{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T13:52:09Z","timestamp":1776865929443,"version":"3.51.2"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"am","delay-in-days":354,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","pathologyjournal.rcpa.edu.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.pathol.2023.09.013","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:21:16Z","timestamp":1700526076000},"page":"65-74","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Diabetes can increase the prevalence of EBV infection and worsen the prognosis of nasopharyngeal carcinoma"],"prefix":"10.1016","volume":"56","author":[{"given":"Shin","family":"Midorikawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2920-582X","authenticated-orcid":false,"given":"Hiroki","family":"Mizukami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Kudoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2235-581X","authenticated-orcid":false,"given":"Takanori","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanae","family":"Kushibiki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenchao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Itakura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Kudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiko","family":"Nagaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Wakasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1634-1462","authenticated-orcid":false,"given":"Atsushi","family":"Matsubara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pathol.2023.09.013_bib1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0140-6736(19)30956-0","article-title":"Nasopharyngeal carcinoma","volume":"394","author":"Chen","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.pathol.2023.09.013_bib2","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1002\/ijc.30660","article-title":"Global trends in nasopharyngeal cancer mortality since 1970 and predictions for 2020: focus on low-risk areas","volume":"140","author":"Carioli","year":"2017","journal-title":"Int J Cancer"},{"key":"10.1016\/j.pathol.2023.09.013_bib3","series-title":"The National Health and Nutrition Survey in Japan","author":"Seino","year":"2022"},{"key":"10.1016\/j.pathol.2023.09.013_bib4","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/jnci\/92.9.709","article-title":"Evidence for a causal association between human papillomavirus and a subset of head and neck cancers","volume":"92","author":"Gillison","year":"2000","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.pathol.2023.09.013_bib5","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2016.0270","article-title":"Epstein-Barr virus infection and nasopharyngeal carcinoma","volume":"372","author":"Tsao","year":"2017","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.pathol.2023.09.013_bib6","doi-asserted-by":"crossref","first-page":"756","DOI":"10.3389\/fonc.2019.00756","article-title":"MicroRNAs as therapeutic targets in nasopharyngeal carcinoma","volume":"9","author":"Wang","year":"2019","journal-title":"Front Oncol"},{"key":"10.1016\/j.pathol.2023.09.013_bib7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.21037\/cco.2016.03.03","article-title":"Advances in systemic treatment for nasopharyngeal carcinoma","volume":"5","author":"Tan","year":"2016","journal-title":"Chin Clin Oncol"},{"key":"10.1016\/j.pathol.2023.09.013_bib8","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1002\/cncr.30588","article-title":"Human papillomavirus in cervical cancer and oropharyngeal cancer: one cause, two diseases","volume":"123","author":"Berman","year":"2017","journal-title":"Cancer"},{"key":"10.1016\/j.pathol.2023.09.013_bib9","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.oraloncology.2013.11.005","article-title":"Translational research in nasopharyngeal carcinoma","volume":"50","author":"Chiang","year":"2014","journal-title":"Oral Oncol"},{"key":"10.1016\/j.pathol.2023.09.013_bib10","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S0140-6736(16)00618-8","article-title":"Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4\u00b74 million participants","volume":"387","author":"Zhou","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.pathol.2023.09.013_bib11","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.3390\/cells9061380","article-title":"Cancer biology and prevention in diabetes","volume":"9","author":"Srivastava","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.pathol.2023.09.013_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-18438-z","article-title":"Worsened outcome in patients with pancreatic ductal carcinoma on long-term diabetes: association with E-cadherin 1 (CDH1) promoter methylation","volume":"7","author":"Saito","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.pathol.2023.09.013_bib13","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/cjp2.326","article-title":"Dual epigenetic changes in diabetes mellitus-associated pancreatic ductal adenocarcinoma correlate with downregulation of E-cadherin and worsened prognosis","volume":"9","author":"Hara","year":"2023","journal-title":"J\u00a0Pathol Clin Res"},{"key":"10.1016\/j.pathol.2023.09.013_bib14","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1038\/s41598-020-57883-1","article-title":"Diabetes, an independent poor prognostic factor of