{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:22:04Z","timestamp":1790382124804,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Parasitology International"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.parint.2020.102179","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T21:36:26Z","timestamp":1598304986000},"page":"102179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["A prospective mechanism and source of cholesterol uptake by Plasmodium falciparum-infected erythrocytes co-cultured with HepG2 cells"],"prefix":"10.1016","volume":"80","author":[{"given":"Eri H.","family":"Hayakawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotomo","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn A.","family":"Nardone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiro","family":"Usukura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.parint.2020.102179_bb0005","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/0005-2736(86)90125-2","article-title":"Effects of very small amounts of cholesterol on gel-phase phosphatidylcholine membranes","volume":"854","author":"Subczynski","year":"1986","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.parint.2020.102179_bb0010","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0005-2736(89)90379-9","article-title":"Phosphatidylcholine-cholesterol interactions: bilayers of heteroacid lipids containing linoleate lose calorimetric transitions at low cholesterol concentration","volume":"983","author":"Keough","year":"1989","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.parint.2020.102179_bb0015","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.bbamem.2009.09.002","article-title":"A calorimetric and spectroscopic comparison of the effects of ergosterol and cholesterol on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes","volume":"1798","author":"Mannock","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.parint.2020.102179_bb0020","doi-asserted-by":"crossref","first-page":"4833","DOI":"10.1242\/jcs.02601","article-title":"Cholesterol facilitates the native mechanism of Ca2+\u2212triggered membrane fusion","volume":"118","author":"Churchward","year":"2005","journal-title":"J. Cell Sci."},{"issue":"5","key":"10.1016\/j.parint.2020.102179_bb0025","doi-asserted-by":"crossref","first-page":"464","DOI":"10.4269\/ajtmh.1996.54.464","article-title":"A novel pathway for ca++ entry into Plasmodium falciparum-infected blood cells","volume":"54","author":"Desai","year":"1996","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"1","key":"10.1016\/j.parint.2020.102179_bb0030","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.molbiopara.2003.08.001","article-title":"Extracellular lysines on the plasmodial surface anion channel involved in Na+ exclusion","volume":"132","author":"Cohn","year":"2003","journal-title":"Mol. Biochem. Parasitol."},{"issue":"12","key":"10.1016\/j.parint.2020.102179_bb0035","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1128\/EC.4.12.2153-2159.2005","article-title":"The plasmodial surface anion channel is functionally conserved in divergent malaria parasites","volume":"4","author":"Lisk","year":"2005","journal-title":"Eukaryot. Cell"},{"issue":"Pt 1","key":"10.1016\/j.parint.2020.102179_bb0040","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1017\/S0031182000066233","article-title":"Hypoxanthine: a low molecular weight factor essential for growth of erythrocytic Plasmodium falciparum in a serum-free medium","volume":"113","author":"Asahi","year":"1996","journal-title":"Parasitology"},{"issue":"47","key":"10.1016\/j.parint.2020.102179_bb0045","doi-asserted-by":"crossref","first-page":"E3278","DOI":"10.1073\/pnas.1209823109","article-title":"Plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state","volume":"109","author":"Babbitt","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.parint.2020.102179_bb0050","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/363505","article-title":"Insights gained from P. falciparum cultivation in modified media","volume":"2013","author":"Desai","year":"2013","journal-title":"ScientificWorldJournal"},{"issue":"Pt 12","key":"10.1016\/j.parint.2020.102179_bb0055","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1017\/S0031182007003137","article-title":"Oleic acid is indispensable for intraerythrocytic proliferation of Plasmodium falciparum","volume":"134","author":"Mi-Ichi","year":"2007","journal-title":"Parasitology"},{"issue":"Pt 4","key":"10.1016\/j.parint.2020.102179_bb0060","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1017\/S0031182006000540","article-title":"Intraerythrocytic Plasmodium falciparum utilize a broad range of serum-derived fatty acids with limited modification for their growth","volume":"133","author":"Mi-Ichi","year":"2006","journal-title":"Parasitology"},{"issue":"1","key":"10.1016\/j.parint.2020.102179_bb0065","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.exppara.2004.10.002","article-title":"Investigating serum factors promoting erythrocytic growth of Plasmodium falciparum","volume":"109","author":"Asahi","year":"2005","journal-title":"Exp. Parasitol."