{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T00:49:15Z","timestamp":1793666955801,"version":"4.5.1"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T00:00:00Z","timestamp":1732320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20H03155"],"award-info":[{"award-number":["20H03155"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K01932"],"award-info":[{"award-number":["24K01932"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Parasitology International"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.parint.2024.102998","type":"journal-article","created":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T02:46:09Z","timestamp":1732329969000},"page":"102998","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Dr. Jekyll and Mr. Hyde in sand fly saliva"],"prefix":"10.1016","volume":"105","author":[{"given":"Hirotomo","family":"Kato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.parint.2024.102998_bb0005","first-page":"143","article-title":"Blood-feeding arthropods: live syringes or invertebrate pharmacologists?","volume":"4","author":"Ribeiro","year":"1995","journal-title":"Infect. Agents Dis."},{"key":"10.1016\/j.parint.2024.102998_bb0010","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/S0965-1748(02)00083-8","article-title":"High-throughput approaches to study salivary proteins and genes from vectors of disease","volume":"32","author":"Valenzuela","year":"2002","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.parint.2024.102998_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2915.1990.tb00255.x","article-title":"Phlebotomine vectors of the leishmaniases: a review","volume":"4","author":"Killick-Kendrick","year":"1990","journal-title":"Med. Vet. Entomol."},{"key":"10.1016\/j.parint.2024.102998_bb0020","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.ijpara.2007.04.003","article-title":"Transmission of Leishmania metacyclic promastigotes by phlebotomine sand flies","volume":"37","author":"Bates","year":"2007","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.parint.2024.102998_bb0025","doi-asserted-by":"crossref","first-page":"814","DOI":"10.3390\/ijerph7030814","article-title":"Molecular epidemiology for vector research on leishmaniasis","volume":"7","author":"Kato","year":"2010","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.parint.2024.102998_bb0030","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1126\/science.3344436","article-title":"Salivary gland lysates from the sand fly Lutzomyia longipalpis enhance Leishmania infectivity","volume":"239","author":"Titus","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.parint.2024.102998_bb0035","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1084\/jem.173.1.49","article-title":"A mouse model of Leishmania braziliensis braziliensis infection produced by coinjection with sand fly saliva","volume":"173","author":"Samuelson","year":"1991","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.parint.2024.102998_bb0040","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1128\/iai.59.5.1592-1598.1991","article-title":"Analysis of enhancing effect of sand fly saliva on Leishmania infection in mice","volume":"59","author":"Theodos","year":"1991","journal-title":"Infect. Immun."},{"key":"10.1016\/j.parint.2024.102998_bb0045","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3389\/fpubh.2014.00099","article-title":"Vector saliva in vaccines for visceral leishmaniasis: a brief encounter of high consequence?","volume":"2","author":"Kamhawi","year":"2014","journal-title":"Front. Public Health"},{"key":"10.1016\/j.parint.2024.102998_bb0050","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1084\/jem.188.10.1941","article-title":"Development of a natural model of cutaneous leishmaniasis: powerful effects of vector saliva and saliva preexposure on the long-term outcome of Leishmania major infection in the mouse ear dermis","volume":"188","author":"Belkaid","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.parint.2024.102998_bb0055","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1126\/science.290.5495.1351","article-title":"Protection against cutaneous leishmaniasis resulting from bites of uninfected sand flies","volume":"290","author":"Kamhawi","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.parint.2024.102998_bb0060","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1084\/jem.194.3.331","article-title":"Toward a defined anti-Leishmania vaccine targeting vector antigens: characterization of a protective salivary protein","volume":"194","author":"Valenzuela","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.parint.2024.102998_bb0065","doi-asserted-by":"crossref","first-page":"15155","DOI":"10.1073\/pnas.96.26.15155","article-title":"Toward an understanding of the biochemical and pharmacological complexity of the saliva of a hematophagous sand fly Lutzomyia longipalpis","volume":"96","author":"Charlab","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.parint.2024.102998_bb0070","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1242\/jeb.01185","article-title":"Identification of the most abundant secreted proteins from the salivary glands of the sand fly Lutzomyia longipalpis, vector of Leishmania chagasi","volume":"207","author":"Valenzuela","year":"2004","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.parint.2024.102998_bb0075","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1471-2164-7-52","article-title":"Comparative salivary gland transcriptomics of sandfly vectors