{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T13:36:17Z","timestamp":1780839377385,"version":"3.54.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T00:00:00Z","timestamp":1611619200000},"content-version":"vor","delay-in-days":147,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006388","name":"Geneva University Hospitals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006388","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swiss Research Foundation","award":["#320030-159459"],"award-info":[{"award-number":["#320030-159459"]}]},{"name":"Switzerland-based Foundation"},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swiss Research Foundation","award":["320030_169876"],"award-info":[{"award-number":["320030_169876"]}]},{"name":"Swiss Research Foundation","award":["320030_185028"],"award-info":[{"award-number":["320030_185028"]}]},{"DOI":"10.13039\/100007214","name":"Velux Foundation","doi-asserted-by":"publisher","award":["1123"],"award-info":[{"award-number":["1123"]}],"id":[{"id":"10.13039\/100007214","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","prd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Parkinsonism & Related Disorders"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.parkreldis.2020.07.008","type":"journal-article","created":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T21:42:30Z","timestamp":1594503750000},"page":"38-43","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Extrastriatal 123I-FP-CIT SPECT impairment in degenerative parkinsonisms"],"prefix":"10.1016","volume":"78","author":[{"given":"Nicolas","family":"Nicastro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Fleury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Broc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre R.","family":"Burkhard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Garibotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.parkreldis.2020.07.008_bib1","doi-asserted-by":"crossref","first-page":"w14621","DOI":"10.4414\/smw.2018.14621","article-title":"The role of molecular imaging in assessing degenerative parkinsonism - an updated review","volume":"148","author":"Nicastro","year":"2018","journal-title":"Swiss Med. Wkly."},{"key":"10.1016\/j.parkreldis.2020.07.008_bib2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.parkreldis.2016.07.002","article-title":"Scan without evidence of dopaminergic deficit: a 10-year retrospective study","volume":"31","author":"Nicastro","year":"2016","journal-title":"Park. Relat. Disord."},{"issue":"10","key":"10.1016\/j.parkreldis.2020.07.008_bib3","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1007\/s00259-014-2785-8","article-title":"Extrastriatal binding of [(1)(2)(3)I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls","volume":"41","author":"Koch","year":"2014","journal-title":"Eur. J. Nucl. Med. Mol. Imag."},{"issue":"4","key":"10.1016\/j.parkreldis.2020.07.008_bib4","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jchemneu.2003.10.002","article-title":"The human raphe nuclei and the serotonergic system","volume":"26","author":"Hornung","year":"2003","journal-title":"J. Chem. Neuroanat."},{"issue":"9","key":"10.1016\/j.parkreldis.2020.07.008_bib5","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1001\/archneur.60.9.1223","article-title":"Positron emission tomography of striatal serotonin transporters in Parkinson disease","volume":"60","author":"Kerenyi","year":"2003","journal-title":"Arch. Neurol."},{"issue":"4","key":"10.1016\/j.parkreldis.2020.07.008_bib6","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1016\/j.neurobiolaging.2015.01.016","article-title":"Effects of aging and gender on striatal and extrastriatal [123I]FP-CIT binding in Parkinson's disease","volume":"36","author":"Kaasinen","year":"2015","journal-title":"Neurobiol. Aging"},{"issue":"11","key":"10.1016\/j.parkreldis.2020.07.008_bib7","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1007\/s00259-012-2207-8","article-title":"Voxel-based analysis of whole-brain effects of age and gender on dopamine transporter SPECT imaging in healthy subjects","volume":"39","author":"Eusebio","year":"2012","journal-title":"Eur. J. Nucl. Med. Mol. Imag."},{"issue":"5","key":"10.1016\/j.parkreldis.2020.07.008_bib8","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1007\/s11307-017-1052-3","article-title":"Source-based morphometry multivariate approach to analyze [(123)I]FP-CIT SPECT imaging","volume":"19","author":"Premi","year":"2017","journal-title":"Mol. Imag. Biol."},{"issue":"1","key":"10.1016\/j.parkreldis.2020.07.008_bib9","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s12883-020-01777-2","article-title":"Extrastriatal (123)I-FP-CIT SPECT impairment in Parkinson's disease - the PPMI cohort","volume":"20","author":"Nicastro","year":"2020","journal-title":"BMC Neurol."