{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T05:50:46Z","timestamp":1763358646177},"reference-count":121,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","pathologyjournal.rcpa.edu.au","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.pathol.2017.07.008","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T19:11:59Z","timestamp":1507835519000},"page":"707-714","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Insights into the molecular roles of Zika virus in human reproductive complications and congenital neuropathologies"],"prefix":"10.1016","volume":"49","author":[{"given":"Rajendra","family":"Gharbaran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Latchman","family":"Somenarain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pathol.2017.07.008_bib1","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1056\/NEJMoa1601824","article-title":"Zika virus infection with prolonged maternal viremia and fetal brain abnormalities","volume":"374","author":"Driggers","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.pathol.2017.07.008_bib2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0035-9203(54)90006-1","article-title":"Zika virus: a report on three cases of human infection during an epidemic of jaundice in Nigeria","volume":"48","author":"Macnamara","year":"1954","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.pathol.2017.07.008_bib3","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/0035-9203(56)90090-6","article-title":"Zika virus infection experimentally induced in a human volunteer","volume":"50","author":"Bearcroft","year":"1956","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.pathol.2017.07.008_bib4","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0035-9203(64)90201-9","article-title":"Zika virus infection in man","volume":"58","author":"Simpson","year":"1964","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.pathol.2017.07.008_bib5","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1056\/NEJMoa0805715","article-title":"Zika virus outbreak on Yap island, Federated States of Micronesia","volume":"360","author":"Duffy","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.pathol.2017.07.008_bib6","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0140-6736(16)00320-2","article-title":"Zika virus and microcephaly: why is this situation a PHEIC?","volume":"387","author":"Heymann","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.pathol.2017.07.008_bib7","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.00500-14","article-title":"Complete coding sequence of zika virus from a French Polynesia outbreak in 2013","volume":"2","author":"Baronti","year":"2014","journal-title":"Genome Announc"},{"key":"10.1016\/j.pathol.2017.07.008_bib8","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1067\/mpd.2001.115314","article-title":"Congenital microcephaly: phenotypic features in a consecutive sample of newborn infants","volume":"139","author":"Vargas","year":"2001","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.pathol.2017.07.008_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5935\/0004-2749.20160002","article-title":"Ophthalmological findings in infants with microcephaly and presumable intra-uterus Zika virus infection","volume":"79","author":"Ventura","year":"2016","journal-title":"Arq Bras Oftalmol"},{"key":"10.1016\/j.pathol.2017.07.008_bib10","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0140-6736(16)00006-4","article-title":"Zika virus in Brazil and macular atrophy in a child with microcephaly","volume":"387","author":"Ventura","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.pathol.2017.07.008_bib11","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0140-6736(16)00339-1","article-title":"Guillain-Barre syndrome","volume":"388","author":"Willison","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.pathol.2017.07.008_bib12","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1056\/NEJMoa1605564","article-title":"Guillain-Barre syndrome associated with Zika virus infection in Colombia","volume":"375","author":"Parra","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.pathol.2017.07.008_bib13","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nrneurol.2014.121","article-title":"Guillain-Barre syndrome: pathogenesis, diagnosis, treatment and prognosis","volume":"10","author":"van den Berg","year":"2014","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.pathol.2017.07.008_bib14","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.conb.2004.01.003","article-title":"Human microcephaly","volume":"14","author":"Woods","year":"2004","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.pathol.2017.07.008_bib15","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1136\/archdischild-2012-302882","article-title":"Investigating microcephaly","volume":"98","author":"Woods","year":"2013","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.pathol.2017.07.008_bib16","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.bbrc.2006.05.040","article-title":"Molecular genetic determinants of human brain