{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:37:42Z","timestamp":1777534662269,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860036"],"award-info":[{"award-number":["81860036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","pathologyjournal.rcpa.edu.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.pathol.2020.11.003","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T17:29:25Z","timestamp":1612632565000},"page":"613-622","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["LncRNA PVT1 promotes the malignant progression of acute myeloid leukaemia via sponging miR-29 family to increase WAVE1 expression"],"prefix":"10.1016","volume":"53","author":[{"given":"Jing","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7200-9229","authenticated-orcid":false,"given":"Ji-Fu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pathol.2020.11.003_bib1","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1056\/NEJMra1406184","article-title":"Acute myeloid leukemia","volume":"373","author":"Dohner","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.pathol.2020.11.003_bib2","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.gde.2016.03.011","article-title":"Genetic and epigenetic heterogeneity in acute myeloid leukemia","volume":"36","author":"Li","year":"2016","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.pathol.2020.11.003_bib3","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.cell.2009.02.006","article-title":"Evolution and functions of long noncoding RNAs","volume":"136","author":"Ponting","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.pathol.2020.11.003_bib4","doi-asserted-by":"crossref","first-page":"117161","DOI":"10.1016\/j.lfs.2019.117161","article-title":"LncRNA KCNQ1OT1 contributes to the progression and chemoresistance in acute myeloid leukemia by modulating Tspan3 through suppressing miR-193a-3p","volume":"241","author":"Sun","year":"2020","journal-title":"Life Sci"},{"key":"10.1016\/j.pathol.2020.11.003_bib5","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1093\/jb\/mvz107","article-title":"LncRNA CCAT1\/miR-490-3p\/MAPK1\/c-Myc positive feedback loop drives progression of acute myeloid leukemia","volume":"167","author":"Wang","year":"2019","journal-title":"J\u00a0Biochem"},{"key":"10.1016\/j.pathol.2020.11.003_bib6","doi-asserted-by":"crossref","first-page":"964","DOI":"10.3390\/genes10120964","article-title":"Long noncoding RNA from PVT1 Exon 9 is overexpressed in prostate cancer and induces malignant transformation and castration resistance in prostate epithelial cells","volume":"10","author":"Pal","year":"2019","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.pathol.2020.11.003_bib7","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s12943-019-1064-5","article-title":"LncRNA PVT1 up-regulation is a poor prognosticator and serves as a therapeutic target in esophageal adenocarcinoma","volume":"18","author":"Xu","year":"2019","journal-title":"Mol Cancer"},{"key":"10.1016\/j.pathol.2020.11.003_bib8","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.gene.2019.03.055","article-title":"The prognostic significance of the long non-coding RNAs \"CCAT1, PVT1\" in t(8;21) associated acute myeloid leukemia","volume":"707","author":"El-Khazragy","year":"2019","journal-title":"Gene"},{"key":"10.1016\/j.pathol.2020.11.003_bib9","first-page":"595","article-title":"Research progress on the interactions between long non-coding RNAs and microRNAs in human cancer","volume":"19","author":"Sun","year":"2020","journal-title":"Oncol Lett"},{"key":"10.1016\/j.pathol.2020.11.003_bib10","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3389\/fonc.2019.00609","article-title":"PVT1 promotes cancer progression via microRNAs","volume":"9","author":"Wang","year":"2019","journal-title":"Front Oncol"},{"key":"10.1016\/j.pathol.2020.11.003_bib11","doi-asserted-by":"crossref","first-page":"G222","DOI":"10.1152\/ajpgi.00357.2018","article-title":"Knockdown of long noncoding RNA PVT1 suppresses cell proliferation and invasion of colorectal cancer via upregulation of microRNA-214-3p","volume":"317","author":"Shang","year":"2019","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.pathol.2020.11.003_bib12","doi-asserted-by":"crossref","first-page":"681","DOI":"10.3727\/096504018X15424939990246","article-title":"Knockdown of lncRNA PVT1 inhibits glioma progression by regulating miR-424 expression","volume":"27","author":"Han","year":"2019","journal-title":"Oncol Res"},{"key":"10.1016\/j.pathol.2020.11.003_bib13","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1016\/j.febslet.2015.06.005","article-title":"Tumour-suppressive microRNA-29s directly regulate LOXL2 expression and inhibit cancer cell migration and invasion in renal cell carcinoma","volume":"589","author":"Nishikawa","year":"2015","journal-title":"FEBS Lett"},{"key":"10.1016\/j.pathol.2020.11.003_bib14","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.neulet.2015.01.060","article-title":"miR-29s inhibit the malignant behavior of U87MG glioblastoma cell line by targeting DNMT3A and 3B","volume":"590","author":"Xu","year":"2015","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pathol.2020.11.003_bib15","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3892\/ijo.2014.2437","article-title":"Fig 2FS5Csuppressive microRNA-29s inhibit cancer cell migration and invasion via targeting LAMC1 in prostate cancer","volume":"45","author":"Nishikawa","year":"2014","journal-title":"Int J Oncol"},{"key":"10.1016\/j.pathol.2020.11.003_bib16","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/cdd.2013.133","article-title":"The role, mechanism