of visceral leishmaniasis","volume":"7","author":"Anderson","year":"2006","journal-title":"BMC Genomics"},{"key":"10.1016\/j.parint.2024.102998_bb0080","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/1471-2164-7-226","article-title":"High degree of conservancy among secreted salivary gland proteins from two geographically distant Phlebotomus duboscqi sandflies populations (Mali and Kenya)","volume":"7","author":"Kato","year":"2006","journal-title":"BMC Genomics"},{"key":"10.1016\/j.parint.2024.102998_bb0085","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.vaccine.2005.07.085","article-title":"From transcriptome to immunome: identification of DTH inducing proteins from a Phlebotomus ariasi salivary gland cDNA library","volume":"24","author":"Oliveira","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.parint.2024.102998_bb0090","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1186\/1471-2164-10-282","article-title":"Analysis of salivary transcripts and antigens of the sand fly Phlebotomus arabicus","volume":"10","author":"Hostomsk\u00e1","year":"2009","journal-title":"BMC Genomics"},{"key":"10.1016\/j.parint.2024.102998_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047347","article-title":"Updating the salivary gland transcriptome of Phlebotomus papatasi (Tunisian strain): the search for sand fly-secreted immunogenic proteins for humans","volume":"7","author":"Abdeladhim","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.parint.2024.102998_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001660","article-title":"Salivary gland transcriptomes and proteomes of Phlebotomus tobbi and Phlebotomus sergenti, vectors of leishmaniasis","volume":"6","author":"Rohou\u0161ov\u00e1","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.parint.2024.102998_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002242","article-title":"Functional transcriptomics of wild-caught Lutzomyia intermedia salivary glands: identification of a protective salivary protein against Leishmania braziliensis infection","volume":"7","author":"de Moura","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.parint.2024.102998_bb0110","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.meegid.2012.08.024","article-title":"Analysis of salivary gland transcripts of the sand fly Lutzomyia ayacuchensis, a vector of Andean-type cutaneous leishmaniasis","volume":"13","author":"Kato","year":"2013","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.parint.2024.102998_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002709","article-title":"Comparative analysis of salivary gland transcriptomes of Phlebotomus orientalis sand flies from endemic and non-endemic foci of visceral leishmaniasis","volume":"8","author":"Vlkova","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.parint.2024.102998_bb0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004771","article-title":"Molecular diversity between salivary proteins from New World and Old World sand flies with emphasis on Bichromomyia olmeca, the sand Fly vector of Leishmania mexicana in Mesoamerica","volume":"10","author":"Abdeladhim","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.parint.2024.102998_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0230537","article-title":"Sergentomyia schwetzi: salivary gland transcriptome, proteome and enzymatic activities in two lineages adapted to different blood sources","volume":"15","author":"Polanska","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.parint.2024.102998_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000712","article-title":"Immunity to Lutzomyia intermedia saliva modulates the inflammatory environment induced by Leishmania braziliensis","volume":"4","author":"de Moura","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.parint.2024.102998_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005600","article-title":"Insights into the sand fly saliva: blood-feeding and immune interactions between sand flies, hosts, and Leishmania","volume":"11","author":"Lestinova","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.parint.2024.102998_bb0140","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1365-3024.1993.tb00634.x","article-title":"Salivary gland material from the sand fly Lutzomyia longipalpis has an inhibitory effect on macrophage function in vitro","volume":"15","author":"Theodos","year":"1993","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.parint.2024.102998_bb0145","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1017\/S0031182003003329","article-title":"Anti-complement activity in the saliva of phlebotomine sand flies and other haematophagous insects","volume":"127","author":"Cavalcante","year":"2003","journal-title":"Parasitology"},{"key":"10.1016\/j.parint.2024.102998_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0079787","article-title":"Different host complement systems and their interactions with saliva from Lutzomyia longipalpis (Diptera, Psychodidae) and Leishmania infantum promastigotes","volume":"8","author":"Mendes-Sousa","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.parint.2024.102998_bb0155","doi-asserted-by":"crossref","first-page":"5442","DOI":"10.1128\/iai.64.12.5442-5445.1996","article-title":"Effects of sand fly vector saliva on development of cutaneous lesions and the immune response to Leishmania braziliensis in BALB\/c mice","volume":"64","author":"Lima","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.parint.2024.102998_bb0160","doi-asserted-by":"crossref","first-page":"5571","DOI":"10.4049\/jimmunol.161.10.5571","article-title":"Phlebotomus