{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:29:18Z","timestamp":1777901358164,"version":"3.51.4"},"reference-count":80,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Parasitology International"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.parint.2016.09.003","type":"journal-article","created":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T22:45:56Z","timestamp":1473720356000},"page":"196-206","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Phagocytosis of hemozoin by RAW 264.7 cells, but not THP-1 cells, promotes infection by Leishmania donovani with a nitric oxide-independent mechanism"],"prefix":"10.1016","volume":"66","author":[{"given":"Erika","family":"van den Bogaart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e8tra F.","family":"Mens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily R.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin P.","family":"Grobusch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henk D.F.H.","family":"Schallig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.parint.2016.09.003_bb0005","first-page":"169","article-title":"lmmunosuppression in children with malaria","volume":"1","author":"Greenwood","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.parint.2016.09.003_bb0010","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1365-3024.1986.tb00868.x","article-title":"Suppression of blood monocyte and neutrophil chemotaxis in acute human malaria","volume":"8","author":"Nielsen","year":"1986","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.parint.2016.09.003_bb0015","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1586\/erv.10.16","article-title":"Suppression of vaccine responses by malaria: insignificant or overlooked?","volume":"9","author":"Cunnington","year":"2010","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.parint.2016.09.003_bb0020","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1086\/511437","article-title":"Bacteremia in Malawian children with severe malaria: prevalence, etiology, HIV co-infection, and outcome","volume":"195","author":"Bronzan","year":"2007","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.parint.2016.09.003_bb0025","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1186\/1475-2875-13-335","article-title":"Plasmodium falciparum malaria and invasive bacterial co-infection in young African children: the dysfunctional spleen hypothesis","volume":"13","author":"G\u00f3mez-P\u00e9rez","year":"2014","journal-title":"Malar. J."},{"key":"10.1016\/j.parint.2016.09.003_bb0030","first-page":"233","article-title":"Effect of Plasmodium falciparum malaria on concentration of HIV-1-RNA in the blood of adults in rural Malawi: a prospective cohort study","volume":"365","author":"Kublin","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.parint.2016.09.003_bb0035","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1093\/infdis\/155.6.1319","article-title":"Plasmodium falciparum malaria and Salmonella infections in Gambian children","volume":"155","author":"Mabey","year":"1987","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.parint.2016.09.003_bb0040","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1086\/511984","article-title":"Exposure to holoendemic malaria results in suppression of Epstein\u2013Barr virus-specific T cell immunosurveillance in Kenyan children","volume":"195","author":"Moormann","year":"2007","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.parint.2016.09.003_bb0045","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.nonrwa.2011.11.002","article-title":"Does co-infection with malaria boost persistence of trypanosomiasis?","volume":"13","author":"Nannyonga","year":"2012","journal-title":"Nonlinear Anal. Real World Appl."},{"key":"10.1016\/j.parint.2016.09.003_bb0050","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/1471-2334-13-117","article-title":"Endotoxaemia is common in children with Plasmodium falciparum malaria","volume":"13","author":"Olupot-Olupot","year":"2013","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.parint.2016.09.003_bb0055","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4269\/ajtmh.2004.71.16","article-title":"Pediatric mortality in Africa: Plasmodium falciparum malaria as a cause or risk?","volume":"71","author":"Snow","year":"2004","journal-title":"Am.J.Trop. Med. Hyg."