{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T09:53:18Z","timestamp":1770889998100,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","prd-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Parkinsonism & Related Disorders"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.parkreldis.2016.06.003","type":"journal-article","created":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T02:45:57Z","timestamp":1465181157000},"page":"10-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Reduced intraepidermal nerve fiber density in patients with REM sleep behavior disorder"],"prefix":"10.1016","volume":"29","author":[{"given":"Wiebke","family":"Schrempf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0955-8911","authenticated-orcid":false,"given":"Istvan","family":"Katona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imis","family":"Dogan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verena v.","family":"Felbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Wienecke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Heller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Maier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Linse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moritz D.","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinz","family":"Reichmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg B.","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Schiefer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang H.","family":"Oertel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Storch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Weis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin","family":"Reetz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.parkreldis.2016.06.003_bib1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/sleep\/9.2.293","article-title":"Chronic behavioral disorders of human REM sleep: a new category of parasomnia","volume":"9","author":"Schenck","year":"1986","journal-title":"Sleep"},{"key":"10.1016\/j.parkreldis.2016.06.003_bib2","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1093\/brain\/awm056","article-title":"Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease","volume":"130","author":"Boeve","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.parkreldis.2016.06.003_bib3","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1212\/01.wnl.0000203648.80727.5b","article-title":"Potential early markers of Parkinson disease in idiopathic REM sleep behavior disorder","volume":"66","author":"Postuma","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2016.06.003_bib4","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1212\/01.wnl.0000340980.19702.6e","article-title":"Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder","volume":"72","author":"Postuma","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2016.06.003_bib5","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/sleep\/25.2.120","article-title":"REM sleep behavior disorder: clinical, developmental, and neuroscience perspectives 16 years after its formal identification in SLEEP","volume":"25","author":"Schenck","year":"2002","journal-title":"Sleep"},{"key":"10.1016\/j.parkreldis.2016.06.003_bib6","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S1474-4422(06)70476-8","article-title":"Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: a descriptive study","volume":"5","author":"Iranzo","year":"2006","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.parkreldis.2016.06.003_bib7","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1001\/jamaneurol.2014.4563","article-title":"Rapid eye movement sleep behavior disorder and neurodegenerative disease","volume":"72","author":"Howell","year":"2015","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.parkreldis.2016.06.003_bib8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1749-6632.2009.05115.x","article-title":"REM sleep behavior disorder: updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directions","volume":"1184","author":"Boeve","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.parkreldis.2016.06.003_bib9","doi-asserted-by":"crossref","first-page":"3298","DOI":"10.1093\/brain\/awp244","article-title":"Markers of neurodegeneration in idiopathic rapid eye movement sleep behaviour disorder and Parkinson\u2019s disease","volume":"132","author":"Postuma","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.parkreldis.2016.06.003_bib10","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1093\/brain\/awh322","article-title":"Combination of \u2019idiopathic\u2019 REM sleep behaviour disorder and olfactory dysfunction as possible indicator for alpha-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT","volume":"128","author":"Stiasny-Kolster","year":"2005","journal-title":"Brain"},{"issue":"Pt 6","key":"10.1016\/j.parkreldis.2016.06.003_bib11","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1093\/brain\/123.6.1155","article-title":"Reduced striatal dopamine transporters in idiopathic rapid eye movement sleep behaviour disorder. Comparison with Parkinson\u2019s disease and controls","volume":"123","author":"Eisensehr","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.parkreldis.2016.06.003_bib12","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/S1474-4422(10)70216-7","article-title":"Decreased striatal dopamine transporter uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study [corrected]","volume":"9","author":"Iranzo","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.parkreldis.2016.06.003_bib13","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson\u2019s disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.parkreldis.2016.06.003_bib14","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00401-014-1284-0","article-title":"Cutaneous neuropathy in Parkinson\u2019s disease: a window into brain