{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T18:39:17Z","timestamp":1764873557690,"version":"3.37.3"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,5,18]],"date-time":"2018-05-18T00:00:00Z","timestamp":1526601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005725","name":"CHDI Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","prd-journal.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Parkinsonism & Related Disorders"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.parkreldis.2018.05.016","type":"journal-article","created":{"date-parts":[[2018,5,18]],"date-time":"2018-05-18T01:54:27Z","timestamp":1526608467000},"page":"55-60","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Perinatal insults and neurodevelopmental disorders may impact Huntington's disease age of diagnosis"],"prefix":"10.1016","volume":"55","author":[{"given":"Melinda","family":"Barkhuizen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filipe B.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David G.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bjorn","family":"Winkens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward J.","family":"Wild","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris W.","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.W.Danilo","family":"Gavilanes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.parkreldis.2018.05.016_bib1","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/mds.25075","article-title":"The incidence and prevalence of Huntington's disease: a systematic review and meta-analysis","volume":"27","author":"Pringsheim","year":"2012","journal-title":"Mov. Disord."},{"issue":"2","key":"10.1016\/j.parkreldis.2018.05.016_bib2","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000443738","article-title":"The prevalence of Huntington's disease","volume":"46","author":"Rawlins","year":"2016","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.parkreldis.2018.05.016_bib3","series-title":"CHDI 12th Annual HD Therapeutics Conference","article-title":"[122] Therapeutic interventions for symptomatic treatment in Huntington's disease \u2013 a Cochrane review","author":"Rodrigues","year":"2017"},{"issue":"8","key":"10.1016\/j.parkreldis.2018.05.016_bib4","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/gm80","article-title":"Huntington's disease: the case for genetic modifiers","volume":"1","author":"Gusella","year":"2009","journal-title":"Genome Med."},{"issue":"3","key":"10.1016\/j.parkreldis.2018.05.016_bib5","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.cell.2015.07.003","article-title":"Identification of genetic factors that modify clinical onset of Huntington's disease","volume":"162","author":"Lee","year":"2015","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.parkreldis.2018.05.016_bib6","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1073\/pnas.0308679101","article-title":"Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset","volume":"101","author":"Wexler","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"4","key":"10.1016\/j.parkreldis.2018.05.016_bib7","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1007\/s12035-017-0477-7","article-title":"Huntington disease as a neurodevelopmental disorder and early signs of the disease in stem cells","volume":"55","author":"Wiatr","year":"2017","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.parkreldis.2018.05.016_bib8","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.neuron.2016.11.035","article-title":"Huntingtin-mediated multipolar-bipolar transition of newborn cortical neurons is critical for their postnatal neuronal morphology","volume":"93","author":"Barnat","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.parkreldis.2018.05.016_bib9","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.nbd.2016.09.006","article-title":"Postnatal and adult consequences of loss of huntingtin during development: implications for Huntington's disease","volume":"96","author":"Arteaga-Bracho","year":"2016","journal-title":"Neurobiol. Dis."},{"issue":"20","key":"10.1016\/j.parkreldis.2018.05.016_bib10","doi-asserted-by":"crossref","first-page":"5736","DOI":"10.1073\/pnas.1603871113","article-title":"Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington's disease","volume":"113","author":"Molero","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"issue":"12","key":"10.1016\/j.parkreldis.2018.05.016_bib11","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1136\/jnnp.2010.209668","article-title":"Observing Huntington's disease: the European Huntington's disease network's REGISTRY","volume":"82","author":"Orth","year":"2010","journal-title":"J. Neurol. Neurosurg. Psychiatr."},{"key":"10.1016\/j.parkreldis.2018.05.016_bib12","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/mdc3.12388","article-title":"Data analytics from enroll-HD, a global clinical research platform for Huntington's disease","volume":"4","author":"Landwehrmeyer","year":"2016","journal-title":"Mov. Disord. Clin. Pract."},{"issue":"9814","key":"10.1016\/j.parkreldis.2018.05.016_bib13","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0140-6736(11)61577-8","article-title":"Long-term neurodevelopmental outcomes after intrauterine and neonatal insults: a systematic review","volume":"379","author":"Mwaniki","year":"2012","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.parkreldis.2018.05.016_bib14","first-page":"593","article-title":"Anticipation and instability of IT-15 (CAG) n repeats in parent-offspring pairs with Huntington disease","volume":"57","author":"Ranen","year":"1995","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.parkreldis.2018.05.016_bib15","series-title":"The Neurological Outcome of Perinatal Asphyxia. Early Brain Damage V1: Research Orientations and Clinical Observations","first-page":"151","author":"Volpe","year":"2012"},{"issue":"S1","key":"10.1016\/j.parkreldis.2018.05.016_bib16","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/pr.2013.206","article-title":"Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990","volume":"74","author":"Lee","year":"2013","journal-title":"Pediatr. Res."