{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T16:53:07Z","timestamp":1758473587353},"reference-count":14,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","prd-journal.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Parkinsonism &amp; Related Disorders"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.parkreldis.2018.12.013","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T09:43:41Z","timestamp":1544694221000},"page":"1-2","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Is neuromelanin the imaging biomarker for the early diagnosis of Parkinson's disease that we were looking for?"],"prefix":"10.1016","volume":"58","author":[{"given":"Nicola","family":"Pavese","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.parkreldis.2018.12.013_bib1","first-page":"414","article-title":"Substantia nigra neuromelanin: structure, synthesis, and molecular behaviour","volume":"54","author":"Zecca","year":"2001","journal-title":"Mol. Pathol."},{"key":"10.1016\/j.parkreldis.2018.12.013_bib2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/brain\/97.1.489","article-title":"Lipoprotein pigments\u2014their relationship to ageing in the human nervous system. II. The melanin content of pigmented nerve cells","volume":"97","author":"Mann","year":"1974","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.parkreldis.2018.12.013_bib3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1136\/jnnp.54.1.30","article-title":"The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method","volume":"54","author":"Pakkenberg","year":"1991","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"2","key":"10.1016\/j.parkreldis.2018.12.013_bib4","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/mdc3.12590","article-title":"Nigrosome imaging and neuromelanin sensitive MRI in diagnostic evaluation of parkinsonism","volume":"5","author":"Pavese","year":"2018","journal-title":"Mov. Disord. Clin. Pract."},{"issue":"7","key":"10.1016\/j.parkreldis.2018.12.013_bib5","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/mds.26182","article-title":"Substantia nigra neuromelanin-MR imaging differentiates essential tremor from Parkinson's disease","volume":"30","author":"Reim\u00e3o","year":"2015","journal-title":"Mov. Disord."},{"issue":"8","key":"10.1016\/j.parkreldis.2018.12.013_bib6","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1001\/archneur.63.8.1100","article-title":"Common misdiagnosis of a common neurological disorder: how are we misdiagnosing essential tremor?","volume":"63","author":"Jain","year":"2006","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.parkreldis.2018.12.013_bib7","doi-asserted-by":"crossref","DOI":"10.1093\/brain\/awx376","article-title":"Progression of tremor in early stages of Parkinson's disease: a clinical and neuroimaging study","author":"Pasquini","year":"2018","journal-title":"Brain"},{"issue":"3","key":"10.1016\/j.parkreldis.2018.12.013_bib8","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1001\/archneur.60.3.405","article-title":"Rest tremor in patients with essential tremor: prevalence, clinical correlates, and electrophysiologic characteristics","volume":"60","author":"Cohen","year":"2003","journal-title":"Arch. Neurol."},{"issue":"4","key":"10.1016\/j.parkreldis.2018.12.013_bib9","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1136\/jnnp.2008.147223","article-title":"Neurological Disorders in Central Spain Study Group Risk of incident Parkinson's disease and parkinsonism in essential tremor: a population based study","volume":"80","author":"Benito-Le\u00f3n","year":"2009","journal-title":"J. Neurol. Neurosurg. Psychiatr."},{"issue":"3","key":"10.1016\/j.parkreldis.2018.12.013_bib10","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/1531-8257(200005)15:3<503::AID-MDS1013>3.0.CO;2-V","article-title":"Accurate differentiation of parkinsonism and essential tremor using visual assessment of [123 I]-FP-CIT SPECT imaging: the [123 I]-FP-CIT study group","volume":"15","author":"Benamer","year":"2000","journal-title":"Mov. Disord."},{"key":"10.1016\/j.parkreldis.2018.12.013_bib11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1471-2377-7-27","article-title":"Meta-analysis of the literature on diagnostic accuracy of SPECT in parkinsonian syndromes","volume":"7","author":"Vlaar","year":"2007","journal-title":"BMC Neurol."},{"issue":"15","key":"10.1016\/j.parkreldis.2018.12.013_bib12","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1212\/WNL.0000000000002461","article-title":"Age at onset and Parkinson disease phenotype","volume":"86","author":"Pagano","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2018.12.013_bib13","series-title":"Parkinsonism Relat Disord","article-title":"Neuromelanin-sensitive MRI of the substantia nigra: an imaging biomarker to differentiate essential tremor from tremor-dominant Parkinson's disease","author":"Wang","year":"2018"},{"key":"10.1016\/j.parkreldis.2018.12.013_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.parkreldis.2017.06.006","article-title":"Hyperechogenicity of substantia nigra for differential diagnosis of Parkinson's disease: a meta-analysis","volume":"42","author":"Shafieesabet","year":"2017","journal-title":"Park. Relat. Disord."}],"container-title":["Parkinsonism &amp; Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802018305479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802018305479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T07:14:36Z","timestamp":1552288476000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1353802018305479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":14,"alternative-id":["S1353802018305479"],"URL":"https:\/\/doi.org\/10.1016\/j.parkreldis.2018.12.013","relation":{},"ISSN":["1353-8020"],"issn-type":[{"value":"1353-8020","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is neuromelanin the imaging biomarker for the early diagnosis of Parkinson's disease that we were looking for?","name":"articletitle","label":"Article Title"},{"value":"Parkinsonism & Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.parkreldis.2018.12.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}