},{"issue":"5","key":"10.1016\/j.parkreldis.2020.07.008_bib10","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1468-1331.2007.01727.x","article-title":"Brain serotonin transporter binding in non-depressed patients with Parkinson's disease","volume":"14","author":"Guttman","year":"2007","journal-title":"Eur. J. Neurol. : Off. J. Eur. Fed. Neurol. Soc."},{"issue":"7","key":"10.1016\/j.parkreldis.2020.07.008_bib11","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.2967\/jnumed.116.182139","article-title":"Analysis of extrastriatal (123)I-FP-CIT binding contributes to the differential diagnosis of parkinsonian diseases","volume":"58","author":"Joling","year":"2017","journal-title":"J. Nucl. Med. : Off. Publ. Soc. Nucl. Med."},{"issue":"8","key":"10.1016\/j.parkreldis.2020.07.008_bib12","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1007\/s00259-019-04324-5","article-title":"Extrastriatal dopaminergic and serotonergic pathways in Parkinson's disease and in dementia with Lewy bodies: a (123)I-FP-CIT SPECT study","volume":"46","author":"Pilotto","year":"2019","journal-title":"Eur. J. Nucl. Med. Mol. Imag."},{"issue":"12","key":"10.1016\/j.parkreldis.2020.07.008_bib13","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson's disease, Movement disorders","volume":"30","author":"Postuma","year":"2015","journal-title":"Off. J. Mov. Disord. Soc."},{"issue":"9","key":"10.1016\/j.parkreldis.2020.07.008_bib14","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1212\/01.wnl.0000324625.00404.15","article-title":"Second consensus statement on the diagnosis of multiple system atrophy","volume":"71","author":"Gilman","year":"2008","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.parkreldis.2020.07.008_bib15","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/mds.26987","article-title":"Movement Disorder Society-endorsed, Clinical diagnosis of progressive supranuclear palsy: the movement disorder society criteria, Movement disorders","volume":"32","author":"Hoglinger","year":"2017","journal-title":"Off. J. Mov. Disord. Soc."},{"issue":"5","key":"10.1016\/j.parkreldis.2020.07.008_bib16","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1212\/WNL.0b013e31827f0fd1","article-title":"Criteria for the diagnosis of corticobasal degeneration","volume":"80","author":"Armstrong","year":"2013","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.parkreldis.2020.07.008_bib17","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1212\/WNL.0000000000004058","article-title":"Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB Consortium","volume":"89","author":"McKeith","year":"2017","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.parkreldis.2020.07.008_bib18","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s11307-015-0889-6","article-title":"Establishing on-site reference values for (123)I-FP-CIT SPECT (DaTSCAN(R)) using a cohort of individuals with non-degenerative conditions","volume":"18","author":"Nicastro","year":"2016","journal-title":"Mol. Imag. Biol."},{"key":"10.1016\/j.parkreldis.2020.07.008_bib19","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.neuroimage.2016.12.077","article-title":"PETPVE12: an SPM toolbox for Partial Volume Effects correction in brain PET - application to amyloid imaging with AV45-PET","volume":"147","author":"Gonzalez-Escamilla","year":"2017","journal-title":"Neuroimage"},{"key":"10.1016\/j.parkreldis.2020.07.008_bib20","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.nicl.2018.04.009","article-title":"Lower (123)I-FP-CIT binding to the striatal dopamine transporter, but not to the extrastriatal serotonin transporter, in Parkinson's disease compared with dementia with Lewy bodies","volume":"19","author":"Joling","year":"2018","journal-title":"Neuroimage Clin."},{"issue":"4","key":"10.1016\/j.parkreldis.2020.07.008_bib21","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/hbm.10123","article-title":"Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe","volume":"19","author":"Hammers","year":"2003","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.parkreldis.2020.07.008_bib22","doi-asserted-by":"crossref","first-page":"101755","DOI":"10.1016\/j.nicl.2019.101755","article-title":"Striatal DAT and extrastriatal SERT binding in early-stage Parkinson's disease and dementia with Lewy bodies, compared with healthy controls: an (123)I-FP-CIT SPECT study","volume":"22","author":"Joling","year":"2019","journal-title":"Neuroimage Clin."