{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:15:01Z","timestamp":1792638901611,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","prd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Parkinsonism &amp; Related Disorders"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.parkreldis.2018.07.007","type":"journal-article","created":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T09:15:55Z","timestamp":1531905355000},"page":"3-8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Neuromelanin-sensitive MRI of the substantia nigra: An imaging biomarker to differentiate essential tremor from tremor-dominant Parkinson's disease"],"prefix":"10.1016","volume":"58","author":[{"given":"Jian","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanfang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changpeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqiang","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengsu","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjiu","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.parkreldis.2018.07.007_bib1","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1212\/01.WNL.0000099075.19951.8C","article-title":"Prevalence of essential tremor: door-to-door neurologic exams in Mersin Province, Turkey","volume":"61","author":"Dogu","year":"2003","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/j.parkreldis.2018.07.007_bib2","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1586\/14737175.2014.936389","article-title":"Twelve clinical pearls to help distinguish essential tremor from other tremors","volume":"14","author":"Louis","year":"2014","journal-title":"Expert Rev. Neurother."},{"issue":"4","key":"10.1016\/j.parkreldis.2018.07.007_bib3","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/00002826-199408000-00001","article-title":"Tremors in Parkinson's disease: symptom analysis and rating","volume":"17","author":"Zimmermann","year":"1994","journal-title":"Clin. Neuropharmacol."},{"issue":"3","key":"10.1016\/j.parkreldis.2018.07.007_bib4","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1001\/archneur.60.3.405","article-title":"Rest tremor in patients with essential tremor: prevalence, clinical correlates, and electrophysiologic characteristics","volume":"60","author":"Cohen","year":"2003","journal-title":"Arch. Neurol."},{"issue":"8","key":"10.1016\/j.parkreldis.2018.07.007_bib5","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1001\/archneur.63.8.1100","article-title":"Common misdiagnosis of a common neurological disorder: how are we misdiagnosing essential tremor?","volume":"63","author":"Jain","year":"2006","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.parkreldis.2018.07.007_bib6","doi-asserted-by":"crossref","first-page":"252","DOI":"10.5334\/tohm.227","article-title":"Essential Tremor: a Neurodegenerative Disease?","volume":"4","author":"Benito-Leon","year":"2014","journal-title":"Tremor Other Hyperkinet Mov (NY)"},{"issue":"Suppl 1","key":"10.1016\/j.parkreldis.2018.07.007_bib7","doi-asserted-by":"crossref","first-page":"S162","DOI":"10.1016\/j.parkreldis.2015.09.032","article-title":"The relationship between essential tremor and Parkinson's disease","volume":"22","author":"Thenganatt","year":"2016","journal-title":"Park. Relat. Disord."},{"issue":"Suppl 1","key":"10.1016\/j.parkreldis.2018.07.007_bib8","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1016\/j.parkreldis.2015.08.034","article-title":"Non-motor symptoms in essential tremor: a review of the current data and state of the field","volume":"22","author":"Louis","year":"2016","journal-title":"Park. Relat. Disord."},{"issue":"12","key":"10.1016\/j.parkreldis.2018.07.007_bib9","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1093\/brain\/awm266","article-title":"Neuropathological changes in essential tremor: 33 cases compared with 21 controls","volume":"130","author":"Louis","year":"2007","journal-title":"Brain"},{"issue":"5","key":"10.1016\/j.parkreldis.2018.07.007_bib10","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.parkreldis.2012.01.013","article-title":"Essential tremor is not dependent upon cerebellar Purkinje cell loss","volume":"18","author":"Rajput","year":"2012","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.parkreldis.2018.07.007_bib11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0074-7742(10)90014-7","article-title":"Transcranial sonography in essential tremor","volume":"90","author":"Stockner","year":"2010","journal-title":"Int. Rev. Neurobiol."},{"issue":"2","key":"10.1016\/j.parkreldis.2018.07.007_bib12","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/mds.25263","article-title":"Brain iron deposition in essential tremor: a quantitative 3-Tesla magnetic resonance imaging study","volume":"28","author":"Novellino","year":"2013","journal-title":"Mov. Disord."},{"issue":"6","key":"10.1016\/j.parkreldis.2018.07.007_bib13","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/mds.22870","article-title":"Imaging essential tremor","volume":"25","author":"Isaias","year":"2010","journal-title":"Mov. Disord."},{"issue":"4","key":"10.1016\/j.parkreldis.2018.07.007_bib14","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1111\/j.1471-4159.2008.05541.x","article-title":"Neuromelanin can protect against iron-mediated oxidative damage in system modeling iron overload of brain aging and Parkinson's disease","volume":"106","author":"Zecca","year":"2008","journal-title":"J. Neurochem."