{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:09:47Z","timestamp":1792595387666,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T00:00:00Z","timestamp":1597449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008444","name":"Parkinsonfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008444","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","prd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Parkinsonism & Related Disorders"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.parkreldis.2020.08.004","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T02:37:13Z","timestamp":1597286233000},"page":"18-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Automated brainstem volumetry can aid in the diagnostics of parkinsonian disorders"],"prefix":"10.1016","volume":"79","author":[{"given":"Henrik","family":"Sj\u00f6str\u00f6m","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Granberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farouk","family":"Hashim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Westman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Svenningsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.parkreldis.2020.08.004_bib1","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson's disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.parkreldis.2020.08.004_bib2","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S1474-4422(09)70042-0","article-title":"Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges","volume":"8","author":"Williams","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.parkreldis.2020.08.004_bib3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1474-4422(03)00662-8","article-title":"Multiple system atrophy","volume":"3","author":"Wenning","year":"2004","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.parkreldis.2020.08.004_bib4","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1148\/rg.345140009","article-title":"Structural and functional imaging in parkinsonian syndromes","volume":"34","author":"Broski","year":"2014","journal-title":"Radiographics"},{"key":"10.1016\/j.parkreldis.2020.08.004_bib5","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s00702-017-1717-8","article-title":"Magnetic resonance imaging for the diagnosis of Parkinson's disease","volume":"124","author":"Heim","year":"2017","journal-title":"J. Neural. Transm."},{"key":"10.1016\/j.parkreldis.2020.08.004_bib6","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.parkreldis.2017.08.029","article-title":"Quantitative susceptibility mapping differentiates between parkinsonian disorders","volume":"44","author":"Sj\u00f6str\u00f6m","year":"2017","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.parkreldis.2020.08.004_bib7","doi-asserted-by":"crossref","first-page":"6079","DOI":"10.1038\/s41598-019-42565-4","article-title":"Mapping of apparent susceptibility yields promising diagnostic separation of progressive supranuclear palsy from other causes of parkinsonism","volume":"9","author":"Sj\u00f6str\u00f6m","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.parkreldis.2020.08.004_bib8","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.clinimag.2017.04.005","article-title":"Can loss of the swallow tail sign help distinguish between Parkinson Disease and the Parkinson-Plus syndromes?","volume":"44","author":"Oustwani","year":"2017","journal-title":"Clin. Imag."},{"key":"10.1016\/j.parkreldis.2020.08.004_bib9","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/mds.26932","article-title":"Meta-analysis of dorsolateral nigral hyperintensity on magnetic resonance imaging as a marker for Parkinson's disease","volume":"32","author":"Mahlknecht","year":"2017","journal-title":"Mov. Disord."},{"key":"10.1016\/j.parkreldis.2020.08.004_bib10","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1097\/01.wnr.0000227984.84927.a7","article-title":"Neuromelanin magnetic resonance imaging of locus ceruleus and substantia nigra in Parkinson's disease","volume":"17","author":"Sasaki","year":"2006","journal-title":"Neuroreport"},{"key":"10.1016\/j.parkreldis.2020.08.004_bib11","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1080\/00207454.2017.1325883","article-title":"Neuromelanin in parkinsonian disorders: an update","volume":"127","author":"Martin-Bastida","year":"2017","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.parkreldis.2020.08.004_bib12","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1212\/01.WNL.0000165960.04422.D0","article-title":"New and reliable MRI diagnosis for progressive supranuclear palsy","volume":"64","author":"Oba","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2020.08.004_bib13","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1148\/radiol.2453061703","article-title":"MR imaging index for differentiation of progressive supranuclear palsy from Parkinson disease and the Parkinson variant of multiple system atrophy","volume":"246","author":"Quattrone","year":"2008","journal-title":"Radiology"},{"key":"10.1016\/j.parkreldis.2020.08.004_bib14","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/mds.23529","article-title":"Accuracy of magnetic resonance parkinsonism index for differentiation of progressive supranuclear palsy from probable or possible Parkinson disease","volume":"26","author":"Morelli","year":"2011","journal-title":"Mov. Disord."