papatasi sand fly salivary gland lysate down-regulates a Th1, but up-regulates a Th2, response in mice infected with Leishmania major","volume":"161","author":"Mbow","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.parint.2024.102998_bb0165","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1017\/S003118200400681X","article-title":"Detection of species-specific antibody response of humans and mice bitten by sand flies","volume":"130","author":"Rohousova","year":"2005","journal-title":"Parasitology"},{"key":"10.1016\/j.parint.2024.102998_bb0170","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1128\/IAI.72.3.1240-1247.2004","article-title":"Sand fly saliva enhances Leishmania amazonensis infection by modulating interleukin-10 production","volume":"72","author":"Norsworthy","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.parint.2024.102998_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2021.106271","article-title":"Effects of Migonemyia migonei salivary gland homogenates on Leishmania (Viannia) braziliensis infection in BALB\/c mice","volume":"227","author":"Miranda","year":"2022","journal-title":"Acta Trop."},{"key":"10.1016\/j.parint.2024.102998_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003600","article-title":"Nucleosides present on phlebotomine saliva induce immunossuppression and promote the infection establishment","volume":"9","author":"Carregaro","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.parint.2024.102998_bb0185","doi-asserted-by":"crossref","first-page":"665","DOI":"10.4269\/ajtmh.1996.54.665","article-title":"Immunomodulatory properties of maxadilan, the vasodilator peptide from sand fly salivary gland extracts","volume":"54","author":"Qureshi","year":"1996","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.parint.2024.102998_bb0190","doi-asserted-by":"crossref","first-page":"5226","DOI":"10.4049\/jimmunol.167.9.5226","article-title":"Sandfly maxadilan exacerbates infection with Leishmania major and vaccinating against it protects against L. major infection","volume":"167","author":"Morris","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.parint.2024.102998_bb0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003923","article-title":"Lundep, a sand fly salivary endonuclease increases Leishmania parasite survival in neutrophils and inhibits XIIa contact activation in human plasma","volume":"10","author":"Chagas","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.parint.2024.102998_bb0200","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa3043","article-title":"A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in nonhuman primates","volume":"7","author":"Oliveira","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.parint.2024.102998_bb0205","article-title":"DNA plasmid coding for Phlebotomus sergenti salivary protein PsSP9, a member of the SP15 family of proteins, protects against Leishmania tropica","volume":"13","author":"Gholami","year":"2019","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.parint.2024.102998_bb0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005078","article-title":"Immunity to Lutzomyia whitmani saliva protects against experimental Leishmania braziliensis infection","volume":"10","author":"Gomes","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.parint.2024.102998_bb0215","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.actatropica.2015.01.005","article-title":"Phlebotomus papatasi exposure cross-protects mice against Leishmania major co-inoculated with Phlebotomus duboscqi salivary gland homogenate","volume":"144","author":"Lestinova","year":"2015","journal-title":"Acta Trop."},{"key":"10.1016\/j.parint.2024.102998_bb0220","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1038\/jid.2012.205","article-title":"Immunity to sand fly salivary protein LJM11 modulates host response to vector-transmitted leishmania conferring ulcer-free protection","volume":"132","author":"Gomes","year":"2012","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.parint.2024.102998_bb0225","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.actatropica.2017.10.009","article-title":"Immunization with LJM11 salivary protein protects against infection with Leishmania braziliensis in the presence of Lutzomyia longipalpis saliva","volume":"177","author":"Cunha","year":"2018","journal-title":"Acta Trop."},{"key":"10.1016\/j.parint.2024.102998_bb0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001169","article-title":"Lutzomyia longipalpis saliva or salivary protein LJM19 protects against Leishmania braziliensis and the saliva of its vector, Lutzomyia intermedia","volume":"5","author":"Tavares","year":"2011","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.parint.2024.102998_bb0235","doi-asserted-by":"crossref","first-page":"18653","DOI":"10.1038\/s41598-020-75410-0","article-title":"Engineering a vector-based pan-Leishmania vaccine for humans: proof of principle","volume":"10","author":"Cec\u00edlio","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.parint.2024.102998_bb0240","doi-asserted-by":"crossref","first-page":"7845","DOI":"10.1073\/pnas.0712153105","article-title":"Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model","volume":"105","author":"Gomes","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.parint.2024.102998_bb0245","doi-asserted-by":"crossref","first-page":"6611","DOI":"10.1016\/j.vaccine.2017.10.039","article-title":"Immunization against full-length protein and peptides from the Lutzomyia longipalpis sand fly salivary component maxadilan protects against Leishmania major infection in a murine model","volume":"35","author":"Wheat","year":"2017","journal-title":"Vaccine"},{"key":"10.1016\/j.parint.2024.102998_bb0250","doi-asserted-by":"crossref","unstructured":"I. Martin-Martin, A.C. Chagas, A.B. Guimaraes-Costa, L. Amo, F. Oliveira, I.N. Moore, T.S. DeSouza-Vieira, E.E. Sanchez, M. Suntravat, J.G. Valenzuela, J.M.C Ribeiro, E. Calvo, Immunity to LuloHya and Lundep, the salivary spreading factors from Lutzomyia longipalpis, protects against Leishmania major infection, PLoS Pathog. 