{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:40:46Z","timestamp":1780587646078,"version":"3.54.1"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T00:00:00Z","timestamp":1455840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","prd-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Parkinsonism & Related Disorders"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.parkreldis.2016.02.011","type":"journal-article","created":{"date-parts":[[2016,2,14]],"date-time":"2016-02-14T01:53:28Z","timestamp":1455414808000},"page":"29-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"special_numbering":"C","title":["Association between cerebral small vessel diseases and mild parkinsonian signs in the elderly with vascular risk factors"],"prefix":"10.1016","volume":"26","author":[{"given":"Jun","family":"Hatate","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Miwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Yagita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Kitagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Mochizuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.parkreldis.2016.02.011_bib1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S1474-4422(10)70104-6","article-title":"Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges","volume":"9","author":"Pantoni","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.parkreldis.2016.02.011_bib2","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1002\/mds.21085","article-title":"Relation of cerebral small-vessel disease and brain atrophy to mild Parkinsonism in the elderly","volume":"21","author":"Reitz","year":"2006","journal-title":"Mov. Disord."},{"key":"10.1016\/j.parkreldis.2016.02.011_bib3","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1161\/STROKEAHA.112.657130","article-title":"Cerebral white matter lesions and lacunar infarcts contribute to the presence of mild parkinsonian signs","volume":"43","author":"De Laat","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.parkreldis.2016.02.011_bib4","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1002\/mds.21433","article-title":"Mild Parkinsonian signs: an overview of an emerging concept","volume":"22","author":"Louis","year":"2007","journal-title":"Mov. Disord."},{"key":"10.1016\/j.parkreldis.2016.02.011_bib5","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1212\/WNL.0000000000002082","article-title":"Cerebral small vessel disease and incident parkinsonism: the RUN DMC study","volume":"85","author":"van der Holst","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2016.02.011_bib6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S1474-4422(09)70013-4","article-title":"Cerebral microbleeds: a guide to detection and interpretation","volume":"8","author":"Greenberg","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.parkreldis.2016.02.011_bib7","first-page":"153","article-title":"Members of the UPDRS Development Committee","volume":"vol. 2","author":"Fahn","year":"1987"},{"key":"10.1016\/j.parkreldis.2016.02.011_bib8","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1001\/archneur.63.5.717","article-title":"History of vascular disease and mild parkinsonian signs in community-dwelling elderly individuals","volume":"63","author":"Louis","year":"2006","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.parkreldis.2016.02.011_bib9","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1212\/01.wnl.0000307750.41970.d9","article-title":"Prevalence and risk factors of cerebral microbleeds: the Rotterdam scan study","volume":"70","author":"Vernoij","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2016.02.011_bib10","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1161\/STROKEAHA.111.621193","article-title":"Relations of blood inflammatory marker levels with cerebral microbleeds","volume":"42","author":"Miwa","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.parkreldis.2016.02.011_bib11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0022-510X(93)90041-V","article-title":"A\u00a0semiquantitative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging","volume":"114","author":"Scheltens","year":"1993","journal-title":"J.\u00a0Neurol. Sci."},{"key":"10.1016\/j.parkreldis.2016.02.011_bib12","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2214\/ajr.149.2.351","article-title":"MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging","volume":"149","author":"Fazekas","year":"1987","journal-title":"AJR Am. J. Roentgenol."},{"key":"10.1016\/j.parkreldis.2016.02.011_bib13","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1212\/WNL.0000000000000837","article-title":"Stroke subtype, vascular risk factors, and total MRI brain small-vessel disease burden","volume":"83","author":"Staals","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2016.02.011_bib14","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1161\/STROKEAHA.110.596122","article-title":"Microbleeds are independently related to gait disturbances in elderly individuals with cerebral small vessel disease","volume":"42","author":"de Laat","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.parkreldis.2016.02.011_bib15","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.parkreldis.2015.06.019","article-title":"The prevalence and risk factors of cerebral microbleeds in patients with Parkinson's disease","volume":"21","author":"Yamashiro","year":"2015","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.parkreldis.2016.02.011_bib16","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1161\/STROKEAHA.111.623462","article-title":"Cerebrovascular disease pathology and parkinsonian signs in old age","volume":"42","author":"Buchman","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.parkreldis.2016.02.011_bib17","unstructured":"B. Vesely, A. Antonini, I. Rektor, The contribution of white matter lesions to Parkinson's disease motor and gait symptoms: a critical review of the literature.\u00a0J. Neural Transm. Vienna. pp. 1\u201310. First online: 19 October 2015"}],"container-title":["Parkinsonism & Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802016300396?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802016300396?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,15]],"date-time":"2018-09-15T08:22:46Z","timestamp":1536999766000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1353802016300396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":17,"alternative-id":["S1353802016300396"],"URL":"https:\/\/doi.org\/10.1016\/j.parkreldis.2016.02.011","relation":{},"ISSN":["1353-8020"],"issn-type":[{"value":"1353-8020","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between cerebral small vessel diseases and mild parkinsonian signs in the elderly with vascular risk factors","name":"articletitle","label":"Article Title"},{"value":"Parkinsonism & Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.parkreldis.2016.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}