{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T10:52:03Z","timestamp":1693738323848},"reference-count":58,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathologie Biologie"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.patbio.2013.01.001","type":"journal-article","created":{"date-parts":[[2013,2,8]],"date-time":"2013-02-08T23:32:06Z","timestamp":1360366326000},"page":"21-27","source":"Crossref","is-referenced-by-count":3,"title":["Sensibilit\u00e9 g\u00e9n\u00e9tique \u00e0 l\u2019enc\u00e9phalite herp\u00e9tique"],"prefix":"10.1016","volume":"61","author":[{"given":"F.","family":"Rozenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.patbio.2013.01.001_bib0005","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1128\/JVI.02110-06","article-title":"Herpes simplex virus type 2 (HSV-2) establishes latent infection in a different population of ganglionic neurons than HSV-1: role of latency-associated transcripts","volume":"81","author":"Margolis","year":"2007","journal-title":"J Virol"},{"issue":"5","key":"10.1016\/j.patbio.2013.01.001_bib0010","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1086\/422643","article-title":"Presence of viremia in patients with primary herpetic gingivostomatitis","volume":"39","author":"Harel","year":"2004","journal-title":"Clin Infect Dis"},{"issue":"1","key":"10.1016\/j.patbio.2013.01.001_bib0015","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1086\/588676","article-title":"Herpes simplex virus viremia during primary genital infection","volume":"198","author":"Johnston","year":"2008","journal-title":"J Infect Dis"},{"issue":"1","key":"10.1016\/j.patbio.2013.01.001_bib0020","first-page":"55","article-title":"Isolation of the virus of herpes simplex and the demonstration of intranuclear inclusions in a case of acute encephalitis","volume":"17","author":"Smith","year":"1941","journal-title":"Am J Pathol"},{"issue":"12","key":"10.1016\/j.patbio.2013.01.001_bib0025","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.1128\/JVI.62.12.4819-4823.1988","article-title":"Detection and preliminary characterization of herpes simplex virus type 1\u00a0transcripts in latently infected human trigeminal ganglia","volume":"62","author":"Krause","year":"1988","journal-title":"J Virol"},{"issue":"2","key":"10.1016\/j.patbio.2013.01.001_bib0030","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/jmv.21687","article-title":"Detection of varicella-zoster virus DNA in 414\u00a0human trigeminal ganglia from cadavers by the polymerase chain reaction: a comparison of the detection rate of varicella-zoster virus and herpes simplex virus type 1","volume":"82","author":"Inoue","year":"2010","journal-title":"J Med Virol"},{"issue":"7","key":"10.1016\/j.patbio.2013.01.001_bib0035","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1136\/jnnp.57.7.869","article-title":"Herpes simplex virus type 2\u00a0ascending myeloradiculitis: MRI findings and rapid diagnosis by the polymerase chain method","volume":"57","author":"Ellie","year":"1994","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"2\u20133","key":"10.1016\/j.patbio.2013.01.001_bib0040","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.antiviral.2006.04.002","article-title":"Herpes simplex encephalitis: adolescents and adults","volume":"71","author":"Whitley","year":"2006","journal-title":"Antiviral Res"},{"issue":"Suppl. 2","key":"10.1016\/j.patbio.2013.01.001_bib0045","first-page":"65A","article-title":"Herpes simplex virus, meningitis and encephalitis in neonates","volume":"11","author":"Kimberlin","year":"2004","journal-title":"Herpes"},{"issue":"10","key":"10.1016\/j.patbio.2013.01.001_bib0050","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1086\/374839","article-title":"Limits of early diagnosis of herpes simplex encephalitis in children: a retrospective study of 38\u00a0cases","volume":"36","author":"De Tiege","year":"2003","journal-title":"Clin Infect Dis"},{"issue":"4","key":"10.1016\/j.patbio.2013.01.001_bib0055","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.jpeds.2010.04.020","article-title":"Age-dependent Mendelian predisposition to herpes simplex virus type 1\u00a0encephalitis in childhood","volume":"157","author":"Abel","year":"2010","journal-title":"J Pediatr"},{"issue":"2","key":"10.1016\/j.patbio.2013.01.001_bib0060","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1212\/01.WNL.0000073985.71759.7C","article-title":"Herpes simplex encephalitis relapses in children: differentiation of two neurologic entities","volume":"61","author":"De Tiege","year":"2003","journal-title":"Neurology"},{"issue":"17","key":"10.1016\/j.patbio.2013.01.001_bib0065","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1056\/NEJM198210213071706","article-title":"Dna restriction-enzyme analysis of herpes simplex virus isolates obtained from patients with encephalitis","volume":"307","author":"Whitley","year":"1982","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.patbio.2013.01.001_bib0070","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/infdis\/141.4.436","article-title":"Temporal