14 (2018) e1007006, doi: https:\/\/doi.org\/10.1371\/journal.ppat.1007006.","DOI":"10.1371\/journal.ppat.1007006"},{"key":"10.1016\/j.parint.2024.102998_bb0255","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.jid.2017.09.043","article-title":"Phlebotomus papatasi yellow-related and apyrase salivary proteins are candidates for vaccination against human cutaneous Leishmaniasis","volume":"138","author":"Tlili","year":"2018","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.parint.2024.102998_bb0260","doi-asserted-by":"crossref","first-page":"1335307","DOI":"10.3389\/fimmu.2024.1335307","article-title":"Immune response profiles from humans experimentally exposed to Phlebotomus duboscqi bites","volume":"15","author":"de Araujo","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.parint.2024.102998_bb0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000084","article-title":"Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva","volume":"1","author":"de Moura","year":"2007","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.parint.2024.102998_bb0270","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/infdis\/jiv020","article-title":"Interleukin 10-dominant immune response and increased risk of cutaneous Leishmaniasis after natural exposure to Lutzomyia intermedia sand flies","volume":"212","author":"Carvalho","year":"2015","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.parint.2024.102998_bb0275","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/cid\/ciac258","article-title":"Immune response to LinB13, a Lutzomyia Intermedia salivary protein correlates with disease severity in Tegumentary Leishmaniasis","volume":"75","author":"Carvalho","year":"2022","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.parint.2024.102998_bb0280","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.ijpara.2011.01.003","article-title":"The protective effect against Leishmania infection conferred by sand fly bites is limited to short-term exposure","volume":"41","author":"Rohou\u0161ov\u00e1","year":"2011","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.parint.2024.102998_bb0285","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/jmedent\/47.1.74","article-title":"Differences in the salivary effects of wild-caught versus colonized Phlebotomus papatasi (Diptera: Psychodidae) on the development of zoonotic cutaneous leishmaniasis in BALB\/c mice","volume":"47","author":"Ahmed","year":"2010","journal-title":"J. Med. Entomol."},{"key":"10.1016\/j.parint.2024.102998_bb0290","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/1756-3305-4-126","article-title":"Colonization of Phlebotomus papatasi changes the effect of pre-immunization with saliva from lack of protection towards protection against experimental challenge with Leishmania major and saliva","volume":"4","author":"Ahmed","year":"2011","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.parint.2024.102998_bb0295","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4269\/ajtmh.2000.62.145","article-title":"Adenosine, AMP, and protein phosphatase activity in sandfly saliva","volume":"62","author":"Katz","year":"2000","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.parint.2024.102998_bb0300","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1645\/0022-3395(2001)087[0915:TSAACO]2.0.CO;2","article-title":"The salivary adenosine\/AMP content of Phlebotomus argentipes Annandale and Brunetti, the main vector of human kala-azar","volume":"87","author":"Ribeiro","year":"2001","journal-title":"J. Parasitol."},{"key":"10.1016\/j.parint.2024.102998_bb0305","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1242\/jeb.001289","article-title":"Identification and characterization of a salivary adenosine deaminase from the sand fly Phlebotomus duboscqi, the vector of Leishmania major in sub-Saharan Africa","volume":"210","author":"Kato","year":"2007","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.parint.2024.102998_bb0310","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20205139","article-title":"A2B adenosine receptor and Cancer","volume":"20","author":"Gao","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.parint.2024.102998_bb0315","doi-asserted-by":"crossref","first-page":"11234","DOI":"10.1016\/S0021-9258(18)99153-2","article-title":"Isolation of maxadilan, a potent vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis","volume":"266","author":"Lerner","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.parint.2024.102998_bb0320","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1074\/jbc.272.2.966","article-title":"Maxadilan, the vasodilator from sand flies, is a specific pituitary adenylate cyclase activating peptide type I receptor agonist","volume":"272","author":"Moro","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.parint.2024.102998_bb0325","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1242\/jeb.204.2.229","article-title":"The salivary apyrase of the blood-sucking sand fly Phlebotomus papatasi belongs to the novel Cimex family of apyrases","volume":"204","author":"Valenzuela","year":"2001","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.parint.2024.102998_bb0330","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.jinsphys.2009.07.010","article-title":"Functional characterization of a salivary apyrase from the sand fly, Phlebotomus duboscqi, a vector of Leishmania major","volume":"55","author":"Hamasaki","year":"2009","journal-title":"J. Insect Physiol."