{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:03:38Z","timestamp":1791324218129,"version":"4.3.1"},"reference-count":77,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathologie Biologie"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.patbio.2013.04.001","type":"journal-article","created":{"date-parts":[[2013,9,10]],"date-time":"2013-09-10T20:54:37Z","timestamp":1378846477000},"page":"228-238","source":"Crossref","is-referenced-by-count":19,"title":["Les aspects g\u00e9n\u00e9tiques de la maladie d\u2019Alzheimer (Revue)"],"prefix":"10.1016","volume":"61","author":[{"given":"N.","family":"El Kadmiri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Hamzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"El Moutawakil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Slassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Nadifi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.patbio.2013.04.001_bib0005","doi-asserted-by":"crossref","first-page":"33","DOI":"10.55782\/ane-2004-1489","article-title":"Tauphosphorylation and assembly","volume":"64","author":"Gomez-Ramos","year":"2004","journal-title":"Acta Neurobiol Exp (Wars)"},{"key":"10.1016\/j.patbio.2013.04.001_bib0010","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/S1357-2725(03)00133-X","article-title":"Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer's disease","volume":"35","author":"Ling","year":"2003","journal-title":"Int J Bioch Cell Biol"},{"key":"10.1016\/j.patbio.2013.04.001_bib0015","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/oxfordjournals.epirev.a036092","article-title":"Epidemiology of Alzheimer's disease","volume":"14","author":"Breteler","year":"1992","journal-title":"Epidemiol Rev"},{"key":"10.1016\/j.patbio.2013.04.001_bib0020","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1100\/tsw.2003.39","article-title":"Genetics of early-onset Alzheimer dementia","volume":"3","author":"Rademakers","year":"2003","journal-title":"Sci World J"},{"key":"10.1016\/j.patbio.2013.04.001_bib0025","first-page":"345","article-title":"\u00c9pid\u00e9miologie des maladies neurod\u00e9g\u00e9n\u00e9ratives\u00a0: l\u2019exemple des d\u00e9mences","volume":"58","author":"Amouyel","year":"2000","journal-title":"Ann Biol Clin"},{"key":"10.1016\/j.patbio.2013.04.001_bib0390","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1136\/pgmj.2005.035030","article-title":"Treating vascular risk factors and maintaining vascular health: is this the waytowards successful cognitive ageing and preventing cognitive decline?","volume":"82","author":"Alagiakrishnan","year":"2006","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.patbio.2013.04.001_bib0035","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0149-7634(94)90052-3","article-title":"Impaired brain microcirculation may trigger Alzheimer's disease","volume":"18","author":"De La Torre","year":"1994","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.patbio.2013.04.001_bib0040","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1001\/archinte.162.18.2046","article-title":"The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study","volume":"162","author":"Forette","year":"2002","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.patbio.2013.04.001_bib0045","first-page":"1213","article-title":"Vascular, degenerative and mixed dementia. A clinicopathological study in 33\u00a0cases","volume":"7","author":"Zekry","year":"1997","journal-title":"Brain Pathol"},{"key":"10.1016\/j.patbio.2013.04.001_bib0050","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00401-001-0493-5","article-title":"Degenerative and vascular lesions of the brain have synergistic effects in dementia of the elderly","volume":"103","author":"Zekry","year":"2002","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.patbio.2013.04.001_bib0055","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0197-4580(02)00066-0","article-title":"The vascular lesions in vascular and mixed dementia: the weight of functional neuroanatomy","volume":"24","author":"Zekry","year":"2003","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.patbio.2013.04.001_bib0060","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jalz.2012.11.007","article-title":"The global prevalence of dementia: review and systematic meta analysis","volume":"9","author":"Prince","year":"2013","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.patbio.2013.04.001_bib0065","first-page":"405","article-title":"PAQUID [Prevalence of dementia and Alzheimer's disease among subjects aged 75\u00a0years or over: updated results of the PAQUID cohort]","volume":"159","author":"Ramaroson","year":"2003","journal-title":"Rev Neurol"},{"key":"10.1016\/j.patbio.2013.04.001_bib0070","first-page":"225","article-title":"The Paquid research program