{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:53:59Z","timestamp":1790103239374,"version":"4.0.1"},"reference-count":69,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathologie Biologie"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.patbio.2008.02.016","type":"journal-article","created":{"date-parts":[[2008,5,6]],"date-time":"2008-05-06T18:30:52Z","timestamp":1210098652000},"page":"127-132","source":"Crossref","is-referenced-by-count":22,"title":["The biology of chikungunya: A brief review of what we still do not know"],"prefix":"10.1016","volume":"57","author":[{"given":"N.","family":"Pardigon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.patbio.2008.02.016_bib1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/0035-9203(55)90080-8","article-title":"An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952\u201353. I. Clinical features","volume":"49","author":"Robinson","year":"1955","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"7619","key":"10.1016\/j.patbio.2008.02.016_bib2","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1136\/bmj.39332.708738.DB","article-title":"Europe witnesses first local transmission of chikungunya fever in Italy","volume":"335","author":"Watson","year":"2007","journal-title":"BMJ"},{"issue":"2","key":"10.1016\/j.patbio.2008.02.016_bib3","doi-asserted-by":"crossref","first-page":"281","DOI":"10.4269\/ajtmh.1999.60.281","article-title":"Vectors of Chikungunya virus in Senegal: current data and transmission cycles","volume":"60","author":"Diallo","year":"1999","journal-title":"Am J Trop Med Hyg"},{"issue":"1","key":"10.1016\/j.patbio.2008.02.016_bib4","first-page":"35","article-title":"What is the potential for future outbreaks of chikungunya, dengue and yellow fever in southern Africa?","volume":"86","author":"Jupp","year":"1996","journal-title":"S Afr Med J"},{"key":"10.1016\/j.patbio.2008.02.016_bib5","first-page":"137","article-title":"Chikungunya virus disease","volume":"2","author":"Jupp","year":"1988"},{"issue":"8","key":"10.1016\/j.patbio.2008.02.016_bib6","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S1473-3099(06)70531-X","article-title":"Aedes albopictus as an epidemic vector of chikungunya virus: another emerging problem?","volume":"6","author":"Reiter","year":"2006","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.patbio.2008.02.016_bib7","series-title":"Virus taxonomy: Eighth report of the international committee on taxonomy of viruses","first-page":"999","article-title":"Togaviridae","author":"Weaver","year":"2005"},{"issue":"6","key":"10.1016\/j.patbio.2008.02.016_bib8","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1371\/journal.ppat.0030089","article-title":"Characterization of reemerging chikungunya virus","volume":"3","author":"Sourisseau","year":"2007","journal-title":"PLoS Pathog"},{"issue":"Pt 12","key":"10.1016\/j.patbio.2008.02.016_bib9","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1099\/0022-1317-83-12-3075","article-title":"Complete nucleotide sequence of chikungunya virus and evidence for an internal polyadenylation site","volume":"83","author":"Khan","year":"2002","journal-title":"J Gen Virol"},{"issue":"7","key":"10.1016\/j.patbio.2008.02.016_bib10","doi-asserted-by":"crossref","first-page":"e263","DOI":"10.1371\/journal.pmed.0030263","article-title":"Genome microevolution of chikungunya viruses causing the Indian Ocean outbreak","volume":"3","author":"Schuffenecker","year":"2006","journal-title":"PLoS Med"},{"key":"10.1016\/j.patbio.2008.02.016_bib11","series-title":"The Togaviridae and Flaviridae","first-page":"35","article-title":"Structure and replication of the alphavirus genome","author":"Strauss","year":"1986"},{"issue":"10","key":"10.1016\/j.patbio.2008.02.016_bib12","doi-asserted-by":"crossref","first-page":"4992","DOI":"10.1128\/JVI.80.10.4992-4997.2006","article-title":"Effects of an opal termination codon preceding the nsP4 gene sequence in the O\u2019Nyong-Nyong virus genome on Anopheles gambiae infectivity","volume":"80","author":"Myles","year":"2006","journal-title":"J Virol"},{"issue":"2","key":"10.1016\/j.patbio.2008.02.016_bib13","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1006\/viro.1996.0445","article-title":"Complete nucleotide sequence and full-length cDNA clone of S.A. AR86 a South African alphavirus related to