{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:35:52Z","timestamp":1790807752473,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","prd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Parkinsonism &amp; Related Disorders"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.parkreldis.2010.04.004","type":"journal-article","created":{"date-parts":[[2010,5,11]],"date-time":"2010-05-11T08:02:22Z","timestamp":1273564942000},"page":"404-408","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"title":["In vivo detection of neuropathologic changes in presymptomatic MAPT mutation carriers: A PET and MRI study"],"prefix":"10.1016","volume":"16","author":[{"given":"Michie","family":"Miyoshi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Shinotoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zbigniew K.","family":"Wszolek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey J.","family":"Strongosky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Ikoma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"Yasuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Fukushi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Irie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Suhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.parkreldis.2010.04.004_bib1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1750-1172-1-30","article-title":"Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)","volume":"1","author":"Wszolek","year":"2006","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S1566-0702(02)00205-9","article-title":"Physiologic assessment of autonomic dysfunction in pallidopontonigral degeneration with N279K mutation in the tau gene on chromosome 17","volume":"102","author":"Cheshire","year":"2002","journal-title":"Auton Neurosci"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib3","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1353-8020(02)00098-6","article-title":"Early and pre-symptomatic neuropsychological dysfunction in the PPND family with the N279K tau mutation","volume":"9","author":"Ferman","year":"2003","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib4","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.parkreldis.2006.10.007","article-title":"Clinical-pathologic study of biomarkers in FTDP-17 (PPND family with N279K tau mutation)","volume":"13","author":"Arvanitakis","year":"2007","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1440-1789.2006.00742.x","article-title":"Frontotemporal dementia and Parkinsonism linked to chromosome 17 with the N279K tau mutation","volume":"27","author":"Slowinski","year":"2007","journal-title":"Neuropathology"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib6_1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neuron.2007.01.010","article-title":"Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model","volume":"53","author":"Yoshiyama","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib6_2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.neuron.2007.03.022","volume":"54","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib7","first-page":"26","article-title":"Histological and biochemical pathology in a family with autosomal dominant parkinsonism and dementia","volume":"2","author":"Yamada","year":"1993","journal-title":"Neurol Psych Brain Res"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib8","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.2174\/138161208786549443","article-title":"PET imaging of the peripheral benzodiazepine receptor: monitoring disease progression and therapy response in neurodegenerative disorders","volume":"14","author":"Doorduin","year":"2008","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib9","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.biopsych.2008.04.021","article-title":"Increased binding of peripheral benzodiazepine receptor in Alzheimer\u2019s disease measured by positron emission tomography with [11C]DAA1106","volume":"64","author":"Yasuno","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib10","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1212\/WNL.47.6.1588","article-title":"Presynaptic nigrostriatal function in genetically tested asymptomatic relatives from the pallido-ponto-nigral degeneration family","volume":"47","author":"Kishore","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib11","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1212\/01.wnl.0000208515.50924.94","article-title":"Brain acetylcholinesterase activity in FTDP-17 studied by PET","volume":"66","author":"Hirano","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib12","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The clinical dementia rating (CDR): current version and scoring rules","volume":"4","author":"Morris","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib13","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d: a practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib14","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1212\/WNL.55.11.1621","article-title":"The FAB: a frontal assessment battery at bedside","volume":"55","author":"Dubois","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib15","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1207\/s15327752jpa6703_13","article-title":"Comparison of beck depression inventories -IA and -II in psychiatric outpatients","volume":"67","author":"Beck","year":"1996","journal-title":"J Pers Assess"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib16","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1212\/WNL.44.12.2308","article-title":"The Neuropsychiatric inventory: comprehensive assessment of psychopathology in dementia","volume":"44","author":"Cummings","year":"1994","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib17","series-title":"Recent developments in Parkinson\u2019s disease","first-page":"293","article-title":"Unified Parkinson\u2019s disease, version 3.0","author":"Fahn","year":"1987"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib18","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/sj.jcbfm.9600325","article-title":"Quantitative analysis for estimating binding potential of the peripheral benzodiazepine receptor with [11C]DAA1106","volume":"27","author":"Ikoma","year":"2007","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib19","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1097\/01.mnm.0000230069.08576.6d","article-title":"Quantitative analysis of dopamine synthesis in human brain using positron emission tomography with L-[\u03b2-11C]dopa","volume":"27","author":"Ito","year":"2006","journal-title":"Nucl Med Commun"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib20","first-page":"151","article-title":"Dosimetry of an iodine-123-labeled tropane to image dopamine transporters","volume":"37","author":"Mozley","year":"1996","journal-title":"J Nucl Med"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib21","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/1531-8249(199907)46:1<62::AID-ANA10>3.0.CO;2-P","article-title":"Positron emission tomographic measurement of acetylcholinesterase activity reveals differential loss of ascending cholinergic systems in Parkinson\u2019s disease and progressive supranuclear palsy","volume":"46","author":"Shinotoh","year":"1999","journal-title":"Ann Neurol"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib22","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.nurt.2007.04.006","article-title":"Positron emission tomography imaging of neuroinflammation","volume":"4","author":"Cagnin","year":"2007","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib23","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1002\/ana.20332","article-title":"In vivo detection of microglial activation in frontotemporal dementia","volume":"56","author":"Cagnin","year":"2004","journal-title":"Ann Neurol"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib24","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1093\/brain\/awm044","article-title":"Microglial activation in presymptomatic Huntington\u2019s disease gene carrier","volume":"130","author":"Tai","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib25","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1097\/NEN.0b013e318188b204","article-title":"The positron emission tomography ligand DAA1106 binds with high affinity to activated microglia in human neurological disorders","volume":"67","author":"Venneti","year":"2008","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib26","doi-asserted-by":"crossref","first-page":"12255","DOI":"10.1523\/JNEUROSCI.2312-08.2008","article-title":"Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer\u2019s and other CNS pathologies","volume":"28","author":"Ji","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib27","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.nbd.2005.08.002","article-title":"In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson\u2019s disease","volume":"21","author":"Gerhard","year":"2006","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib28","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1353-8020(00)00026-2","article-title":"Positron emission tomography in pallido-ponto-nigral degeneration (PPND) family (frontotemporal dementia with parkinsonism linked to chromosome 17 and point mutation in tau gene)","volume":"7","author":"Pal","year":"2001","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.parkreldis.2010.04.004_bib29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/002383099200500102","article-title":"Some immunohistochemical features of argyrophilic grain dementia with normal cortical choline acetyltransferase levels but extensive subcortical pathology and markedly reduced dopamine","volume":"5","author":"Yamada","year":"1992","journal-title":"J\u00a0Geriatr Psychiatry Neurol"}],"container-title":["Parkinsonism &amp; Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802010000817?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802010000817?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:11:14Z","timestamp":1761178274000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1353802010000817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S1353802010000817"],"URL":"https:\/\/doi.org\/10.1016\/j.parkreldis.2010.04.004","relation":{},"ISSN":["1353-8020"],"issn-type":[{"value":"1353-8020","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vivo detection of neuropathologic changes in presymptomatic MAPT mutation carriers: A PET and MRI study","name":"articletitle","label":"Article Title"},{"value":"Parkinsonism & Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.parkreldis.2010.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}