{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T03:41:01Z","timestamp":1768448461490,"version":"3.49.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.pathol.2015.11.011","type":"journal-article","created":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T08:23:00Z","timestamp":1450340580000},"page":"35-40","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["EGFR, COX2, p-AKT expression and PIK3CA mutation in distal extrahepatic bile duct carcinoma"],"prefix":"10.1016","volume":"48","author":[{"given":"Ahrim","family":"Moon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susie","family":"Chin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Kyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Ja","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Suk","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youn Wha","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kee-Taek","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pathol.2015.11.011_bib1","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.jhep.2006.09.001","article-title":"Cholangiocarcinoma: modern advances in understanding a deadly old disease","volume":"45","author":"Malhi","year":"2006","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.pathol.2015.11.011_bib2","first-page":"1159","article-title":"Comparison of incidence of intrahepatic and extrahepatic cholangiocarcinoma\u2014focus on East and South-Eastern Asia","volume":"11","author":"Shin","year":"2010","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1016\/j.pathol.2015.11.011_bib3","doi-asserted-by":"crossref","first-page":"G31","DOI":"10.1152\/ajpgi.00536.2002","article-title":"Bile acids activate EGF receptor via a TGF-alpha-dependent mechanism in human cholangiocyte cell lines","volume":"285","author":"Werneburg","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.pathol.2015.11.011_bib4","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1053\/gast.2002.32410","article-title":"Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line","volume":"122","author":"Yoon","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pathol.2015.11.011_bib5","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/hep.20143","article-title":"Celecoxib-induced apoptosis in rat cholangiocarcinoma cells mediated by Akt inactivation and Bax translocation","volume":"39","author":"Zhang","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.pathol.2015.11.011_bib6","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nrc2664","article-title":"Targeting PI3K signalling in cancer: opportunities, challenges and limitations","volume":"9","author":"Engelman","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.pathol.2015.11.011_bib7","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1002\/cncr.25630","article-title":"Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers","volume":"117","author":"Baba","year":"2011","journal-title":"Cancer"},{"key":"10.1016\/j.pathol.2015.11.011_bib8","doi-asserted-by":"crossref","first-page":"6473","DOI":"10.1038\/onc.2008.313","article-title":"PI3K\/Akt: getting it right matters","volume":"27","author":"Franke","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.pathol.2015.11.011_bib9","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/sj.bjc.6604129","article-title":"Clinicopathological and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinoma","volume":"98","author":"Yoshikawa","year":"2008","journal-title":"Br J Cancer"},{"key":"10.1016\/j.pathol.2015.11.011_bib10","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1111\/j.1440-1746.2006.04373.x","article-title":"Akt expression may predict favorable prognosis in cholangiocarcinoma","volume":"21","author":"Javle","year":"2006","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1016\/j.pathol.2015.11.011_bib11","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/path.1779","article-title":"Amplification and overexpression of c-erbB-2, epidermal growth factor receptor, and c-met in biliary tract cancers","volume":"206","author":"Nakazawa","year":"2005","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.pathol.2015.11.011_bib12","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1200\/JCO.2005.05.3579","article-title":"Phase II study of erlotinib in patients with advanced biliary cancer","volume":"24","author":"Philip","year":"2006","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.pathol.2015.11.011_bib13","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000111117","article-title":"Cetuximab plus gemcitabine-oxaliplatin (GEMOX) in patients with refractory advanced intrahepatic cholangiocarcinomas","volume":"72","author":"Paule","year":"2007","journal-title":"Oncology"},{"key":"10.1016\/j.pathol.2015.11.011_bib14","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.humpath.2009.10.002","article-title":"Epidermal growth factor receptor and HER-2\/neu status by immunohistochemistry and fluorescence in situ hybridization in adenocarcinomas of the biliary tree and gallbladder","volume":"41","author":"Shafizadeh","year":"2010","journal-title":"Hum Pathol"},{"key":"10.1016\/j.pathol.2015.11.011_bib15","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1126\/science.1096502","article-title":"High frequency of mutations of the PIK3CA gene in human cancers","volume":"304","author":"Samuels","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.pathol.2015.11.011_bib16","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.prp.2011.10.002","article-title":"Frequency of KRAS, BRAF, and PIK3CA mutations in advanced colorectal cancers: comparison of peptide nucleic acid-mediated PCR clamping and direct sequencing in formalin-fixed, paraffin-embedded tissue","volume":"207","author":"Kwon","year":"2011","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.pathol.2015.11.011_bib17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.biopha.2010.06.009","article-title":"KRAS and PIK3CA but not BRAF genes are frequently mutated in Chinese cholangiocarcinoma patients","volume":"65","author":"Xu","year":"2011","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.pathol.2015.11.011_bib18","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1158\/1078-0432.CCR-08-1084","article-title":"The expression of phospho-AKT, phospho-mTOR, and PTEN in extrahepatic cholangiocarcinoma","volume":"15","author":"Chung","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.pathol.2015.11.011_bib19","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1056\/NEJMc1214189","article-title":"Aspirin, PIK3CA mutation, and colorectal-cancer survival","volume":"368","author":"Ogino","year":"2013","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.pathol.2015.11.011_bib20","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1053\/jhep.2001.28198","article-title":"Differential expression of cyclooxygenase-2 (COX-2) in human bile duct epithelial cells and bile duct neoplasm","volume":"34","author":"Hayashi","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.pathol.2015.11.011_bib21","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/gcc.20540","article-title":"Rare PIK3CA hotspot mutations in carcinomas of the biliary tract","volume":"47","author":"Riener","year":"2008","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.pathol.2015.11.011_bib22","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.humpath.2012.11.006","article-title":"Molecular profiling of cholangiocarcinoma shows potential for targeted therapy treatment decisions","volume":"44","author":"Voss","year":"2013","journal-title":"Hum Pathol"},{"key":"10.1016\/j.pathol.2015.11.011_bib23","first-page":"20","article-title":"Evaluation of phosphatidylinositol-3-kinase catalytic subunit (PIK3CA) and epidermal growth factor receptor (EGFR) gene mutations in pancreaticobiliary adenocarcinoma","volume":"4","author":"Weiss","year":"2013","journal-title":"J\u00a0Gastrointest Oncol"},{"key":"10.1016\/j.pathol.2015.11.011_bib24","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.18632\/oncotarget.1943","article-title":"Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups","volume":"5","author":"Simbolo","year":"2014","journal-title":"Oncotarget"}],"container-title":["Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302515000124?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302515000124?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T23:23:45Z","timestamp":1537140225000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031302515000124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0031302515000124"],"URL":"https:\/\/doi.org\/10.1016\/j.pathol.2015.11.011","relation":{},"ISSN":["0031-3025"],"issn-type":[{"value":"0031-3025","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"EGFR, COX2, p-AKT expression and PIK3CA mutation in distal extrahepatic bile duct carcinoma","name":"articletitle","label":"Article Title"},{"value":"Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pathol.2015.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}