Sindbis","volume":"222","author":"Simpson","year":"1996","journal-title":"Virology"},{"issue":"1","key":"10.1016\/j.patbio.2008.02.016_bib14","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1006\/viro.1998.9437","article-title":"Emergence of epidemic O\u2019nyong-nyong fever in Uganda after a 35-year absence: genetic characterization of the virus","volume":"252","author":"Lanciotti","year":"1998","journal-title":"Virology"},{"issue":"5","key":"10.1016\/j.patbio.2008.02.016_bib15","doi-asserted-by":"crossref","first-page":"4316","DOI":"10.1128\/JVI.73.5.4316-4326.1999","article-title":"Genetic and fitness changes accompanying adaptation of an arbovirus to vertebrate and invertebrate cells","volume":"73","author":"Weaver","year":"1999","journal-title":"J Virol"},{"issue":"Pt 6","key":"10.1016\/j.patbio.2008.02.016_bib16","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1099\/vir.0.18936-0","article-title":"Amino acid mutations in the replicase protein nsP3 of Semliki Forest virus cumulatively affect neurovirulence","volume":"84","author":"Tuittila","year":"2003","journal-title":"J Gen Virol"},{"issue":"1","key":"10.1016\/j.patbio.2008.02.016_bib17","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.virol.2004.03.009","article-title":"Regulation of Semliki Forest virus RNA replication: a model for the control of alphavirus pathogenesis in invertebrate hosts","volume":"323","author":"Kim","year":"2004","journal-title":"Virology"},{"issue":"3","key":"10.1016\/j.patbio.2008.02.016_bib18","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1128\/JVI.68.3.1874-1885.1994","article-title":"Regulation of Sindbis virus RNA replication: uncleaved P123 and nsP4 function in minus-strand RNA synthesis, whereas cleaved products from P123 are required for efficient plus-strand RNA synthesis","volume":"68","author":"Shirako","year":"1994","journal-title":"J Virol"},{"issue":"3","key":"10.1016\/j.patbio.2008.02.016_bib19","first-page":"447","article-title":"Chikungunya infection--an emerging disease in Malaysia","volume":"32","author":"Lam","year":"2001","journal-title":"Southeast Asian J Trop Med Public Health"},{"issue":"2","key":"10.1016\/j.patbio.2008.02.016_bib20","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.trstmh.2004.03.013","article-title":"Tracking the re-emergence of epidemic chikungunya virus in Indonesia","volume":"99","author":"Laras","year":"2005","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"10","key":"10.1016\/j.patbio.2008.02.016_bib21","first-page":"243","article-title":"The history of dengue in tropical Asia and its probable relationship to the mosquito Aedes aegypti","volume":"59","author":"Smith","year":"1956","journal-title":"J Trop Med Hyg"},{"issue":"3","key":"10.1016\/j.patbio.2008.02.016_bib22","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.0269-283X.2004.00513.x","article-title":"Critical review of the vector status of Aedes albopictus","volume":"18","author":"Gratz","year":"2004","journal-title":"Med Vet Entomol"},{"key":"10.1016\/j.patbio.2008.02.016_bib23","first-page":"521","article-title":"\u00c9tudes biologique et syst\u00e9matique des Culicinae de l\u2019\u00cele de la R\u00e9union","volume":"E4","author":"Hamon","year":"1953","journal-title":"Mem Inst Sc Madagascar"},{"issue":"4","key":"10.1016\/j.patbio.2008.02.016_bib24","first-page":"323","article-title":"[Aedes albopictus and Aedes aegypti at \u00cele de la Reunion]","volume":"74","author":"Salvan","year":"1994","journal-title":"Ann Soc Belg Med Trop"},{"issue":"2\u20133","key":"10.1016\/j.patbio.2008.02.016_bib25","first-page":"91","article-title":"Global distribution and continuing spread of Aedes albopictus","volume":"37","author":"Knudsen","year":"1995","journal-title":"Parassitologia"},{"key":"10.1016\/j.patbio.2008.02.016_bib26","first-page":"1","article-title":"The biology of Aedes albopictus","volume":"1","author":"Hawley","year":"1988","journal-title":"J Am Mosq Control Assoc Suppl"},{"issue":"Pt 2","key":"10.1016\/j.patbio.2008.02.016_bib27","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1099\/0022-1317-81-2-471","article-title":"Re-emergence of Chikungunya and O\u2019nyong-nyong viruses: evidence for distinct geographical lineages and distant evolutionary relationships","volume":"81","author":"Powers","year":"2000","journal-title":"J Gen