{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:20:20Z","timestamp":1791400820075,"version":"4.3.3"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T00:00:00Z","timestamp":1572912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Parasitology International"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.parint.2019.102004","type":"journal-article","created":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T02:17:29Z","timestamp":1572747449000},"page":"102004","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Mitochondrial complex III in larval stage of Echinococcus multilocularis as a potential chemotherapeutic target and in vivo efficacy of atovaquone against primary hydatid cysts"],"prefix":"10.1016","volume":"75","author":[{"given":"Shigehiro","family":"Enkai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Ken","family":"Inaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Kouguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Irie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinpei","family":"Yagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Kita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.parint.2019.102004_bb0005","series-title":"Global Plan to Combat Neglected Tropical Diseases 2008\u20132015","author":"WHO","year":"2007"},{"issue":"28","key":"10.1016\/j.parint.2019.102004_bb0010","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.4254\/wjh.v8.i28.1169","article-title":"Current status of diagnosis and treatment of hepatic echinococcosis","volume":"8","author":"Mihmanli","year":"2016","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.parint.2019.102004_bb0015","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/bs.apar.2016.09.006","article-title":"The Echinococcoses: Diagnosis, clinical management and burden of disease","volume":"96","author":"Kern","year":"2017","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.parint.2019.102004_bb0020","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.e3866","article-title":"Diagnosis, treatment, and management of echinococcosis","volume":"344","author":"McManus","year":"2012","journal-title":"BMJ."},{"key":"10.1016\/j.parint.2019.102004_bb0025","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nrd4683","article-title":"Hit and lead criteria in drug discovery for infectious diseases of the developing world","volume":"14","author":"Katsuno","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"issue":"4","key":"10.1016\/j.parint.2019.102004_bb0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006422","article-title":"Progress in the pharmacological treatment of human cystic and alveolar echinococcosis: compounds and therapeutic targets","volume":"12","author":"Siles-Lucas","year":"2018","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.parint.2019.102004_bb0035","series-title":"Echinococcosis","article-title":"Medical treatment of Echinococcus multilocularis and new horizons for drug discovery: Characterization of mitochondrial complex II as a potential drug target","author":"Enkai","year":"2017"},{"key":"10.1016\/j.parint.2019.102004_bb0040","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1128\/AAC.00378-07","article-title":"Anaerobic NADH-fumarate reductase system is predominant in the respiratory chain of Echinococcus multilocularis, providing a novel target for the chemotherapy of alveolar echinococcosis","volume":"52","author":"Matsumoto","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.parint.2019.102004_bb0045","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1073\/pnas.98.1.60","article-title":"An anthelmintic compound, nafuredin, shows selective inhibition of complex I in helminth mitochondria","volume":"98","author":"Omura","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.parint.2019.102004_bb0050","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.bbabio.2013.01.005","article-title":"Diversity of parasite complex II","volume":"1827","author":"Harada","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.parint.2019.102004_bb0055","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1017\/S0031182000048769","article-title":"Differences in the chemical composition and carbohydrate metabolism of Echinococcus granulosus (horse and sheep strains) and E. multilocularis","volume":"77","author":"McManus","year":"1978","journal-title":"Parasitology."},{"key":"10.1016\/j.parint.2019.102004_bb0060","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/s00436-003-1046-8","article-title":"Long-term in vitro cultivation of Echinococcus multilocularis metacestodes under axenic conditions","volume":"92","author":"Spiliotis","year":"2004","journal-title":"Parasitol. Res."},{"issue":"1","key":"10.1016\/j.parint.2019.102004_bb0065","first-page":"1","article-title":"Quinazolinone and quinazoline derivatives: recent structures with potent antimicrobial and cytotoxic activities","volume":"11","author":"Jafari","year":"2016","journal-title":"Res. Pharm. Sci."},{"key":"10.1016\/j.parint.2019.102004_bb0070","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.bbagen.2011.12.013","article-title":"Mitochondrial fumarate reductase as a target of chemotherapy: from parasites to cancer cells","volume":"1820","author":"Sakai","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.parint.2019.102004_bb0075","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.parint.2005.09.003","article-title":"Chemotherapeutic efficacy of ascofuranone in Trypanosoma vivax-infected mice without glycerol","volume":"55","author":"Yabu","year":"2006","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.parint.2019.102004_bb0080","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/j.ijpara.2010.07.009","article-title":"H, Paragonimus westermani possesses aerobic and anaerobic mitochondria in different tissues, adapting to fluctuating oxygen tension in microaerobic habitats","volume":"40","author":"Takamiya","year":"2010","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.parint.2019.102004_bb0085","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1006\/abbi.1994.1292","article-title":"Respiratory chain of the lung fluke Paragonimus westermani: facultative anaerobic mitochondria","volume":"312","author":"Takamiya","year":"1994","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.parint.2019.102004_bb0090","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1021\/acsinfecdis.8b00133","volume":"4","author":"McConnell","year":"2018","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.parint.2019.102004_bb0095","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2174\/1568026616666160719164542","article-title":"New opportunities in the structure-based design of anti-protozoan agents","volume":"17","author":"Gordon","year":"2017","journal-title":"Curr. Trop. Med. Chem."