size","volume":"345","author":"Tang","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.pathol.2017.07.008_bib17","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/547986","article-title":"Molecular and cellular basis of autosomal recessive primary microcephaly","volume":"2014","author":"Barbelanne","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.pathol.2017.07.008_bib18","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.clp.2014.11.001","article-title":"TORCH infections","volume":"42","author":"Neu","year":"2015","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.pathol.2017.07.008_bib19","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.ijpara.2009.02.004","article-title":"Toxoplasmosis: a history of clinical observations","volume":"39","author":"Weiss","year":"2009","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.pathol.2017.07.008_bib20","first-page":"397","article-title":"Viral molecular characterization of the first congenital rubella syndrome case in Vietnam","volume":"57","author":"Tran","year":"2011","journal-title":"Clin Lab"},{"key":"10.1016\/j.pathol.2017.07.008_bib21","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/NEN.0000000000000038","article-title":"Cytomegalovirus-induced brain malformations in fetuses","volume":"73","author":"Teissier","year":"2014","journal-title":"J\u00a0Neuropathol Exp Neurol"},{"key":"10.1016\/j.pathol.2017.07.008_bib22","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1111\/j.1755-3768.1979.tb00543.x","article-title":"Chorioretinitis of the newborn with herpes simplex virus type 1. Report of a case","volume":"57","author":"Reersted","year":"1979","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.pathol.2017.07.008_bib23","doi-asserted-by":"crossref","first-page":"242","DOI":"10.15585\/mmwr.mm6509e2","article-title":"Increase in reported prevalence of microcephaly in infants born to women living in areas with confirmed Zika Virus transmission during the first trimester of pregnancy - Brazil, 2015","volume":"65","author":"Kleber de Oliveira","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.pathol.2017.07.008_bib24","doi-asserted-by":"crossref","first-page":"59","DOI":"10.15585\/mmwr.mm6503e2","article-title":"Possible association between Zika virus infection and microcephaly - Brazil, 2015","volume":"65","author":"Schuler-Faccini","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.pathol.2017.07.008_bib25","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1056\/NEJMoa1602412","article-title":"Zika virus infection in pregnant women in Rio de Janeiro","volume":"375","author":"Brasil","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.pathol.2017.07.008_bib26","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.coviro.2016.04.002","article-title":"Zika crisis in Brazil: challenges in research and development","volume":"18","author":"Ribeiro","year":"2016","journal-title":"Curr Opin Virol"},{"key":"10.1016\/j.pathol.2017.07.008_bib27","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.3201\/eid1509.090442","article-title":"Zika virus outside Africa","volume":"15","author":"Hayes","year":"2009","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.pathol.2017.07.008_bib28","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3201\/eid1705.101939","article-title":"Probable non-vector-borne transmission of Zika virus, Colorado, USA","volume":"17","author":"Foy","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.pathol.2017.07.008_bib29","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S1473-3099(16)00095-5","article-title":"Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study","volume":"16","author":"Calvet","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.pathol.2017.07.008_bib30","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES2014.19.14.20761","article-title":"Potential for Zika virus transmission through blood transfusion demonstrated during an outbreak in French Polynesia, November 2013 to February 2014","volume":"19","author":"Musso","year":"2014","journal-title":"Euro Surveill"},{"key":"10.1016\/j.pathol.2017.07.008_bib31","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jcv.2015.04.021","article-title":"Detection of Zika virus in saliva","volume":"68","author":"Musso","year":"2015","journal-title":"J\u00a0Clin Virol"},{"key":"10.1016\/j.pathol.2017.07.008_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jmv.24696","article-title":"Potential use of saliva samples to diagnose Zika virus infection","volume":"89","author":"Tauro","year":"2017","journal-title":"J\u00a0Med Virol"},{"key":"10.1016\/j.pathol.2017.07.008_bib33","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1016\/j.ejim.2016.04.022","article-title":"Zika virus in saliva-New challenges for prevention of human to human transmission","volume":"33","author":"Liuzzi","year":"2016","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.pathol.2017.07.008_bib34","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S1473-3099(16)30070-6","article-title":"Excretion of infectious Zika virus in urine","volume":"16","author":"Zhang","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.pathol.2017.07.008_bib35","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0140-6736(16)00624-3","article-title":"Infectious