{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:15:53Z","timestamp":1784823353929,"version":"3.55.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Empire State Clinical Research Training Program"},{"name":"Marcled Foundation"},{"name":"NIH-NINDS","award":["NS073836"],"award-info":[{"award-number":["NS073836"]}]},{"name":"CTSA","award":["UL1RR025750"],"award-info":[{"award-number":["UL1RR025750"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parkinsonism &amp; Related Disorders"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.parkreldis.2012.09.007","type":"journal-article","created":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T14:01:09Z","timestamp":1351173669000},"page":"186-191","source":"Crossref","is-referenced-by-count":26,"title":["Transcranial sonography and functional imaging in glucocerebrosidase mutation Parkinson disease"],"prefix":"10.1016","volume":"19","author":[{"given":"M.J.","family":"Barrett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hagenah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Dhawan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Stanley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Raymond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Deik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.J.","family":"Gross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Schreiber-Agus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mirelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Marder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.J.","family":"Ozelius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Eidelberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.B.","family":"Bressman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Saunders-Pullman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.parkreldis.2012.09.007_bib1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1212\/01.WNL.0000072482.70963.D7","article-title":"Gaucher's disease with Parkinson's disease: clinical and pathological aspects","volume":"61","author":"Bembi","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib2","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1136\/jmg.2004.024455","article-title":"Parkinsonism among Gaucher disease carriers","volume":"41","author":"Goker-Alpan","year":"2004","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib3","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/mgme.2001.3201","article-title":"Gaucher disease and parkinsonism: a phenotypic and genotypic characterization","volume":"73","author":"Tayebi","year":"2001","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib4","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1001\/archneurol.2009.72","article-title":"Mutations for Gaucher disease confer high susceptibility to Parkinson disease","volume":"66","author":"Mitsui","year":"2009","journal-title":"Arch Neurol"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ymgme.2007.03.004","article-title":"Glucocerebrosidase mutations in Chinese subjects from Taiwan with sporadic Parkinson disease","volume":"91","author":"Ziegler","year":"2007","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib6","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.neurobiolaging.2007.11.016","article-title":"Complete screening for glucocerebrosidase mutations in Parkinson disease patients from Portugal","volume":"30","author":"Bras","year":"2009","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.neulet.2009.01.029","article-title":"Complete screening for glucocerebrosidase mutations in Parkinson disease patients from Greece","volume":"452","author":"Kalinderi","year":"2009","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib8","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1056\/NEJMoa0901281","article-title":"Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease","volume":"361","author":"Sidransky","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib9","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s10048-009-0198-9","article-title":"LRRK2 and GBA mutations differentially affect the initial presentation of Parkinson disease","volume":"11","author":"Gan-Or","year":"2010","journal-title":"Neurogenetics"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib10","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1093\/brain\/awp044","article-title":"Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease","volume":"132","author":"Neumann","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib11","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1212\/01.wnl.0000327823.81237.d1","article-title":"Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset","volume":"72","author":"Nichols","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib12","first-page":"684","article-title":"Echogenicity of the substantia nigra in Parkinson's disease and its relation to clinical findings","volume":"248","author":"Berg","year":"2001","journal-title":"J\u00a0Neurol"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib13","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1007\/s00702-010-0504-6","article-title":"Microglia activation is related to substantia nigra echogenicity","volume":"117","author":"Berg","year":"2010","journal-title":"J\u00a0Neural Transm"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib14","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1002\/mds.20550","article-title":"In\u00a0vivo detection of iron and neuromelanin by transcranial sonography: a new approach for early detection of substantia nigra damage","volume":"20","author":"Zecca","year":"2005","journal-title":"Mov Disord"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib15","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1001\/archneurol.2010.281","article-title":"Recessively inherited parkinsonism: effect of ATP13A2 mutations on the clinical and neuroimaging phenotype","volume":"67","author":"Bruggemann","year":"2010","journal-title":"Arch Neurol"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib16","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1136\/jnnp.2007.142174","article-title":"Transcranial sonography findings in a large family with homozygous and heterozygous PINK1 mutations","volume":"79","author":"Hagenah","year":"2008","journal-title":"J\u00a0Neurol Neurosurg Psychiatr"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib17","first-page":"1407","article-title":"Substantia nigra hyperechogenicity correlates with clinical status and number of Parkin mutated alleles","volume":"254","author":"Hagenah","year":"2007","journal-title":"J\u00a0Neurol"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib18","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1212\/01.wnl.0000338439.00992.c7","article-title":"Re: alpha-synuclein gene duplication is present in sporadic Parkinson