},{"issue":"11","key":"10.1016\/j.parkreldis.2018.07.007_bib15","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1097\/01.wnr.0000227984.84927.a7","article-title":"Neuromelanin magnetic resonance imaging of locus ceruleus and substantia nigra in Parkinson's disease","volume":"17","author":"Sasaki","year":"2006","journal-title":"Neuroreport"},{"issue":"7","key":"10.1016\/j.parkreldis.2018.07.007_bib16","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/mds.26182","article-title":"Substantia nigra neuromelanin-MR imaging differentiates essential tremor from Parkinson's disease","volume":"30","author":"Reimao","year":"2015","journal-title":"Mov. Disord."},{"issue":"Suppl 3","key":"10.1016\/j.parkreldis.2018.07.007_bib17","first-page":"2","article-title":"Consensus statement of the movement disorder society on tremor","volume":"13","author":"Deuschl","year":"1998","journal-title":"Ad Hoc Scientific committee, Mov. Disord."},{"issue":"12","key":"10.1016\/j.parkreldis.2018.07.007_bib18","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson's disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov. Disord."},{"issue":"7","key":"10.1016\/j.parkreldis.2018.07.007_bib19","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1111\/j.1468-1331.2011.03658.x","article-title":"Nigral iron deposition occurs across motor phenotypes of Parkinson's disease","volume":"19","author":"Jin","year":"2012","journal-title":"Eur. J. Neurol."},{"issue":"2","key":"10.1016\/j.parkreldis.2018.07.007_bib20","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/sim.2929","article-title":"Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond","volume":"27","author":"Pencina","year":"2008","journal-title":"Stat. Med."},{"issue":"5","key":"10.1016\/j.parkreldis.2018.07.007_bib21","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1093\/brain\/114.5.2283","article-title":"Ageing and Parkinson's disease: substantia nigra regional selectivity","volume":"114","author":"Fearnley","year":"1991","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.parkreldis.2018.07.007_bib22","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/MNM.0b013e3282f4d307","article-title":"Striatal dopamine transporter abnormalities in patients with essential tremor","volume":"29","author":"Isaias","year":"2008","journal-title":"Nucl. Med. Commun."},{"issue":"9","key":"10.1016\/j.parkreldis.2018.07.007_bib23","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/s11910-013-0378-8","article-title":"The pathophysiology of essential tremor and Parkinson's tremor","volume":"13","author":"Helmich","year":"2013","journal-title":"Curr. Neurol. Neurosci. Rep."},{"issue":"3","key":"10.1016\/j.parkreldis.2018.07.007_bib24","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/1531-8257(200005)15:3<503::AID-MDS1013>3.0.CO;2-V","article-title":"Accurate differentiation of parkinsonism and essential tremor using visual assessment of [(123) I]-FP-CIT SPECT imaging: the [(123) I]-FP-CIT study group","volume":"15","author":"Benamer","year":"2000","journal-title":"Mov. Disord."},{"key":"10.1016\/j.parkreldis.2018.07.007_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.parkreldis.2017.06.006","article-title":"Hyperechogenicity of substantia nigra for differential diagnosis of Parkinson's disease: a meta-analysis","volume":"42","author":"Shafieesabet","year":"2017","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.parkreldis.2018.07.007_bib26","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3389\/fnagi.2016.00196","article-title":"Neuromelanin imaging and dopaminergic loss in Parkinson's disease","volume":"8","author":"Isaias","year":"2016","journal-title":"Front. Aging Neurosci."},{"issue":"2","key":"10.1016\/j.parkreldis.2018.07.007_bib27","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00330-013-3025-5","article-title":"Quantitative regional validation of the visual rating scale for posterior cortical atrophy","volume":"24","author":"Moller","year":"2014","journal-title":"Eur. Radiol."},{"issue":"4","key":"10.1016\/j.parkreldis.2018.07.007_bib28","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1093\/brain\/aww006","article-title":"The coeruleus\/subcoeruleus complex in idiopathic rapid eye movement sleep behaviour disorder","volume":"139","author":"Ehrminger","year":"2016","journal-title":"Brain"},{"issue":"24","key":"10.1016\/j.parkreldis.2018.07.007_bib29","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1056\/NEJMoa033447","article-title":"G. Parkinson Study, Levodopa and the progression of Parkinson's disease","volume":"351","author":"Fahn","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.parkreldis.2018.07.007_bib30","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neulet.2016.09.011","article-title":"A longitudinal study of neuromelanin-sensitive magnetic resonance imaging in Parkinson's disease,","volume":"633","author":"Matsuura","year":"2016","journal-title":"Neurosci. Lett."}],"container-title":["Parkinsonism &amp; Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802018303092?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802018303092?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:14:37Z","timestamp":1761178477000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1353802018303092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":30,"alternative-id":["S1353802018303092"],"URL":"https:\/\/doi.org\/10.1016\/j.parkreldis.2018.07.007","relation":{},"ISSN":["1353-8020"],"issn-type":[{"value":"1353-8020","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuromelanin-sensitive MRI of the substantia nigra: An imaging biomarker to differentiate essential tremor from tremor-dominant Parkinson's disease","name":"articletitle","label":"Article Title"},{"value":"Parkinsonism & Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.parkreldis.2018.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}