},{"issue":"2","key":"10.1016\/j.parint.2020.102179_bb0070","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.exppara.2008.10.008","article-title":"Plasmodium falciparum: development and validation of a measure of intraerythrocytic growth using SYBR green I in a flow cytometer","volume":"121","author":"Izumiyama","year":"2009","journal-title":"Exp. Parasitol."},{"issue":"4","key":"10.1016\/j.parint.2020.102179_bb0075","doi-asserted-by":"crossref","DOI":"10.1007\/s11306-017-1174-2","article-title":"Lipid response patterns in acute phase paediatric Plasmodium falciparum malaria","volume":"13","author":"Orikiiriza","year":"2017","journal-title":"Metabolomics"},{"issue":"3","key":"10.1016\/j.parint.2020.102179_bb0080","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.jacl.2018.02.019","article-title":"Undetectable high-density lipoprotein cholesterol in acute malaria","volume":"12","author":"Rakovac Tisdall","year":"2018","journal-title":"J. Clin. Lipidol."},{"issue":"4","key":"10.1016\/j.parint.2020.102179_bb0085","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1159\/000430812","article-title":"Serum Apolipoprotein-A1 and cholesterol levels in Nigerian children with Plasmodium falciparum infection","volume":"24","author":"Orimadegun","year":"2015","journal-title":"Med. Princ. Pract."},{"issue":"9","key":"10.1016\/j.parint.2020.102179_bb0090","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1128\/EC.00063-07","article-title":"Serum lipoproteins promote efficient presentation of the malaria virulence protein PfEMP1 at the erythrocyte surface","volume":"6","author":"Frankland","year":"2007","journal-title":"Eukaryot. Cell"},{"issue":"2","key":"10.1016\/j.parint.2020.102179_bb0095","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/BF00558233","article-title":"Effects of simvastatin and fenofibrate on serum lipoproteins and apolipoproteins in primary hypercholesterolaemia","volume":"37","author":"Stohler","year":"1989","journal-title":"Eur. J. Clin. Pharmacol."},{"issue":"1","key":"10.1016\/j.parint.2020.102179_bb0100","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0021-5198(19)43099-0","article-title":"Preventive effect of MK-733 (simvastatin), an inhibitor of HMG-CoA reductase, on hypercholesterolemia and atherosclerosis induced by cholesterol feeding in rabbits","volume":"49","author":"Kobayashi","year":"1989","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.parint.2020.102179_bb0105","series-title":"Simvastatin","author":"Talreja","year":"2019"},{"issue":"2","key":"10.1016\/j.parint.2020.102179_bb0110","first-page":"200","article-title":"Effects of simvastatin, a cholesterol synthesis inhibitor, on phosphatidylcholine synthesis in HepG2 cells","volume":"16","author":"Yanagita","year":"1994","journal-title":"Clin. Ther."},{"issue":"2","key":"10.1016\/j.parint.2020.102179_bb0115","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/sj.bjp.0704260","article-title":"Ezetimibe selectively inhibits intestinal cholesterol absorption in rodents in the presence and absence of exocrine pancreatic function","volume":"134","author":"van Heek","year":"2001","journal-title":"Br. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.parint.2020.102179_bb0120","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1161\/hq1101.098228","article-title":"Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression","volume":"21","author":"Post","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.parint.2020.102179_bb0125","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/01.pap.0000249920.70815.2d","article-title":"Ciprofibrate treatment decreases non-high density lipoprotein cholesterol and triglycerides and increases high density lipoprotein cholesterol in patients with Frederickson type IV dyslipidemia phenotype","volume":"14","author":"Bermudez-Pirela","year":"2007","journal-title":"Am. J. Ther."},{"issue":"4","key":"10.1016\/j.parint.2020.102179_bb0130","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1021\/acsinfecdis.8b00277","article-title":"Diverse chemical compounds target Plasmodium falciparum plasma membrane lipid homeostasis","volume":"5","author":"Bhatnagar","year":"2019","journal-title":"ACS Infect Dis"},{"key":"10.1016\/j.parint.2020.102179_bb0135","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/642729","article-title":"Physicochemical aspects of the Plasmodium chabaudi-infected erythrocyte","volume":"2015","author":"Hayakawa","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.parint.2020.102179_bb0140","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.exppara.2015.03.021","article-title":"Imaging of the subsurface structures of \u201cunroofed\u201d Plasmodium falciparum-infected erythrocytes","volume":"153","author":"Hayakawa","year":"2015","journal-title":"Exp. Parasitol."