{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T06:30:49Z","timestamp":1763620249670,"version":"3.37.3"},"reference-count":49,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["308600\/2015-0","447218\/2014-0"],"award-info":[{"award-number":["308600\/2015-0","447218\/2014-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005286","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa\u00a0do Estado de\u00a0Mato Grosso","doi-asserted-by":"publisher","award":["158088\/2014"],"award-info":[{"award-number":["158088\/2014"]}],"id":[{"id":"10.13039\/501100005286","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["23038.008852\/2011-84"],"award-info":[{"award-number":["23038.008852\/2011-84"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Parasitology International"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.parint.2017.02.005","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T01:23:07Z","timestamp":1488331387000},"page":"299-304","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["In vitro immunomodulatory effects of microemulsions with levamisole delivery systems on blood phagocytes interacting with Giardia lamblia"],"prefix":"10.1016","volume":"66","author":[{"given":"Mara Rosa Gil","family":"Hernandes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc\u00e9lia Campelo Albuquerque","family":"Moraes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elton Brito","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danny Laura Gomes","family":"Fagundes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adenilda Cristina","family":"Honorio-Fran\u00e7a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo Luz\u00eda","family":"Fran\u00e7a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.parint.2017.02.005_bb0005","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1471-2458-10-85","article-title":"Could giardiasis be a risk factor for low zinc status in school children from north western Mexico? A cross-sectional study with longitudinal follow-up","volume":"10","author":"Quihui","year":"2010","journal-title":"BMC Public Health"},{"key":"10.1016\/j.parint.2017.02.005_bb0010","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.pt.2009.11.010","article-title":"Giardiasis\u2014why do the symptoms sometimes never stop?","volume":"26","author":"Robertson","year":"2010","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.parint.2017.02.005_bb0015","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S2222-1808(14)60659-9","article-title":"A survey of intestinal parasites in a population in Qazvin, north of Iran","volume":"5","author":"Sadeghi","year":"2015","journal-title":"Asian Pac. J. Trop. Dis."},{"key":"10.1016\/j.parint.2017.02.005_bb0020","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.1128\/IAI.70.7.3673-3680.2002","article-title":"Strain-dependent induction of enterocyte apoptosis by Giardia lamblia disrupts epithelial barrier function in a caspase-3-dependent manner","volume":"70","author":"Chin","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.parint.2017.02.005_bb0025","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.actbio.2009.07.009","article-title":"Modular scaffolds assembled around living cells using poly [ethylene glycol] microspheres with macroporation via a non-cytotoxic porogen","volume":"6","author":"Scott","year":"2010","journal-title":"Acta Biomater."},{"key":"10.1016\/j.parint.2017.02.005_bb0030","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1128\/IAI.70.1.11-18.2002","article-title":"Central importance of immunoglobulin A in host defense against Giardia spp","volume":"70","author":"Langford","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.parint.2017.02.005_bb0035","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.exppara.2010.06.014","article-title":"Giardia duodenalis: the double-edged sword of immune responses in giardiasis","volume":"126","author":"Solaymani-Mohammadi","year":"2010","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.parint.2017.02.005_bb0040","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1128\/iai.55.12.3155-3161.1987","article-title":"Ingestion of Giardia lamblia trophozoites by human mononuclear phagocytes","volume":"55","author":"Hill","year":"1987","journal-title":"Infect. Immun."},{"key":"10.1016\/j.parint.2017.02.005_bb0045","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1365-2249.1992.tb02992.x","article-title":"Phagocytosis of Giardia lamblia trophozoites by cytokine-activated macrophages","volume":"87","author":"Belosevic","year":"1992","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.parint.2017.02.005_bb0050","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1128\/CMR.14.1.114-128.2001","article-title":"Treatment of giardiasis","volume":"14","author":"Gardner","year":"2001","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.parint.2017.02.005_bb0055","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1651-2227.2006.tb02258.x","article-title":"Phagocytosis of Giardia lamblia trophozoites by human colostral leukocytes","volume":"95","author":"Fran\u00e7a-Botelho","year":"2006","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.parint.2017.02.005_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/a28fd8eb-b0a9-47f1-935c-7912050dc19b","article-title":"Prevalence and spatial distribution of Entamoeba histolytica\/dispar and Giardia lamblia among school children in Agboville area [C\u00f4te d'Ivoire]","volume":"4","author":"Ouattara","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.parint.2017.02.005_bb0065","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1179\/136485908X267894","article-title":"The treatment of giardiasis in children: single-dose tinidazole compared with 3 days of nitazoxanide","volume":"102","author":"Escobedo","year":"2008","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/j.parint.2017.02.005_bb0070","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1128\/CMR.14.1.150-164.2001","article-title":"Drug