Zika viral particles in breastmilk","volume":"387","author":"Dupont-Rouzeyrol","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.pathol.2017.07.008_bib36","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3201\/eid2304.161692","article-title":"Presence and persistence of Zika virus RNA in semen, United Kingdom, 2016","volume":"23","author":"Atkinson","year":"2017","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.pathol.2017.07.008_bib37","article-title":"Infection dynamics in a traveller with persistent shedding of Zika virus RNA in semen for six months after returning from Haiti to Italy, January 2016","volume":"21","author":"Barzon","year":"2016","journal-title":"Euro Surveill"},{"key":"10.1016\/j.pathol.2017.07.008_bib38","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nature.2016.19502","article-title":"First Zika-linked birth defects detected in Colombia","volume":"531","author":"Butler","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.pathol.2017.07.008_bib39","doi-asserted-by":"crossref","first-page":"211","DOI":"10.15585\/mmwr.mm6508e1","article-title":"Zika virus infection among US pregnant travelers - August 2015-February 2016","volume":"65","author":"Meaney-Delman","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.pathol.2017.07.008_bib40","doi-asserted-by":"crossref","first-page":"159","DOI":"10.15585\/mmwr.mm6506e1","article-title":"Notes from the field: evidence of Zika virus infection in brain and placental tissues from two congenitally infected newborns and two fetal losses \u2013 Brazil, 2015","volume":"65","author":"Martines","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.pathol.2017.07.008_bib41","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2016.21.24.30261","article-title":"Confirmed case of Zika virus congenital infection, Spain, March 2016","volume":"21","author":"Perez","year":"2016","journal-title":"Euro Surveill"},{"key":"10.1016\/j.pathol.2017.07.008_bib42","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1590\/0074-02760160085","article-title":"Zika virus damages the human placental barrier and presents marked fetal neurotropism","volume":"111","author":"Noronha","year":"2016","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.pathol.2017.07.008_bib43","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/S0140-6736(16)30253-7","article-title":"Positive IgM for Zika virus in the cerebrospinal fluid of 30 neonates with microcephaly in Brazil","volume":"387","author":"Cordeiro","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.pathol.2017.07.008_bib44","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1001\/jamapediatrics.2016.2974","article-title":"Estimating the number of pregnant women infected with Zika virus and expected infants with microcephaly following the Zika virus outbreak in Puerto Rico","volume":"170","author":"Ellington","year":"2016","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.pathol.2017.07.008_bib45","article-title":"Microcephaly risk with Zika infection is 1\u201313% in first trimester, study shows","volume":"353","author":"McCarthy","year":"2016","journal-title":"BMJ"},{"key":"10.1016\/j.pathol.2017.07.008_bib46","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1016\/S0140-6736(16)00651-6","article-title":"Association between Zika virus and microcephaly in French Polynesia, 2013-15: a retrospective study","volume":"387","author":"Cauchemez","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.pathol.2017.07.008_bib47","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1093\/cid\/ciw613","article-title":"Fetal infection by Zika virus in the third trimester - report of 2 cases","volume":"63","author":"Soares de Souza","year":"2016","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.pathol.2017.07.008_bib48","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s00381-016-3074-6","article-title":"Microcephaly and Zika virus: neonatal neuroradiological aspects","volume":"32","author":"Cavalheiro","year":"2016","journal-title":"Childs Nerv Syst"},{"key":"10.1016\/j.pathol.2017.07.008_bib49","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1148\/radiol.2016161584","article-title":"Congenital brain abnormalities and Zika virus: what the radiologist can expect to see prenatally and postnatally","volume":"281","author":"Soares de Oliveira-Szejnfeld","year":"2016","journal-title":"Radiology"},{"key":"10.1016\/j.pathol.2017.07.008_bib50","article-title":"Clinical features and neuroimaging (CT and MRI) findings in presumed Zika virus related congenital infection and microcephaly: retrospective case series study","volume":"353","author":"de Fatima Vasco Aragao","year":"2016","journal-title":"BMJ"},{"key":"10.1016\/j.pathol.2017.07.008_bib51","doi-asserted-by":"crossref","first-page":"68","DOI":"10.5858\/arpa.2016-0343-OA","article-title":"Autopsy and postmortem studies are concordant: pathology of Zika virus infection is neurotropic in fetuses and infants with microcephaly following transplacental transmission","volume":"141","author":"Schwartz","year":"2017","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.pathol.2017.07.008_bib52","doi-asserted-by":"crossref","first-page":"917","DOI":"10.15585\/mmwr.mm6534e3","article-title":"Hearing