{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:04:02Z","timestamp":1780394642334,"version":"3.54.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Parasitology International"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.parint.2020.102062","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T02:32:51Z","timestamp":1579573971000},"page":"102062","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Molecular cloning and characterization of plerocercoid-immunosuppressive factor from Spirometra erinaceieuropaei"],"prefix":"10.1016","volume":"76","author":[{"given":"Yoko","family":"Kondo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayuri","family":"Tademoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanase","family":"Itami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuma","family":"Nishikata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eizo","family":"Takashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Tsuboi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soji","family":"Fukumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Otsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.parint.2020.102062_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molbiopara.2009.04.008","article-title":"Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity","volume":"167","author":"Hewitson","year":"2009","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.parint.2020.102062_bb0010","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3201\/eid2304.160791","article-title":"Molecular identification of Spirometra erinaceieuropaei tapeworm in cases of human sparganosis, Hong Kong","volume":"23","author":"Tang","year":"2017","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.parint.2020.102062_bb0015","doi-asserted-by":"crossref","first-page":"198","DOI":"10.4269\/ajtmh.2012.12-0406","article-title":"Molecular diagnosis of subcutaneous Spirometra erinaceieuropaei sparganosis in a Japanese immigrant","volume":"88","author":"Tappe","year":"2013","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.parint.2020.102062_bb0020","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/S1473-3099(15)00133-4","article-title":"Human sparganosis, a neglected food borne zoonosis","volume":"15","author":"Liu","year":"2015","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.parint.2020.102062_bb0025","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3347\/kjp.1990.28.3.161","article-title":"Experimental life history of Spirometra erinacei","volume":"28","author":"Lee","year":"1990","journal-title":"Korean J. Parasitol."},{"key":"10.1016\/j.parint.2020.102062_bb0030","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1046\/j.1365-3024.1997.d01-215.x","article-title":"Excretory\/secretory products from plerocercoids of Spirometra erinacei reduce iNOS and chemokine mRNA levels in peritoneal macrophages stimulated with cytokines and\/or LPS","volume":"19","author":"Fukumoto","year":"1997","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.parint.2020.102062_bb0035","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0020-7519(02)00090-5","article-title":"Excretory\/secretory products from plerocercoids of Spirometra erinaceieuropaei suppress the TNF-\u03b1 gene expression by reducing phosphorylation of ERK1\/2 and p38 MAPK in macrophages","volume":"32","author":"Dirgahayu","year":"2002","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.parint.2020.102062_bb0040","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.ijpara.2003.12.006","article-title":"Excretory\/secretory products from plerocercoids of Spirometra erinaceieuropaei suppress interleukin-1\u03b2 gene expression in murine macrophages","volume":"34","author":"Dirgahayu","year":"2004","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.parint.2020.102062_bb0045","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.ijpara.2005.05.012","article-title":"A glycoprotein from Spirometra erinaceieuropaei plerocercoids suppresses osteoclastogenesis and proinflammatory cytokine gene expression","volume":"35","author":"Kina","year":"2005","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.parint.2020.102062_bb0050","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1128\/IAI.01539-07","article-title":"Wheat germ cell-free system-based production of malaria proteins for discovery of novel vaccine candidates","volume":"76","author":"Tsuboi","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.parint.2020.102062_bb0055","doi-asserted-by":"crossref","first-page":"735","DOI":"10.2307\/3283554","article-title":"Comparison of isozyme patterns between Spirometra erinacei and Spirometra mansonoides by isoelectric focusing","volume":"78","author":"Fukumoto","year":"1992","journal-title":"J. Parasitol."},{"key":"10.1016\/j.parint.2020.102062_bb0060","doi-asserted-by":"crossref","first-page":"8998","DOI":"10.1073\/pnas.85.23.8998","article-title":"Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer","volume":"85","author":"Frohman","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.parint.2020.102062_bb0065","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s10038-003-0109-0","article-title":"3\u2032 rapid amplification of cDNA ends (RACE) walking for rapid structural analysis of large transcripts","volume":"49","author":"Ozawa","year":"2004","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.parint.2020.102062_bb0070","unstructured":"GenBank accession number: LN247998.1, LN363412.1, LN.100485.1."},{"key":"10.1016\/j.parint.2020.102062_bb0075","unstructured":"GenBank accession number: VDN08887.1, VDN34634.1, VDK39544.1, VDK45826.1, VDN37785.1."},{"key":"10.1016\/j.parint.2020.102062_bb0080","unstructured":"GenBank accession number: VDM00388.1, VDM05095.1, VDM06344.1."