},{"key":"10.1016\/j.parint.2016.09.003_bb0060","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/0140-6736(91)93194-E","article-title":"The effect of insecticide-treated bed nets on mortality of Gambian children","volume":"337","author":"Alonso","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.parint.2016.09.003_bb0065","doi-asserted-by":"crossref","first-page":"882","DOI":"10.4269\/ajtmh.2009.80.882","article-title":"Marked increase in child survival after four years of intensive malaria control","volume":"80","author":"Kleinschmidt","year":"2009","journal-title":"Am.J.Trop. Med. Hyg."},{"key":"10.1016\/j.parint.2016.09.003_bb0070","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4269\/ajtmh.2006.75.63","article-title":"An epidemiologic model of severe morbidity and mortality caused by Plasmodium falciparum","volume":"75","author":"Ross","year":"2006","journal-title":"Am.J.Trop. Med. Hyg."},{"key":"10.1016\/j.parint.2016.09.003_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0163-7258(98)00008-4","article-title":"Severe falciparum malaria in children: current understanding of pathophysiology and supportive treatment","volume":"79","author":"Newton","year":"1998","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.parint.2016.09.003_bb0080","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1365-3024.1993.tb00579.x","article-title":"Reduced microbicidal and anti-tumour activities of human monocytes after ingestion of Plasmodium falciparum-infected red blood cells","volume":"15","author":"Fiori","year":"1993","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.parint.2016.09.003_bb0085","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1084\/jem.176.4.1033","article-title":"Impairment of macrophage functions after ingestion of Plasmodium falciparum-infected erythrocytes or isolated malarial pigment","volume":"176","author":"Schwarzer","year":"1992","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.parint.2016.09.003_bb0090","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0952-7915(02)00368-0","article-title":"Malaria, monocytes, macrophages and myeloid dendritic cells: sticking of infected erythrocytes switches off host cells","volume":"14","author":"Urban","year":"2002","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.parint.2016.09.003_bb0095","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1046\/j.1365-3024.1999.00254.x","article-title":"Hemozoin is a key factor in the induction of malaria-associated immunosuppression","volume":"21","author":"Scorza","year":"1999","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.parint.2016.09.003_bb0100","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1017\/S003118200006580X","article-title":"Patterns of haemozoin accumulation in tissue","volume":"112","author":"Sullivan","year":"1996","journal-title":"Parasitology"},{"key":"10.1016\/j.parint.2016.09.003_bb0105","first-page":"373086","article-title":"In vivo hemozoin kinetics after clearance of Plasmodium berghei infection in mice","volume":"2012","author":"Frita","year":"2012","journal-title":"Malar. Res. Treat."},{"key":"10.1016\/j.parint.2016.09.003_bb0110","doi-asserted-by":"crossref","first-page":"570","DOI":"10.2307\/3285800","article-title":"Splenic and hepatic hemozoin in mice after malaria parasite clearance","volume":"85","author":"Levesque","year":"1999","journal-title":"J. Parasitol."},{"key":"10.1016\/j.parint.2016.09.003_bb0115","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0925-4439(96)00021-X","article-title":"Phagocytosis of malarial pigment hemozoin inhibits NADPH-oxidase activity in human monocyte-derived macrophages","volume":"1316","author":"Schwarzer","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.parint.2016.09.003_bb0120","doi-asserted-by":"crossref","first-page":"430","DOI":"10.4269\/ajtmh.1994.51.430","article-title":"Plasmodium falciparum pigment induces monocytes to release high levels of tumor necrosis factor-\u03b1 and interleukin-1\u03b2","volume":"51","author":"Pichyangkul","year":"1994","journal-title":"Am.J.Trop. Med. Hyg."},{"key":"10.1016\/j.parint.2016.09.003_bb0125","first-page":"239","article-title":"Neutrophils and monocytes from subjects with the Mediterranean G6PD variant: effect of Plasmodium falciparum hemozoin on G6PD activity, oxidative burst and cytokine production","volume":"9","author":"Mordm\u00fcller","year":"1998","journal-title":"Eur. Cytokine Netw."},{"key":"10.1016\/j.parint.2016.09.003_bb0130","first-page":"109","article-title":"Hemozoin differentially modulates the production of interleukin 6 and tumor necrosis factor in murine malaria","volume":"6","author":"Prada","year":"1995","journal-title":"Eur. Cytokine Netw."},{"key":"10.1016\/j.parint.2016.09.003_bb0135","first-page":"85","article-title":"Malaria-specific metabolite hemozoin mediates the release of several potent endogenous pyrogens (TNF, MIP-1\u03b1, and MIP-1\u03b2) in vitro, and altered thermoregulation in vivo","volume":"45","author":"Sherry","year":"1995","journal-title":"J. Inflamm."