{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:01:39Z","timestamp":1791450099266,"version":"4.3.3"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:00:00Z","timestamp":1695513600000},"content-version":"am","delay-in-days":327,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["81XWH18-1-0666"],"award-info":[{"award-number":["81XWH18-1-0666"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006751","name":"U.S. Army","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013301","name":"Parkinson's Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013301","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014479","name":"Georgia Department of Public Health","doi-asserted-by":"publisher","award":["81XWH18-1-0665"],"award-info":[{"award-number":["81XWH18-1-0665"]}],"id":[{"id":"10.13039\/100014479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014479","name":"Georgia Department of Public Health","doi-asserted-by":"publisher","award":["81XWH19-1-0443"],"award-info":[{"award-number":["81XWH19-1-0443"]}],"id":[{"id":"10.13039\/100014479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016156","name":"US Army Medical Research and Development Command","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","prd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Parkinsonism & Related Disorders"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.parkreldis.2022.09.005","type":"journal-article","created":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T01:21:36Z","timestamp":1663982496000},"page":"7-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Physical activity intensity is associated with cognition and functional connectivity in Parkinson's disease"],"prefix":"10.1016","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2342-5015","authenticated-orcid":false,"given":"Erin K.","family":"Donahue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8112-0578","authenticated-orcid":false,"given":"Siva","family":"Venkadesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0620-7312","authenticated-orcid":false,"given":"Vy","family":"Bui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelie Cabrera","family":"Tuazon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9681-4695","authenticated-orcid":false,"given":"Ryan K.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8989-2903","authenticated-orcid":false,"given":"Danielle","family":"Haase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan P.","family":"Foreman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1568-8402","authenticated-orcid":false,"given":"Jared J.","family":"Duran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Petkus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1883-9448","authenticated-orcid":false,"given":"David","family":"Wing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9639-3352","authenticated-orcid":false,"given":"Michael","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4297-8280","authenticated-orcid":false,"given":"Daniel P.","family":"Holschneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6875-4242","authenticated-orcid":false,"given":"Ece","family":"Bayram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Litvan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4523-2329","authenticated-orcid":false,"given":"Michael W.","family":"Jakowec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Darrell","family":"Van Horn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5787-6650","authenticated-orcid":false,"given":"Dawn M.","family":"Schiehser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giselle M.","family":"Petzinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.parkreldis.2022.09.005_bib1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nrneurol.2017.27","article-title":"Cognitive decline in Parkinson disease","volume":"13","author":"Aarsland","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.parkreldis.2022.09.005_bib2","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.parkreldis.2014.07.004","article-title":"Severity of mild cognitive impairment in early Parkinson's disease contributes to poorer quality of life","volume":"20","author":"Lawson","year":"2014","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.parkreldis.2022.09.005_bib3","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.nicl.2017.03.002","article-title":"Functional connectivity disruptions correlate with cognitive phenotypes in Parkinson's disease","volume":"14","author":"Hassan","year":"2017","journal-title":"NeuroImage Clin"},{"key":"10.1016\/j.parkreldis.2022.09.005_bib4","first-page":"51","article-title":"Physical exercise and cognitive performance in the elderly: current perspectives","volume":"9","author":"Kirk-Sanchez","year":"2014","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.parkreldis.2022.09.005_bib5","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s11556-019-0217-2","article-title":"Functional and\/or structural brain changes in response to resistance exercises and resistance training lead to cognitive improvements - a systematic review","volume":"16","author":"Herold","year":"2019","journal-title":"Eur. Rev. Aging Phys. Act. Off. J. Eur. Group Res. Elder. Phys. Act."},{"key":"10.1016\/j.parkreldis.2022.09.005_bib6","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1123\/jpah.2021-0012","article-title":"The relations between physical activity level, executive function, and white matter microstructure in older adults","volume":"18","author":"Gogniat","year":"2021","journal-title":"J. Phys. Activ. Health"},{"key":"10.1016\/j.parkreldis.2022.09.005_bib7","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.neuroimage.2010.07.070","article-title":"Interactive effects of physical activity and APOE-\u03b54 on BOLD semantic memory activation in healthy elders","volume":"54","author":"Smith","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.parkreldis.2022.09.005_bib8","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3389\/fpubh.2018.00288","article-title":"Physical activity, inactivity, and sedentary behaviors: definitions and implications in occupational health","volume":"6","author":"Thivel","year":"2018","journal-title":"Front. Public Health"},{"key":"10.1016\/j.parkreldis.2022.09.005_bib9","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.jagp.2019.04.011","article-title":"Changes in moderate intensity physical activity are associated with better cognition in the multilevel intervention for physical activity in retirement communities (MIPARC) study","volume":"27","author":"Zlatar","year":"2019","journal-title":"Am. J. Geriatr. Psychiatr."},{"key":"10.1016\/j.parkreldis.2022.09.005_bib10","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1093\/gerona\/glu136","article-title":"Moderate-intensity physical activity, hippocampal volume, and memory in older adults with mild cognitive impairment","volume":"70","author":"Makizako","year":"2015","journal-title":"J. Gerontol. Ser. A."},{"key":"10.1016\/j.parkreldis.2022.09.005_bib11","series-title":"WHO Guidelines on Physical Activity and Sedentary Behaviour","author":"World Health Organization","year":"2020"},{"key":"10.1016\/j.parkreldis.2022.09.005_bib12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.dhjo.2017.05.004","article-title":"A pilot study evaluating the association between physical activity and cognition among individuals with Parkinson's disease","volume":"11","author":"Loprinzi","year":"2018","journal-title":"Disabil. Health J."