cluster of herpes simplex encephalitis: investigation by restriction endonuclease cleavage of viral DNA","volume":"141","author":"Hammer","year":"1980","journal-title":"J Infect Dis"},{"issue":"1","key":"10.1016\/j.patbio.2013.01.001_bib0075","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3109\/13550289809113488","article-title":"Variations of HSV-1\u00a0glycoprotein B in human herpes simplex encephalitis","volume":"4","author":"Sivadon","year":"1998","journal-title":"J Neurovirol"},{"issue":"9","key":"10.1016\/j.patbio.2013.01.001_bib0080","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1111\/j.1462-5822.2008.01175.x","article-title":"Autophagy and viral neurovirulence","volume":"10","author":"Orvedahl","year":"2008","journal-title":"Cell Microbiol"},{"issue":"1","key":"10.1016\/j.patbio.2013.01.001_bib0085","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.chom.2006.12.001","article-title":"HSV-1\u00a0ICP34.5\u00a0confers neurovirulence by targeting the Beclin 1\u00a0autophagy protein","volume":"1","author":"Orvedahl","year":"2007","journal-title":"Cell Host Microbe"},{"issue":"3","key":"10.1016\/j.patbio.2013.01.001_bib0090","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.chom.2012.07.013","article-title":"A neuron-specific role for autophagy in antiviral defense against herpes simplex virus","volume":"12","author":"Yordy","year":"2012","journal-title":"Cell Host Microbe"},{"issue":"5","key":"10.1016\/j.patbio.2013.01.001_bib0095","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1084\/jem.144.5.1316","article-title":"Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. II. Studies with herpes simplex, Moloney sarcoma, vesicular stomatitis, Newcastle disease, and influenza viruses","volume":"144","author":"Gresser","year":"1976","journal-title":"J Exp Med"},{"issue":"5","key":"10.1016\/j.patbio.2013.01.001_bib0100","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1128\/JVI.64.5.2187-2192.1990","article-title":"Ocular avirulence of a herpes simplex virus type 1\u00a0strain is associated with heightened sensitivity to alpha\/beta interferon","volume":"64","author":"Su","year":"1990","journal-title":"J Virol"},{"issue":"3","key":"10.1016\/j.patbio.2013.01.001_bib0105","doi-asserted-by":"crossref","first-page":"979","DOI":"10.3390\/v1030979","article-title":"Innate and adaptive immune responses to herpes simplex virus","volume":"1","author":"Chew","year":"2009","journal-title":"Viruses"},{"issue":"8","key":"10.1016\/j.patbio.2013.01.001_bib0110","doi-asserted-by":"crossref","first-page":"3846","DOI":"10.1128\/JVI.78.8.3846-3850.2004","article-title":"Interplay between alpha\/beta and gamma interferons with B T, and natural killer cells in the defense against herpes simplex virus type 1","volume":"78","author":"Vollstedt","year":"2004","journal-title":"J Virol"},{"issue":"4","key":"10.1016\/j.patbio.2013.01.001_bib0115","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1084\/jem.189.4.663","article-title":"Interferons regulate the phenotype of wild-type and mutant herpes simplex viruses in vivo","volume":"189","author":"Leib","year":"1999","journal-title":"J Exp Med"},{"issue":"20","key":"10.1016\/j.patbio.2013.01.001_bib0120","doi-asserted-by":"crossref","first-page":"11082","DOI":"10.1128\/JVI.77.20.11082-11093.2003","article-title":"Bioluminescence imaging reveals systemic dissemination of herpes simplex virus type 1\u00a0in the absence of interferon receptors","volume":"77","author":"Luker","year":"2003","journal-title":"J Virol"},{"issue":"1","key":"10.1016\/j.patbio.2013.01.001_bib0125","first-page":"120","article-title":"Increased severity of HSV-1\u00a0keratitis and mortality in mice lacking the 2-5A-dependent RNase L gene","volume":"42","author":"Zheng","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"10.1016\/j.patbio.2013.01.001_bib0130","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1073\/pnas.0607038104","article-title":"IFN-stimulated gene 15\u00a0functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses","volume":"104","author":"Lenschow","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4985","key":"10.1016\/j.patbio.2013.01.001_bib0135","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1126\/science.2173860","article-title":"Mapping of herpes simplex virus-1\u00a0neurovirulence to gamma 134.5, a gene nonessential for growth in culture","volume":"250","author":"Chou","year":"1990","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.patbio.2013.01.001_bib0140","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1128\/JVI.68.1.48-55.1994","article-title":"ICP34.5\u00a0mutants of herpes simplex virus type 1\u00a0strain 17syn+ are attenuated for neurovirulence in mice and for replication in confluent primary mouse embryo cell cultures","volume":"68","author":"Bolovan","year":"1994","journal-title":"J Virol"},{"issue":"11","key":"10.1016\/j.patbio.2013.01.001_bib0145","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1073\/pnas.100415697","article-title":"Specific