non-B non-C hepatocellular carcinoma, correlates with dihydropyrimidinase-like 3 promoter methylation","volume":"10","author":"Umetsu","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.pathol.2023.09.013_bib15","first-page":"187","article-title":"Impaired immune responses in diabetes mellitus: analysis of the factors and mechanisms involved. Relevance to the increased susceptibility of diabetic patients to specific infections","volume":"18","author":"Moutschen","year":"1992","journal-title":"Diabete Metab"},{"key":"10.1016\/j.pathol.2023.09.013_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0222607","article-title":"Prevalence of Epstein-Barr virus, human papillomavirus, cytomegalovirus and herpes simplex virus type 1 in patients with diabetes mellitus type 2 in south-eastern Poland","volume":"14","author":"Dworza\u0144ski","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.pathol.2023.09.013_bib17","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1111\/odi.14091","article-title":"Association of Epstein-Barr virus, cytomegalovirus and lipocalin with periodontitis in type 2 diabetic subjects","volume":"29","author":"Mahendra","year":"2023","journal-title":"Oral Dis"},{"key":"10.1016\/j.pathol.2023.09.013_bib18","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s12672-020-00389-z","article-title":"Epithelial mesenchymal transition and progression of breast cancer promoted by diabetes mellitus in mice are associated with increased expression of glycolytic and proteolytic enzymes","volume":"11","author":"Viedma-Rodr\u00edguez","year":"2020","journal-title":"Horm Cancer"},{"key":"10.1016\/j.pathol.2023.09.013_bib19","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","article-title":"Epithelial-mesenchymal transitions in development and disease","volume":"139","author":"Thiery","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.pathol.2023.09.013_bib20","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1096\/fj.201600388R","article-title":"The epithelial-mesenchymal transition (EMT) is regulated by oncoviruses in cancer","volume":"30","author":"Chen","year":"2016","journal-title":"FASEB J"},{"key":"10.1016\/j.pathol.2023.09.013_bib21","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.2040-1124.2010.00074.x","article-title":"Report of the committee on the classification and diagnostic criteria of diabetes mellitus","volume":"1","author":"Seino","year":"2010","journal-title":"J\u00a0Diabetes Investig"},{"key":"10.1016\/j.pathol.2023.09.013_bib22","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s12105-017-0787-0","article-title":"Update from the 4th Edition of the World Health Organization classification of head and neck tumours: nasopharynx","volume":"11","author":"Stelow","year":"2017","journal-title":"Head Neck Pathol"},{"key":"10.1016\/j.pathol.2023.09.013_bib23","first-page":"122","article-title":"Head and neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual","volume":"67","author":"Lydiatt","year":"2017","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.pathol.2023.09.013_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111716","article-title":"Diabetes in humans activates pancreatic stellate cells via RAGE in pancreatic ductal adenocarcinoma","volume":"22","author":"Uchida","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.pathol.2023.09.013_bib25","doi-asserted-by":"crossref","first-page":"Fso606","DOI":"10.2144\/fsoa-2020-0052","article-title":"Evaluating of HPV-DNA ISH as an adjunct to p16 testing in oropharyngeal cancer","volume":"6","author":"Chi","year":"2020","journal-title":"Future Sci OA"},{"key":"10.1016\/j.pathol.2023.09.013_bib26","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0046-8177(99)90123-5","article-title":"Downregulation and abnormal expression of E-cadherin and beta-catenin in nasopharyngeal carcinoma: close association with advanced disease stage and lymph node metastasis","volume":"30","author":"Zheng","year":"1999","journal-title":"Hum Pathol"},{"key":"10.1016\/j.pathol.2023.09.013_bib27","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/(SICI)1097-0142(19960115)77:2<231::AID-CNCR2>3.0.CO;2-P","article-title":"Expression of EBER1 in primary and metastatic nasopharyngeal carcinoma tissues using in situ hybridization. A correlation with WHO histologic subtypes","volume":"77","author":"Tsai","year":"1996","journal-title":"Cancer"},{"key":"10.1016\/j.pathol.2023.09.013_bib28","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1385\/MO:23:3:341","article-title":"Impact of diabetes mellitus on treatment outcomes in patients with nasopharyngeal cancer","volume":"23","author":"Liu","year":"2006","journal-title":"Med Oncol"},{"key":"10.1016\/j.pathol.2023.09.013_bib29","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.3390\/cancers11081180","article-title":"Third epidemiological analysis of nasopharyngeal carcinoma in the central region of Japan from 2006 to 2015","volume":"11","author":"Kanno","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.pathol.2023.09.013_bib30","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.2337\/diacare.24.6.1044","article-title":"Diabetes and the risk of infection-related mortality in the U.S","volume":"24","author":"Bertoni","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/j.pathol.2023.09.013_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.678771","article-title":"A\u00a0bittersweet