Virol"},{"issue":"11","key":"10.1016\/j.patbio.2008.02.016_bib28","doi-asserted-by":"crossref","first-page":"e1168","DOI":"10.1371\/journal.pone.0001168","article-title":"Two chikungunya isolates from the outbreak of La Reunion (Indian Ocean) exhibit different patterns of infection in the mosquito, Aedes albopictus","volume":"2","author":"Vazeille","year":"2007","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.patbio.2008.02.016_bib29","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1128\/MMBR.64.1.115-137.2000","article-title":"Genetics of mosquito vector competence","volume":"64","author":"Beerntsen","year":"2000","journal-title":"Microbiol Mol Biol Rev"},{"issue":"1","key":"10.1016\/j.patbio.2008.02.016_bib30","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4269\/ajtmh.1984.33.176","article-title":"Replication and dissemination of Rift Valley fever virus in Culex pipiens","volume":"33","author":"Turell","year":"1984","journal-title":"Am J Trop Med Hyg"},{"issue":"12","key":"10.1016\/j.patbio.2008.02.016_bib31","doi-asserted-by":"crossref","first-page":"e201","DOI":"10.1371\/journal.ppat.0030201","article-title":"A Single mutation in chikungunya virus affects vector specificity and epidemic potential","volume":"3","author":"Tsetsarkin","year":"2007","journal-title":"PLoS Pathog"},{"issue":"10","key":"10.1016\/j.patbio.2008.02.016_bib32","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.3201\/eid1210.060529","article-title":"Chikungunya outbreaks caused by African genotype, India","volume":"12","author":"Yergolkar","year":"2006","journal-title":"Emerg Infect Dis"},{"issue":"Pt 7","key":"10.1016\/j.patbio.2008.02.016_bib33","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1099\/vir.0.82714-0","article-title":"Genetic divergence of Chikungunya viruses in India (1963\u20132006) with special reference to the 2005\u20132006 explosive epidemic","volume":"88","author":"Arankalle","year":"2007","journal-title":"J Gen Virol"},{"issue":"1","key":"10.1016\/j.patbio.2008.02.016_bib34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1083\/jcb.140.1.91","article-title":"A single point mutation controls the cholesterol dependence of Semliki Forest virus entry and exit","volume":"140","author":"Vashishtha","year":"1998","journal-title":"J Cell Biol"},{"issue":"2","key":"10.1016\/j.patbio.2008.02.016_bib35","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1006\/viro.1999.9932","article-title":"Growth and stability of a cholesterol-independent Semliki Forest virus mutant in mosquitoes","volume":"262","author":"Ahn","year":"1999","journal-title":"Virology"},{"issue":"5","key":"10.1016\/j.patbio.2008.02.016_bib36","doi-asserted-by":"crossref","first-page":"4272","DOI":"10.1128\/JVI.73.5.4272-4278.1999","article-title":"The cholesterol requirement for sindbis virus entry and exit and characterization of a spike protein region involved in cholesterol dependence","volume":"73","author":"Lu","year":"1999","journal-title":"J Virol"},{"key":"10.1016\/j.patbio.2008.02.016_bib37","series-title":"Fields Virology","first-page":"713","article-title":"Alphaviruses","author":"Peters","year":"1990"},{"key":"10.1016\/j.patbio.2008.02.016_bib38","unstructured":"Outbreak news. Chikungunya and dengue, southwest Indian Ocean. Wkly Epidemiol Rec, 2006. 81(12): p. 106\u2013108."},{"key":"10.1016\/j.patbio.2008.02.016_bib39","unstructured":"Outbreak news. Chikungunya, India. Wkly Epidemiol Rec, 2006. 81(43): p. 409\u201310."},{"issue":"5","key":"10.1016\/j.patbio.2008.02.016_bib40","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S1473-3099(07)70091-9","article-title":"Chikungunya epidemic in India: a major public-health disaster","volume":"7","author":"Mavalankar","year":"2007","journal-title":"Lancet Infect Dis"},{"issue":"10","key":"10.1016\/j.patbio.2008.02.016_bib41","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.3201\/eid1210.060596","article-title":"Chikungunya virus strains. Reunion Island outbreak","volume":"12","author":"Bessaud","year":"2006","journal-title":"Emerg Infect Dis"},{"issue":"11","key":"10.1016\/j.patbio.2008.02.016_bib42","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1086\/517537","article-title":"Outbreak of chikungunya on Reunion Island: early clinical and laboratory features in 157 adult patients","volume":"44","author":"Borgherini","year":"2007","journal-title":"Clin Infect Dis"},{"issue":"1","key":"10.1016\/j.patbio.2008.02.016_bib43","first-page":"22","article-title":"[Acute