phenotypic restoration of an attenuated virus by knockout of a host resistance gene","volume":"97","author":"Leib","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.patbio.2013.01.001_bib0150","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/rmv.716","article-title":"Sensing herpes: more than toll","volume":"22","author":"Melchjorsen","year":"2012","journal-title":"Rev Med Virol"},{"issue":"5","key":"10.1016\/j.patbio.2013.01.001_bib0155","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1073\/pnas.0308057100","article-title":"Herpes simplex virus 1\u00a0interaction with toll-like receptor 2\u00a0contributes to lethal encephalitis","volume":"101","author":"Kurt-Jones","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.patbio.2013.01.001_bib0160","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1128\/JVI.06010-11","article-title":"Role of specific innate immune responses in herpes simplex virus infection of the central nervous system","volume":"86","author":"Wang","year":"2012","journal-title":"J Virol"},{"issue":"5","key":"10.1016\/j.patbio.2013.01.001_bib0165","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/S0002-9440(10)62359-0","article-title":"Lethal encephalitis in myeloid differentiation factor 88-deficient mice infected with herpes simplex virus 1","volume":"166","author":"Mansur","year":"2005","journal-title":"Am J Pathol"},{"issue":"46","key":"10.1016\/j.patbio.2013.01.001_bib0170","doi-asserted-by":"crossref","first-page":"17343","DOI":"10.1073\/pnas.0605102103","article-title":"Dual recognition of herpes simplex viruses by TLR2\u00a0and TLR9\u00a0in dendritic cells","volume":"103","author":"Sato","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"10.1016\/j.patbio.2013.01.001_bib0175","doi-asserted-by":"crossref","first-page":"8604","DOI":"10.4049\/jimmunol.181.12.8604","article-title":"TLR2\u00a0and TLR9\u00a0synergistically control herpes simplex virus infection in the brain","volume":"181","author":"Sorensen","year":"2008","journal-title":"J Immunol"},{"issue":"5","key":"10.1016\/j.patbio.2013.01.001_bib0180","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.2353\/ajpath.2010.100121","article-title":"Toll-like receptor (TLR) 2\u00a0and TLR9\u00a0expressed in trigeminal ganglia are critical to viral control during herpes simplex virus 1\u00a0infection","volume":"177","author":"Lima","year":"2010","journal-title":"Am J Pathol"},{"issue":"24","key":"10.1016\/j.patbio.2013.01.001_bib0185","doi-asserted-by":"crossref","first-page":"p1481","DOI":"10.1056\/NEJM198306163082415","article-title":"Two cases of herpes simplex virus encephalitis in the same family","volume":"308","author":"Lerner","year":"1983","journal-title":"N Engl J Med"},{"issue":"9005","key":"10.1016\/j.patbio.2013.01.001_bib0190","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/S0140-6736(96)91398-7","article-title":"Familial herpes encephalitis","volume":"347","author":"Gazquez","year":"1996","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.patbio.2013.01.001_bib0195","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/ana.10110","article-title":"Familial herpes simplex encephalitis","volume":"51","author":"Jackson","year":"2002","journal-title":"Ann Neurol"},{"issue":"8989","key":"10.1016\/j.patbio.2013.01.001_bib0200","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/S0140-6736(95)92081-1","article-title":"Familial herpes encephalitis","volume":"346","author":"Koskiniemi","year":"1995","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.patbio.2013.01.001_bib0205","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/ng1097","article-title":"Impaired response to interferon-alpha\/beta and lethal viral disease in human STAT1\u00a0deficiency","volume":"33","author":"Dupuis","year":"2003","journal-title":"Nat Genet"},{"issue":"6","key":"10.1016\/j.patbio.2013.01.001_bib0210","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1016\/j.jaci.2004.08.047","article-title":"Nuclear factor kappaB essential modulator-deficient child with immunodeficiency yet without anhidrotic ectodermal dysplasia","volume":"114","author":"Niehues","year":"2004","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.patbio.2013.01.001_bib0215","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.coi.2004.11.004","article-title":"Genetic dissection of innate immunity to infection: the mouse cytomegalovirus model","volume":"17","author":"Beutler","year":"2005","journal-title":"Curr Opin Immunol"},{"issue":"2","key":"10.1016\/j.patbio.2013.01.001_bib0220","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/ni1297","article-title":"The Unc93b1\u00a0mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7\u00a0and 9","volume":"7","author":"Tabeta","year":"2006","journal-title":"Nat Immunol"},{"issue":"5797","key":"10.1016\/j.patbio.2013.01.001_bib0225","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1126\/science.1128346","article-title":"Herpes simplex virus encephalitis in human UNC-93B