{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T04:09:12Z","timestamp":1768968552604,"version":"3.49.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Dutch Brain Foundation"},{"DOI":"10.13039\/100002129","name":"Dutch Heart Foundation","doi-asserted-by":"publisher","award":["2014 T060"],"award-info":[{"award-number":["2014 T060"]}],"id":[{"id":"10.13039\/100002129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"The Netherlands Organisation for Health Research and Development","doi-asserted-by":"crossref","award":["016.126.351"],"award-info":[{"award-number":["016.126.351"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"crossref"}]},{"name":"MIRA Institute for Biomedical Technology and Technical Medicine"},{"DOI":"10.13039\/501100001834","name":"University of Twente","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001834","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","prd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Parkinsonism & Related Disorders"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.parkreldis.2018.11.010","type":"journal-article","created":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T02:11:13Z","timestamp":1541643073000},"page":"94-100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Brain atrophy and strategic lesion location increases risk of parkinsonism in cerebral small vessel disease"],"prefix":"10.1016","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9448-5464","authenticated-orcid":false,"given":"Mayra I.","family":"Bergkamp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil M.","family":"Tuladhar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena M.","family":"van der Holst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther M.C.","family":"van Leijsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Ghafoorian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingeborg W.M.","family":"van Uden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewoud J.","family":"van Dijk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David G.","family":"Norris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bram","family":"Platel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rianne A.J.","family":"Esselink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank-Erik de","family":"Leeuw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.parkreldis.2018.11.010_bib1","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1056\/NEJMoa070972","article-title":"Incidental findings on brain mri in the general population","volume":"357","author":"Vernooij","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.parkreldis.2018.11.010_bib2","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.1161\/STROKEAHA.110.595181","article-title":"Prevalence and risk factors of cerebral microbleeds: an update of the rotterdam scan study","volume":"41","author":"Poels","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.parkreldis.2018.11.010_bib3","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00401-003-0676-3","article-title":"Prevalence of cerebrovascular lesions in Parkinson's disease. A postmortem study","volume":"105","author":"Jellinger","year":"2003","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.parkreldis.2018.11.010_bib4","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1093\/brain\/awr139","article-title":"Leucoaraiosis, nigrostriatal denervation and motor symptoms in Parkinson's disease","volume":"134","author":"Bohnen","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.parkreldis.2018.11.010_bib5","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.parkreldis.2012.03.017","article-title":"The relationship between cerebral vascular disease and parkinsonism: the vado study","volume":"18","author":"Antonini","year":"2012","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.parkreldis.2018.11.010_bib6","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jns.2014.09.002","article-title":"The relationship of leukoaraiosis and the clinical severity of vascular parkinsonism","volume":"346","author":"Chen","year":"2014","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.parkreldis.2018.11.010_bib7","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1212\/WNL.0000000000002082","article-title":"Cerebral small vessel disease and incident parkinsonism. The run dmc study","volume":"85","author":"van der Holst","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2018.11.010_bib8","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1161\/STROKEAHA.112.657130","article-title":"Cerebral white matter lesions and lacunar infarcts contribute to the presence of mild parkinsonian signs","volume":"43","author":"de Laat","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.parkreldis.2018.11.010_bib9","first-page":"26","article-title":"Association between cerebral small vessel diseases and mild parkinsonian signs in the elderly with vascular risk factors","author":"Hatate","year":"2016","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.parkreldis.2018.11.010_bib10","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/j.neurobiolaging.2009.10.013","article-title":"White matter hyperintensities and cognition: testing the reserve hypothesis","volume":"32","author":"Brickman","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.parkreldis.2018.11.010_bib11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1471-2377-11-29","article-title":"Causes and consequences of cerebral small vessel disease. The run dmc study: a prospective cohort study. Study rationale and protocol","volume":"11","author":"van Norden","year":"2011","journal-title":"BMC Neurol."},{"key":"10.1016\/j.parkreldis.2018.11.010_bib12","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S1474-4422(13)70124-8","article-title":"Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration","volume":"12","author":"Wardlaw","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.parkreldis.2018.11.010_bib13","doi-asserted-by":"crossref","first-page":"6246","DOI":"10.1118\/1.4966029","article-title":"Automated detection of white matter hyperintensities of all sizes in cerebral small vessel disease","volume":"43","author":"Ghafoorian","year":"2016","journal-title":"Med. Phys."