{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T18:46:06Z","timestamp":1793472366834,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["prd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Parkinsonism & Related Disorders"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.parkreldis.2013.09.025","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T04:04:12Z","timestamp":1381550652000},"page":"99-105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":279,"title":["The influence of age and gender on motor and non-motor features of early Parkinson's disease: Initial findings from the Oxford Parkinson Disease Center (OPDC) discovery cohort"],"prefix":"10.1016","volume":"20","author":[{"given":"Konrad","family":"Szewczyk-Krolikowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Tomlinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kannan","family":"Nithi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Wade-Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Talbot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoav","family":"Ben-Shlomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele T.M.","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.parkreldis.2013.09.025_bib1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/mds.23346","article-title":"Clinical subtypes of Parkinson's disease","volume":"26","author":"van Rooden","year":"2011","journal-title":"Mov Disord"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1474-4422(06)70373-8","article-title":"Non-motor symptoms of Parkinson's disease: diagnosis and management","volume":"5","author":"Chaudhuri","year":"2006","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib3","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1136\/jnnp.2008.168211","article-title":"Incidence of Parkinson's disease in Norway: the Norwegian ParkWest study","volume":"80","author":"Alves","year":"2009","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib4","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1002\/mds.25175","article-title":"Design innovations and baseline findings in a long-term Parkinson's trial: The national institute of neurological disorders and stroke exploratory trials in Parkinson's Disease Long-Term Study-1","volume":"27","author":"Elm","year":"2012","journal-title":"Mov Disord"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib5","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1001\/archneur.1989.00520460028009","article-title":"DATATOP: a multicenter controlled clinical trial in early Parkinson's disease. Parkinson Study Group","volume":"46","author":"Parkinson Study Group","year":"1989","journal-title":"Arch Neurol-Chicago"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib6","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1001\/archneur.60.4.529","article-title":"Parkinson disease with old-age onset: a comparative study with subjects with middle-age onset","volume":"60","author":"Diederich","year":"2003","journal-title":"Arch Neurol-Chicago"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib7","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/mds.23469","article-title":"The motor phenotype of Parkinson's disease in relation to age at onset","volume":"26","author":"Wickremaratchi","year":"2011","journal-title":"Mov Disord"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib8","doi-asserted-by":"crossref","first-page":"e27899","DOI":"10.1371\/journal.pone.0027899","article-title":"Age and gender differences in physical capability levels from mid-life onwards: the harmonisation and meta-analysis of data from eight UK cohort studies","volume":"6","author":"Cooper","year":"2011","journal-title":"Plos One"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib9","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1001\/archneur.64.9.1242","article-title":"The relationship of Parkinson disease with aging","volume":"64","author":"Levy","year":"2007","journal-title":"Arch Neurol-Chicago"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib10","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/ana.22284","article-title":"Age-specific progression of nigrostriatal dysfunction in Parkinson's disease","volume":"69","author":"la Fuente-Fernandez de","year":"2011","journal-title":"Ann Neurol"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib11","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1097\/WCO.0b013e3283489687","article-title":"Impulse control disorders in Parkinson's disease: recent advances","volume":"24","author":"Voon","year":"2011","journal-title":"Curr Opin Neurol"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib12","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1001\/archneur.1996.00550120077019","article-title":"Visual hallucinations associated with Parkinson disease","volume":"53","author":"Sanchez-Ramos","year":"1996","journal-title":"Arch Neurol-Chicago"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib13","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1212\/01.wnl.0000265593.34438.00","article-title":"Risk factors for somnolence, edema, and hallucinations in early Parkinson disease","volume":"69","author":"Biglan","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib14","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1468-1331.2011.03402.x","article-title":"Oro-buccal symptoms (dysphagia, dysarthria, and sialorrhea) in patients with Parkinson's disease: preliminary analysis from the French COPARK