targets and mechanisms of resistance in the anaerobic protozoa","volume":"14","author":"Upcroft","year":"2001","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.parint.2017.02.005_bb0075","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1128\/AAC.00384-11","article-title":"Impaired parasite attachment as fitness cost of metronidazole resistance in Giardia lamblia","volume":"55","author":"Tejman-Yarden","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.parint.2017.02.005_bb0080","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.addr.2012.09.018","article-title":"Microemulsion-based media as novel drug delivery systems","volume":"64","author":"Lawrence","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.parint.2017.02.005_bb0085","first-page":"21","article-title":"Microemulsion of babassu oil as a natural product to improve human immune system function","volume":"9","author":"Pessoa","year":"2015","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.parint.2017.02.005_bb0090","first-page":"214","article-title":"Effects of microemulsion incorporated with Orbignya martiana Rodr on the functional activity of blood phagocytes","volume":"23","author":"Lanes","year":"2016","journal-title":"Wulfenia J."},{"key":"10.1016\/j.parint.2017.02.005_bb0095","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1166\/sam.2015.2003","article-title":"Microemulsions with levamisole delivery systems as novel immunomodulating agents with potential for amebiasis therapies","volume":"7","author":"Ribeiro","year":"2015","journal-title":"Sci. Adv. Mater."},{"key":"10.1016\/j.parint.2017.02.005_bb0100","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cdp.2005.08.002","article-title":"Immunomodulation with low dose levamisole in patients with colonic polyps","volume":"30","author":"Holcombe","year":"2006","journal-title":"Cancer Detect. Prev."},{"key":"10.1016\/j.parint.2017.02.005_bb0105","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/BF03189626","article-title":"Pharmacokinetics of levamisole in healthy subjects and cancer patients","volume":"7","author":"Luyckx","year":"1982","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.parint.2017.02.005_bb0110","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/bdd.2510070110","article-title":"Novel assay and pharmacokinetics of levamisole and p-hydroxylevamisole in human plasma and urine","volume":"7","author":"Kouassi","year":"1986","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.parint.2017.02.005_bb0115","first-page":"827","article-title":"Effect of immunomodulation with levamisole on the course and pathogenesis of acute experimental Trypanosoma congolense infection in sheep","volume":"8","author":"Bisalla","year":"2009","journal-title":"Afr. J. Biotechnol."},{"key":"10.1016\/j.parint.2017.02.005_bb0120","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0035-9203(83)90120-7","article-title":"Axenic culture of Giardia lamblia in TYI-S-33 medium supplemented with bile","volume":"77","author":"Keister","year":"1983","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.parint.2017.02.005_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmii.2011.01.002","article-title":"Human colostral phagocytes eliminate enterotoxigenic Escherichia coli opsonized by colostrum supernatant","volume":"44","author":"Fran\u00e7a","year":"2011","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"10.1016\/j.parint.2017.02.005_bb0130","first-page":"6021","article-title":"Nanoparticles of barium induce apoptosis in human phagocytes","volume":"10","author":"Mores","year":"2015","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.parint.2017.02.005_bb0135","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1590\/S0100-40422012000900023","article-title":"Nanoemulsions as parenteral drug delivery systems","volume":"35","author":"Bruxel","year":"2012","journal-title":"Quim Nova"},{"key":"10.1016\/j.parint.2017.02.005_bb0140","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0192-0561(92)90179-O","article-title":"Levamisole, the story and the lessons","volume":"14","author":"Amery","year":"1992","journal-title":"Int. J. Immunopharmacol."},{"key":"10.1016\/j.parint.2017.02.005_bb0145","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1200\/JCO.1993.11.1.125","article-title":"Dose-related immunologic effects of levamisole in patients with c\u00e2ncer","volume":"11","author":"Janik","year":"1993","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.parint.2017.02.005_bb0150","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3816\/CCC.2006.n.030","article-title":"Randomized clinical trial of high-dose levamisole combined with 5-fluorouracil and leucovorin as surgical adjuvant therapy for high-risk colon cancer","volume":"6","author":"Connell","year":"2006","journal-title":"Clin. Colorectal Cancer"},{"key":"10.1016\/j.parint.2017.02.005_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clinthera.2010.01.005","article-title":"Effects of oral levamisole as an adjuvant to hepatitis B vaccine in adults with end-stage renal disease: a meta-analysis of controlled clinical trials","volume":"32","author":"Alavian","year":"2010","journal-title":"Clin. Ther."},{"key":"10.1016\/j.parint.2017.02.005_bb0160","doi-asserted-by":"crossref","first-page":"6642","DOI":"10.1128\/IAI.72.11.6642-6649.2004","article-title":"Mast cell-dependent control of Giardia lamblia infections in mice","volume":"72","author":"Li","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.parint.2017.02.005_bb0165","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1166\/sam.2011.1236","article-title":"Immunomodulatory effects of poly [ethylene glycol] microspheres adsorbed with nanofractions of Momordica charantia L. on diabetic human blood phagocytes","volume":"3","author":"Scherer","year":"2011","journal-title":"Sci. Adv. Mater."