response to infection in diabetes; targeting neutrophils to modify inflammation and improve host immunity","volume":"12","author":"Dowey","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.pathol.2023.09.013_bib32","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/638058","article-title":"Early detection of nasopharyngeal carcinoma","volume":"2011","author":"Tabuchi","year":"2011","journal-title":"Int J Otolaryngol"},{"key":"10.1016\/j.pathol.2023.09.013_bib33","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/bjc.1989.250","article-title":"Induction of malignant nasal cavity tumours in Wistar rats fed Chinese salted fish","volume":"60","author":"Yu","year":"1989","journal-title":"Br J Cancer"},{"key":"10.1016\/j.pathol.2023.09.013_bib34","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3109\/00016489409126024","article-title":"Induction of nasal and nasopharyngeal tumours in Sprague-Dawley rats fed with Chinese salted fish","volume":"114","author":"Zheng","year":"1994","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.pathol.2023.09.013_bib35","doi-asserted-by":"crossref","first-page":"38539","DOI":"10.18632\/oncotarget.9533","article-title":"Diabetes mellitus stimulates pancreatic cancer growth and epithelial-mesenchymal transition-mediated metastasis via a p38 MAPK pathway","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.pathol.2023.09.013_bib36","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1002\/hed.23743","article-title":"Effect of metformin on the incidence of head and neck cancer in diabetics","volume":"37","author":"Yen","year":"2015","journal-title":"Head Neck"},{"key":"10.1016\/j.pathol.2023.09.013_bib37","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.radonc.2021.06.029","article-title":"Impact of smoking on survival in nasopharyngeal carcinoma: a cohort study with 23,325 patients diagnosed from 1990 to 2016","volume":"162","author":"Sun","year":"2021","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.pathol.2023.09.013_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111073","article-title":"Diabetes, prediabetes and the survival of nasopharyngeal carcinoma: a study of 5,860 patients","volume":"9","author":"OuYang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.pathol.2023.09.013_bib39","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/hed.26976","article-title":"Nasopharyngeal cancer: incidence and prognosis of human papillomavirus and Epstein\u2013Barr virus association at a single North American institution","volume":"44","author":"Wu","year":"2022","journal-title":"Head Neck"},{"key":"10.1016\/j.pathol.2023.09.013_bib40","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1002\/cncr.34266","article-title":"Clinical presentation and outcome of human papillomavirus-positive nasopharyngeal carcinoma in a North American cohort","volume":"128","author":"Huang","year":"2022","journal-title":"Cancer"},{"key":"10.1016\/j.pathol.2023.09.013_bib41","doi-asserted-by":"crossref","first-page":"215","DOI":"10.5468\/ogs.2020.63.3.215","article-title":"Associations between metabolic syndrome and gynecologic cancer","volume":"63","author":"Lee","year":"2020","journal-title":"Obstet Gynecol Sci"},{"key":"10.1016\/j.pathol.2023.09.013_bib42","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1002\/hed.21216","article-title":"HPV-positive\/p16-positive\/EBV-negative nasopharyngeal carcinoma in white North Americans","volume":"32","author":"Maxwell","year":"2010","journal-title":"Head Neck"},{"key":"10.1016\/j.pathol.2023.09.013_bib43","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/hed.23362","article-title":"Human papillomavirus 16 detected in nasopharyngeal carcinomas in white Americans but not in endemic Southern Chinese patients","volume":"36","author":"Lin","year":"2014","journal-title":"Head Neck"},{"key":"10.1016\/j.pathol.2023.09.013_bib44","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.ijrobp.2013.11.246","article-title":"Nonendemic HPV-positive nasopharyngeal carcinoma: association with poor prognosis","volume":"88","author":"Stenmark","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.pathol.2023.09.013_bib45","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1002\/lio2.832","article-title":"Clinical impact of p16 positivity in nasopharyngeal carcinoma","volume":"7","author":"Shimizu","year":"2022","journal-title":"Laryngoscope Investig Otolaryngol"}],"container-title":["Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302523002921?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302523002921?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T16:31:30Z","timestamp":1758472290000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031302523002921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S0031302523002921"],"URL":"https:\/\/doi.org\/10.1016\/j.pathol.2023.09.013","relation":{},"ISSN":["0031-3025"],"issn-type":[{"value":"0031-3025","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diabetes can increase the prevalence of EBV infection and worsen the prognosis of nasopharyngeal carcinoma","name":"articletitle","label":"Article Title"},{"value":"Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pathol.2023.09.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}