loss in infants with microcephaly and evidence of congenital Zika virus infection - Brazil, November 2015-May 2016","volume":"65","author":"Leal","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.pathol.2017.07.008_bib53","first-page":"79","article-title":"Guillain-Barre syndrome presenting as facial diplegia","volume":"129","author":"Singh","year":"2016","journal-title":"NZ Med J"},{"key":"10.1016\/j.pathol.2017.07.008_bib54","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S1474-4422(13)70150-9","article-title":"Neurological complications of dengue virus infection","volume":"12","author":"Carod-Artal","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.pathol.2017.07.008_bib55","doi-asserted-by":"crossref","first-page":"8880","DOI":"10.1128\/JVI.00354-15","article-title":"Biology of Zika virus infection in human skin cells","volume":"89","author":"Hamel","year":"2015","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.pathol.2017.07.008_bib56","series-title":"Heat shock protein 70 (Hsp70) is involved in the Zika virus cellular infection process","author":"Pujhari","year":"2017"},{"key":"10.1016\/j.pathol.2017.07.008_bib57","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1089\/dna.2016.3404","article-title":"Mechanisms of Zika virus infection and neuropathogenesis","volume":"35","author":"Olagnier","year":"2016","journal-title":"DNA Cell Biol"},{"key":"10.1016\/j.pathol.2017.07.008_bib58","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.stem.2016.11.011","article-title":"Genetic ablation of AXL does not protect human neural progenitor cells and cerebral organoids from Zika virus infection","volume":"19","author":"Wells","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.pathol.2017.07.008_bib59","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.1016\/j.celrep.2016.08.079","article-title":"Zika virus infection in mice causes panuveitis with shedding of virus in tears","volume":"16","author":"Miner","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.pathol.2017.07.008_bib60","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1016\/j.celrep.2016.08.038","article-title":"Zika virus disrupts phospho-TBK1 localization and mitosis in human neuroepithelial stem cells and radial glia","volume":"16","author":"Onorati","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.pathol.2017.07.008_bib61","doi-asserted-by":"crossref","first-page":"20014","DOI":"10.1074\/jbc.M112.438895","article-title":"Exosomes derived from HIV-1-infected cells contain trans-activation response element RNA","volume":"288","author":"Narayanan","year":"2013","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.pathol.2017.07.008_bib62","doi-asserted-by":"crossref","first-page":"13109","DOI":"10.1073\/pnas.1221899110","article-title":"Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells","volume":"110","author":"Ramakrishnaiah","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.pathol.2017.07.008_bib63","doi-asserted-by":"crossref","first-page":"22284","DOI":"10.1074\/jbc.M114.549659","article-title":"Human T-lymphotropic virus type 1-infected cells secrete exosomes that contain Tax protein","volume":"289","author":"Jaworski","year":"2014","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.pathol.2017.07.008_bib64","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/cmi.12339","article-title":"IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infection","volume":"17","author":"Zhu","year":"2015","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.pathol.2017.07.008_bib65","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/cr.2015.29","article-title":"Heparanase activates the syndecan-syntenin-ALIX exosome pathway","volume":"25","author":"Roucourt","year":"2015","journal-title":"Cell Res"},{"key":"10.1016\/j.pathol.2017.07.008_bib66","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/ncb2502","article-title":"Syndecan-syntenin-ALIX regulates the biogenesis of exosomes","volume":"14","author":"Baietti","year":"2012","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.pathol.2017.07.008_bib67","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/pd.2908","article-title":"Evaluation of placental syndecan-1 expression in early pregnancy as a predictive fetal factor for pregnancy outcome","volume":"32","author":"Schmedt","year":"2012","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.pathol.2017.07.008_bib68","unstructured":"Linscheid CR, Petroff MG. Characterization of trophoblast-derived microparticles and their effects on the maternal immune system. Society for Reproductive Investigation, 62nd Annual Scientific Meeting, March 25\u201328, 2015. Late Breaking Abstracts. https:\/\/www.sri-online.org\/UserFiles\/file\/SRI15_Abstracts_LB_Final.pdf."