pathology","volume":"128","author":"Doppler","year":"2014","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.parkreldis.2016.06.003_bib15","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1093\/brain\/awn102","article-title":"Sensory deficit in Parkinson\u2019s disease: evidence of a cutaneous denervation","volume":"131","author":"Nolano","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.parkreldis.2016.06.003_bib16","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1093\/brain\/awv138","article-title":"Phosphorylated alpha-synuclein in skin nerve fibres differentiates Parkinson\u2019s disease from multiple system atrophy","volume":"138","author":"Zange","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.parkreldis.2016.06.003_bib17","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1002\/mds.26293","article-title":"Distinctive distribution of phospho-alpha-synuclein in dermal nerves in multiple system atrophy","volume":"30","author":"Doppler","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.parkreldis.2016.06.003_bib18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.parkreldis.2013.09.007","article-title":"Prevalence and features of peripheral neuropathy in Parkinson\u2019s disease patients under different therapeutic regimens","volume":"20","author":"Mancini","year":"2014","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.parkreldis.2016.06.003_bib19","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1002\/mds.21740","article-title":"The REM sleep behavior disorder screening questionnaire\u2013a new diagnostic instrument","volume":"22","author":"Stiasny-Kolster","year":"2007","journal-title":"Mov. Disord."},{"key":"10.1016\/j.parkreldis.2016.06.003_bib20","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1002\/mds.20141","article-title":"Detection of presymptomatic Parkinson\u2019s disease: combining smell tests, transcranial sonography, and SPECT","volume":"19","author":"Sommer","year":"2004","journal-title":"Mov. Disord."},{"key":"10.1016\/j.parkreldis.2016.06.003_bib21","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1002\/mds.20844","article-title":"International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson\u2019s disease: the NMSQuest study","volume":"21","author":"Chaudhuri","year":"2006","journal-title":"Mov. Disord."},{"key":"10.1016\/j.parkreldis.2016.06.003_bib22","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00405-006-0173-0","article-title":"Normative data for the \u201cSniffin\u2019 Sticks\u201d including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects","volume":"264","author":"Hummel","year":"2007","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1016\/j.parkreldis.2016.06.003_bib23","series-title":"Das EMG-Buch. EMG und periphere Neurologie in Frage und Antwort","author":"Bischoff","year":"2011"},{"key":"10.1016\/j.parkreldis.2016.06.003_bib24","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1212\/WNL.0b013e31821e553a","article-title":"Small-fiber neuropathy in patients with ALS","volume":"76","author":"Weis","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2016.06.003_bib25","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1529-8027.2010.00271.x","article-title":"Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study","volume":"15","author":"Lauria","year":"2010","journal-title":"J.\u00a0Peripher Nerv. Syst."},{"key":"10.1016\/j.parkreldis.2016.06.003_bib26","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/mds.20153","article-title":"Assessment of autonomic dysfunction in Parkinson\u2019s disease: the SCOPA-AUT","volume":"19","author":"Visser","year":"2004","journal-title":"Mov. Disord."},{"key":"10.1016\/j.parkreldis.2016.06.003_bib27","first-page":"1112","article-title":"Autonomic symptoms in idiopathic REM behavior disorder: a multicentre case-control study","volume":"261","author":"Ferini-Strambi","year":"2014","journal-title":"J.\u00a0Neurol."},{"key":"10.1016\/j.parkreldis.2016.06.003_bib28","first-page":"1568","article-title":"Prevalence and timeline of nonmotor symptoms in idiopathic rapid eye movement sleep behavior disorder","volume":"262","author":"Aguirre-Mardones","year":"2015","journal-title":"J.\u00a0Neurol."},{"key":"10.1016\/j.parkreldis.2016.06.003_bib29","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1212\/WNL.0000000000001265","article-title":"Olfactory dysfunction predicts early transition to a Lewy body disease in idiopathic RBD","volume":"84","author":"Mahlknecht","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2016.06.003_bib30","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1001\/jamaneurol.2015.0703","article-title":"New clinical subtypes of Parkinson disease and their longitudinal progression: a prospective cohort comparison with other phenotypes","volume":"72","author":"Fereshtehnejad","year":"2015","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.parkreldis.2016.06.003_bib31","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1093\/brain\/awv251","article-title":"Skin biopsies in the differential diagnosis of parkinsonism: are we ready for simplified protocols?","volume":"139","author":"Doppler","year":"2016","journal-title":"Brain"}],"container-title":["Parkinsonism & Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802016301997?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802016301997?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T10:44:08Z","timestamp":1668768248000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1353802016301997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":31,"alternative-id":["S1353802016301997"],"URL":"https:\/\/doi.org\/10.1016\/j.parkreldis.2016.06.003","relation":{},"ISSN":["1353-8020"],"issn-type":[{"value":"1353-8020","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reduced intraepidermal nerve fiber density in patients with REM sleep behavior disorder","name":"articletitle","label":"Article Title"},{"value":"Parkinsonism & Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.parkreldis.2016.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}