{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:56:03Z","timestamp":1790733363743,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","pathologyjournal.rcpa.edu.au","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.pathol.2016.11.008","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T06:46:31Z","timestamp":1488869191000},"page":"285-291","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Detection of copy number variations in melanocytic lesions utilising array based comparative genomic hybridisation"],"prefix":"10.1016","volume":"49","author":[{"given":"Nima","family":"Mesbah Ardakani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleo","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kym","family":"Mina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan Tobias","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benhur","family":"Amanuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin Andrew","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pathol.2016.11.008_bib1","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1200\/JCO.1996.14.4.1218","article-title":"Interobserver variability on the histopathologic diagnosis of cutaneous melanoma and other pigmented skin lesions","volume":"14","author":"Corona","year":"1996","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.pathol.2016.11.008_bib2","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/S0046-8177(96)90157-4","article-title":"Discordance in the histopathologic diagnosis of melanoma and melanocytic nevi between expert pathologists","volume":"27","author":"Farmer","year":"1996","journal-title":"Hum Pathol"},{"key":"10.1016\/j.pathol.2016.11.008_bib3","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1001\/archderm.138.5.617","article-title":"Pathology review of cases presenting to a multidisciplinary pigmented lesion clinic","volume":"138","author":"McGinnis","year":"2002","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.pathol.2016.11.008_bib4","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/PAS.0b013e31823836bb","article-title":"Trends in pathology malpractice claims","volume":"36","author":"Troxel","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.pathol.2016.11.008_bib5","first-page":"2170","article-title":"Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization","volume":"58","author":"Bastian","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/j.pathol.2016.11.008_bib6","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/S0002-9440(10)63536-5","article-title":"Classifying melanocytic tumors based on DNA copy number changes","volume":"163","author":"Bastian","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.pathol.2016.11.008_bib7","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/PAS.0b013e31820393ee","article-title":"Copy number variations and clinical outcome in atypical spitz tumors","volume":"35","author":"Raskin","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.pathol.2016.11.008_bib8","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature12477","article-title":"Signatures of mutational processes in human cancer","volume":"500","author":"Alexandrov","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.pathol.2016.11.008_bib9","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1097\/PAS.0b013e3181a1ef36","article-title":"Fluorescence in situ hybridization (FISH) as an ancillary diagnostic tool in the diagnosis of melanoma","volume":"33","author":"Gerami","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.pathol.2016.11.008_bib10","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.jmoldx.2013.04.001","article-title":"A\u00a0genome-wide high-resolution array-CGH analysis of cutaneous melanoma and comparison of array-CGH to FISH in diagnostic evaluation","volume":"15","author":"Wang","year":"2013","journal-title":"J\u00a0Mol Diagn"},{"key":"10.1016\/j.pathol.2016.11.008_bib11","doi-asserted-by":"crossref","first-page":"830","DOI":"10.5858\/2011-0048-RAIR.1","article-title":"Update on fluorescence in situ hybridization in melanoma: state of the art","volume":"135","author":"Gerami","year":"2011","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.pathol.2016.11.008_bib12","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/PAS.0b013e31822d5ff8","article-title":"Enhanced detection of spitzoid melanomas using fluorescence in situ hybridization with 9p21 as an adjunctive probe","volume":"36","author":"Gammon","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.pathol.2016.11.008_bib13","doi-asserted-by":"crossref","first-page":"D986","DOI":"10.1093\/nar\/gkt958","article-title":"The Database of Genomic Variants: a curated collection of structural variation in the human genome","volume":"42","author":"MacDonald","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.pathol.2016.11.008_bib14","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.cell.2015.05.044","article-title":"Genomic classification of cutaneous melanoma","volume":"161","author":"Cancer Genome Atlas Network","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.pathol.2016.11.008_bib15","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/gm62","article-title":"Copy number variations and cancer","volume":"1","author":"Shlien","year":"2009","journal-title":"Genome Med"},{"key":"10.1016\/j.pathol.2016.11.008_bib16","first-page":"1968","article-title":"Gene amplifications characterize acral melanoma and permit the detection of occult tumor cells in the surrounding skin","volume":"60","author":"Bastian","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.pathol.2016.11.008_bib17","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1056\/NEJMoa050092","article-title":"Distinct