},{"key":"10.1016\/j.parkreldis.2022.09.005_bib13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","article-title":"Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases","volume":"55","author":"Hughes","year":"1992","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.parkreldis.2022.09.005_bib15","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1249\/MSS.0b013e3182399dcc","article-title":"Modeling physical activity outcomes from wearable monitors","volume":"44","author":"Heil","year":"2012","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.parkreldis.2022.09.005_bib16","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1249\/MSS.0b013e3182399e5b","article-title":"Best practices for using physical activity monitors in population-based research","volume":"44","author":"Matthews","year":"2012","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.parkreldis.2022.09.005_bib17","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1249\/MSS.0b013e3181ed61a3","article-title":"Validation of accelerometer wear and nonwear time classification algorithm","volume":"43","author":"Choi","year":"2011","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.parkreldis.2022.09.005_bib18","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1249\/MSS.0b013e3182399b7e","article-title":"Assessment of physical activity using wearable monitors: recommendations for monitor calibration and use in the field","volume":"44","author":"Freedson","year":"2012","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.parkreldis.2022.09.005_bib19","year":"2022","journal-title":"Move More; Sit Less, Cent. Dis. Control Prev."},{"key":"10.1016\/j.parkreldis.2022.09.005_bib20","first-page":"825","article-title":"Intensity, but not duration, of physical activities is related to cognitive function","volume":"14","author":"Angevaren","year":"2007","journal-title":"Eur. J. Cardiovasc. Prev. Rehabil. Off. J. Eur. Soc. Cardiol. Work. Groups Epidemiol. Prev. Card. Rehabil. Exerc. Physiol."},{"key":"10.1016\/j.parkreldis.2022.09.005_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroimage.2010.06.010","article-title":"Automatic parcellation of human cortical gyri and sulci using standard anatomical nomenclature","volume":"53","author":"Destrieux","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.parkreldis.2022.09.005_bib22","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0896-6273(02)00569-X","article-title":"Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain","volume":"33","author":"Fischl","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.parkreldis.2022.09.005_bib23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fnhum.2014.00051","article-title":"Systematic network lesioning reveals the core white matter scaffold of the human brain","volume":"8","author":"Irimia","year":"2014","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.parkreldis.2022.09.005_bib24","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.neuroimage.2012.01.107","article-title":"Circular representation of human cortical networks for subject and population-level connectomic visualization","volume":"60","author":"Irimia","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.parkreldis.2022.09.005_bib25","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.3389\/fninf.2014.00014","article-title":"Machine learning for neuroimaging with scikit-learn","volume":"8","author":"Abraham","year":"2014","journal-title":"Front. Neuroinf."},{"key":"10.1016\/j.parkreldis.2022.09.005_bib26","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1109\/TAU.1967.1161901","article-title":"The use of fast Fourier transform for the estimation of power spectra: a method based on time averaging over short, modified periodograms","volume":"15","author":"Welch","year":"1967","journal-title":"IEEE Trans. Audio Electroacoust."},{"key":"10.1016\/j.parkreldis.2022.09.005_bib27","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1152\/jn.00804.2013","article-title":"Lag structure in resting-state fMRI","volume":"111","author":"Mitra","year":"2014","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.parkreldis.2022.09.005_bib28","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/hbm.23260","article-title":"Parkinson's disease-related network topographies characterized with resting state functional MRI","volume":"38","author":"Vo","year":"2017","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.parkreldis.2022.09.005_bib29","first-page":"9","article-title":"Tests of moderation effects: difference in simple slopes versus the interaction","volume":"39","author":"Robinson","year":"2013","journal-title":"Term"},{"key":"10.1016\/j.parkreldis.2022.09.005_bib30","series-title":"Statsmodels: Econometric and Statistical Modeling with Python","first-page":"92","author":"Seabold","year":"2010"},{"key":"10.1016\/j.parkreldis.2022.09.005_bib31","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2018.2421","article-title":"Association of levels of physical activity with risk of Parkinson disease: a systematic review and meta-analysis","volume":"1","author":"Fang","year":"2018","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.parkreldis.2022.09.005_bib32","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1249\/MSS.0000000000001936","article-title":"FOR 2018 physical activity guidelines advisory committee*, physical activity, cognition, and brain outcomes: a review of the 2018 physical activity guidelines","volume":"51","author":"Erickson","year":"2019","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.parkreldis.2022.09.005_bib33","article-title":"Accelerometer assessed moderate-to-vigorous physical activity and successful ageing: results from the Whitehall II study","volume":"8","author":"Menai","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.parkreldis.2022.09.005_bib34","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1212\/WNL.0000000000000644","article-title":"Phase I\/II randomized trial of aerobic exercise in Parkinson disease in a community setting","volume":"83","author":"Uc","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.parkreldis.2022.09.005_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.682233","article-title":"What is moderate to vigorous exercise intensity?","volume":"12","author":"MacIntosh","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.parkreldis.2022.09.005_bib36","doi-asserted-by":"crossref","first-page":"6223","DOI":"10.3390\/ijms23116223","article-title":"Physical activity rewires the human brain against neurodegeneration","volume":"23","author":"Santiago","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.parkreldis.2022.09.005_bib37","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.nbd.2013.11.017","article-title":"Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease","volume":"63","author":"Toy","year":"2014","journal-title":"Neurobiol. Dis."}],"container-title":["Parkinsonism & Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802022002954?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1353802022002954?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:25:44Z","timestamp":1761179144000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1353802022002954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":36,"alternative-id":["S1353802022002954"],"URL":"https:\/\/doi.org\/10.1016\/j.parkreldis.2022.09.005","relation":{},"ISSN":["1353-8020"],"issn-type":[{"value":"1353-8020","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Physical activity intensity is associated with cognition and functional connectivity in Parkinson's disease","name":"articletitle","label":"Article Title"},{"value":"Parkinsonism & Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.parkreldis.2022.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}