{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:37:47Z","timestamp":1786995467326,"version":"build-2736575974"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","pathologyjournal.rcpa.edu.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.pathol.2022.08.004","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T07:57:25Z","timestamp":1665647845000},"page":"375-382","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinicopathological spectrums and prognosis of primary appendiceal adenocarcinoma, goblet cell adenocarcinoma, and low-grade appendiceal mucinous neoplasms"],"prefix":"10.1016","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5202-2111","authenticated-orcid":false,"given":"Irene","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4478-2935","authenticated-orcid":false,"given":"Xiaoqin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sierra","family":"Kovar-Peltz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie J.","family":"Conrad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah H.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5052-0632","authenticated-orcid":false,"given":"Xiaoyan","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pathol.2022.08.004_bib1","series-title":"World Health Organization Classification of Tumours. Digestive System Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2019"},{"key":"10.1016\/j.pathol.2022.08.004_bib2","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/01.pas.0000202039.74837.7d","article-title":"Pseudomyxoma peritonei of appendiceal origin: a clinicopathologic analysis of 101 patients uniformly treated at a single institution, with literature review","volume":"30","author":"Bradley","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.pathol.2022.08.004_bib3","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/his.13324","article-title":"The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritonei","volume":"71","author":"Carr","year":"2017","journal-title":"Histopathology"},{"key":"10.1016\/j.pathol.2022.08.004_bib4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/ajcp\/94.1.27","article-title":"Goblet cell carcinoids and related tumors of the vermiform appendix","volume":"94","author":"Burke","year":"1990","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.pathol.2022.08.004_bib5","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1097\/PAS.0b013e31817f1816","article-title":"Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix","volume":"32","author":"Tang","year":"2008","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.pathol.2022.08.004_bib6","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1097\/PAS.0000000000001056","article-title":"Histologic and outcome study supports reclassifying appendiceal goblet cell carcinoids as goblet cell adenocarcinomas, and grading and staging similarly to colonic adenocarcinomas","volume":"42","author":"Yozu","year":"2018","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.pathol.2022.08.004_bib7","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/00000478-198104000-00001","article-title":"Crypt cell carcinoma of the appendix (so-called adenocarcinoid tumor)","volume":"5","author":"Isaacson","year":"1981","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.pathol.2022.08.004_bib8","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1365-2559.1992.tb00992.x","article-title":"The histogenesis of appendiceal carcinoid tumours","volume":"20","author":"Goddard","year":"1992","journal-title":"Histopathology"},{"key":"10.1016\/j.pathol.2022.08.004_bib9","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2013.07.004","article-title":"The intestinal crypt, a prototype stem cell compartment","volume":"154","author":"Clevers","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.pathol.2022.08.004_bib10","doi-asserted-by":"crossref","first-page":"246","DOI":"10.15386\/mpr-1218","article-title":"Assessment of beta-catenin expression by immunohistochemistry in colorectal neoplasms and its role as an additional prognostic marker in colorectal adenocarcinoma","volume":"92","author":"Bhattacharya","year":"2019","journal-title":"Med Pharm Rep"},{"key":"10.1016\/j.pathol.2022.08.004_bib11","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1007\/s12253-012-9547-3","article-title":"Characteristics of advanced- and non advanced sporadic polypoid colorectal adenomas: correlation to KRAS mutations","volume":"18","author":"Yadamsuren","year":"2012","journal-title":"Pathol Oncol Res"},{"key":"10.1016\/j.pathol.2022.08.004_bib12","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1186\/s12885-020-06913-2","article-title":"Colorectal carcinomas with mucinous differentiation are associated with high frequent mutation of KRAS or BRAF mutations, irrespective of quantity of mucinous component","volume":"20","author":"Li","year":"2020","journal-title":"BMC Cancer"},{"key":"10.1016\/j.pathol.2022.08.004_bib13","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.humpath.2018.11.011","article-title":"Heterogeneous mutational profile and prognosis conferred by TP53 mutations in appendiceal mucinous neoplasms","volume":"85","author":"Zhu","year":"2019","journal-title":"Hum Pathol"},{"key":"10.1016\/j.pathol.2022.08.004_bib14","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1080\/10408363.2021.1881756","article-title":"Immunohistochemistry