-r and IL-4 responses in individuals naturally exposed to malaria in the Brazilian Amazon","volume":"28","author":"Lima-Junior","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.parint.2012.05.010_bb0130","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1745-7580-5-2","article-title":"Functional recombinant MHC class II molecules and high-throughput peptide-binding assays","volume":"5","author":"Justesen","year":"2009","journal-title":"Immunome Research"},{"key":"10.1016\/j.parint.2012.05.010_bb0135","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1471-2172-6-24","article-title":"Generation of functional HLA-DR*1101 tetramers receptive for loading with pathogen- or tumour-derived synthetic peptides","volume":"6","author":"Moro","year":"2005","journal-title":"BMC Immunology"},{"key":"10.1016\/j.parint.2012.05.010_bb0140","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1074\/mcp.M800538-MCP200","article-title":"Excretory\/secretory proteome of the adult developmental stage of human blood fluke, Schistosoma japonicum","volume":"8","author":"Liu","year":"2009","journal-title":"Molecular & Cellular Proteomics"},{"key":"10.1016\/j.parint.2012.05.010_bb0145","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature08140","article-title":"The Schistosoma japonicum genome reveals features of host\u2013parasite interplay","volume":"460","author":"The Schistosoma japonicum Genome Sequencing and Functional Analysis Consortium","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.parint.2012.05.010_bb0150","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.ijpara.2009.10.002","article-title":"Exposed proteins of the Schistosoma japonicum tegument","volume":"40","author":"Mulvenna","year":"2010","journal-title":"International Journal of Parasitology"},{"key":"10.1016\/j.parint.2012.05.010_bb0155","first-page":"11","article-title":"Immunological identification of Th1-type epitope in tegumental membrane-associated antigen Sj22.6 of Schistosoma japonicum","volume":"21","author":"Wang","year":"2009","journal-title":"Chinese Journal of Schistosomiasis Control"},{"key":"10.1016\/j.parint.2012.05.010_bb0160","doi-asserted-by":"crossref","first-page":"4110","DOI":"10.1016\/j.vaccine.2009.04.073","article-title":"Th1-type epitopes-based cocktail PDDV attenuates hepatic fibrosis in C57BL\/6 mice with chronic Schistosoma japonicum infection","volume":"27","author":"Tao","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.parint.2012.05.010_bb0165","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1046\/j.1365-3024.1997.d01-225.x","article-title":"A dominant B-cell epitope on the 22 kDa tegumental membrane-associated antigen of Schistosoma japonicum maps to an EF-hand calcium binding domain","volume":"19","author":"Waine","year":"1997","journal-title":"Parasite Immunology"},{"key":"10.1016\/j.parint.2012.05.010_bb0170","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000023995","article-title":"Identification of the Schistosoma japonicum 22.6-kDa antigen as a major target of the human IgE response similarity of IgE-binding epitopes to allergen peptides","volume":"117","author":"Santiago","year":"1998","journal-title":"International Archives of Allergy and Immunology"},{"key":"10.1016\/j.parint.2012.05.010_bb0175","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1084\/jem.20082462","article-title":"The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)","volume":"206","author":"Svenja","year":"2009","journal-title":"JEM"},{"key":"10.1016\/j.parint.2012.05.010_bb0180","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1128\/IAI.73.1.395-402.2005","article-title":"Dendritic cells activated with products released by schistosome larvae drive Th2-Type immune responses, which can be inhibited by manipulation of CD40 costimulation","volume":"73","author":"Stephen","year":"2005","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.parint.2012.05.010_bb0185","doi-asserted-by":"crossref","first-page":"3942","DOI":"10.4049\/jimmunol.162.7.3942","article-title":"Adjuvant-guided type-1 and type-2 immunity infectious noninfectious dichotomy defines the class of response","volume":"162","author":"Hualin","year":"1999","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.parint.2012.05.010_bb0190","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.4049\/jimmunol.164.12.6166","article-title":"M-1\/M-2 macrophages and the Th1\/Th2 paradigm","volume":"164","author":"Mills","year":"2000","journal-title":"Journal of Immunology"}],"container-title":["Parasitology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383576912000803?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383576912000803?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T21:42:11Z","timestamp":1687470131000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1383576912000803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S1383576912000803"],"URL":"https:\/\/doi.org\/10.1016\/j.parint.2012.05.010","relation":{},"ISSN":["1383-5769"],"issn-type":[{"value":"1383-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}