on the epidemiology of dementia. Methods and initial results","volume":"147","author":"Dartigues","year":"1991","journal-title":"Rev Neurol"},{"key":"10.1016\/j.patbio.2013.04.001_bib0075","first-page":"227","article-title":"PAQUID: bilan 1993\u20131996","volume":"11","author":"Dartigues","year":"1997","journal-title":"Ann Gerontol"},{"key":"10.1016\/j.patbio.2013.04.001_bib0080","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1046\/j.1365-2389.2003.51260.x","article-title":"Efficacy of donepezil on maintenance of activities of daily living in patients with moderate to severe Alzheimer's disease and the effect on caregiver burden","volume":"51","author":"Feldman","year":"2003","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.patbio.2013.04.001_bib0085","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/gps.1355","article-title":"The need for a consensus in the use of assessment tools for Alzheimer's disease: the Feasibility Study (assessment tools for dementia in Alzheimer Centres across Europe), a European Alzheimer's Disease Consortium's (EADC) survey","volume":"20","author":"Ramirez Diaz","year":"2005","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1016\/j.patbio.2013.04.001_bib0090","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.revmed.2010.08.006","article-title":"Alzheimer's and related diseases: toward earlier and more accurate diagnosis","volume":"31","author":"Fortin","year":"2010","journal-title":"Rev Med Interne"},{"key":"10.1016\/j.patbio.2013.04.001_bib0095","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa1202753","article-title":"Clinical and biomarker changes in dominantly inherited Alzheimer's disease","volume":"367","author":"Bateman","year":"2012","journal-title":"N Engl J Med"},{"issue":"367","key":"10.1016\/j.patbio.2013.04.001_bib0100","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1056\/NEJMp1208061","article-title":"Brain amyloid imaging-FDA approval of florbetapir F18\u00a0injection","volume":"6","author":"Yang","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.patbio.2013.04.001_bib0105","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/0006-8993(83)91273-8","article-title":"The isolation and amino acid composition of senile plaque core amyloid","volume":"259","author":"Allsop","year":"1983","journal-title":"Brain Res"},{"key":"10.1016\/j.patbio.2013.04.001_bib0110","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/0006-8993(88)90673-7","article-title":"Protein chemical and immunocytochemical studies of meningovascular \u00df-amyloid protein in Alzheimer's disease and normal aging","volume":"474","author":"Joachim","year":"1988","journal-title":"Brain Res"},{"key":"10.1016\/j.patbio.2013.04.001_bib0115","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1073\/pnas.83.13.4913","article-title":"Abnormal phosphorylation of the microtubule-associated protein tau in Alzheimer cytoskeletal pathology","volume":"83","author":"Grundke-iqbal","year":"1986","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.patbio.2013.04.001_bib0120","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/BF00305876","article-title":"Subtypes and differential laminar distributions of \u00dfA4\u00a0deposits in Alzheimer's disease: relationship with the intellectual status of 26\u00a0cases","volume":"81","author":"Dela\u00e8re","year":"1991","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.patbio.2013.04.001_bib0125","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1212\/WNL.52.6.1158","article-title":"The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease","volume":"52","author":"Delacourte","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.patbio.2013.04.001_bib0130","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1056\/NEJMoa1201356","article-title":"Hereditary systemic amyloidosis due to Asp76Asn variant \u03b22-microglobulin","volume":"366","author":"Valleix","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.patbio.2013.04.001_bib0135","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1056\/NEJMoa1206524","article-title":"Diagnostic exome sequencing in persons with severe intellectual disability","volume":"367","author":"de Ligt","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.patbio.2013.04.001_bib0140","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/GIM.0b013e31816b64dc","article-title":"Genetic aspects of Alzheimer disease","volume":"10","author":"Bird","year":"2008","journal-title":"Genet Med"},{"key":"10.1016\/j.patbio.2013.04.001_bib0145","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1001\/archpsyc.63.2.168","article-title":"Role of genes and environments for explaining Alzheimer disease","volume":"63","author":"Gatz","year":"2006","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.patbio.2013.04.001_bib0150","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cell.2005.02.008","article-title":"Twenty