},{"key":"10.1016\/j.parint.2016.09.003_bb0140","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.4049\/jimmunol.171.8.4243","article-title":"Hemozoin increases IFN-\u03b3-inducible macrophage nitric oxide generation through extracellular signal-regulated kinase- and NF-\u03baB-dependent pathways","volume":"171","author":"Jaramillo","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.parint.2016.09.003_bb0145","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0925-4439(93)90089-J","article-title":"Phagocytosis of P. falciparum malarial pigment hemozoin by human monocytes inactivates monocyte protein kinase C","volume":"1181","author":"Schwarzer","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.parint.2016.09.003_bb0150","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1128\/IAI.66.4.1601-1606.1998","article-title":"Phagocytosis of malarial pigment, hemozoin, impairs expression of major histocompatibility complex class II antigen, CD54, and CD11c in human monocytes","volume":"66","author":"Schwarzer","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.parint.2016.09.003_bb0155","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.4049\/jimmunol.173.6.4066","article-title":"Hemozoin (malarial pigment) inhibits differentiation and maturation of human monocyte-derived dendritic cells: a peroxisome proliferator-activated receptor-gamma-mediated effect","volume":"173","author":"Skorokhod","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.parint.2016.09.003_bb0160","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.4049\/jimmunol.0903824","article-title":"Protein-DNA complex is the exclusive malaria parasite component that activates dendritic cells and triggers innate immune responses","volume":"184","author":"Wu","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.parint.2016.09.003_bb0165","doi-asserted-by":"crossref","first-page":"5674","DOI":"10.1182\/blood-2010-10-312413","article-title":"Host fibrinogen stably bound to hemozoin rapidly activates monocytes via TLR-4 and CD11b\/CD18-integrin: a new paradigm of hemozoin action","volume":"117","author":"Barrera","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.parint.2016.09.003_bb0170","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s00775-006-0147-0","article-title":"The basis of the immunomodulatory activity of malaria pigment (hemozoin)","volume":"11","author":"Carney","year":"2006","journal-title":"J. Biol. Inorg. Chem."},{"key":"10.1016\/j.parint.2016.09.003_bb0175","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.plefa.2005.05.018","article-title":"Anti-inflammatory pathways as a host evasion mechanism for pathogens","volume":"73","author":"Aliberti","year":"2005","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.parint.2016.09.003_bb0180","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1002\/1521-4141(200211)32:11<3050::AID-IMMU3050>3.0.CO;2-K","article-title":"Mycobacterium tuberculosis subverts the differentiation of human monocytes into dendritic cells","volume":"32","author":"Mariotti","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.parint.2016.09.003_bb0185","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1128\/CMR.18.2.293-305.2005","article-title":"Subversion mechanisms by which Leishmania parasites can escape the host immune response: a signaling point of view","volume":"18","author":"Olivier","year":"2005","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.parint.2016.09.003_bb0190","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/0035-9203(95)90091-8","article-title":"Co-existent kala-azar and malaria in India","volume":"89","author":"Nandy","year":"1995","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.parint.2016.09.003_bb0195","doi-asserted-by":"crossref","first-page":"382","DOI":"10.5858\/2002-126-0382-KAAWM","article-title":"Kala azar associated with malaria","volume":"126","author":"Sah","year":"2002","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.parint.2016.09.003_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001617","article-title":"Prevalence, features and risk factors of malaria co-infections among visceral leishmaniasis patients from Amudat Hospital, Uganda","volume":"6","author":"van den Bogaart","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.parint.2016.09.003_bb0205","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1186\/1471-2458-13-332","article-title":"Concomitant malaria among visceral leishmaniasis in-patients from Gedarif and Sennar States, Sudan: a retrospective case\u2013control study","volume":"13","author":"van den Bogaart","year":"2013","journal-title":"BMC Public Health"},{"key":"10.1016\/j.parint.2016.09.003_bb0210","doi-asserted-by":"crossref","first-page":"540","DOI":"10.4269\/ajtmh.1988.39.540","article-title":"Interactions between Plasmodium yoelii and Leishmania mexicana amazonensis in Leishmania resistant C57B1\/6 mice","volume":"39","author":"Coleman","year":"1988","journal-title":"Am.J.Trop. Med. Hyg."