{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:51:13Z","timestamp":1792144273970,"version":"4.4.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["prd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Parkinsonism &amp; Related Disorders"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.parkreldis.2015.01.007","type":"journal-article","created":{"date-parts":[[2015,1,17]],"date-time":"2015-01-17T07:01:18Z","timestamp":1421478078000},"page":"355-360","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Inducible nitric oxide synthase gene methylation and parkinsonism in manganese-exposed welders"],"prefix":"10.1016","volume":"21","author":[{"given":"Susan","family":"Searles Nielsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey","family":"Checkoway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan R.","family":"Criswell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico M.","family":"Farin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia L.","family":"Stapleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianne","family":"Sheppard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad A.","family":"Racette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.parkreldis.2015.01.007_bib1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1080\/15459620903454600","article-title":"Manganese, iron, and total particulate exposures to welders","volume":"7","author":"Flynn","year":"2010","journal-title":"J\u00a0Occup Environ Hyg"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib2","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1212\/WNL.0b013e3182698ced","article-title":"Associations of welding and manganese exposure with Parkinson disease: review and meta-analysis","volume":"79","author":"Mortimer","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib3","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.neuro.2012.08.011","article-title":"Increased risk of parkinsonism associated with welding exposure","volume":"33","author":"Racette","year":"2012","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib4","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1212\/01.WNL.0000149511.19487.44","article-title":"Prevalence of parkinsonism and relationship to exposure in a large sample of Alabama welders","volume":"64","author":"Racette","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib5","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1212\/WNL.38.4.550","article-title":"Chronic exposure to the fungicide maneb may produce symptoms and signs of CNS manganese intoxication","volume":"38","author":"Ferraz","year":"1988","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib6","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1136\/oemed-2011-100119","article-title":"Basal ganglia intensity indices and diffusion weighted imaging in manganese-exposed welders","volume":"69","author":"Criswell","year":"2012","journal-title":"Occup Environ Med"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib7","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1212\/WNL.0b013e3182152830","article-title":"Reduced uptake of [18F]FDOPA PET in asymptomatic welders with occupational manganese exposure","volume":"76","author":"Criswell","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib8","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.neuro.2013.12.008","article-title":"Quantitative neuropathology associated with chronic manganese exposure in South African mine workers","volume":"45","author":"Gonzalez-Cuyar","year":"2014","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib9","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1007\/s11481-013-9475-3","article-title":"Improved visualization of neuronal injury following glial activation by manganese enhanced MRI","volume":"8","author":"Bade","year":"2013","journal-title":"J\u00a0Neuroimmune Pharmacol"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-2952(03)00145-X","article-title":"Iron interactions and other biological reactions mediating the physiological and toxic actions of manganese","volume":"66","author":"Roth","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib11","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1749-6632.2002.tb04077.x","article-title":"Role of nitric oxide in inflammation-mediated neurodegeneration","volume":"962","author":"Liu","year":"2002","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib12","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0301-0082(97)00052-X","article-title":"Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide","volume":"54","author":"Minghetti","year":"1998","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib13","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neubiorev.2014.06.002","article-title":"Pathologic role of glial nitric oxide in adult and pediatric neuroinflammatory diseases","volume":"45","author":"Ghasemi","year":"2014","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib14","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00204-010-0525-9","article-title":"Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes","volume":"84","author":"Sriram","year":"2010","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib15","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/toxsci\/kfr335","article-title":"Gene deletion of Nos2 protects against manganese-induced neurological dysfunction in juvenile mice","volume":"126","author":"Streifel","year":"2012","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib16","doi-asserted-by":"crossref","first-page":"3846","DOI":"10.4049\/jimmunol.175.6.3846","article-title":"Epigenetic basis for the transcriptional hyporesponsiveness of the human inducible nitric oxide synthase gene in vascular