neurologic and sensorial disorders in dengue and Chikungunya fever]","volume":"64","author":"Mazaud","year":"1971","journal-title":"Bull Soc Pathol Exot Filiales"},{"issue":"2","key":"10.1016\/j.patbio.2008.02.016_bib44","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4103\/0255-0857.25175","article-title":"Re-emergence of chikungunya virus in India","volume":"24","author":"Ravi","year":"2006","journal-title":"Indian J Med Microbiol"},{"issue":"10","key":"10.1016\/j.patbio.2008.02.016_bib45","first-page":"921","article-title":"Chikungunya virus infection with haemorrhagic manifestations","volume":"53","author":"Sarkar","year":"1965","journal-title":"Indian J Med Res"},{"issue":"6","key":"10.1016\/j.patbio.2008.02.016_bib46","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S0368-2315(06)76447-X","article-title":"[Chikungunya infection in pregnancy: Evidence for intrauterine infection in pregnant women and vertical transmission in the parturient Survey of the Reunion Island outbreak]","volume":"35","author":"Lenglet","year":"2006","journal-title":"J Gynecol Obstet Biol Reprod (Paris)"},{"issue":"12","key":"10.1016\/j.patbio.2008.02.016_bib47","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.3201\/eid1212.060710","article-title":"Chikungunya disease outbreak, Reunion Island","volume":"12","author":"Josseran","year":"2006","journal-title":"Emerg Infect Dis"},{"issue":"6","key":"10.1016\/j.patbio.2008.02.016_bib48","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1128\/JB.91.6.2185-2191.1966","article-title":"Leukocytes and interferon in the host response to viral infections. II. Enhanced interferon response of leukocytes from immune animals","volume":"91","author":"Glasgow","year":"1966","journal-title":"J Bacteriol"},{"issue":"2","key":"10.1016\/j.patbio.2008.02.016_bib49","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1128\/AEM.19.2.389-391.1970","article-title":"Chikungunya virus infection of cell monolayers by cell-to-cell and extracellular transmission","volume":"19","author":"Hahon","year":"1970","journal-title":"Appl Microbiol"},{"issue":"5","key":"10.1016\/j.patbio.2008.02.016_bib50","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1128\/IAI.12.5.1070-1077.1975","article-title":"Viral replication and interferon production in fetal and adult ovine leukocytes and spleen cells","volume":"12","author":"Rinaldo","year":"1975","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.patbio.2008.02.016_bib51","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1128\/JVI.51.1.254-258.1984","article-title":"Structural proteins of Chikungunya virus","volume":"51","author":"Simizu","year":"1984","journal-title":"J Virol"},{"issue":"6","key":"10.1016\/j.patbio.2008.02.016_bib52","doi-asserted-by":"crossref","first-page":"e527","DOI":"10.1371\/journal.pone.0000527","article-title":"Human muscle satellite cells as targets of Chikungunya virus infection","volume":"2","author":"Ozden","year":"2007","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.patbio.2008.02.016_bib53","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/ar.1091820207","article-title":"Regeneration of single skeletal muscle fibers in vitro","volume":"182","author":"Bischoff","year":"1975","journal-title":"Anat Rec"},{"issue":"2","key":"10.1016\/j.patbio.2008.02.016_bib54","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0307-742X(21)00556-7","article-title":"Epidemic polyarthritis and Ross River virus disease","volume":"12","author":"Fraser","year":"1986","journal-title":"Clin Rheum Dis"},{"issue":"4","key":"10.1016\/j.patbio.2008.02.016_bib55","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1128\/CMR.14.4.909-932.2001","article-title":"Ross River virus transmission, infection, and disease: a cross-disciplinary review","volume":"14","author":"Harley","year":"2001","journal-title":"Clin Microbiol Rev"},{"issue":"Pt 2","key":"10.1016\/j.patbio.2008.02.016_bib56","first-page":"199","article-title":"Ross River virus infection of human synovial cells in vitro","volume":"63","author":"Cunningham","year":"1985","journal-title":"Aust J Exp Biol Med Sci"},{"issue":"Pt 12","key":"10.1016\/j.patbio.2008.02.016_bib57","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1099\/0022-1317-68-12-3165","article-title":"Prolonged infection of human synovial cells with Ross River