{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:08:24Z","timestamp":1790842104503,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","pathologyjournal.rcpa.edu.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.pathol.2015.11.012","type":"journal-article","created":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T11:31:14Z","timestamp":1450438274000},"page":"30-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Serrated lesions of the appendix in serrated polyposis patients"],"prefix":"10.1016","volume":"48","author":[{"given":"Mark","family":"Bettington","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian S.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Rosty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pathol.2015.11.012_bib1","series-title":"WHO Classification of Tumours of the Digestive System","article-title":"Serrated polyps of the colon and rectum and serrated polyposis","author":"Snover","year":"2010"},{"key":"10.1016\/j.pathol.2015.11.012_bib2","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/his.12055","article-title":"The serrated pathway to colorectal carcinoma: current concepts and challenges","volume":"62","author":"Bettington","year":"2013","journal-title":"Histopathology"},{"key":"10.1016\/j.pathol.2015.11.012_bib3","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00535-012-0720-y","article-title":"Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management","volume":"48","author":"Rosty","year":"2013","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1016\/j.pathol.2015.11.012_bib4","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/modpathol.2014.122","article-title":"A\u00a0clinicopathological and molecular analysis of 200 traditional serrated adenomas","volume":"28","author":"Bettington","year":"2015","journal-title":"Mod Pathol"},{"key":"10.1016\/j.pathol.2015.11.012_bib5","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1097\/01.pas.0000213313.36306.85","article-title":"Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points","volume":"30","author":"O'Brien","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.pathol.2015.11.012_bib6","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1053\/j.gastro.2006.08.038","article-title":"High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy","volume":"131","author":"Spring","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pathol.2015.11.012_bib7","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1097\/PAS.0b013e3181b6da19","article-title":"Beta-catenin nuclear labeling is a common feature of sessile serrated adenomas and correlates with early neoplastic progression after BRAF activation","volume":"33","author":"Yachida","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.pathol.2015.11.012_bib8","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1309\/AJCPVT7LC4CRPZSK","article-title":"Clinicopathologic and genetic characterization of traditional serrated adenomas of the colon","volume":"138","author":"Fu","year":"2012","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.pathol.2015.11.012_bib9","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1097\/PAS.0b013e318224cd2e","article-title":"Molecular features of colorectal hyperplastic polyps and sessile serrated adenoma\/polyps from Korea","volume":"35","author":"Kim","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.pathol.2015.11.012_bib10","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1309\/AJCP1UJPX6UURLCH","article-title":"Serrated lesions of the appendix: a morphologic and immunohistochemical appraisal","volume":"133","author":"Bellizzi","year":"2010","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.pathol.2015.11.012_bib11","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.humpath.2013.10.021","article-title":"Serrated lesions of the appendix frequently harbor KRAS mutations and not BRAF mutations indicating a distinctly different serrated neoplastic pathway in the appendix","volume":"45","author":"Pai","year":"2014","journal-title":"Hum Pathol"},{"key":"10.1016\/j.pathol.2015.11.012_bib12","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1097\/PAS.0b013e31806bee6d","article-title":"A\u00a0comprehensive study of nondysplastic and dysplastic serrated polyps of the vermiform appendix","volume":"31","author":"Yantiss","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.pathol.2015.11.012_bib13","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1136\/gut.2009.200741","article-title":"Increased colorectal cancer risk in first-degree relatives of patients with hyperplastic polyposis syndrome","volume":"59","author":"Boparai","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.pathol.2015.11.012_bib14","doi-asserted-by":"crossref","first-page":"e11636","DOI":"10.1371\/journal.pone.0011636","article-title":"Risk factors for colorectal cancer in patients with multiple serrated polyps: a cross-sectional case series from genetics clinics","volume":"5","author":"Buchanan","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.pathol.2015.11.012_bib15","first-page":"157073","article-title":"Serrated polyposis: an enigmatic model of colorectal cancer predisposition","volume":"2011","author":"Rosty","year":"2011","journal-title":"Patholog Res Int"},{"key":"10.1016\/j.pathol.2015.11.012_bib16","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S1542-3565(04)00673-1","article-title":"Evidence for BRAF mutation and variable levels of microsatellite instability in a syndrome of familial colorectal cancer","volume":"3","author":"Young","year":"2005","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.pathol.2015.11.012_bib17","doi-asserted-by":"crossref","first-page":"543","DOI":"10.2353\/jmoldx.2009.090057","article-title":"A\u00a0multicenter blinded study to evaluate KRAS mutation testing methodologies in the clinical setting","volume":"11","author":"Whitehall","year":"2009","journal-title":"J\u00a0Mol Diagn"},{"key":"10.1016\/j.pathol.2015.11.012_bib18","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/ng1834","article-title":"CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer","volume":"38","author":"Weisenberger","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.pathol.2015.11.012_bib19","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1002\/1097-0142(197312)32:6<1525::AID-CNCR2820320632>3.0.CO;2-C","article-title":"Mucosal hyperplasia, mucinous cystadenoma, and mucinous cystadenocarcinoma of the appendix. A re-evaluation of appendiceal \u201cmucocele\u201d","volume":"32","author":"Higa","year":"1973","journal-title":"Cancer"},{"key":"10.1016\/j.pathol.2015.11.012_bib20","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1136\/jcp.25.9.809","article-title":"Mucosal metaplasia in the appendix","volume":"25","author":"MacGillivray","year":"1972","journal-title":"J\u00a0Clin Pathol"},{"key":"10.1016\/j.pathol.2015.11.012_bib21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1365-2559.1995.tb00617.x","article-title":"Association between mucosal hyperplasia of the appendix and adenocarcinoma of the colon","volume":"26","author":"Younes","year":"1995","journal-title":"Histopathology"},{"key":"10.1016\/j.pathol.2015.11.012_bib22","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1136\/jcp.2004.018317","article-title":"Serrated adenomas of the appendix","volume":"57","author":"Rubio","year":"2004","journal-title":"J\u00a0Clin Pathol"},{"key":"10.1016\/j.pathol.2015.11.012_bib23","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1097\/PAS.0b013e318282649b","article-title":"High-level microsatellite instability in appendiceal carcinomas","volume":"37","author":"Taggart","year":"2013","journal-title":"Am J Surg Pathol"}],"container-title":["Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302515000136?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302515000136?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T16:20:23Z","timestamp":1758471623000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031302515000136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0031302515000136"],"URL":"https:\/\/doi.org\/10.1016\/j.pathol.2015.11.012","relation":{},"ISSN":["0031-3025"],"issn-type":[{"value":"0031-3025","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serrated lesions of the appendix in serrated polyposis patients","name":"articletitle","label":"Article Title"},{"value":"Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pathol.2015.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}