},{"key":"10.1016\/j.parint.2020.102062_bb0085","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.1016\/j.vaccine.2012.04.019","article-title":"Protection of pigs against Taenia solium cysticercosis by immunization with novel recombinant antigens","volume":"30","author":"Gauci","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.parint.2020.102062_bb0090","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0166-6851(03)00005-7","article-title":"Molecular cloning of genes encoding oncosphere proteins reveals conservation of modular protein structure in cestode antigens","volume":"127","author":"Gauci","year":"2003","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.parint.2020.102062_bb0095","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.actatropica.2016.12.018","article-title":"A cysteine protease from Spirometra erinaceieuropaei plerocercoid is a critical factor for host tissue invasion and migration","volume":"167","author":"Tsubokawa","year":"2017","journal-title":"Acta Trop."},{"key":"10.1016\/j.parint.2020.102062_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0003807","article-title":"Characterization of Spirometra erinaceieuropaei plerocercoid cysteine protease and potential application for serodiagnosis of sparganosis","volume":"9","author":"Liu","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.parint.2020.102062_bb0105","doi-asserted-by":"crossref","first-page":"4737","DOI":"10.1007\/s00436-015-4758-7","article-title":"Molecular cloning and characterization of a Spirometra erinacei casein kinase I","volume":"114","author":"Liu","year":"2015","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.parint.2020.102062_bb0110","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-1-4419-1601-3_8","article-title":"Helminth-derived immunomodulatory molecules","volume":"666","author":"Adisakwattana","year":"2009","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.parint.2020.102062_bb0115","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0166-6851(99)00113-9","article-title":"Molecular cloning and demonstration of an aminopeptidase activity in a filarial nematode glycoprotein","volume":"104","author":"Harnett","year":"1999","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.parint.2020.102062_bb0120","doi-asserted-by":"crossref","first-page":"284","DOI":"10.4049\/jimmunol.174.1.284","article-title":"Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62","volume":"174","author":"Goodridge","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.parint.2020.102062_bb0125","doi-asserted-by":"crossref","first-page":"940","DOI":"10.4049\/jimmunol.167.2.940","article-title":"Modulation of macrophage cytokine production by ES-62, a secreted product of the filarial nematode Acanthocheilonema viteae","volume":"167","author":"Goodridge","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.parint.2020.102062_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2018.01016","article-title":"Protection against arthritis by the parasitic worm product ES-62, and its drug-like small molecule analogues, is associated with inhibition of osteoclastogenesis","volume":"9","author":"Doonan","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.parint.2020.102062_bb0135","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0166-6851(00)00209-7","article-title":"Cloning and expression of a gene encoding Sm16, an anti-inflammatory protein from Schistosoma mansoni","volume":"108","author":"Rao","year":"2000","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.parint.2020.102062_bb0140","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1128\/IAI.01126-08","article-title":"The Schistosoma mansoni protein Sm16\/SmSLP\/SmSPO-1 assembles into a nine-subunit oligomer with potential to inhibit toll-like receptor signaling","volume":"77","author":"Br\u00e4nnstr\u00f6m","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.parint.2020.102062_bb0145","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cellimm.2012.04.007","article-title":"Suppression of IP-10\/CXCL10 gene expression in LPS- and\/or IFN-\u03b3-stimulated macrophages by parasite-secreted products","volume":"276","author":"Fukumoto","year":"2012","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.parint.2020.102062_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2017.02164","article-title":"Parasite-derived proteins for the treatment of allergies and autoimmune diseases","volume":"8","author":"Wu","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.parint.2020.102062_bb0155","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00005-017-0489-z","article-title":"The effects of intestinal nematode L4 stage on mouse experimental autoimmune encephalomyelitis","volume":"66","author":"\u0141ysoniewska","year":"2018","journal-title":"Arch. Immunol. Ther. Exp."}],"container-title":["Parasitology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138357692030012X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138357692030012X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T10:30:37Z","timestamp":1761301837000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S138357692030012X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":31,"alternative-id":["S138357692030012X"],"URL":"https:\/\/doi.org\/10.1016\/j.parint.2020.102062","relation":{},"ISSN":["1383-5769"],"issn-type":[{"value":"1383-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular cloning and characterization of plerocercoid-immunosuppressive factor from Spirometra erinaceieuropaei","name":"articletitle","label":"Article Title"},{"value":"Parasitology International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.parint.2020.102062","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102062"}}