},{"key":"10.1016\/j.pathol.2017.07.008_bib69","doi-asserted-by":"crossref","first-page":"12048","DOI":"10.1073\/pnas.1304718110","article-title":"Human placental trophoblasts confer viral resistance to recipient cells","volume":"110","author":"Delorme-Axford","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.pathol.2017.07.008_bib70","doi-asserted-by":"crossref","first-page":"4893","DOI":"10.2147\/IJN.S70999","article-title":"Neural stem cell-derived exosomes mediate viral entry","volume":"9","author":"Sims","year":"2014","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.pathol.2017.07.008_bib71","doi-asserted-by":"crossref","first-page":"8610","DOI":"10.1093\/nar\/gkw765","article-title":"Molecular signatures associated with ZIKV exposure in human cortical neural progenitors","volume":"44","author":"Zhang","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.pathol.2017.07.008_bib72","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.stem.2016.04.014","article-title":"Zika virus depletes neural progenitors in human cerebral organoids through activation of the innate immune receptor TLR3","volume":"19","author":"Dang","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.pathol.2017.07.008_bib73","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.stem.2016.07.019","article-title":"Zika virus NS4A and NS4B proteins deregulate Akt-mTOR signaling in human fetal neural stem cells to inhibit neurogenesis and induce autophagy","volume":"19","author":"Liang","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.pathol.2017.07.008_bib74","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.15252\/embr.201642627","article-title":"Zika virus inhibits type-I interferon production and downstream signaling","volume":"17","author":"Kumar","year":"2016","journal-title":"EMBO Rep"},{"key":"10.1016\/j.pathol.2017.07.008_bib75","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1128\/MCB.15.3.1312","article-title":"Role of STAT2 in the alpha interferon signaling pathway","volume":"15","author":"Leung","year":"1995","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.pathol.2017.07.008_bib76","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.chom.2016.05.009","article-title":"Zika virus targets human STAT2 to inhibit type I interferon signaling","volume":"19","author":"Grant","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pathol.2017.07.008_bib77","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1056\/NEJMoa1600651","article-title":"Zika virus associated with microcephaly","volume":"374","author":"Mlakar","year":"2016","journal-title":"N\u00a0Engl J Med"},{"issue":"Suppl 6","key":"10.1016\/j.pathol.2017.07.008_bib78","first-page":"59","article-title":"Angiogenesis and implantation","volume":"15","author":"Smith","year":"2000","journal-title":"Hum Reprod"},{"key":"10.1016\/j.pathol.2017.07.008_bib79","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/imm.12218","article-title":"The up side of decidual natural killer cells: new developments in immunology of pregnancy","volume":"141","author":"Jabrane-Ferrat","year":"2014","journal-title":"Immunology"},{"key":"10.1016\/j.pathol.2017.07.008_bib80","doi-asserted-by":"crossref","first-page":"35296","DOI":"10.1038\/srep35296","article-title":"ZIKA virus reveals broad tissue and cell tropism during the first trimester of pregnancy","volume":"6","author":"El Costa","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.pathol.2017.07.008_bib81","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1749-6632.2001.tb03798.x","article-title":"The mechanisms of placental viral infection","volume":"943","author":"Koi","year":"2001","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.pathol.2017.07.008_bib82","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0140-6736(07)61515-3","article-title":"H5N1 infection of the respiratory tract and beyond: a molecular pathology study","volume":"370","author":"Gu","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.pathol.2017.07.008_bib83","first-page":"1019","article-title":"Coxsackie virus infection of the placenta associated with neurodevelopmental delays in the newborn","volume":"98","author":"Euscher","year":"2001","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.pathol.2017.07.008_bib84","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1093\/infdis\/141.6.712","article-title":"Transplacental infection with Japanese encephalitis virus","volume":"141","author":"Chaturvedi","year":"1980","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.pathol.2017.07.008_bib85","first-page":"e1","article-title":"Comparison of presentation, course, and outcome of congenital and acquired cytomegalovirus infection in twins","volume":"6","author":"Samedi","year":"2016","journal-title":"AJP Rep"},{"key":"10.1016\/j.pathol.2017.07.008_bib86","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1542\/peds.76.1.64","article-title":"Coxsackievirus group B antibodies in the ventricular fluid of infants with severe anatomic defects in the central nervous system","volume":"76","author":"Gauntt","year":"1985","journal-title":"Pediatrics"},{"key":"10.1016\/j.pathol.2017.07.008_bib87","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.chom.2016.03.008","article-title":"Type III interferons produced by human placental trophoblasts confer protection against Zika virus infection","volume":"19","author":"Bayer","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pathol.2017.07.008_bib88","article-title":"Characterization of lethal Zika virus infection in AG129 