},{"key":"10.1016\/j.parkreldis.2020.08.004_bib15","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/mds.27038","article-title":"Movement Disorder Society-endorsed PSP Study Group, Radiological biomarkers for diagnosis in PSP: where are we and where do we need to be?","volume":"32","author":"Whitwell","year":"2017","journal-title":"Mov. Disord."},{"key":"10.1016\/j.parkreldis.2020.08.004_bib16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/bs.irn.2018.08.010","article-title":"Structural imaging in atypical parkinsonism","volume":"142","author":"Heim","year":"2018","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.parkreldis.2020.08.004_bib17","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3988\/jcn.2015.11.3.268","article-title":"Utility of the midbrain tegmentum diameter in the differential diagnosis of progressive supranuclear palsy from idiopathic Parkinson's disease","volume":"11","author":"Kim","year":"2015","journal-title":"J. Clin. Neurol."},{"key":"10.1016\/j.parkreldis.2020.08.004_bib18","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.parkreldis.2019.08.007","article-title":"Diagnostic validity of magnetic resonance parkinsonism index in differentiating patients with progressive supranuclear palsy from patients with Parkinson's disease","volume":"66","author":"Zhang","year":"2019","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.parkreldis.2020.08.004_bib19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.parkreldis.2018.07.016","article-title":"A new MR imaging index for differentiation of progressive supranuclear palsy-parkinsonism from Parkinson's disease","volume":"54","author":"Quattrone","year":"2018","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.parkreldis.2020.08.004_bib20","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1007\/s00330-016-4622-x","article-title":"Magnetic Resonance Parkinsonism Index: diagnostic accuracy of a fully automated algorithm in comparison with the manual measurement in a large Italian multicentre study in patients with progressive supranuclear palsy","volume":"27","author":"Nigro","year":"2017","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.parkreldis.2020.08.004_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1212\/WNL.47.1.1","article-title":"Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop","volume":"47","author":"Litvan","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2020.08.004_bib22","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1212\/01.wnl.0000324625.00404.15","article-title":"Second consensus statement on the diagnosis of multiple system atrophy","volume":"71","author":"Gilman","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2020.08.004_bib23","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0896-6273(02)00569-X","article-title":"Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain","volume":"33","author":"Fischl","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.parkreldis.2020.08.004_bib24","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuroimage.2012.01.021","volume":"62","author":"Fischl","year":"2012","journal-title":"FreeSurfer, Neuroimage."},{"key":"10.1016\/j.parkreldis.2020.08.004_bib25","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.neuroimage.2015.02.065","article-title":"Alzheimer's disease neuroimaging initiative, bayesian segmentation of brainstem structures in MRI","volume":"113","author":"Iglesias","year":"2015","journal-title":"Neuroimage"},{"key":"10.1016\/j.parkreldis.2020.08.004_bib26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3389\/fninf.2013.00049","article-title":"TheHiveDB image data management and analysis framework","volume":"7","author":"Muehlboeck","year":"2014","journal-title":"Front. Neuroinf."},{"key":"10.1016\/j.parkreldis.2020.08.004_bib27","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3389\/fnagi.2014.00264","article-title":"Alzheimer's Disease Neuroimaging Initiative, the effects of intracranial volume adjustment approaches on multiple regional MRI volumes in healthy aging and Alzheimer's disease","volume":"6","author":"Voevodskaya","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.parkreldis.2020.08.004_bib28","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.3155\/1047-3289.59.9.1032","article-title":"Estimating precision using duplicate measurements","volume":"59","author":"Hyslop","year":"2009","journal-title":"J. Air Waste Manag. Assoc."},{"key":"10.1016\/j.parkreldis.2020.08.004_bib29","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery rate - a practical and powerful approach","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B-Methodol."