{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T21:14:08Z","timestamp":1775510048567,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["prd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Parkinsonism & Related Disorders"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.parkreldis.2014.02.010","type":"journal-article","created":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T03:15:14Z","timestamp":1392866114000},"page":"520-524","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Hyposmia and cardiovascular dysautonomia correlatively appear in early-stage Parkinson's disease"],"prefix":"10.1016","volume":"20","author":[{"given":"Yasuaki","family":"Mizutani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinori","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichiro","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohisa","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Hirayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen","family":"Sobue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.parkreldis.2014.02.010_bib1","first-page":"969","article-title":"Olfactory dysfunction and cardiovascular dysautonomia in Parkinson's disease","volume":"257","author":"Oka","year":"2010","journal-title":"J\u00a0Neurol"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib2","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1002\/mds.21083","article-title":"Correlation between cardiac 123I-MIBG and odor identification in patients with Parkinson's disease and multiple system atrophy","volume":"21","author":"Lee","year":"2006","journal-title":"Mov Disord"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib3","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/ana.21291","article-title":"Association of olfactory dysfunction with risk for future Parkinson's disease","volume":"63","author":"Ross","year":"2008","journal-title":"Ann Neurol"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jns.2005.10.014","article-title":"Cardiovascular dysautonomia in de novo Parkinson's disease","volume":"241","author":"Oka","year":"2006","journal-title":"J\u00a0Neurol Sci"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib5","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/mds.20369","article-title":"FP-CIT and MIBG scintigraphy in early Parkinson's disease","volume":"20","author":"Spiegel","year":"2005","journal-title":"Mov Disord"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib6","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1136\/jnnp.51.6.745","article-title":"The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease","volume":"51","author":"Gibb","year":"1988","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib7","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1007\/s00702-005-0332-2","article-title":"How to diagnose MSA early: the role of magnetic resonance imaging","volume":"112","author":"Seppi","year":"2005","journal-title":"J\u00a0Neural Transm"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib8","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.2169\/internalmedicine.47.1345","article-title":"Smell identification in Japanese Parkinson's disease patients: using the odor stick identification test for Japanese subjects","volume":"47","author":"Iijima","year":"2008","journal-title":"Intern Med"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib9","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/mds.23602","article-title":"Association of olfactory dysfunction and brain. Metabolism in Parkinson's disease","volume":"26","author":"Baba","year":"2011","journal-title":"Mov Disord"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib10","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1002\/mds.23744","article-title":"Does cardiovascular autonomic dysfunction contribute to fatigue in Parkinson's disease?","volume":"26","author":"Nakamura","year":"2011","journal-title":"Mov Disord"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib11","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jns.2007.07.005","article-title":"Dobutamine stress test unmasks cardiac sympathetic denervation in Parkinson's disease","volume":"263","author":"Nakamura","year":"2007","journal-title":"J\u00a0Neurol Sci"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib12","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF02281627","article-title":"Clinical and physiological characteristics of autonomic failure with Parkinson's disease","volume":"9","author":"Niimi","year":"1999","journal-title":"Clin Auton Res"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib13","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1212\/WNL.46.5.1470","article-title":"Consensus statement on the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy. The Consensus Committee of the American Autonomic Society and the American Academy of Neurology","volume":"46","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib14","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1002\/mds.20993","article-title":"Prognosis of Parkinson's disease: time to stage III, IV, V, and to motor fluctuations","volume":"21","author":"Sato","year":"2006","journal-title":"Mov Disord"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib15","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1001\/jamaneurol.2013.2110","article-title":"Prognosis of mild cognitive impairment in early Parkinson disease: the Norwegian ParkWest Study","volume":"70","author":"Pedersen","year":"2013","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib16","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/mds.23001","article-title":"Cardiac sympathetic degeneration correlates with olfactory function in Parkinson's disease","volume":"25","author":"Iijima","year":"2010","journal-title":"Mov Disord"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib17","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1136\/jnnp.62.5.436","article-title":"Olfactory dysfunction in Parkinson's disease","volume":"62","author":"Hawkes","year":"1997","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib18","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1586\/ern.09.115","article-title":"Olfactory dysfunction as a diagnostic marker for Parkinson's disease","volume":"9","author":"Haehner","year":"2009","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib19","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson's disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib20","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1365-2990.2007.00874.x","article-title":"Parkinson's disease: a dual-hit hypothesis","volume":"33","author":"Hawkes","year":"2007","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib21","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1212\/WNL.52.6.1269","article-title":"Lewy body-type degeneration in cardiac plexus in Parkinson's and incidental Lewy body diseases","volume":"52","author":"Iwanaga","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib22","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1750-3639.2006.00032.x","article-title":"Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson's disease","volume":"17","author":"Orimo","year":"2007","journal-title":"Brain Pathol"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.parkreldis.2012.07.005","article-title":"Alpha-synuclein aggregates in epicardial fat tissue in living subjects without parkinsonism","volume":"19","author":"Navarro-Otano","year":"2013","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib24","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00401-008-0345-7","article-title":"Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease","volume":"115","author":"Dickson","year":"2008","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib25","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.1365-2990.2006.00727.x","article-title":"Alpha-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects","volume":"32","author":"Bloch","year":"2006","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1440-1789.2012.01329.x","article-title":"Neuropathologic analysis of Lewy-related alpha-synucleinopathy in olfactory mucosa","volume":"33","author":"Funabe","year":"2013","journal-title":"Neuropathology"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib27","first-page":"H151","article-title":"Assessment of autonomic function in humans by heart rate spectral analysis","volume":"248","author":"Pomeranz","year":"1985","journal-title":"Am J Physiol"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib28","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1212\/01.wnl.0000184504.13173.ef","article-title":"Blood pressure recovery from Valsalva maneuver in patients with autonomic failure","volume":"65","author":"Vogel","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib29","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1152\/jappl.1991.71.4.1563","article-title":"Pharmacological dissection of components of the Valsalva maneuver in adrenergic failure","volume":"71","author":"Sandroni","year":"1991","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.parkreldis.2014.02.010_bib30","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jns.2008.09.005","article-title":"Cardiac parasympathetic dysfunction concurrent with cardiac sympathetic denervation in Parkinson's disease","volume":"276","author":"Shibata","year":"2009","journal-title":"J\u00a0Neurol Sci"}],"container-title":["Parkinsonism & Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802014000637?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802014000637?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T20:04:09Z","timestamp":1565208249000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1353802014000637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S1353802014000637"],"URL":"https:\/\/doi.org\/10.1016\/j.parkreldis.2014.02.010","relation":{},"ISSN":["1353-8020"],"issn-type":[{"value":"1353-8020","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyposmia and cardiovascular dysautonomia correlatively appear in early-stage Parkinson's disease","name":"articletitle","label":"Article Title"},{"value":"Parkinsonism & Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.parkreldis.2014.02.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}