features and molecular pathology of appendiceal neoplasms","volume":"58","author":"Mikaeel","year":"2021","journal-title":"Crit Rev Clin Lab Sci"},{"key":"10.1016\/j.pathol.2022.08.004_bib15","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/his.13986","article-title":"Mutation profile of high-grade appendiceal mucinous neoplasm","volume":"76","author":"Liao","year":"2020","journal-title":"Histopathology"},{"key":"10.1016\/j.pathol.2022.08.004_bib16","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.humpath.2018.03.026","article-title":"Genomic profile of appendiceal goblet cell carcinoid is distinct compared to appendiceal neuroendocrine tumor and conventional adenocarcinoma","volume":"77","author":"Wen","year":"2018","journal-title":"Hum Pathol"},{"key":"10.1016\/j.pathol.2022.08.004_bib17","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/his.13894","article-title":"Loss of SMAD4 protein expression in gastrointestinal and extra-gastrointestinal carcinomas","volume":"75","author":"Ritterhouse","year":"2019","journal-title":"Histopathology"},{"key":"10.1016\/j.pathol.2022.08.004_bib18","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/modpathol.2017.184","article-title":"Appendiceal goblet cell carcinoids and adenocarcinomas ex-goblet cell carcinoid are genetically distinct from primary colorectal-type adenocarcinoma of the appendix","volume":"31","author":"Jesinghaus","year":"2018","journal-title":"Mod Pathol"},{"key":"10.1016\/j.pathol.2022.08.004_bib19","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/s41379-018-0003-0","article-title":"Mutational landscape of goblet cell carcinoids and adenocarcinoma ex goblet cell carcinoids of the appendix is distinct from typical carcinoids and colorectal adenocarcinomas","volume":"31","author":"Johncilla","year":"2018","journal-title":"Mod Pathol"},{"key":"10.1016\/j.pathol.2022.08.004_bib20","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/PAS.0000000000000553","article-title":"SATB2 expression distinguishes ovarian metastases of colorectal and appendiceal origin from primary ovarian tumors of mucinous or endometrioid type","volume":"40","author":"Moh","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.pathol.2022.08.004_bib21","doi-asserted-by":"crossref","first-page":"221","DOI":"10.14740\/gr1015w","article-title":"SATB2 shows different profiles between appendiceal adenocarcinomas ex goblet cell carcinoids and appendiceal\/colorectal conventional adenocarcinomas: an immunohistochemical study with comparison to CDX2","volume":"11","author":"Yang","year":"2018","journal-title":"Gastroenterol Res"},{"key":"10.1016\/j.pathol.2022.08.004_bib22","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1097\/PAS.0b013e318282649b","article-title":"High-level microsatellite instability in appendiceal carcinomas","volume":"37","author":"Taggart","year":"2013","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.pathol.2022.08.004_bib23","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.prp.2015.06.004","article-title":"A\u00a0mutation spectrum that includes GNAS, KRAS and TP53 may be shared by mucinous neoplasms of the appendix","volume":"211","author":"Hara","year":"2015","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.pathol.2022.08.004_bib24","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.prp.2014.01.002","article-title":"EGFR, KRAS, BRAF-mutations and microsatellite instability are absent in goblet cell carcinoids of the appendix","volume":"210","author":"Dimmler","year":"2014","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.pathol.2022.08.004_bib25","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1158\/1535-7163.MCT-20-0318","article-title":"Molecular characterization of appendiceal goblet cell carcinoid","volume":"19","author":"Arai","year":"2020","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.pathol.2022.08.004_bib26","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1055\/s-0035-1564433","article-title":"Management of appendix cancer","volume":"28","author":"Kelly","year":"2015","journal-title":"Clin Colon Rectal Surg"},{"key":"10.1016\/j.pathol.2022.08.004_bib27","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1245\/s10434-021-10945-8","article-title":"Establishing novel molecular subtypes of appendiceal cancer","volume":"29","author":"Garland-Kledzik","year":"2022","journal-title":"Ann Surg Oncol"}],"container-title":["Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302522002707?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302522002707?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T16:30:21Z","timestamp":1758472221000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031302522002707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S0031302522002707"],"URL":"https:\/\/doi.org\/10.1016\/j.pathol.2022.08.004","relation":{},"ISSN":["0031-3025"],"issn-type":[{"value":"0031-3025","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinicopathological spectrums and prognosis of primary appendiceal adenocarcinoma, goblet cell adenocarcinoma, and low-grade appendiceal mucinous neoplasms","name":"articletitle","label":"Article Title"},{"value":"Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pathol.2022.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}