and potentially therapeutic application of microRNA-29 family in acute myeloid leukemia","volume":"21","author":"Gong","year":"2014","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.pathol.2020.11.003_bib17","first-page":"1515","article-title":"WAVE1 is associated with invasiveness and growth of prostate cancer cells","volume":"180","author":"Fernando","year":"2008","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.pathol.2020.11.003_bib18","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.3892\/ijo.2016.3446","article-title":"Knockdown of WAVE1 enhances apoptosis of leukemia cells by downregulating autophagy","volume":"48","author":"Zhang","year":"2016","journal-title":"Int J Oncol"},{"key":"10.1016\/j.pathol.2020.11.003_bib19","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1002\/jcb.29336","article-title":"lncRNA SNHG3 facilitates acute myeloid leukemia cell growth via the regulation of miR-758-3p\/SRGN axis","volume":"121","author":"Peng","year":"2020","journal-title":"J\u00a0Cell Biochem"},{"key":"10.1016\/j.pathol.2020.11.003_bib20","doi-asserted-by":"crossref","first-page":"e441","DOI":"10.1038\/bcj.2016.50","article-title":"Acute myeloid leukemia: a comprehensive review and 2016 update","volume":"6","author":"De Kouchkovsky","year":"2016","journal-title":"Blood Cancer J"},{"key":"10.1016\/j.pathol.2020.11.003_bib21","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s12943-019-1107-y","article-title":"Long noncoding RNA LCAT1 functions as a ceRNA to regulate RAC1 function by sponging miR-4715-5p in lung cancer","volume":"18","author":"Yang","year":"2019","journal-title":"Mol Cancer"},{"key":"10.1016\/j.pathol.2020.11.003_bib22","doi-asserted-by":"crossref","first-page":"5809","DOI":"10.1093\/nar\/gky214","article-title":"Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer","volume":"46","author":"Lan","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.pathol.2020.11.003_bib23","first-page":"8956","article-title":"LncRNA PVT1 aggravates the progression of glioma via downregulating UPF1","volume":"23","author":"Lv","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.pathol.2020.11.003_bib24","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cell.2013.06.020","article-title":"lincRNAs: genomics, evolution, and mechanisms","volume":"154","author":"Ulitsky","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.pathol.2020.11.003_bib25","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cell.2011.07.014","article-title":"A\u00a0ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?","volume":"146","author":"Salmena","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.pathol.2020.11.003_bib26","first-page":"1609","article-title":"Long noncoding RNA PCA3 contributes to the progression of choriocarcinoma by acting as a ceRNA against miR-106b","volume":"12","author":"Wang","year":"2019","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.pathol.2020.11.003_bib27","doi-asserted-by":"crossref","first-page":"11487","DOI":"10.2147\/OTT.S228439","article-title":"LncRNA SNHG5 promotes proliferation of glioma by regulating miR-205-5p\/ZEB2 axis","volume":"12","author":"Meng","year":"2019","journal-title":"Onco Targets Ther"},{"key":"10.1016\/j.pathol.2020.11.003_bib28","doi-asserted-by":"crossref","first-page":"8812","DOI":"10.12659\/MSM.911972","article-title":"miR-29 family inhibits resistance to methotrexate and promotes cell apoptosis by targeting COL3A1 and MCL1 in osteosarcoma","volume":"24","author":"Xu","year":"2018","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.pathol.2020.11.003_bib29","doi-asserted-by":"crossref","first-page":"5331","DOI":"10.1182\/blood-2009-03-211938","article-title":"MicroRNA 29b functions in acute myeloid leukemia","volume":"114","author":"Garzon","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.pathol.2020.11.003_bib30","doi-asserted-by":"crossref","first-page":"4750","DOI":"10.1038\/onc.2011.193","article-title":"microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer","volume":"30","author":"Braconi","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.pathol.2020.11.003_bib31","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1016\/j.bbamcr.2017.08.001","article-title":"lncRNA H19 regulates epithelial-mesenchymal transition and metastasis of bladder cancer by miR-29b-3p as competing endogenous RNA","volume":"1864","author":"Lv","year":"2017","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"10.1016\/j.pathol.2020.11.003_bib32","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ygyno.2013.05.005","article-title":"WAVE1 gene silencing via RNA interference reduces ovarian cancer cell invasion, migration and proliferation","volume":"130","author":"Zhang","year":"2013","journal-title":"Gynecol Oncol"}],"container-title":["Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302521000210?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302521000210?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:56:23Z","timestamp":1777395383000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031302521000210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S0031302521000210"],"URL":"https:\/\/doi.org\/10.1016\/j.pathol.2020.11.003","relation":{},"ISSN":["0031-3025"],"issn-type":[{"value":"0031-3025","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LncRNA PVT1 promotes the malignant progression of acute myeloid leukaemia via sponging miR-29 family to increase WAVE1 expression","name":"articletitle","label":"Article Title"},{"value":"Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pathol.2020.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}