},{"key":"10.1016\/j.parkreldis.2018.11.010_bib14","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2214\/ajr.149.2.351","article-title":"Mr signal abnormalities at 1.5 t in alzheimer's dementia and normal aging","volume":"149","author":"Fazekas","year":"1987","journal-title":"AJR Am. J. Roentgenol."},{"key":"10.1016\/j.parkreldis.2018.11.010_bib15","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/mds.10459","article-title":"Movement disorders society scientific issues committee report: sic task force appraisal of clinical diagnostic criteria for parkinsonian disorders","volume":"18","author":"Litvan","year":"2003","journal-title":"Mov. Disord."},{"key":"10.1016\/j.parkreldis.2018.11.010_bib16","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/mds.20083","article-title":"Clinicopathological investigation of vascular parkinsonism, including clinical criteria for diagnosis","volume":"19","author":"Zijlmans","year":"2004","journal-title":"Mov. Disord."},{"key":"10.1016\/j.parkreldis.2018.11.010_bib17","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1093\/sleep\/26.8.1049","article-title":"Assessment of sleep and sleepiness in Parkinson disease","volume":"26","author":"Marinus","year":"2003","journal-title":"Sleep"},{"key":"10.1016\/j.parkreldis.2018.11.010_bib18","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/014662167700100306","article-title":"The ces-d scale:A self-report depression scale for research in the general population","volume":"1","author":"Radloff","year":"1977","journal-title":"Appl. Psychol. Meas."},{"key":"10.1016\/j.parkreldis.2018.11.010_bib19","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1214\/aos\/1176350951","article-title":"A class of k-sample tests for comparing the cumulative incidence of a competing risk","volume":"16","author":"Gray","year":"1988","journal-title":"Ann. Stat."},{"key":"10.1016\/j.parkreldis.2018.11.010_bib20","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/sj.bmt.1705727","article-title":"Competing risk analysis using r: an easy guide for clinicians","volume":"40","author":"Scrucca","year":"2007","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.parkreldis.2018.11.010_bib21","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nrneurol.2015.61","article-title":"Vascular parkinsonism--characteristics, pathogenesis and treatment","volume":"11","author":"Korczyn","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.parkreldis.2018.11.010_bib22","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/nrneurol.2011.21","article-title":"White matter lesions in Parkinson disease","volume":"7","author":"Bohnen","year":"2011","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.parkreldis.2018.11.010_bib23","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1037\/0894-4105.7.3.273","article-title":"Brain reserve capacity on symptom onset after brain injury: a formulation and review of evidence for threshold theory","volume":"7","author":"Satz","year":"1993","journal-title":"Neuropsychology"},{"key":"10.1016\/j.parkreldis.2018.11.010_bib24","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1017\/S1355617702813248","article-title":"What is cognitive reserve? Theory and research application of the reserve concept","volume":"8","author":"Stern","year":"2002","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10.1016\/j.parkreldis.2018.11.010_bib25","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1212\/WNL.0000000000001502","article-title":"Acute infarcts cause focal thinning in remote cortex via degeneration of connecting fiber tracts","volume":"84","author":"Duering","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2018.11.010_bib26","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1093\/brain\/aww009","article-title":"Longitudinal patterns of leukoaraiosis and brain atrophy in symptomatic small vessel disease","volume":"139","author":"Lambert","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.parkreldis.2018.11.010_bib27","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.parkreldis.2015.01.015","article-title":"Topography of cortical thinning associated with white matter hyperintensities in Parkinson's disease","volume":"21","author":"Ham","year":"2015","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.parkreldis.2018.11.010_bib28","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1212\/01.wnl.0000316799.86917.37","article-title":"Impact of white matter hyperintensity volume progression on rate of cognitive and motor decline","volume":"71","author":"Silbert","year":"2008","journal-title":"Neurology"},{"issue":"Suppl","key":"10.1016\/j.parkreldis.2018.11.010_bib29","first-page":"743","article-title":"White matter atrophy and loss of white matter integrity are associated with gait decline in older adults with cerebral small vessel disease","volume":"1","author":"van der Holst","year":"2016","journal-title":"Europ. Stroke J."},{"key":"10.1016\/j.parkreldis.2018.11.010_bib30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.parkreldis.2017.12.030","article-title":"An updated diagnostic approach to subtype definition of vascular parkinsonism - recommendations from an expert working group","volume":"49","author":"Rektor","year":"2018","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.parkreldis.2018.11.010_bib31","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/mds.26312","article-title":"Gray and white matter imaging: a biomarker for cognitive impairment in early Parkinson's disease?","volume":"31","author":"Duncan","year":"2016","journal-title":"Mov. Disord."}],"container-title":["Parkinsonism & Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802018304917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802018304917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:17:01Z","timestamp":1761178621000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1353802018304917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":31,"alternative-id":["S1353802018304917"],"URL":"https:\/\/doi.org\/10.1016\/j.parkreldis.2018.11.010","relation":{},"ISSN":["1353-8020"],"issn-type":[{"value":"1353-8020","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain atrophy and strategic lesion location increases risk of parkinsonism in cerebral small vessel disease","name":"articletitle","label":"Article Title"},{"value":"Parkinsonism & Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.parkreldis.2018.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}