{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:20:57Z","timestamp":1790871657042,"version":"4.1.0"},"reference-count":12,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parkinsonism & Related Disorders"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.parkreldis.2009.05.005","type":"journal-article","created":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T04:29:45Z","timestamp":1243830585000},"page":"57-59","source":"Crossref","is-referenced-by-count":173,"title":["[11C]-PK11195 PET: Quantification of neuroinflammation and a monitor of anti-inflammatory treatment in Parkinson's disease?"],"prefix":"10.1016","volume":"16","author":[{"given":"A.L.","family":"Bartels","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.T.M.","family":"Willemsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Doorduin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.F.J.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.A.","family":"Dierckx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.L.","family":"Leenders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.parkreldis.2009.05.005_bib1","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1212\/WNL.38.8.1285","article-title":"Reactive microglia are positive for Hla-Dr in the substantia nigra of Parkinsons and Alzheimers-disease brains","volume":"38","author":"Mcgeer","year":"1988","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.parkreldis.2009.05.005_bib2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/mds.10332","article-title":"Pathogenic role of glial cells in Parkinson's disease","volume":"18","author":"Teismann","year":"2003","journal-title":"Mov Disord"},{"issue":"8","key":"10.1016\/j.parkreldis.2009.05.005_bib3","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1001\/archneur.60.8.1059","article-title":"Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease","volume":"60","author":"Chen","year":"2003","journal-title":"Arch Neurol"},{"issue":"1","key":"10.1016\/j.parkreldis.2009.05.005_bib4","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1742-2094-1-6","article-title":"Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease","volume":"1","author":"Sanchez-Pernaute","year":"2004","journal-title":"J Neuroinflammation"},{"issue":"9","key":"10.1016\/j.parkreldis.2009.05.005_bib5","doi-asserted-by":"crossref","first-page":"5473","DOI":"10.1073\/pnas.0837397100","article-title":"Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration","volume":"100","author":"Teismann","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1016\/j.parkreldis.2009.05.005_bib6","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/ana.20338","article-title":"Microglial activation and dopamine terminal loss in early Parkinson's disease","volume":"57","author":"Ouchi","year":"2005","journal-title":"Ann Neurol"},{"issue":"2","key":"10.1016\/j.parkreldis.2009.05.005_bib7","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.nbd.2005.08.002","article-title":"In vivo imaging of microglial activation with [C-11](R)-PK11195 PET in idiopathic Parkinson's disease","volume":"21","author":"Gerhard","year":"2006","journal-title":"Neurobiol Dis"},{"issue":"Pt 11","key":"10.1016\/j.parkreldis.2009.05.005_bib8","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1093\/brain\/123.11.2321","article-title":"The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity","volume":"123","author":"Banati","year":"2000","journal-title":"Brain"},{"issue":"9","key":"10.1016\/j.parkreldis.2009.05.005_bib9","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1038\/sj.jcbfm.9600459","article-title":"Evaluation of methods for generating parametric (R-[11C]PK11195 binding images","volume":"27","author":"Schuitemaker","year":"2007","journal-title":"J Cereb Blood Flow Metab"},{"issue":"1","key":"10.1016\/j.parkreldis.2009.05.005_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00063030-200115010-00001","article-title":"Potential adverse effects of cyclooxygenase-2 inhibition: evidence from animal models of inflammation","volume":"15","author":"Colville-Nash","year":"2001","journal-title":"BioDrugs"},{"issue":"4","key":"10.1016\/j.parkreldis.2009.05.005_bib11","doi-asserted-by":"crossref","first-page":"573","DOI":"10.2967\/jnumed.106.036764","article-title":"11C-DPA-713: a novel peripheral benzodiazepine receptor PET ligand for in vivo imaging of neuroinflammation","volume":"48","author":"Boutin","year":"2007","journal-title":"J Nucl Med"},{"issue":"3","key":"10.1016\/j.parkreldis.2009.05.005_bib12","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.neuroimage.2007.09.063","article-title":"Brain and whole-body imaging in nonhuman primates of [11C]PBR28, a promising PET radioligand for peripheral benzodiazepine receptors","volume":"39","author":"Imaizumi","year":"2008","journal-title":"Neuroimage"}],"container-title":["Parkinsonism & Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802009001163?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802009001163?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T01:26:48Z","timestamp":1545182808000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1353802009001163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S1353802009001163"],"URL":"https:\/\/doi.org\/10.1016\/j.parkreldis.2009.05.005","relation":{},"ISSN":["1353-8020"],"issn-type":[{"value":"1353-8020","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}