},{"key":"10.1016\/j.parkreldis.2020.07.008_bib23","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.parkreldis.2018.02.039","article-title":"Pallidal dopaminergic denervation and rest tremor in early Parkinson's disease: PPMI cohort analysis","volume":"51","author":"Lee","year":"2018","journal-title":"Park. Relat. Disord."},{"issue":"1","key":"10.1016\/j.parkreldis.2020.07.008_bib24","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.nbd.2010.05.028","article-title":"Staging of serotonergic dysfunction in Parkinson's disease: an in vivo 11C-DASB PET study","volume":"40","author":"Politis","year":"2010","journal-title":"Neurobiol. Dis."},{"issue":"Pt 9","key":"10.1016\/j.parkreldis.2020.07.008_bib25","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1093\/brain\/aww162","article-title":"The prominent role of serotonergic degeneration in apathy, anxiety and depression in de novo Parkinson's disease","volume":"139","author":"Maillet","year":"2016","journal-title":"Brain"},{"issue":"Pt 4","key":"10.1016\/j.parkreldis.2020.07.008_bib26","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1093\/brain\/119.4.1137","article-title":"The nucleus raphe interpositus in the Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy)","volume":"119","author":"Revesz","year":"1996","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.parkreldis.2020.07.008_bib27","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.nbd.2011.12.053","article-title":"Brain monoamine systems in multiple system atrophy: a positron emission tomography study","volume":"46","author":"Lewis","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.parkreldis.2020.07.008_bib28","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1093\/brain\/awh485","article-title":"Voxel-wise analysis of [123I]beta-CIT SPECT differentiates the Parkinson variant of multiple system atrophy from idiopathic Parkinson's disease","volume":"128","author":"Scherfler","year":"2005","journal-title":"Brain: J. Neurol."},{"key":"10.1016\/j.parkreldis.2020.07.008_bib29","doi-asserted-by":"crossref","first-page":"345132","DOI":"10.1155\/2014\/345132","article-title":"Serotonin transporter availability in early stage Parkinson's disease and multiple system atrophy","volume":"2014","author":"Suwijn","year":"2014","journal-title":"ISRN Neurol"},{"key":"10.1016\/j.parkreldis.2020.07.008_bib30","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2967\/jnumed.111.095224","article-title":"Subregional patterns of preferential striatal dopamine transporter loss differ in Parkinson disease, progressive supranuclear palsy, and multiple-system atrophy","volume":"53","author":"Oh","year":"2012","journal-title":"J. Nucl. Med.: Off. Publ. Soc. Nucl. Med."},{"key":"10.1016\/j.parkreldis.2020.07.008_bib31","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jns.2017.11.039","article-title":"Scan without evidence of dopaminergic deficit (SWEDD) in degenerative parkinsonism and dementia with Lewy bodies: a prospective study","volume":"385","author":"Nicastro","year":"2018","journal-title":"J. Neurol. Sci."},{"issue":"Pt 7","key":"10.1016\/j.parkreldis.2020.07.008_bib32","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1093\/brain\/awq120","article-title":"Cholinergic imaging in corticobasal syndrome, progressive supranuclear palsy and frontotemporal dementia","volume":"133","author":"Hirano","year":"2010","journal-title":"Brain"},{"issue":"Pt 7","key":"10.1016\/j.parkreldis.2020.07.008_bib33","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1093\/brain\/awq123","article-title":"Does corticobasal degeneration exist? A clinicopathological re-evaluation","volume":"133","author":"Ling","year":"2010","journal-title":"Brain"},{"issue":"7","key":"10.1016\/j.parkreldis.2020.07.008_bib34","first-page":"1129","article-title":"SPECT imaging of dopamine transporters in human brain with iodine-123-fluoroalkyl analogs of beta-CIT","volume":"37","author":"Abi-Dargham","year":"1996","journal-title":"J. Nucl. Med. : Off. Publ. Soc. Nucl. Med."}],"container-title":["Parkinsonism & Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802020306453?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802020306453?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:19:01Z","timestamp":1761178741000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1353802020306453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":34,"alternative-id":["S1353802020306453"],"URL":"https:\/\/doi.org\/10.1016\/j.parkreldis.2020.07.008","relation":{},"ISSN":["1353-8020"],"issn-type":[{"value":"1353-8020","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extrastriatal 123I-FP-CIT SPECT impairment in degenerative parkinsonisms","name":"articletitle","label":"Article Title"},{"value":"Parkinsonism & Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.parkreldis.2020.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}