},{"key":"10.1016\/j.parint.2017.02.005_bb0170","doi-asserted-by":"crossref","first-page":"510","DOI":"10.3923\/ijp.2012.510.518","article-title":"Immunomodulatory effects of poly [ethylene glycol] microspheres adsorbed with cortisol on activity of colostrum phagocytes","volume":"8","author":"Fagundes","year":"2012","journal-title":"Int. J. Pharmacol."},{"key":"10.1016\/j.parint.2017.02.005_bb0175","first-page":"209","article-title":"Natural material adsorbed onto a polymer to enhance immune function","volume":"6","author":"Reinaque","year":"2012","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.parint.2017.02.005_bb0180","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/973179","article-title":"Melatonin nanoparticles adsorbed to polyethylene glycol microspheres as activators of human colostrum macrophages","volume":"2013","author":"Hara","year":"2013","journal-title":"J. Nanomater."},{"key":"10.1016\/j.parint.2017.02.005_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/541018","article-title":"Brazilian propolis: a natural product that improved the fungicidal activity by blood phagocytes","volume":"2013","author":"Possamai","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.parint.2017.02.005_bb0190","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1189\/jlb.69.2.289","article-title":"Colostral neutrophils express IgA Fc receptors [CD89] lacking y chain association that mediate non-inflammatory properties of secretory IgA","volume":"69","author":"Honorio-Fran\u00e7a","year":"2001","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.parint.2017.02.005_bb0195","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/mi.2008.5","article-title":"Mucins in the mucosal barrier to infection","volume":"1","author":"Linden","year":"2008","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.parint.2017.02.005_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0056915","article-title":"Antioxidant effect of melatonin on the functional activity of colostral phagocytes in diabetic women","volume":"8","author":"Morceli","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.parint.2017.02.005_bb0205","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2478\/v10136-012-0039-2","article-title":"Human colostrum melatonin exhibits a day-night variation and modulates the activity of colostral phagocytes","volume":"11","author":"Honorio-Fran\u00e7a","year":"2013","journal-title":"J. Appl. Biomed."},{"key":"10.1016\/j.parint.2017.02.005_bb0210","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0165-5728(01)00325-3","article-title":"Melatonin modulation of lymphocyte proliferation and Th1\/Th2 cytokine expression","volume":"117","author":"K\u00fchlwein","year":"2001","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.parint.2017.02.005_bb0215","doi-asserted-by":"crossref","DOI":"10.1186\/1756-3305-4-62","article-title":"Melatonin reduces the severity of experimental amoebiasis","volume":"4","author":"Fran\u00e7a-Botelho","year":"2011","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.parint.2017.02.005_bb0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/845270","article-title":"Modulation of human colostrum phagocyte activity by the glycine-adsorbed polyethylene glycol microspheres","volume":"2013","author":"Guimar\u00e3es","year":"2013","journal-title":"J. Chem."},{"key":"10.1016\/j.parint.2017.02.005_bb0225","doi-asserted-by":"crossref","DOI":"10.1186\/s13071-015-1028-6","article-title":"The effect of IFN-\u03b3 and TGF-\u03b2 in the functional activity of mononuclear cells in the presence of Entamoeba histolytica","volume":"8","author":"Moraes","year":"2015","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.parint.2017.02.005_bb0230","first-page":"1","article-title":"Intracellular calcium is a target of modulation of apoptosis in MCF-7 cells in the presence of IgA adsorbed to polyethylene glycol","volume":"9","author":"Honorio-Fran\u00e7a","year":"2016","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.parint.2017.02.005_bb0235","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bbamem.2010.08.002","article-title":"Characterization of superoxide over production by the D-LoopNox4-Nox2 cytochrome b558 in phagocytes-differential sensitivity to calcium and phosphorylation events","volume":"1808","author":"Carrichon","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.parint.2017.02.005_bb0240","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000439277","article-title":"The effect of melatonin adsorbed to polyethylene glycol microspheres on the survival of MCF-7 cells","volume":"23","author":"Fran\u00e7a","year":"2016","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.parint.2017.02.005_bb0245","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/590190","article-title":"The role of cytokines in the functional activity of phagocytes in blood and colostrum of diabetic mothers","volume":"2013","author":"Fagundes","year":"2013","journal-title":"Clin. Dev. Immunol."}],"container-title":["Parasitology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383576916304032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383576916304032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T12:05:34Z","timestamp":1692705934000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1383576916304032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S1383576916304032"],"URL":"https:\/\/doi.org\/10.1016\/j.parint.2017.02.005","relation":{},"ISSN":["1383-5769"],"issn-type":[{"type":"print","value":"1383-5769"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro immunomodulatory effects of microemulsions with levamisole delivery systems on blood phagocytes interacting with Giardia lamblia","name":"articletitle","label":"Article Title"},{"value":"Parasitology International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.parint.2017.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}