},{"issue":"1","key":"10.1016\/j.parint.2020.102179_bb0145","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-59552-9","article-title":"Real-time cholesterol sorting in Plasmodium falciparum-erythrocytes as revealed by 3D label-free imaging","volume":"10","author":"Hayakawa","year":"2020","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.parint.2020.102179_bb0150","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1128\/AAC.00527-15","article-title":"Assessment of the worldwide antimalarial resistance network standardized procedure for in vitro malaria drug sensitivity testing using SYBR green assay for field samples with various initial Parasitemia levels","volume":"60","author":"Cheruiyot","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"issue":"5","key":"10.1016\/j.parint.2020.102179_bb0155","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1128\/JCM.02250-09","article-title":"Reliability of antimalarial sensitivity tests depends on drug mechanisms of action","volume":"48","author":"Wein","year":"2010","journal-title":"J. Clin. Microbiol."},{"issue":"23","key":"10.1016\/j.parint.2020.102179_bb0160","doi-asserted-by":"crossref","first-page":"8132","DOI":"10.1073\/pnas.0500269102","volume":"102","author":"Garcia-Calvo","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5323","key":"10.1016\/j.parint.2020.102179_bb0165","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1126\/science.277.5323.228","article-title":"R.R. O\u2019Neill, O.P. van Diggelen, M. Elleder, M.C. Patterson, R.O. Brady, M.T. Vanier, P.G. Pentchev, D.a. Tagle, Niemann-pick C1 disease gene: homology to mediators of cholesterol homeostasis","volume":"277","author":"Carstea","year":"1997","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.parint.2020.102179_bb0170","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1172\/JCI0216500","article-title":"Intracellular cholesterol transport","volume":"110","author":"Maxfield","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.parint.2020.102179_bb0175","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.50832","article-title":"Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid","volume":"8","author":"McCauliff","year":"2019","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.parint.2020.102179_bb0180","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-11425-0","article-title":"Lysosomal integral membrane protein-2 (LIMP-2\/SCARB2) is involved in lysosomal cholesterol export","volume":"10","author":"Heybrock","year":"2019","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.parint.2020.102179_bb0185","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.bbalip.2012.03.004","article-title":"Niemann-pick C1-like 1 and cholesterol uptake","volume":"1821","author":"Wang","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.parint.2020.102179_bb0190","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.bbrc.2017.03.065","article-title":"N-terminal domain of the cholesterol transporter Niemann-pick C1-like 1 (NPC1L1) is essential for alpha-tocopherol transport","volume":"486","author":"Kamishikiryo","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.parint.2020.102179_bb0195","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.40529","article-title":"Plasmodium Niemann-pick type C1-related protein is a druggable target required for parasite membrane homeostasis","volume":"8","author":"Istvan","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.parint.2020.102179_bb0200","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.foodres.2018.01.031","article-title":"Transport of cowpea bean derived peptides and their modulator effects on mRNA expression of cholesterol-related genes in Caco-2 and HepG2 cells","volume":"107","author":"Marques","year":"2018","journal-title":"Food Res. Int."},{"issue":"3","key":"10.1016\/j.parint.2020.102179_bb0205","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1194\/jlr.M011080","article-title":"Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men","volume":"52","author":"Tremblay","year":"2011","journal-title":"J. Lipid Res."