deficiency","volume":"314","author":"Casrouge","year":"2006","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.patbio.2013.01.001_bib0230","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.immuni.2005.09.016","article-title":"Human TLR-7,-8-, and -9-mediated induction of IFN-alpha\/beta and -lambda Is IRAK-4\u00a0dependent and redundant for protective immunity to viruses","volume":"23","author":"Yang","year":"2005","journal-title":"Immunity"},{"issue":"20","key":"10.1016\/j.patbio.2013.01.001_bib0235","doi-asserted-by":"crossref","first-page":"12893","DOI":"10.1128\/JVI.79.20.12893-12904.2005","article-title":"Virus infection switches TLR-3-positive human neurons to become strong producers of beta interferon","volume":"79","author":"Prehaud","year":"2005","journal-title":"J Virol"},{"issue":"5844","key":"10.1016\/j.patbio.2013.01.001_bib0240","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1126\/science.1139522","article-title":"TLR3\u00a0deficiency in patients with herpes simplex encephalitis","volume":"317","author":"Zhang","year":"2007","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.patbio.2013.01.001_bib0245","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1084\/jem.20101568","article-title":"Herpes simplex virus encephalitis in a patient with complete TLR3\u00a0deficiency: TLR3\u00a0is otherwise redundant in protective immunity","volume":"208","author":"Guo","year":"2011","journal-title":"J Exp Med"},{"issue":"7426","key":"10.1016\/j.patbio.2013.01.001_bib0250","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nature11583","article-title":"Impaired intrinsic immunity to HSV-1\u00a0in human iPSC-derived TLR3-deficient CNS cells","volume":"491","author":"Lafaille","year":"2012","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.patbio.2013.01.001_bib0255","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.immuni.2010.08.014","article-title":"Human TRAF3\u00a0adaptor molecule deficiency leads to impaired toll-like receptor 3\u00a0response and susceptibility to herpes simplex encephalitis","volume":"33","author":"Perez de Diego","year":"2010","journal-title":"Immunity"},{"issue":"12","key":"10.1016\/j.patbio.2013.01.001_bib0260","doi-asserted-by":"crossref","first-page":"4889","DOI":"10.1172\/JCI59259","article-title":"Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency","volume":"121","author":"Sancho-Shimizu","year":"2011","journal-title":"J Clin Invest"},{"issue":"9","key":"10.1016\/j.patbio.2013.01.001_bib0265","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1084\/jem.20111316","article-title":"Heterozygous TBK1\u00a0mutations impair TLR3\u00a0immunity and underlie herpes simplex encephalitis of childhood","volume":"209","author":"Herman","year":"2012","journal-title":"J Exp Med"},{"issue":"6","key":"10.1016\/j.patbio.2013.01.001_bib0270","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/ACI.0b013e3282f151d2","article-title":"Genetic susceptibility to herpes simplex virus 1\u00a0encephalitis in mice and humans","volume":"7","author":"Sancho-Shimizu","year":"2007","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"4","key":"10.1016\/j.patbio.2013.01.001_bib0275","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1172\/JCI60893","article-title":"TLR3\u00a0deficiency renders astrocytes permissive to herpes simplex virus infection and facilitates establishment of CNS infection in mice","volume":"122","author":"Reinert","year":"2012","journal-title":"J Clin Invest"},{"issue":"5","key":"10.1016\/j.patbio.2013.01.001_bib0280","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1086\/590671","article-title":"Effect of pretreatment with toll-like receptor agonists in a mouse model of herpes simplex virus type 1\u00a0encephalitis","volume":"198","author":"Boivin","year":"2008","journal-title":"J Infect Dis"},{"issue":"11","key":"10.1016\/j.patbio.2013.01.001_bib0285","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1111\/j.1462-5822.2011.01649.x","article-title":"Innate immune control of West Nile virus infection","volume":"13","author":"Arjona","year":"2011","journal-title":"Cell Microbiol"},{"issue":"30","key":"10.1016\/j.patbio.2013.01.001_bib0290","doi-asserted-by":"crossref","first-page":"23208","DOI":"10.1074\/jbc.M109.047464","article-title":"A role for Toll-like receptor 3\u00a0variants in host susceptibility to enteroviral myocarditis and dilated cardiomyopathy","volume":"285","author":"Gorbea","year":"2010","journal-title":"J Biol Chem"}],"container-title":["Pathologie Biologie"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0369811413000023?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0369811413000023?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T03:10:16Z","timestamp":1595387416000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0369811413000023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0369811413000023"],"URL":"https:\/\/doi.org\/10.1016\/j.patbio.2013.01.001","relation":{},"ISSN":["0369-8114"],"issn-type":[{"value":"0369-8114","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}