},{"key":"10.1016\/j.parint.2016.09.003_bb0215","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0014-4894(88)90131-2","article-title":"Leishmania mexicana: effect of concomitant malaria on cutaneous leishmaniasis. Development of lesions in a Leishmania-susceptible (BALB\/c) strain of mouse","volume":"65","author":"Coleman","year":"1988","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.parint.2016.09.003_bb0220","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1590\/S0074-02762005000800011","article-title":"Studies in a co-infection murine model of Plasmodium chabaudi chabaudi and Leishmania infantum: interferon-gamma and interleukin-4 mRNA expression","volume":"100","author":"Marques","year":"2005","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.parint.2016.09.003_bb0225","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0035-9203(54)90145-5","article-title":"The behaviour of Plasmodium berghei in the golden hamster Mesocricetus auratus infected with visceral leishmaniasis","volume":"48","author":"Adler","year":"1954","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.parint.2016.09.003_bb0230","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1128\/AAC.00751-13","article-title":"Simple colorimetric trypanothione reductase-based assay for high-throughput screening of drugs against Leishmania intracellular amastigotes","volume":"58","author":"van den Bogaart","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.parint.2016.09.003_bb0235","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0092-8674(78)90101-0","article-title":"Functional macrophage cell lines transformed by Abelson leukemia virus","volume":"15","author":"Raschke","year":"1978","journal-title":"Cell"},{"key":"10.1016\/j.parint.2016.09.003_bb0240","first-page":"1530","article-title":"Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester","volume":"42","author":"Tsuchiya","year":"1982","journal-title":"Cancer Res."},{"key":"10.1016\/j.parint.2016.09.003_bb0245","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.781840","article-title":"Human malaria parasites in continuous culture","volume":"193","author":"Trager","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.parint.2016.09.003_bb9000","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.ijpara.2011.07.013","article-title":"Characterisation of antimony-resistant Leishmania donovani isolates: biochemical and biophysical studies andinteraction with host cells","volume":"41","author":"Mukhopadhyay","year":"2011","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.parint.2016.09.003_bb0250","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1073\/pnas.0608745104","article-title":"Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9","volume":"104","author":"Parroche","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.parint.2016.09.003_bb0255","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0014-5793(97)00533-4","article-title":"Non-iron porphyrins inhibit beta-haematin (malaria pigment) polymerisation","volume":"409","author":"Basilico","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.parint.2016.09.003_bb0260","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/cber.187901201117","article-title":"Bemerkungen zu der Abhandlung der HH. Weselsky und Benedikt \u201cUeber einige Azoverbindungen Ber\u201d","volume":"12","author":"Griess","year":"1876","journal-title":"Dtsch. Chem. Ges."},{"key":"10.1016\/j.parint.2016.09.003_bb0265","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/j.1365-2141.1994.tb05112.x","article-title":"A luminescence method for the quantitative determination of phagocytosis of erythrocytes, of malaria-parasitized erythrocytes and of malarial pigment","volume":"88","author":"Schwarzer","year":"1994","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.parint.2016.09.003_bb0270","doi-asserted-by":"crossref","first-page":"620","DOI":"10.4269\/ajtmh.1996.54.620","article-title":"Effects of Plasmodium vinckei hemozoin on the production of oxygen radicals and nitrogen oxides in murine macrophages","volume":"54","author":"Prada","year":"1996","journal-title":"Am.J.Trop. Med. Hyg."