disease","volume":"71","author":"Brueggemann","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib19","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/mds.23644","article-title":"Substantia nigra hyperechogenicity with LRRK2 G2019S mutations","volume":"26","author":"Bruggemann","year":"2011","journal-title":"Mov Disord"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib20","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1002\/mds.23046","article-title":"Gaucher disease ascertained through a Parkinson's center: imaging and clinical characterization","volume":"25","author":"Saunders-Pullman","year":"2010","journal-title":"Mov Disord"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib21","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1212\/WNL.0b013e318225ab77","article-title":"GBA-associated PD presents with nonmotor characteristics","volume":"77","author":"Brockmann","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib22","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1002\/mds.23213","article-title":"Functional brain imaging in glucocerebrosidase mutation carriers with and without parkinsonism","volume":"25","author":"Kono","year":"2010","journal-title":"Mov Disord"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib23","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1086\/341282","article-title":"Genome screen to identify susceptibility genes for Parkinson disease in a sample without Parkin mutations","volume":"71","author":"Pankratz","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib24","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1056\/NEJMc055509","article-title":"LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews","volume":"354","author":"Ozelius","year":"2006","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib25","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.neuroimage.2010.01.112","article-title":"Life-long increase of substantia nigra hyperechogenicity in transcranial sonography","volume":"51","author":"Hagenah","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib26","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1212\/WNL.45.11.1995","article-title":"Early differential diagnosis of Parkinson's disease with 18F-fluorodeoxyglucose and positron emission tomography","volume":"45","author":"Eidelberg","year":"1995","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib27","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/ana.20442","article-title":"The metabolic pathology of dopa-responsive dystonia","volume":"57","author":"Asanuma","year":"2005","journal-title":"Ann Neurol"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib28","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1093\/brain\/awl162","article-title":"Network modulation in the treatment of Parkinson's disease","volume":"129","author":"Asanuma","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib29","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.neuroimage.2005.12.024","article-title":"Network modulation by the subthalamic nucleus in the treatment of Parkinson's disease","volume":"31","author":"Trost","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib30","first-page":"1324","article-title":"Comparative analysis of striatal FDOPA uptake in Parkinson's disease: ratio method versus graphical approach","volume":"43","author":"Dhawan","year":"2002","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib31","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/mds.21185","article-title":"Regional metabolic changes in parkinsonian patients with normal dopaminergic imaging","volume":"22","author":"Eckert","year":"2007","journal-title":"Mov Disord"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib32","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1001\/archneur.63.9.1250","article-title":"Clinical features of Parkinson disease patients with homozygous leucine-rich repeat kinase 2 G2019S mutations","volume":"63","author":"Ishihara","year":"2006","journal-title":"Arch Neurol"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib33","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.bcmd.2005.07.005","article-title":"Hematologically important mutations: Gaucher disease","volume":"35","author":"Beutler","year":"2005","journal-title":"Blood Cells Mol Dis"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib34","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/mds.24962","article-title":"The neuropathology of genetic Parkinson's disease","volume":"27","author":"Poulopoulos","year":"2012","journal-title":"Mov Disord"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib35","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1001\/archneurol.2009.54","article-title":"Association of glucocerebrosidase mutations with dementia with Lewy bodies","volume":"66","author":"Clark","year":"2009","journal-title":"Arch Neurol"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib36","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1212\/01.wnl.0000230215.41296.18","article-title":"Glucocerebrosidase mutations are an important risk factor for Lewy body disorders","volume":"67","author":"Goker-Alpan","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib37","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.molmed.2011.05.003","article-title":"Exploring the link between glucocerebrosidase mutations and parkinsonism","volume":"17","author":"Westbroek","year":"2011","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib38","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1002\/mds.20232","article-title":"Brain parenchyma sonography detects preclinical parkinsonism","volume":"19","author":"Walter","year":"2004","journal-title":"Mov Disord"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib39","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1212\/01.wnl.0000304039.11891.29","article-title":"Genotype-phenotype correlations between GBA mutations and Parkinson disease risk and onset","volume":"70","author":"Gan-Or","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2012.09.007_bib40","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/(SICI)1098-1004(1998)12:4<240::AID-HUMU4>3.0.CO;2-J","article-title":"Prevalence of glucocerebrosidase mutations in the Israeli Ashkenazi Jewish population","volume":"12","author":"Horowitz","year":"1998","journal-title":"Hum Mutat"}],"container-title":["Parkinsonism &amp; Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802012003483?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802012003483?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T17:53:00Z","timestamp":1542649980000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1353802012003483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S1353802012003483"],"URL":"https:\/\/doi.org\/10.1016\/j.parkreldis.2012.09.007","relation":{},"ISSN":["1353-8020"],"issn-type":[{"value":"1353-8020","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]}}}