years of the Alzheimer's disease amyloid hypothesis. A genetic perspective","volume":"120","author":"Tanzi","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.patbio.2013.04.001_bib0155","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1046\/j.1471-4159.1995.65041431.x","article-title":"Processing of the beta-amyloid precursor protein and its regulation in Alzheimer's disease","volume":"65","author":"Checler","year":"1995","journal-title":"J Neurochem"},{"key":"10.1016\/j.patbio.2013.04.001_bib0160","first-page":"209","article-title":"Pathog\u00e9nie de la maladie d\u2019Alzheimer\u00a0: les m\u00e9canismes mol\u00e9culaires et cellulaires","volume":"62","author":"Govaerts","year":"2007","journal-title":"Rev Med Liege"},{"key":"10.1016\/j.patbio.2013.04.001_bib0165","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/S0196-9781(02)00063-3","article-title":"Biogenesis and metabolism of Alzheimer's disease Abeta amyloid peptides","volume":"23","author":"Evin","year":"2002","journal-title":"Peptides"},{"key":"10.1016\/j.patbio.2013.04.001_bib0170","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/0304-3940(91)90775-O","article-title":"Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12\u00a0cells","volume":"128","author":"Anderson","year":"1991","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.patbio.2013.04.001_bib0175","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/349704a0","article-title":"Segregation of a missense mutation in the amyloid precursors gene with familial Alzheimer's disease","volume":"349","author":"Goate","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.patbio.2013.04.001_bib0180","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/ng0892-345","article-title":"A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloide","volume":"1","author":"Mullan","year":"1992","journal-title":"Nat Genet"},{"key":"10.1016\/j.patbio.2013.04.001_bib0185","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s004010051040","article-title":"Glycosylation of microtubule-associated protein tau in Alzheimer's disease brain","volume":"97","author":"Takahashi","year":"1999","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.1016\/j.patbio.2013.04.001_bib0190","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/00002093-199205000-00003","article-title":"The seminal role of B-amyloid in the pathogenesis of Alzheimer disease","volume":"6","author":"Joachim","year":"1992","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.1016\/j.patbio.2013.04.001_bib0195","unstructured":"URL: http:\/\/www.molgen.ua.ac.be\/ADMutations."},{"key":"10.1016\/j.patbio.2013.04.001_bib0200","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/ng1943","article-title":"The neuronal sortilin-related receptor SORL1\u00a0is genetically associated with Alzheimer disease","volume":"39","author":"Rogaeva","year":"2007","journal-title":"Nat Genet"},{"key":"10.1016\/j.patbio.2013.04.001_bib0205","doi-asserted-by":"crossref","first-page":"19","DOI":"10.55782\/ane-2004-1488","article-title":"Genetic aspects of Alzheimer's disease","volume":"64","author":"Cezary","year":"2004","journal-title":"Acta Neurobiol"},{"key":"10.1016\/j.patbio.2013.04.001_bib0210","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1093\/hmg\/6.12.2087","article-title":"A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43)","volume":"6","author":"Eckman","year":"1997","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.patbio.2013.04.001_bib0215","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1126\/science.8191290","article-title":"An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants","volume":"264","author":"Suzuki","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.patbio.2013.04.001_bib0220","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1051\/medsci\/2006225468","article-title":"APP duplication causes autosomal dominant Alzheimer disease with cerebral amyloid angiopathy","volume":"22","author":"Campion","year":"2006","journal-title":"Medecine Sciences: M\/S"},{"key":"10.1016\/j.patbio.2013.04.001_bib0225","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/ng1718","article-title":"APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy","volume":"38","author":"Rovelet-Lecrux","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.patbio.2013.04.001_bib0230","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S0140-6736(04)17103-1","article-title":"Alpha synuclein locus duplication as a cause of familial Parkinson disease","volume":"364","author":"Chartier-Harlin","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.patbio.2013.04.001_bib0235","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0140-6736(04)17104-3","article-title":"Causal