},{"key":"10.1016\/j.parint.2016.09.003_bb0275","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1006\/expr.1995.1143","article-title":"The heme moiety of malaria pigment (\u03b2-hematin) mediates the inhibition of nitric oxide and tumor necrosis factor-\u03b1 production by lipopolysaccharide-stimulated macrophages","volume":"81","author":"Taramelli","year":"1995","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.parint.2016.09.003_bb0280","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.niox.2003.09.006","article-title":"Protein kinase C-eta (PKC-\u03b7) is required for the development of inducible nitric oxide synthase (iNOS) positive phenotype in human monocytic cells","volume":"9","author":"Pham","year":"2003","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.parint.2016.09.003_bb0285","doi-asserted-by":"crossref","first-page":"4804","DOI":"10.1128\/IAI.62.11.4804-4810.1994","article-title":"Abrogation of gamma interferon-induced inhibition of Ehrlichia chaffeensis infection in human monocytes with iron-transferrin","volume":"62","author":"Barnewall","year":"1994","journal-title":"Infect. Immun."},{"key":"10.1016\/j.parint.2016.09.003_bb0290","first-page":"45","article-title":"Endogenous nitric oxide production by human monocytic cells regulates LPS-induced TNF production","volume":"6","author":"Zinetti","year":"1995","journal-title":"Eur. Cytokine Netw."},{"key":"10.1016\/j.parint.2016.09.003_bb0295","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/eji.1830240836","article-title":"Nitric oxide synthase: mRNA expression of different isoforms in human monocytes\/macrophages","volume":"24","author":"Reiling","year":"1994","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.parint.2016.09.003_bb0300","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cellimm.2010.05.011","article-title":"Regulation of lipopolysaccharide-induced inflammatory response by heat shock protein 27 in THP-1 cells","volume":"264","author":"Liu","year":"2010","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.parint.2016.09.003_bb0305","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.pt.2013.07.005","article-title":"The hemozoin conundrum: is malaria pigment immune-activating, inhibiting, or simply a bystander?","volume":"29","author":"Boura","year":"2013","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.parint.2016.09.003_bb0310","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S1473-3099(07)70238-4","article-title":"Haemozoin: from melatonin pigment to drug target, diagnostic tool, and immune modulator","volume":"7","author":"H\u00e4nscheid","year":"2007","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.parint.2016.09.003_bb0315","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1165\/rcmb.2012-0450OC","article-title":"Hemozoin induces lung inflammation and correlates with malaria-associated acute respiratory distress syndrome","volume":"48","author":"Deroost","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.parint.2016.09.003_bb0320","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.micinf.2010.05.013","article-title":"Malaria exacerbates experimental mycobacterial infection in vitro and in vivo","volume":"12","author":"Hawkes","year":"2010","journal-title":"Microbes Infect."},{"key":"10.1016\/j.parint.2016.09.003_bb0325","doi-asserted-by":"crossref","first-page":"4794","DOI":"10.4049\/jimmunol.144.12.4794","article-title":"Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine","volume":"144","author":"Liew","year":"1990","journal-title":"J. Immunol."},{"key":"10.1016\/j.parint.2016.09.003_bb9005","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00436-015-4793-4","article-title":"Cross-resistance of Leishmania infantumisolates to nitric oxide from patients refractory to antimony treatment, and greater tolerance to antileishmanial responses by macrophages","volume":"115","author":"de Moura","year":"2016","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.parint.2016.09.003_bb0330","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1475-2875-6-73","article-title":"Malarial pigment haemozoin, IFN-gamma, TNF-alpha, IL-1beta and LPS do not stimulate expression of inducible nitric oxide synthase and production of nitric oxide in immuno-purified human monocytes","volume":"6","author":"Skorokhod","year":"2007","journal-title":"Malar. J."