},{"key":"10.1016\/j.parint.2019.102004_bb0100","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.bbabio.2007.02.014","article-title":"Parameters determining the relative efficacy of hydroxy-naphthoquinone inhibitors of the cytochrome bc1 complex","volume":"1767","author":"Kessl","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.parint.2019.102004_bb0105","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.ijpddr.2018.10.011","article-title":"Repurposing of an old drug: in vitro and in vivo efficacies of buparvaquone against Echinococcus multilocularis","volume":"8","author":"Rufener","year":"2018","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.parint.2019.102004_bb0110","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1128\/AAC.35.2.293","article-title":"Remarkable in vitro and in vivo activities of the hydroxynaphthoquinone against tachyzoites and tissue cysts of Toxoplasma gondii","volume":"35","author":"Araujo","year":"1991","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.parint.2019.102004_bb0115","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1128\/AAC.34.2.225","article-title":"Efficacy of a hydroxynaphthoquinone, 566C80, in experimental Pneumocystis carinii pneumonitis","volume":"34","author":"Hughes","year":"1990","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.parint.2019.102004_bb0120","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2307\/3284461","article-title":"Therapeutic efficacy of atovaquone against the bovine intraerythrocytic parasite, Babesia divergens","volume":"83","author":"Pudney","year":"1997","journal-title":"J. Parasitol."},{"key":"10.1016\/j.parint.2019.102004_bb0125","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1056\/NEJM200011163432004","article-title":"Atovaquone and azithromycin for the treatment of babesiosis","volume":"343","author":"Krause","year":"2000","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.parint.2019.102004_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1074\/jbc.R600031200","article-title":"Supramolecular structure of the mitochondrial oxidative phosphorylation system","volume":"283","author":"Boekema","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.parint.2019.102004_bb0135","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.parint.2010.06.003","article-title":"Primary alveolar echinococcosis: course of larval development and antibody responses in intermediate host rodents with different genetic backgrounds after oral infection with eggs of Echinococcus multilocularis","volume":"59","author":"Matsumoto","year":"2010","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.parint.2019.102004_bb0140","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.cell.2005.05.025","article-title":"Crystal structure of mitochondrial respiratory membrane protein complex II","volume":"121","author":"Sun","year":"2005","journal-title":"Cell."},{"key":"10.1016\/j.parint.2019.102004_bb0145","doi-asserted-by":"crossref","first-page":"15287","DOI":"10.3390\/ijms160715287","article-title":"Structural insights into the molecular Design of Flutolanil Derivatives Targeted for Fumarate respiration of parasite mitochondria","volume":"16","author":"Inaoka","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.parint.2019.102004_bb0150","doi-asserted-by":"crossref","first-page":"240","DOI":"10.2307\/3283023","article-title":"Uniform strobilar development of Echinococcus multilocularis in vitro from protoscolex to immature stages","volume":"76","author":"Thompson","year":"1990","journal-title":"J. Parasitol."},{"key":"10.1016\/j.parint.2019.102004_bb0155","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1017\/S0022149X00016722","article-title":"Morphological changes of larval Echinococcus multilocularis in mice treated with albendazole or mebendazole","volume":"72","author":"Nakaya","year":"1998","journal-title":"J. Helminthol."},{"key":"10.1016\/j.parint.2019.102004_bb0160","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature12031","article-title":"The genomes of four tapeworm species reveal adaptations to parasitism","volume":"496","author":"Tsai","year":"2013","journal-title":"Nature."},{"key":"10.1016\/j.parint.2019.102004_bb0165","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.gene.2012.12.025","article-title":"Cloning and characterization of hypoxia-inducible factor-1 subunits from Ascaris suum - a parasitic nematode highly adapted to changes of oxygen conditions during its life cycle","volume":"516","author":"Goto","year":"2013","journal-title":"Gene."},{"key":"10.1016\/j.parint.2019.102004_bb0170","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1074\/mcp.RA117.000445","article-title":"Infection by the helminth parasite Fasciola hepatica requires rapid regulation of metabolic, virulence, and invasive factors to adjust to its mammalian host","volume":"17","author":"Cwiklinski","year":"2018","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.parint.2019.102004_bb0175","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1128\/MMBR.05024-11","article-title":"Biochemistry and evolution of anaerobic energy metabolism in eukaryotes","volume":"76","author":"M\u00fcller","year":"2012","journal-title":"Microbiol. Mol. Biol."