mice","volume":"10","author":"Aliota","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.pathol.2017.07.008_bib89","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.chom.2016.03.010","article-title":"A\u00a0mouse model of Zika virus pathogenesis","volume":"19","author":"Lazear","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pathol.2017.07.008_bib90","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.4269\/ajtmh.16-0111","article-title":"Characterization of a novel murine model to study Zika virus","volume":"94","author":"Rossi","year":"2016","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.pathol.2017.07.008_bib91","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.stem.2016.06.009","article-title":"Modeling Zika virus infection in mice","volume":"19","author":"Rossi","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.pathol.2017.07.008_bib92","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.cell.2016.05.008","article-title":"Zika virus infection during pregnancy in mice causes placental damage and fetal demise","volume":"165","author":"Miner","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.pathol.2017.07.008_bib93","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/aji.12578","article-title":"HSV-2 enhances ZIKV infection of the placenta and induces apoptosis in first-trimester trophoblast cells","volume":"76","author":"Aldo","year":"2016","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.pathol.2017.07.008_bib94","doi-asserted-by":"crossref","first-page":"43","DOI":"10.5858\/arpa.2016-0401-OA","article-title":"Placental pathology of Zika virus: viral infection of the placenta induces villous stromal macrophage (Hofbauer cell) proliferation and hyperplasia","volume":"141","author":"Rosenberg","year":"2017","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.pathol.2017.07.008_bib95","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.chom.2016.07.002","article-title":"Zika virus targets different primary human placental cells, suggesting two routes for vertical transmission","volume":"20","author":"Tabata","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pathol.2017.07.008_bib96","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ijid.2016.08.023","article-title":"Higher incidence of Zika in adult women than adult men in Rio de Janeiro suggests a significant contribution of sexual transmission from men to women","volume":"51","author":"Coelho","year":"2016","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.pathol.2017.07.008_bib97","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S1473-3099(16)30336-X","article-title":"Zika virus in semen and spermatozoa","volume":"16","author":"Mansuy","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.pathol.2017.07.008_bib98","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/19554","article-title":"Tyro-3 family receptors are essential regulators of mammalian spermatogenesis","volume":"398","author":"Lu","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.pathol.2017.07.008_bib99","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1530\/REP-09-0101","article-title":"Functions of TAM RTKs in regulating spermatogenesis and male fertility in mice","volume":"138","author":"Chen","year":"2009","journal-title":"Reproduction"},{"key":"10.1016\/j.pathol.2017.07.008_bib100","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nature20556","article-title":"Zika virus infection damages the testes in mice","volume":"540","author":"Govero","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.pathol.2017.07.008_bib101","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.cell.2017.01.009","article-title":"Zika virus causes testis damage and leads to male infertility in mice","volume":"168","author":"Ma","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.pathol.2017.07.008_bib102","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3201\/eid2102.141363","article-title":"Potential sexual transmission of Zika virus","volume":"21","author":"Musso","year":"2015","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.pathol.2017.07.008_bib103","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.cell.2016.08.004","article-title":"Vaginal exposure to Zika virus during pregnancy leads to fetal brain infection","volume":"166","author":"Yockey","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.pathol.2017.07.008_bib104","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/S1473-3099(16)30387-5","article-title":"Zika virus in the female genital tract","volume":"16","author":"Visseaux","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.pathol.2017.07.008_bib105","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.3201\/eid2212.161280","article-title":"Zika virus infection in the central nervous system and female genital tract","volume":"22","author":"Nicastri","year":"2016","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.pathol.2017.07.008_bib106","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/S1473-3099(16)30193-1","article-title":"Zika virus in the female genital tract","volume":"16","author":"Prisant","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.pathol.2017.07.008_bib107","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF01249709","article-title":"Zika