},{"key":"10.1016\/j.parint.2016.09.003_bb0335","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0166-6851(99)00031-6","article-title":"Hemozoin stability and dormant induction of heme oxygenase in hemozoin-fed human monocytes","volume":"100","author":"Schwarzer","year":"1999","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.parint.2016.09.003_bb0340","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1017\/S0031182001008216","article-title":"Phagocytosis of malarial pigment haemozoin by human monocytes: a confocal microscopy study","volume":"123","author":"Schwarzer","year":"2001","journal-title":"Parasitology"},{"key":"10.1016\/j.parint.2016.09.003_bb0345","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1046\/j.1365-2958.1998.00968.x","article-title":"Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus","volume":"29","author":"Tovar","year":"1998","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.parint.2016.09.003_bb0350","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.1073\/pnas.95.9.5311","article-title":"Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: Effect on parasite intracellular survival","volume":"95","author":"Tovar","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.parint.2016.09.003_bb0355","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1432-1033.1993.tb18348.x","article-title":"Phenotype of recombinant Leishmania donovani and Trypanosoma cruzi which over-express trypanothione reductase. Sensitivity towards agents that are thought to induce oxidative stress","volume":"218","author":"Kelly","year":"1993","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.parint.2016.09.003_bb0360","doi-asserted-by":"crossref","first-page":"681","DOI":"10.4269\/ajtmh.2007.76.681","article-title":"Characterization of natural antimony resistance in Leishmania donovani isolates","volume":"76","author":"Mittal","year":"2007","journal-title":"Am.J.Trop. Med. Hyg."},{"key":"10.1016\/j.parint.2016.09.003_bb0365","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0166-6851(00)00270-X","article-title":"Episomal and stable expression of luciferase reporter gene for quantifying Leishmania spp. infection in macrophages and animal models","volume":"110","author":"Roy","year":"2000","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.parint.2016.09.003_bb0370","first-page":"4054","article-title":"A parasite rescue and transformation assay for antileishmanial screening against intracellular Leishmania donovani amastigotes in THP1 human acute monocytic leukemia cell line","volume":"70","author":"Jain","year":"2012","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.parint.2016.09.003_bb0375","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ijpddr.2013.11.001","article-title":"Duplex quantitative Reverse-Transcriptase PCR for simultaneous assessment of drug activity against Leishmania intracellular amastigotes and their host cells","volume":"4","author":"van den Bogaart","year":"2013","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.parint.2016.09.003_bb0380","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/BF02041244","article-title":"The human leukemia cell line THP-1: a multifacetted model for the study of monocyte\u2013macrophage differentiation","volume":"47","author":"Auwerx","year":"1991","journal-title":"Experientia"},{"key":"10.1016\/j.parint.2016.09.003_bb0385","doi-asserted-by":"crossref","first-page":"697972","DOI":"10.1155\/2013\/697972","article-title":"Monocytes, peripheral blood mononuclear cells, and THP-1 cells exhibit different cytokine expression patterns following stimulation with lipopolysaccharide","volume":"2013","author":"Schildberger","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.parint.2016.09.003_bb0390","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/jbm.a.31930","article-title":"Phenotypic non-equivalence of murine (monocyte-) macrophage cells in biomaterial and inflammatory models","volume":"88","author":"Chamberlain","year":"2009","journal-title":"J. Biomed. Mater. Res. A"}],"container-title":["Parasitology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383576916303336?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383576916303336?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T02:25:18Z","timestamp":1692498318000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1383576916303336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":80,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S1383576916303336"],"URL":"https:\/\/doi.org\/10.1016\/j.parint.2016.09.003","relation":{},"ISSN":["1383-5769"],"issn-type":[{"value":"1383-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phagocytosis of hemozoin by RAW 264.7 cells, but not THP-1 cells, promotes infection by Leishmania donovani with a nitric oxide-independent mechanism","name":"articletitle","label":"Article Title"},{"value":"Parasitology International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.parint.2016.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}