endothelial cells","volume":"175","author":"Chan","year":"2005","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib17","doi-asserted-by":"crossref","first-page":"46954","DOI":"10.1074\/jbc.M407192200","article-title":"Hypermethylation of the inducible nitric-oxide synthase gene promoter inhibits its transcription","volume":"279","author":"Yu","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib18","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2217\/epi.11.106","article-title":"Nasal cell DNA methylation, inflammation, lung function and wheezing in children with asthma","volume":"4","author":"Baccarelli","year":"2012","journal-title":"Epigenomics"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib19","doi-asserted-by":"crossref","first-page":"e000212","DOI":"10.1161\/JAHA.113.000212","article-title":"DNA hypomethylation, ambient particulate matter, and increased blood pressure: findings from controlled human exposure experiments","volume":"2","author":"Bellavia","year":"2013","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib20","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1289\/ehp.1104439","article-title":"Particulate matter, DNA methylation in nitric oxide synthase, and childhood respiratory disease","volume":"120","author":"Breton","year":"2012","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib21","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1093\/aje\/kwr523","article-title":"Air pollution and DNA methylation: interaction by psychological factors in the VA normative aging study","volume":"176","author":"Madrigano","year":"2012","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2011.09.037","article-title":"Genetic and epigenetic variations in inducible nitric oxide synthase promoter, particulate pollution, and exhaled nitric oxide levels in children","volume":"129","author":"Salam","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib23","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1289\/ehp.11898","article-title":"Effects of particulate matter on genomic DNA methylation content and iNOS promoter methylation","volume":"117","author":"Tarantini","year":"2009","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib24","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1080\/15459620902836856","article-title":"Validity and reliability of an occupational exposure questionnaire for parkinsonism in welders","volume":"6","author":"Hobson","year":"2009","journal-title":"J\u00a0Occup Environ Hyg"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib25","first-page":"153","article-title":"Unified Parkinson's disease rating scale","volume":"vol. 2","author":"Fahn","year":"1987"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1476-069X-12-47","article-title":"A\u00a0panel study of occupational exposure to fine particulate matter and changes in DNA methylation over a single workday and years worked in boilermaker welders","volume":"12","author":"Kile","year":"2013","journal-title":"Environ Health"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib27","doi-asserted-by":"crossref","first-page":"D1245","DOI":"10.1093\/nar\/gkr1193","article-title":"MethylomeDB: a database of DNA methylation profiles of the brain","volume":"40","author":"Xin","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib28","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4161\/epi.7.1.18749","article-title":"Aging and epigenetics: longitudinal changes in gene-specific DNA methylation","volume":"7","author":"Madrigano","year":"2012","journal-title":"Epigenetics"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib29","doi-asserted-by":"crossref","first-page":"e39220","DOI":"10.1371\/journal.pone.0039220","article-title":"Temporal stability of epigenetic markers: sequence characteristics and predictors of short-term DNA methylation variations","volume":"7","author":"Byun","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1868-7083-4-3","article-title":"Reproducibility and intraindividual variation over days in buccal cell DNA methylation of two asthma genes, interferon gamma (IFNgamma) and inducible nitric oxide synthase (iNOS)","volume":"4","author":"Torrone","year":"2012","journal-title":"Clin Epigenetics"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib31","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/apha.12414","article-title":"Exercise training and DNA methylation in humans","volume":"213","author":"Voisin","year":"2015","journal-title":"Acta Physiol"},{"key":"10.1016\/j.parkreldis.2015.01.007_bib32","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1093\/aje\/kwq303","article-title":"Metal emissions and urban incident Parkinson disease: a community health study of medicare beneficiaries by using geographic information systems","volume":"172","author":"Wright Willis","year":"2010","journal-title":"Am J Epidemiol"}],"container-title":["Parkinsonism &amp; Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802015000279?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802015000279?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T23:19:32Z","timestamp":1651015172000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1353802015000279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S1353802015000279"],"URL":"https:\/\/doi.org\/10.1016\/j.parkreldis.2015.01.007","relation":{},"ISSN":["1353-8020"],"issn-type":[{"value":"1353-8020","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inducible nitric oxide synthase gene methylation and parkinsonism in manganese-exposed welders","name":"articletitle","label":"Article Title"},{"value":"Parkinsonism & Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.parkreldis.2015.01.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}