{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T08:23:13Z","timestamp":1768551793741,"version":"3.49.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathologie Biologie"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.patbio.2014.07.008","type":"journal-article","created":{"date-parts":[[2014,9,8]],"date-time":"2014-09-08T21:00:04Z","timestamp":1410210004000},"page":"348-353","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Danshensu-mediated protective effect against hepatic fibrosis induced by carbon tetrachloride in rats"],"prefix":"10.1016","volume":"62","author":[{"given":"W.","family":"Qu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.patbio.2014.07.008_bib0005","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.patbio.2014.07.008_bib0010","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1002\/hep.24515","article-title":"Biomarkers of liver fibrosis: what lies beneath the receiver operating characteristic curve?","volume":"54","author":"Guha","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.patbio.2014.07.008_bib0015","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.jhep.2004.08.006","article-title":"Epidemiology of liver disease in cystic fibrosis: a longitudinal study","volume":"41","author":"Lamireau","year":"2004","journal-title":"J Hepatol"},{"key":"10.1016\/j.patbio.2014.07.008_bib0020","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.bbadis.2012.11.002","article-title":"Extracellular matrix degradation in liver fibrosis: biochemistry and regulation","volume":"1832","author":"Iredale","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.patbio.2014.07.008_bib0025","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.5858\/2007-131-1728-HSCALF","article-title":"Hepatic stellate cells and liver fibrosis","volume":"131","author":"Moreira","year":"2007","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.patbio.2014.07.008_bib0030","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/hep.26056","article-title":"Reduced hepatic stellate cell expression of Kruppel-like factor 6 tumor suppressor isoforms amplifies fibrosis during acute and chronic rodent liver injury","volume":"57","author":"Ghiassi-Nejad","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.patbio.2014.07.008_bib0035","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.fct.2013.06.018","article-title":"Nuclear erythroid 2-related factor 2: a novel potential therapeutic target for liver fibrosis","volume":"59","author":"Yang","year":"2013","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.patbio.2014.07.008_bib0040","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.jhep.2012.12.014","article-title":"Progression of liver fibrosis in post-transplant hepatitis C: mechanisms, assessment and treatment","volume":"58","author":"Berenguer","year":"2013","journal-title":"J Hepatol"},{"key":"10.1016\/j.patbio.2014.07.008_bib0045","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ejmech.2012.07.016","article-title":"The synthesis and biological evaluation of novel Danshensu-cysteine analog conjugates as cardiovascular-protective agents","volume":"55","author":"Jia","year":"2012","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.patbio.2014.07.008_bib0050","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ejphar.2010.06.045","article-title":"Danshensu has antitumor activity in B16F10 melanoma by inhibiting angiogenesis and tumor cell invasion","volume":"643","author":"Zhang","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.patbio.2014.07.008_bib0055","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neulet.2013.02.069","article-title":"Danshensu protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebra fish","volume":"543","author":"Chong","year":"2013","journal-title":"Neurosci Lett"},{"issue":"4","key":"10.1016\/j.patbio.2014.07.008_bib0060","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cell.2008.06.049","article-title":"Senescence of activated stellate cells limits liver fibrosis","volume":"134","author":"Krizhanovsky","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.patbio.2014.07.008_bib0065","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.fct.2013.02.051","article-title":"Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-\u03b3 expression and inhibition of PI3K\/Akt pathway","volume":"56","author":"Guo","year":"2013","journal-title":"Food Chem Toxicol"},{"issue":"5","key":"10.1016\/j.patbio.2014.07.008_bib0070","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.autrev.2010.09.015","article-title":"Fibrosis in systemic sclerosis: emerging concepts and implications for targeted therapy","volume":"10","author":"Wei","year":"2011","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.patbio.2014.07.008_bib0075","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.fct.2012.10.059","article-title":"Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function","volume":"52","author":"Li","year":"2013","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.patbio.2014.07.008_bib0080","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1439-0396.2007.00752.x","article-title":"Liver lipid metabolism","volume":"92","author":"Nguyen","year":"2008","journal-title":"J Anim Physiol Anim Nutr (Berl)"},{"key":"10.1016\/j.patbio.2014.07.008_bib0085","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1080\/14767050802211929","article-title":"Liver function test and pregnancy","volume":"22","author":"Jamjute","year":"2009","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.patbio.2014.07.008_bib0090","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/SLA.0b013e31825d5d47","article-title":"Physiological and biochemical basis of clinical liver function tests: a review","volume":"257","author":"Hoekstra","year":"2013","journal-title":"Ann Surg"},{"key":"10.1016\/j.patbio.2014.07.008_bib0095","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1002\/hep.23789","article-title":"Liver enzymes, nonalcoholic fatty liver disease, and incident cardiovascular disease: a narrative review and clinical perspective of prospective data","volume":"52","author":"Ghouri","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.patbio.2014.07.008_bib0100","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1111\/j.1572-0241.1999.01006.x","article-title":"The ratio of aspartate aminotransferase to alanine aminotransferase: potential value in differentiating nonalcoholic steatohepatitis from alcoholic liver disease","volume":"94","author":"Sorbi","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.patbio.2014.07.008_bib0105","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/15216540051081010","article-title":"Oxidative stress, antioxidant defenses, and damage removal, repair, and replacement systems","volume":"50","author":"Davies","year":"2000","journal-title":"IUBMB Life"},{"key":"10.1016\/j.patbio.2014.07.008_bib0110","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1089\/ars.2007.9.49","article-title":"Mechanisms of cell death in oxidative stress","volume":"9","author":"Ryter","year":"2007","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.patbio.2014.07.008_bib0115","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1586\/egh.11.92","article-title":"Update on hepatic stellate cells: pathogenic role in liver fibrosis and novel isolation techniques","volume":"6","author":"Tacke","year":"2012","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.patbio.2014.07.008_bib0120","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1042\/CBI20100321","article-title":"Hepatic stellate cell (vitamin A-storing cell) and its relative\u2014past, present and future","volume":"34","author":"Senoo","year":"2010","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.patbio.2014.07.008_bib0125","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1042\/BJ20040966","article-title":"Uptake of denatured collagen into hepatic stellate cells: evidence for the involvement of urokinase plasminogen activator receptor-associated protein\/Endo180","volume":"387","author":"Mousavi","year":"2005","journal-title":"Biochem J"},{"key":"10.1016\/j.patbio.2014.07.008_bib0130","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1097\/MPG.0b013e3182680be3","article-title":"\u03b1-SMA over-expression associated with increased liver fibrosis in infants with biliary atresia","volume":"55","author":"Dong","year":"2012","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.patbio.2014.07.008_bib0135","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1158\/1078-0432.CCR-12-0284","article-title":"Molecular pathways. Jak\/STAT pathway: mutations, inhibitors, and resistance","volume":"19","author":"Quint\u00e1s-Cardama","year":"2013","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.patbio.2014.07.008_bib0140","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.4049\/jimmunol.178.5.2623","article-title":"The JAK-STAT signaling pathway: input and output integration","volume":"178","author":"Murray","year":"2007","journal-title":"J Immunol"}],"container-title":["Pathologie Biologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0369811414001242?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0369811414001242?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T16:18:17Z","timestamp":1650125897000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0369811414001242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0369811414001242"],"URL":"https:\/\/doi.org\/10.1016\/j.patbio.2014.07.008","relation":{},"ISSN":["0369-8114"],"issn-type":[{"value":"0369-8114","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Danshensu-mediated protective effect against hepatic fibrosis induced by carbon tetrachloride in rats","name":"articletitle","label":"Article Title"},{"value":"Pathologie Biologie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.patbio.2014.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}