},{"key":"10.1016\/j.parint.2024.102998_bb0335","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1006\/expr.2000.4503","article-title":"The salivary adenosine deaminase from the sand fly Lutzomyia longipalpis","volume":"95","author":"Charlab","year":"2000","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.parint.2024.102998_bb0340","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.4049\/jimmunol.164.2.1013","article-title":"Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shock","volume":"164","author":"Hask\u00f3","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.parint.2024.102998_bb0345","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/S0965-1748(02)00109-1","article-title":"Salivary gland hyaluronidase in various species of phlebotomine sand flies (Diptera: psychodidae)","volume":"32","author":"Cern\u00e1","year":"2002","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.parint.2024.102998_bb0350","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1161\/ATVBAHA.112.253906","article-title":"Lufaxin, a novel factor Xa inhibitor from the salivary gland of the sand fly Lutzomyia longipalpis blocks protease-activated receptor 2 activation and inhibits inflammation and thrombosis in vivo","volume":"32","author":"Collin","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.parint.2024.102998_bb0355","doi-asserted-by":"crossref","DOI":"10.1038\/srep19300","article-title":"SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis","volume":"6","author":"Ferreira","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.parint.2024.102998_bb0360","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.biochi.2015.02.011","article-title":"Ayadualin, a novel RGD peptide with dual antihemostatic activities from the sand fly Lutzomyia ayacuchensis, a vector of Andean-type cutaneous leishmaniasis","volume":"112","author":"Kato","year":"2015","journal-title":"Biochimie"},{"key":"10.1016\/j.parint.2024.102998_bb0365","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1161\/ATVBAHA.113.302482","article-title":"Novel family of insect salivary inhibitors blocks contact pathway activation by binding to polyphosphate, heparin, and dextran sulfate","volume":"33","author":"Alvarenga","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.parint.2024.102998_bb0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2022.106602","article-title":"Ayaconin, a novel inhibitor of the plasma contact system from the sand fly Lutzomyia ayacuchensis, a vector of Andean-type cutaneous leishmaniasis","volume":"234","author":"Kawahori","year":"2022","journal-title":"Acta Trop."},{"key":"10.1016\/j.parint.2024.102998_bb0375","doi-asserted-by":"crossref","first-page":"32383","DOI":"10.1074\/jbc.M111.268904","article-title":"Structure and function of a \"yellow\" protein from saliva of the sand fly Lutzomyia longipalpis that confers protective immunity against Leishmania major infection","volume":"286","author":"Xu","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.parint.2024.102998_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.ibmb.2019.103245","article-title":"Amine-binding properties of salivary yellow-related proteins in phlebotomine sand flies","volume":"115","author":"Sumova","year":"2019","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.parint.2024.102998_bb0385","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s13071-020-04105-2","article-title":"Interactions between host biogenic amines and sand fly salivary yellow-related proteins","volume":"13","author":"Spitzova","year":"2020","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.parint.2024.102998_bb0390","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.intimp.2012.02.004","article-title":"The protein LJM 111 from Lutzomyia longipalpis salivary gland extract (SGE) accounts for the SGE-inhibitory effects upon inflammatory parameters in experimental arthritis model","volume":"12","author":"Grespan","year":"2012","journal-title":"Int. Immunopharmacol."}],"container-title":["Parasitology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383576924001491?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383576924001491?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T07:28:09Z","timestamp":1739345289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1383576924001491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":78,"alternative-id":["S1383576924001491"],"URL":"https:\/\/doi.org\/10.1016\/j.parint.2024.102998","relation":{},"ISSN":["1383-5769"],"issn-type":[{"value":"1383-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dr. Jekyll and Mr. Hyde in sand fly saliva","name":"articletitle","label":"Article Title"},{"value":"Parasitology International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.parint.2024.102998","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102998"}}