sets of genetic alterations in melanoma","volume":"353","author":"Curtin","year":"2005","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.pathol.2016.11.008_bib18","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/00008390-200108000-00005","article-title":"Heterogeneity of allelic deletions within melanoma metastases","volume":"11","author":"Bogdan","year":"2001","journal-title":"Melanoma Res"},{"key":"10.1016\/j.pathol.2016.11.008_bib19","first-page":"593","article-title":"Correlating array comparative genomic hybridization findings with histology and outcome in spitzoid melanocytic neoplasms","volume":"3","author":"Ali","year":"2010","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.pathol.2016.11.008_bib20","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fmed.2014.00039","article-title":"Update on molecular pathology of cutaneous melanocytic lesions: What is new in diagnosis and molecular testing for treatment?","volume":"1","author":"van Engen-van Grunsven","year":"2014","journal-title":"Front Med"},{"key":"10.1016\/j.pathol.2016.11.008_bib21","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1097\/PAS.0b013e3181f0a749","article-title":"HRAS-mutated Spitz tumors: a subtype of Spitz tumors with distinct features","volume":"34","author":"Van Engen-van Grunsven","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.pathol.2016.11.008_bib22","doi-asserted-by":"crossref","first-page":"7174","DOI":"10.1038\/ncomms8174","article-title":"Activating MET kinase rearrangements in melanoma and Spitz tumours","volume":"6","author":"Yeh","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.pathol.2016.11.008_bib23","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1097\/PAS.0000000000000187","article-title":"Clinical and pathologic findings of Spitz nevi and atypical spitz tumors with ALK fusions","volume":"38","author":"Busam","year":"2014","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.pathol.2016.11.008_bib24","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1038\/ncomms4116","article-title":"Kinase fusions are frequent in Spitz tumours and spitzoid melanomas","volume":"5","author":"Wiesner","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.pathol.2016.11.008_bib25","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/PAS.0000000000000387","article-title":"Clinical, histopathologic, and genomic features of spitz tumors with ALK fusions","volume":"39","author":"Yeh","year":"2015","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.pathol.2016.11.008_bib26","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1111\/pcmr.12148","article-title":"Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy","volume":"26","author":"Botton","year":"2013","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.pathol.2016.11.008_bib27","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1056\/NEJMoa1502583","article-title":"The genetic evolution of melanoma from precursor lesions","volume":"373","author":"Shain","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.pathol.2016.11.008_bib28","doi-asserted-by":"crossref","first-page":"e29336","DOI":"10.1371\/journal.pone.0029336","article-title":"Intra-and inter-tumor heterogeneity of BRAF (V600E) mutations in primary and metastatic melanoma","volume":"7","author":"Yancovitz","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.pathol.2016.11.008_bib29","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/PAS.0000000000000568","article-title":"Melanomas associated with blue nevi or mimicking cellular blue nevi: clinical, pathologic, and molecular study of 11 cases displaying a high frequency of GNA11 mutations, BAP1 expression loss, and a predilection for the scalp","volume":"40","author":"Costa","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.pathol.2016.11.008_bib30","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1136\/bjophthalmol-2013-303867","article-title":"Genome-wide profiling is a clinically relevant and affordable prognostic test in posterior uveal melanoma","volume":"98","author":"Cassoux","year":"2014","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.pathol.2016.11.008_bib31","first-page":"313","article-title":"Concomitant loss of chromosome 3 and whole arm losses and gains of chromosome 1, 6, or 8 in metastasizing primary uveal melanoma","volume":"42","author":"Aalto","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.pathol.2016.11.008_bib32","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1158\/0008-5472.CAN-12-0928","article-title":"Chromothripsis and focal copy number alterations determine poor outcome in malignant melanoma","volume":"73","author":"Hirsch","year":"2013","journal-title":"Cancer Res"}],"container-title":["Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302516402941?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302516402941?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T10:14:25Z","timestamp":1658744065000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031302516402941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S0031302516402941"],"URL":"https:\/\/doi.org\/10.1016\/j.pathol.2016.11.008","relation":{},"ISSN":["0031-3025"],"issn-type":[{"value":"0031-3025","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Detection of copy number variations in melanocytic lesions utilising array based comparative genomic hybridisation","name":"articletitle","label":"Article Title"},{"value":"Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pathol.2016.11.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2017 Published by Elsevier B.V. on behalf of Royal College of Pathologists of Australasia. All rights reserved.","name":"copyright","label":"Copyright"}]}}