},{"issue":"3","key":"10.1016\/j.parkreldis.2018.05.016_bib17","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s10519-016-9784-4","article-title":"Pre-and perinatal ischemia-hypoxia, the ischemia-hypoxia response pathway, and ADHD risk","volume":"46","author":"Smith","year":"2016","journal-title":"Behav. Genet."},{"key":"10.1016\/j.parkreldis.2018.05.016_bib18","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1146\/annurev-clinpsy-032814-112842","article-title":"Developmental dyslexia","volume":"11","author":"Peterson","year":"2015","journal-title":"Annu. Rev. Clin. Psychol."},{"issue":"5","key":"10.1016\/j.parkreldis.2018.05.016_bib19","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.ejrad.2012.12.006","article-title":"Basal ganglia lesions in children and adults","volume":"82","author":"Bekiesinska-Figatowska","year":"2013","journal-title":"Eur. J. Radiol."},{"issue":"2","key":"10.1016\/j.parkreldis.2018.05.016_bib20","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/cne.10938","article-title":"Evidence for progression in frontal cortical pathology in late-stage Huntington's disease","volume":"468","author":"Selemon","year":"2004","journal-title":"J. Comp. Neurol."},{"issue":"4","key":"10.1016\/j.parkreldis.2018.05.016_bib21","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.exger.2010.01.001","article-title":"The \u201cLEARn\u201d(Latent Early-life Associated Regulation) model integrates environmental risk factors and the developmental basis of Alzheimer's disease, and proposes remedial steps","volume":"45","author":"Lahiri","year":"2010","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.parkreldis.2018.05.016_bib22","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1177\/003591576505800503","article-title":"The environment and disease: association or causation?","volume":"58","author":"Hill","year":"1965","journal-title":"Proc. Roy. Soc. Med."},{"issue":"9832","key":"10.1016\/j.parkreldis.2018.05.016_bib23","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1016\/S0140-6736(12)60820-4","article-title":"National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications","volume":"379","author":"Blencowe","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.parkreldis.2018.05.016_bib24","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.ypmed.2016.08.024","article-title":"Adult outcomes of preterm birth","volume":"91","author":"Crump","year":"2016","journal-title":"Prev. Med."},{"issue":"9","key":"10.1016\/j.parkreldis.2018.05.016_bib25","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1001\/jamaophthalmol.2013.4001","article-title":"Risk factors and genetics in common comitant strabismus: a systematic review of the literature","volume":"131","author":"Maconachie","year":"2013","journal-title":"JAMA Ophthalmol."},{"issue":"1","key":"10.1016\/j.parkreldis.2018.05.016_bib26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1469-7610.2012.02611.x","article-title":"Practitioner review: what have we learnt about the causes of ADHD?","volume":"54","author":"Thapar","year":"2013","journal-title":"JCPP (J. Child Psychol. Psychiatry)"},{"issue":"3","key":"10.1016\/j.parkreldis.2018.05.016_bib27","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1207\/s1532799xssr0903_6","article-title":"A conservative meta-analysis of linkage and linkage-association studies of developmental dyslexia","volume":"9","author":"Grigorenko","year":"2005","journal-title":"Sci. Stud. Read."},{"issue":"S1","key":"10.1016\/j.parkreldis.2018.05.016_bib28","doi-asserted-by":"crossref","DOI":"10.1186\/1742-4755-10-S1-S2","article-title":"Born too soon: the global epidemiology of 15 million preterm births","volume":"10","author":"Blencowe","year":"2013","journal-title":"Reprod. Health"},{"issue":"11","key":"10.1016\/j.parkreldis.2018.05.016_bib29","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1016\/j.ophtha.2009.04.034","article-title":"Prevalence of amblyopia and strabismus in white and African American children aged 6 through 71 months: the Baltimore pediatric eye disease study","volume":"116","author":"Friedman","year":"2009","journal-title":"Ophthalmology"},{"issue":"4","key":"10.1016\/j.parkreldis.2018.05.016_bib30","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2014-3482","article-title":"Prevalence of attention-deficit\/hyperactivity disorder: a systematic review and meta-analysis","volume":"135","author":"Thomas","year":"2015","journal-title":"Pediatrics"}],"container-title":["Parkinsonism & Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802018302463?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802018302463?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T21:42:55Z","timestamp":1661290975000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1353802018302463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":30,"alternative-id":["S1353802018302463"],"URL":"https:\/\/doi.org\/10.1016\/j.parkreldis.2018.05.016","relation":{},"ISSN":["1353-8020"],"issn-type":[{"type":"print","value":"1353-8020"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perinatal insults and neurodevelopmental disorders may impact Huntington's disease age of diagnosis","name":"articletitle","label":"Article Title"},{"value":"Parkinsonism & Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.parkreldis.2018.05.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}