},{"key":"10.1016\/j.parkreldis.2020.08.004_bib30","doi-asserted-by":"crossref","unstructured":"N. Pyatigorskaya, L. Yahia\u2010Cherif, R. Gaurav, C. Ewenczyk, C. Gallea, R. Valabregue, F. Gargouri, B. Magnin, B. Degos, E. Roze, E. Bardinet, C. Poupon, I. Arnulf, M. Vidailhet, S. Lehericy, Multimodal Magnetic Resonance Imaging Quantification of Brain Changes in Progressive Supranuclear Palsy, Mov. Disord.. n\/a (n.d.). https:\/\/doi.org\/10.1002\/mds.27877.","DOI":"10.1002\/mds.27877"},{"key":"10.1016\/j.parkreldis.2020.08.004_bib31","article-title":"Automated brainstem segmentation detects differential involvement in atypical parkinsonian syndromes","author":"Bocchetta","year":"2019","journal-title":"J Mov Disord"},{"key":"10.1016\/j.parkreldis.2020.08.004_bib32","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1212\/WNL.0000000000002518","article-title":"Diagnostic potential of automated subcortical volume segmentation in atypical parkinsonism","volume":"86","author":"Scherfler","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2020.08.004_bib33","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/mds.27877","article-title":"Multimodal magnetic resonance imaging quantification of brain changes in progressive supranuclear palsy","volume":"35","author":"Pyatigorskaya","year":"2020","journal-title":"Mov. Disord."},{"key":"10.1016\/j.parkreldis.2020.08.004_bib34","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/WCO.0b013e32833be924","article-title":"Neuropathology of variants of progressive supranuclear palsy","volume":"23","author":"Dickson","year":"2010","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.parkreldis.2020.08.004_bib35","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.parkreldis.2017.10.020","article-title":"MR planimetry in neurodegenerative parkinsonism yields high diagnostic accuracy for PSP","volume":"46","author":"Mangesius","year":"2018","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.parkreldis.2020.08.004_bib36","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/mds.26921","article-title":"Manual MRI morphometry in Parkinsonian syndromes","volume":"32","author":"M\u00f6ller","year":"2017","journal-title":"Mov. Disord."},{"key":"10.1016\/j.parkreldis.2020.08.004_bib37","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1002\/mds.28007","article-title":"Automated MRI classification in progressive supranuclear palsy: a large international cohort study","volume":"35","author":"Nigro","year":"2020","journal-title":"Mov. Disord."},{"key":"10.1016\/j.parkreldis.2020.08.004_bib38","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/mds.26987","article-title":"Movement Disorder Society-endorsed PSP Study Group, Clinical diagnosis of progressive supranuclear palsy: the movement disorder society criteria, Mov","volume":"32","author":"H\u00f6glinger","year":"2017","journal-title":"Disord"},{"key":"10.1016\/j.parkreldis.2020.08.004_bib39","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.neuroimage.2012.02.084","article-title":"Within-subject template estimation for unbiased longitudinal image analysis","volume":"61","author":"Reuter","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.parkreldis.2020.08.004_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0165719","article-title":"Robustness of automated methods for brain volume measurements across different MRI field strengths","volume":"11","author":"Heinen","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.parkreldis.2020.08.004_bib41","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1007\/s00330-018-5710-x","article-title":"Repeatability and reproducibility of FreeSurfer, FSL-SIENAX and SPM brain volumetric measurements and the effect of lesion filling in multiple sclerosis","volume":"29","author":"Guo","year":"2019","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.parkreldis.2020.08.004_bib42","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1002\/mds.26823","article-title":"1.5 versus 3 tesla magnetic resonance planimetry in neurodegenerative parkinsonism","volume":"31","author":"Mangesius","year":"2016","journal-title":"Mov. Disord."}],"container-title":["Parkinsonism & Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802020306702?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802020306702?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T08:48:28Z","timestamp":1774860508000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1353802020306702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":42,"alternative-id":["S1353802020306702"],"URL":"https:\/\/doi.org\/10.1016\/j.parkreldis.2020.08.004","relation":{},"ISSN":["1353-8020"],"issn-type":[{"value":"1353-8020","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Automated brainstem volumetry can aid in the diagnostics of parkinsonian disorders","name":"articletitle","label":"Article Title"},{"value":"Parkinsonism & Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.parkreldis.2020.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}