{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:02:11Z","timestamp":1792692131128,"version":"4.5.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","pathologyjournal.rcpa.edu.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.pathol.2019.10.009","type":"journal-article","created":{"date-parts":[[2019,12,28]],"date-time":"2019-12-28T00:03:19Z","timestamp":1577491399000},"page":"213-217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Intravenous leiomyomatosis: molecular analysis of 17 cases"],"prefix":"10.1016","volume":"52","author":[{"given":"Bingjian","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanlan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pathol.2019.10.009_bib1","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1016\/j.amjsurg.2009.09.027","article-title":"Intravenous leiomyomatosis: diagnosis and follow-up with multislice computed tomography","volume":"200","author":"Sun","year":"2010","journal-title":"Am J Surg"},{"key":"10.1016\/j.pathol.2019.10.009_bib2","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.humpath.2010.10.015","article-title":"Intravenous leiomyomatosis of the uterus: a clinicopathologic study of 18 cases, with emphasis on early diagnosis and appropriate treatment strategies","volume":"42","author":"Du","year":"2011","journal-title":"Hum Pathol"},{"key":"10.1016\/j.pathol.2019.10.009_bib3","doi-asserted-by":"crossref","first-page":"509","DOI":"10.5468\/ogs.2018.61.4.509","article-title":"Aberrant uterine leiomyomas with extrauterine manifestation: intravenous leiomyomatosis and benign metastasizing leiomyomas","volume":"61","author":"Kim","year":"2018","journal-title":"Obstet Gynecol Sci"},{"key":"10.1016\/j.pathol.2019.10.009_bib4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s004040000115","article-title":"Intracardiac leiomyomatosis. Case report and literature review","volume":"264","author":"Lo","year":"2001","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.pathol.2019.10.009_bib5","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.prp.2018.04.011","article-title":"Intravenous leiomyomatosis of the uterus: a clinicopathologic analysis of 13 cases with an emphasis on histogenesis","volume":"214","author":"Tang","year":"2018","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.pathol.2019.10.009_bib6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.humpath.2013.08.005","article-title":"MED12 exon 2 mutations in uterine and extrauterine smooth muscle tumors","volume":"45","author":"Schwetye","year":"2014","journal-title":"Hum Pathol"},{"key":"10.1016\/j.pathol.2019.10.009_bib7","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/his.12039","article-title":"Prevalence of MED12 mutations in uterine and extrauterine smooth muscle tumours","volume":"62","author":"Matsubara","year":"2013","journal-title":"Histopathology"},{"key":"10.1016\/j.pathol.2019.10.009_bib8","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.ejca.2015.04.023","article-title":"MED12 and uterine smooth muscle oncogenesis: state of the art and perspectives","volume":"51","author":"Croce","year":"2015","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.pathol.2019.10.009_bib9","series-title":"WHO Classification of Tumors of Female Reproductive Organs","author":"Kurman","year":"2014"},{"key":"10.1016\/j.pathol.2019.10.009_bib10","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1038\/modpathol.2013.243","article-title":"MED12 and HMGA2 mutations: two independent genetic events in uterine leiomyoma and leiomyosarcoma","volume":"27","author":"Bertsch","year":"2014","journal-title":"Mod Pathol"},{"key":"10.1016\/j.pathol.2019.10.009_bib11","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/modpathol.2016.36","article-title":"Intravenous leiomyomatosis: an unusual intermediate between benign and malignant uterine smooth muscle tumors","volume":"29","author":"Ordulu","year":"2016","journal-title":"Mod Pathol"},{"key":"10.1016\/j.pathol.2019.10.009_bib12","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1016\/j.humpath.2014.05.010","article-title":"Recurrent chromosomal aberrations in intravenous leiomyomatosis of the uterus: high-resolution array comparative genomic hybridization study","volume":"45","author":"Buza","year":"2014","journal-title":"Hum Pathol"},{"key":"10.1016\/j.pathol.2019.10.009_bib13","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.fertnstert.2014.06.040","article-title":"MED12 mutation frequency in unselected sporadic uterine leiomyomas","volume":"102","author":"Heinonen","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.pathol.2019.10.009_bib14","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/ejhg.2013.33","article-title":"MED12 exon 2 mutations in histopathological uterine leiomyoma variants","volume":"21","author":"M\u00e4kinen","year":"2013","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.pathol.2019.10.009_bib15","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.ygyno.2018.07.007","article-title":"HMGA2 and MED12 alterations frequently co-occur in uterine leiomyomas","volume":"150","author":"Galindo","year":"2018","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.pathol.2019.10.009_bib16","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/molehr\/4.1.83","article-title":"Cytogenetic abnormalities in uterine myomas are associated with myoma size","volume":"4","author":"Rein","year":"1998","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.pathol.2019.10.009_bib17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0165-4608(99)00053-9","article-title":"Allelotype of uterine leiomyomas","volume":"114","author":"Mao","year":"1999","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.pathol.2019.10.009_bib18","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1158\/0008-5472.CAN-16-2990","article-title":"Hypoxia-induced downregulation of DUSP-2 phosphatase drives colon cancer stemness","volume":"77","author":"Hou","year":"2017","journal-title":"Cancer Res"},{"key":"10.1016\/j.pathol.2019.10.009_bib19","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.biopha.2015.08.015","article-title":"Downregulation of CDK-8 inhibits colon cancer hepatic metastasis by regulating Wnt\/\u03b2-catenin pathway","volume":"74","author":"Cai","year":"2015","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.pathol.2019.10.009_bib20","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.ajog.2005.02.097","article-title":"Independent clonal origin of multiple uterine leiomyomas that was determined by X chromosome inactivation and microsatellite analysis","volume":"193","author":"Canevari","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.pathol.2019.10.009_bib21","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1097\/PAT.0b013e328360bf97","article-title":"Mutation status of the mediator complex subunit 12 (MED12) in uterine leiomyomas and concurrent\/metachronous multifocal peritoneal smooth muscle nodules (leiomyomatosis peritonealis disseminata)","volume":"45","author":"Rieker","year":"2013","journal-title":"Pathology"},{"key":"10.1016\/j.pathol.2019.10.009_bib22","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1159\/000164949","article-title":"A\u00a0case of disseminated peritoneal leiomyomatosis developing after laparoscope-assisted myomectomy","volume":"67","author":"Miyake","year":"2009","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.pathol.2019.10.009_bib23","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/modpathol.3880529","article-title":"Intravenous leiomyomatosis: molecular and cytogenetic analysis of a case","volume":"15","author":"Quade","year":"2002","journal-title":"Mod Pathol"}],"container-title":["Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302519304404?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302519304404?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T16:25:54Z","timestamp":1758471954000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031302519304404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S0031302519304404"],"URL":"https:\/\/doi.org\/10.1016\/j.pathol.2019.10.009","relation":{},"ISSN":["0031-3025"],"issn-type":[{"value":"0031-3025","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intravenous leiomyomatosis: molecular analysis of 17 cases","name":"articletitle","label":"Article Title"},{"value":"Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pathol.2019.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}