relation between alpha synuclein gene duplication and familial Parkinson disease","volume":"364","author":"Ib\u00e1\u00f1ez","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.patbio.2013.04.001_bib0240","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1126\/science.1411576","article-title":"Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome\u00a014","volume":"23","author":"Schellenberg","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.patbio.2013.04.001_bib0245","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/375754a0","article-title":"Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease","volume":"375","author":"Sherrington","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.patbio.2013.04.001_bib0250","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1086\/302553","article-title":"Early-onset autosomal dominant Alzheimer disease: prevalence. genetic heterogeneity, and mutation spectrum","volume":"65","author":"Campion","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.patbio.2013.04.001_bib0255","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1212\/WNL.45.1.80","article-title":"Large pedigree with early-onset Alzheimer's disease clinical, neuropathologic, and genetic characterization","volume":"45","author":"Campion","year":"1995","journal-title":"Neurology"},{"key":"10.1016\/j.patbio.2013.04.001_bib0260","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000141483","article-title":"Mutational analysis in early-onset familial dementia in the Japanese population. The role of PSEN1\u00a0and MAPT R406W mutations","volume":"26","author":"Ikeuchi","year":"2008","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1016\/j.patbio.2013.04.001_bib0265","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1097\/00001756-199607080-00009","article-title":"A novel presenilin 1\u00a0mutation resulting in familial Alzheimer's disease with an onset age of 29\u00a0years","volume":"7","author":"Campion","year":"1996","journal-title":"Neuroreport"},{"key":"10.1016\/j.patbio.2013.04.001_bib0270","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/ng.440","article-title":"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease","volume":"41","author":"Harold","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.patbio.2013.04.001_bib0275","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0896-6273(00)80230-5","article-title":"Familial Alzheimer's disease-linked presenilin1\u00a0variants elevate A\u03b21-42\/1-40\u00a0ratio in vitro and in vivo","volume":"17","author":"Borchelt","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.patbio.2013.04.001_bib0280","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/34910","article-title":"Deficiency of presenilin-1\u00a0inhibits the normal cleavage of amyloid precursor protein","volume":"39","author":"De Strooper","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.patbio.2013.04.001_bib0285","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1111\/j.1471-4159.2005.03578.x","article-title":"Presenilin clinical mutations can affect gamma secretase activity by different mechanisms","volume":"96","author":"Bentahir","year":"2006","journal-title":"J Neurochem"},{"key":"10.1016\/j.patbio.2013.04.001_bib0290","series-title":"Epidemiology of Alzheimer's disease: from gene to prevention Springer","article-title":"Genetic factors in early- and late-onset Alzheimer's disease","author":"Tol","year":"1999"},{"key":"10.1016\/j.patbio.2013.04.001_bib0295","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1001\/archneur.55.5.740","article-title":"Is exposure to aluminium a risk factor for the development of Alzheimer disease? Yes","volume":"55","author":"Forbes","year":"1998","journal-title":"Arch Neurol"},{"key":"10.1016\/j.patbio.2013.04.001_bib0300","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1212\/WNL.43.8.1467","article-title":"Association of apolipoprotein E allele \u04544\u00a0with late onset familial and sporadic Alzheimer's disease","volume":"43","author":"Saunders","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.patbio.2013.04.001_bib0305","first-page":"439","article-title":"Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex","volume":"60","author":"Bickeb\u00f6ller","year":"1997","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.patbio.2013.04.001_bib0310","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1146\/annurev.genom.1.1.507","article-title":"Apolipoprotein E: far more than a lipid transport protein","volume":"1","author":"Mahley","year":"2000","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"10.1016\/j.patbio.2013.04.001_bib0315","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of age, sexe and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A