},{"issue":"8","key":"10.1016\/j.parint.2020.102179_bb0210","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1194\/jlr.M067488","article-title":"Statins increase hepatic cholesterol synthesis and stimulate fecal cholesterol elimination in mice","volume":"57","author":"Schonewille","year":"2016","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.parint.2020.102179_bb0215","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1423-0127-16-32","article-title":"Effects of statins on the secretion of human serum albumin in cultured HepG2 cells","volume":"16","author":"Ha","year":"2009","journal-title":"J. Biomed. Sci."},{"issue":"8","key":"10.1016\/j.parint.2020.102179_bb0220","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.bcp.2009.12.007","article-title":"Effect of simvastatin on cholesterol metabolism in C2C12 myotubes and HepG2 cells, and consequences for statin-induced myopathy","volume":"79","author":"Mullen","year":"2010","journal-title":"Biochem. Pharmacol."},{"issue":"5","key":"10.1016\/j.parint.2020.102179_bb0225","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1128\/AAC.38.5.1144","article-title":"3-Hydroxy-3-methylglutaryl coenzyme a reductase inhibitors lovastatin and simvastatin inhibit in vitro development of Plasmodium falciparum and Babesia divergens in human erythrocytes","volume":"38","author":"Grellier","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.parint.2020.102179_bb0230","doi-asserted-by":"crossref","DOI":"10.1155\/2008\/132960","article-title":"Peroxisome proliferator activated receptors and lipoprotein metabolism","volume":"2008","author":"Kersten","year":"2008","journal-title":"PPAR Res."},{"issue":"13","key":"10.1016\/j.parint.2020.102179_bb0235","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.2165\/00003495-200262130-00013","article-title":"Micronised fenofibrate: an updated review of its clinical efficacy in the management of dyslipidaemia","volume":"62","author":"Keating","year":"2002","journal-title":"Drugs"},{"issue":"3","key":"10.1016\/j.parint.2020.102179_bb0240","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2165\/00003495-198733030-00003","article-title":"Lipid-lowering drugs. An overview of indications and optimum therapeutic use","volume":"33","author":"Illingworth","year":"1987","journal-title":"Drugs"},{"issue":"1","key":"10.1016\/j.parint.2020.102179_bb0245","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1432-1033.1995.tb20797.x","article-title":"Regulation of rat liver apolipoprotein A-I, apolipoprotein A-II and acyl-coenzyme a oxidase gene expression by fibrates and dietary fatty acids","volume":"232","author":"Berthou","year":"1995","journal-title":"Eur. J. Biochem."},{"issue":"46","key":"10.1016\/j.parint.2020.102179_bb0250","doi-asserted-by":"crossref","first-page":"16813","DOI":"10.1073\/pnas.0501858102","article-title":"Disruption of a Plasmodium falciparum gene linked to male sexual development causes early arrest in gametocytogenesis","volume":"102","author":"Furuya","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.parint.2020.102179_bb0255","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/00041433-199710000-00004","article-title":"Phospholipid metabolism in cholesterol-loaded macrophages","volume":"8","author":"Tabas","year":"1997","journal-title":"Curr. Opin. Lipidol."},{"issue":"15","key":"10.1016\/j.parint.2020.102179_bb0260","doi-asserted-by":"crossref","first-page":"11337","DOI":"10.1016\/S0021-9258(19)78130-7","article-title":"Free cholesterol loading of macrophages stimulates phosphatidylcholine biosynthesis and up-regulation of CTP: phosphocholine cytidylyltransferase","volume":"269","author":"Shiratori","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.parint.2020.102179_bb0265","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1242\/bio.20147732","article-title":"Inward cholesterol gradient of the membrane system in P. falciparum-infected erythrocytes involves a dilution effect from parasite-produced lipids","volume":"3","author":"Tokumasu","year":"2014","journal-title":"Biol. Open"}],"container-title":["Parasitology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138357692030129X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138357692030129X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T10:31:56Z","timestamp":1761301916000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S138357692030129X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":53,"alternative-id":["S138357692030129X"],"URL":"https:\/\/doi.org\/10.1016\/j.parint.2020.102179","relation":{},"ISSN":["1383-5769"],"issn-type":[{"value":"1383-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A prospective mechanism and source of cholesterol uptake by Plasmodium falciparum-infected erythrocytes co-cultured with HepG2 cells","name":"articletitle","label":"Article Title"},{"value":"Parasitology International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.parint.2020.102179","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102179"}}