cohort","volume":"19","author":"Perez-Lloret","year":"2012","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib15","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.parkreldis.2007.09.002","article-title":"Nonmotor symptoms of Parkinson's disease: prevalence and awareness of patients and families","volume":"14","author":"Cheon","year":"2008","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib16","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1136\/jnnp.2008.157701","article-title":"Swallowing problems in Parkinson disease: frequency and clinical correlates","volume":"80","author":"Miller","year":"2009","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib17","first-page":"1201","article-title":"Gender and the Parkinson's disease phenotype","volume":"252","author":"Baba","year":"2005","journal-title":"J\u00a0Neurol"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jns.2012.07.026","article-title":"Gender differences in motor and non-motor symptoms among Sardinian patients with Parkinson's disease","volume":"323","author":"Solla","year":"2012","journal-title":"J\u00a0Neurol Sci"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib19","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s002590000279","article-title":"Effect of age and gender on dopamine transporter imaging with [123I]FP-CIT SPET in healthy volunteers","volume":"27","author":"Lavalaye","year":"2000","journal-title":"Eur J Nucl Med"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib20","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1176\/appi.ajp.158.9.1492","article-title":"Striatal dopamine transporters and cognitive functioning in healthy men and women","volume":"158","author":"Mozley","year":"2001","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib21","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1136\/jnnp.2006.103788","article-title":"Gender differences in Parkinson's disease","volume":"78","author":"Haaxma","year":"2007","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib22","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/ana.22076","article-title":"Phasic muscle activity in sleep and clinical features of Parkinson disease","volume":"68","author":"Bliwise","year":"2010","journal-title":"Ann Neurol"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib23","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1002\/ana.22259","article-title":"Symmetry of Parkinson's disease and REM sleep: one piece of the puzzle","volume":"69","author":"Postuma","year":"2011","journal-title":"Ann Neurol"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib24","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.clineuro.2009.12.017","article-title":"Factors influencing the symmetry of Parkinson's disease symptoms","volume":"112","author":"G\u00f3mez-Esteban","year":"2010","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib25","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1532-5415.2008.02096.x","article-title":"Montreal cognitive assessment performance in patients with Parkinson's disease with \u2018normal\u2019 global cognition according to mini-mental state examination score","volume":"57","author":"Nazem","year":"2009","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib26","first-page":"1639","article-title":"Gender-related differences in the burden of non-motor symptoms in Parkinson\u2019s disease","volume":"259","author":"Martinez-Martin","year":"2012","journal-title":"J\u00a0Neurol"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib27","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1002\/mds.25086","article-title":"Rapid eye movement sleep behavior disorder and subtypes of Parkinson's disease","volume":"27","author":"Romenets","year":"2012","journal-title":"Mov Disord"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib28","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1212\/01.wnl.0000278114.14096.74","article-title":"REM sleep behavior disorder predicts cognitive impairment in Parkinson disease without dementia","volume":"69","author":"Vendette","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib29","first-page":"619","article-title":"Longitudinal study of cognitive function in idiopathic REM sleep behavior disorder","volume":"34","author":"Fantini","year":"2011","journal-title":"Sleep"},{"key":"10.1016\/j.parkreldis.2013.09.025_bib30","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/mds.24939","article-title":"Rapid eye movement sleep behavior disorder and risk of dementia in Parkinson's disease: A prospective study","volume":"27","author":"Postuma","year":"2012","journal-title":"Mov Disord"}],"container-title":["Parkinsonism & Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802013003568?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802013003568?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T06:52:00Z","timestamp":1539327120000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1353802013003568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S1353802013003568"],"URL":"https:\/\/doi.org\/10.1016\/j.parkreldis.2013.09.025","relation":{},"ISSN":["1353-8020"],"issn-type":[{"value":"1353-8020","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The influence of age and gender on motor and non-motor features of early Parkinson's disease: Initial findings from the Oxford Parkinson Disease Center (OPDC) discovery cohort","name":"articletitle","label":"Article Title"},{"value":"Parkinsonism & Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.parkreldis.2013.09.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}