},{"key":"10.1016\/j.parint.2019.102004_bb0180","first-page":"95","article-title":"The reference values for hepatic oxygen consumption and net lactate production, blood gasses, hemogram, major electrolytes, and kidney and liver profiles in anesthetized large white swine model","volume":"4","author":"Bekheit","year":"2016","journal-title":"Transl. Surg."},{"key":"10.1016\/j.parint.2019.102004_bb0185","doi-asserted-by":"crossref","first-page":"15287","DOI":"10.3390\/ijms160715287","article-title":"Structural insights into the molecular design of flutolanil derivatives targeted for fumarate respiration of parasite mitochondria","volume":"16","author":"Inaoka","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.parint.2019.102004_bb0190","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1046\/j.1365-2958.1997.5431906.x","article-title":"Cascade regulation of the two CRP\/FNR-related transcriptional regulators (ANR and DNR) and the denitrification enzymes in Pseudomonas aeruginosa","volume":"25","author":"Arai","year":"1997","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.parint.2019.102004_bb0195","doi-asserted-by":"crossref","first-page":"4310","DOI":"10.1128\/JB.00240-07","article-title":"The anaerobic regulatory network required for Pseudomonas aeruginosa nitrate respiration","volume":"189","author":"Schreiber","year":"2007","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.parint.2019.102004_bb0200","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1124\/mol.108.045120","article-title":"Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex","volume":"73","author":"Biagini","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.parint.2019.102004_bb0205","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.bbabio.2009.12.003","article-title":"Ascochlorin is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex","volume":"1797","author":"Berry","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.parint.2019.102004_bb0210","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1046\/j.1365-2958.1999.01515.x","article-title":"Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites","volume":"33","author":"Srivastava","year":"1999","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.parint.2019.102004_bb0215","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.parint.2014.09.011","article-title":"Direct evidence for the atovaquone action on the Plasmodium cytochrome bc1 complex","volume":"64","author":"Siregar","year":"2015","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.parint.2019.102004_bb0220","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature05572","article-title":"Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum","volume":"446","author":"Painter","year":"2007","journal-title":"Nature."},{"key":"10.1016\/j.parint.2019.102004_bb0225","doi-asserted-by":"crossref","first-page":"226","DOI":"10.2174\/187152610791163336","article-title":"Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy","volume":"10","author":"A. Phillips","year":"2010","journal-title":"Infect. Disord. Drug Targets."},{"key":"10.1016\/j.parint.2019.102004_bb0230","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.4155\/fmc.13.121","article-title":"Targeting the mitochondrial electron transport chain of Plasmodium falciparum: new strategies towards the development of improved antimalarials for the elimination era","volume":"5","author":"Nixon","year":"2013","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.parint.2019.102004_bb0235","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1292\/jvms.57.93","article-title":"Enzyme activities related to glucose metabolism in Babesia microti and Babesia rodhaini","volume":"57","author":"Shikano","year":"1995","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.parint.2019.102004_bb0240","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1292\/jvms.13-0419","article-title":"Babesia bovis dihydroorotate dehydrogenase (BboDHODH) is a novel molecular target of drug for bovine babesiosis","volume":"76","author":"Kamyingkird","year":"2014","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.parint.2019.102004_bb0245","doi-asserted-by":"crossref","first-page":"31040","DOI":"10.1074\/jbc.273.47.31040","article-title":"Respiration and oxidative phosphorylation in the apicomplexan parasite Toxoplasma gondii","volume":"273","author":"Vercesi","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.parint.2019.102004_bb0250","doi-asserted-by":"crossref","first-page":"8269","DOI":"10.1073\/pnas.1819254116","article-title":"Complete biosynthetic pathways of ascofuranone and ascochlorin in Acremonium egyptiacum: branched pathways encoded at two separate loci","volume":"116","author":"Araki","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.parint.2019.102004_bb0255","article-title":"Comprehensive diagnosis and treatment of alveolar echinococcosis: A single-center, long-term observational study of 312 patients in Germany, GMS","volume":"5","author":"Gr\u00fcner","year":"2017","journal-title":"Infect. Dis."}],"container-title":["Parasitology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383576919303551?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383576919303551?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T10:31:49Z","timestamp":1761301909000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1383576919303551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":51,"alternative-id":["S1383576919303551"],"URL":"https:\/\/doi.org\/10.1016\/j.parint.2019.102004","relation":{},"ISSN":["1383-5769"],"issn-type":[{"value":"1383-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial complex III in larval stage of Echinococcus multilocularis as a potential chemotherapeutic target and in vivo efficacy of atovaquone against primary hydatid cysts","name":"articletitle","label":"Article Title"},{"value":"Parasitology International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.parint.2019.102004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102004"}}