virus infection of the central nervous system of mice","volume":"35","author":"Bell","year":"1971","journal-title":"Arch Gesamte Virusforsch"},{"key":"10.1016\/j.pathol.2017.07.008_bib108","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.stem.2016.03.012","article-title":"Expression analysis highlights AXL as a candidate Zika virus entry receptor in neural stem cells","volume":"18","author":"Nowakowski","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.pathol.2017.07.008_bib109","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.stem.2016.04.017","article-title":"Zika virus disrupts neural progenitor development and leads to microcephaly in mice","volume":"19","author":"Li","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.pathol.2017.07.008_bib110","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.stem.2016.02.016","article-title":"Zika virus infects human cortical neural progenitors and attenuates their growth","volume":"18","author":"Tang","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.pathol.2017.07.008_bib111","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/wdev.89","article-title":"Genetic causes of microcephaly and lessons for neuronal development","volume":"2","author":"Gilmore","year":"2013","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"key":"10.1016\/j.pathol.2017.07.008_bib112","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/cr.2016.58","article-title":"Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice","volume":"26","author":"Wu","year":"2016","journal-title":"Cell Res"},{"key":"10.1016\/j.pathol.2017.07.008_bib113","doi-asserted-by":"crossref","DOI":"10.1038\/srep39775","article-title":"Zika virus infection induces mitosis abnormalities and apoptotic cell death of human neural progenitor cells","volume":"6","author":"Souza","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.pathol.2017.07.008_bib114","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.autrev.2016.03.020","article-title":"Zika virus and autoimmunity: from microcephaly to Guillain-Barre syndrome, and beyond","volume":"15","author":"Lucchese","year":"2016","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.pathol.2017.07.008_bib115","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.chom.2016.09.006","article-title":"Zika virus infection induces cranial neural crest cells to produce cytokines at levels detrimental for neurogenesis","volume":"20","author":"Bayless","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pathol.2017.07.008_bib116","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1056\/NEJMc1607583","article-title":"Prolonged shedding of Zika virus associated with congenital infection","volume":"375","author":"Oliveira","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.pathol.2017.07.008_bib117","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.15585\/mmwr.mm6547e2","article-title":"Description of 13 infants born during October 2015\u2013January 2016 with congenital Zika virus infection without microcephaly at birth \u2013 Brazil","volume":"65","author":"van der Linden","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.pathol.2017.07.008_bib118","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1001\/jamaophthalmol.2016.3417","article-title":"Presence of Zika virus in conjunctival fluid","volume":"134","author":"Sun","year":"2016","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.pathol.2017.07.008_bib119","article-title":"Severe eye damage in infants with microcephaly is presumed to be due to Zika virus","volume":"352","author":"McCarthy","year":"2016","journal-title":"BMJ"},{"key":"10.1016\/j.pathol.2017.07.008_bib120","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nrneurol.2016.30","article-title":"CNS infections: zika virus infection could trigger Guillain-Barre syndrome","volume":"12","author":"Malkki","year":"2016","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.pathol.2017.07.008_bib121","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1056\/NEJMc1602964","article-title":"Zika virus associated with meningoencephalitis","volume":"374","author":"Carteaux","year":"2016","journal-title":"N\u00a0Engl J Med"}],"container-title":["Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302517300983?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302517300983?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T13:12:00Z","timestamp":1659618720000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031302517300983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":121,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S0031302517300983"],"URL":"https:\/\/doi.org\/10.1016\/j.pathol.2017.07.008","relation":{},"ISSN":["0031-3025"],"issn-type":[{"value":"0031-3025","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insights into the molecular roles of Zika virus in human reproductive complications and congenital neuropathologies","name":"articletitle","label":"Article Title"},{"value":"Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pathol.2017.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}