metaanalysis. APOE and Alzheimer disease meta analysis consortium","volume":"278","author":"Farrer","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.patbio.2013.04.001_bib0320","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1073\/pnas.0600549103","article-title":"Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer's disease","volume":"103","author":"Mahley","year":"2006","journal-title":"PNAS"},{"key":"10.1016\/j.patbio.2013.04.001_bib0325","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa1211103","article-title":"Variant of TREM2\u00a0associated with the risk of Alzheimer's disease","volume":"368","author":"Jonsson","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.patbio.2013.04.001_bib0330","doi-asserted-by":"crossref","first-page":"40302","DOI":"10.1074\/jbc.M206428200","article-title":"Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2)","volume":"277","author":"Opazo","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.patbio.2013.04.001_bib0335","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/0896-6273(89)90050-0","article-title":"The microtubule binding domain of tau protein","volume":"2","author":"Lee","year":"1989","journal-title":"Neuron"},{"key":"10.1016\/j.patbio.2013.04.001_bib0340","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0165-0173(00)00019-9","article-title":"Tau protein isoforms, phosphorylation and role in neurodegenerative disorders","volume":"33","author":"Bu\u00e9e","year":"2000","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.patbio.2013.04.001_bib0345","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/hmg\/8.4.711","article-title":"Association of an extended haplotype in the tau gene with progressive supranuclear palsy","volume":"8","author":"Baker","year":"1999","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.patbio.2013.04.001_bib0350","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/1531-8249(200003)47:3<374::AID-ANA15>3.0.CO;2-8","article-title":"Corticobasal degeneration shares a common genetic background with progressive supranuclear palsy","volume":"47","author":"Di Maria","year":"2000","journal-title":"Ann Neurol"},{"key":"10.1016\/j.patbio.2013.04.001_bib0355","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1212\/WNL.56.12.1702","article-title":"Corticobasal degeneration and progressive supranuclear palsy share a common tau haplotype","volume":"56","author":"Houlden","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.patbio.2013.04.001_bib0360","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/ana.1159","article-title":"Relationship of the extended tau haplotype to tau biochemistry and neuropathology in progressive supranuclear palsy","volume":"50","author":"Liu","year":"2001","journal-title":"Ann Neurol"},{"key":"10.1016\/j.patbio.2013.04.001_bib0365","doi-asserted-by":"crossref","first-page":"7751","DOI":"10.1073\/pnas.112194599","article-title":"A polymorphic gene nested within an intron of the tau gene: implications for Alzheimer's disease","volume":"99","author":"Conrad","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.patbio.2013.04.001_bib0370","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1056\/NEJM199911253412207","article-title":"Treatment of Alzheimer's disease","volume":"341","author":"Mayeux","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.patbio.2013.04.001_bib0375","doi-asserted-by":"crossref","first-page":"7943","DOI":"10.1073\/pnas.0602860103","article-title":"Another weapon against amyloid","volume":"103","author":"Greenberg","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.patbio.2013.04.001_bib0380","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1056\/NEJMoa1106668","article-title":"Donepezil and memantine for moderate-to-severe Alzheimer's disease","volume":"366","author":"Howard","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.patbio.2013.04.001_bib0385","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0896-6273(00)80115-4","article-title":"M\u00e9canismes of neuronal degeneration in Alzheimer's disease","volume":"16","author":"Yankner","year":"1996","journal-title":"Neuron"}],"container-title":["Pathologie Biologie"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0369811413000825?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0369811413000825?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T19:48:45Z","timestamp":1715975325000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0369811413000825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":77,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0369811413000825"],"URL":"https:\/\/doi.org\/10.1016\/j.patbio.2013.04.001","relation":{},"ISSN":["0369-8114"],"issn-type":[{"value":"0369-8114","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}