virus","volume":"68","author":"Journeaux","year":"1987","journal-title":"J Gen Virol"},{"issue":"5","key":"10.1016\/j.patbio.2008.02.016_bib58","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1445-5994.1975.tb03056.x","article-title":"Epidemic polyarthritis: a cytological, virological and immunochemical study","volume":"5","author":"Clarris","year":"1975","journal-title":"Aust N Z J Med"},{"issue":"4","key":"10.1016\/j.patbio.2008.02.016_bib59","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1073\/pnas.0607038104","article-title":"IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses","volume":"104","author":"Lenschow","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"10.1016\/j.patbio.2008.02.016_bib60","first-page":"314","article-title":"Virological investigation of cases with neurological complications during the outbreak of haemorrhagic fever in Calcutta","volume":"45","author":"Chatterjee","year":"1965","journal-title":"J Indian Med Assoc"},{"issue":"2","key":"10.1016\/j.patbio.2008.02.016_bib61","first-page":"E060202","article-title":"E-alert 27 January: Chikungunya outbreak in Reunion, a French overseas department","volume":"11","author":"Quatresous","year":"2006","journal-title":"Euro Surveill"},{"issue":"1","key":"10.1016\/j.patbio.2008.02.016_bib62","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00418-004-0667-z","article-title":"Fibroblasts form a body-wide cellular network","volume":"122","author":"Langevin","year":"2004","journal-title":"Histochem Cell Biol"},{"issue":"Pt 5","key":"10.1016\/j.patbio.2008.02.016_bib63","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/icb.1981.52","article-title":"Specific and non-specific immunological changes in epidemic polyarthritis patients","volume":"59","author":"Aaskov","year":"1981","journal-title":"Aust J Exp Biol Med Sci"},{"issue":"11","key":"10.1016\/j.patbio.2008.02.016_bib64","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1136\/jcp.36.11.1256","article-title":"The exanthem of Ross River virus infection: histology, location of virus antigen and nature of inflammatory infiltrate","volume":"36","author":"Fraser","year":"1983","journal-title":"J Clin Pathol"},{"issue":"4","key":"10.1016\/j.patbio.2008.02.016_bib65","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1445-5994.1984.tb03629.x","article-title":"Mononuclear cell types in chronic synovial effusions of Ross River virus disease","volume":"14","author":"Fraser","year":"1984","journal-title":"Aust N Z J Med"},{"issue":"1","key":"10.1016\/j.patbio.2008.02.016_bib66","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1086\/315164","article-title":"Macrophage-induced muscle pathology results in morbidity and mortality for Ross River virus-infected mice","volume":"181","author":"Lidbury","year":"2000","journal-title":"J Infect Dis"},{"issue":"1","key":"10.1016\/j.patbio.2008.02.016_bib67","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000025023","article-title":"An arthrogenic alphavirus induces monocyte chemoattractant protein-1 and interleukin-8","volume":"43","author":"Mateo","year":"2000","journal-title":"Intervirology"},{"issue":"11","key":"10.1016\/j.patbio.2008.02.016_bib68","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.3201\/eid1211.060574","article-title":"Chikungunya fever, Hong Kong","volume":"12","author":"Lee","year":"2006","journal-title":"Emerg Infect Dis"},{"issue":"2","key":"10.1016\/j.patbio.2008.02.016_bib69","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.0040029","article-title":"A mouse model for Chikungunya: young age and inefficient type-I interferon signalling are risk factors for severe disease","volume":"4","author":"Couderc","year":"2008","journal-title":"PLoS Pathog"}],"container-title":["Pathologie Biologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0369811408000400?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0369811408000400?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T23:59:46Z","timestamp":1631231986000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0369811408000400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":69,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S0369811408000400"],"URL":"https:\/\/doi.org\/10.1016\/j.patbio.2008.02.016","relation":{},"ISSN":["0369-8114"],"issn-type":[{"value":"0369-8114","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}