{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T23:09:40Z","timestamp":1785193780908,"version":"3.55.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["110-2314-B-002-072"],"award-info":[{"award-number":["110-2314-B-002-072"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","pathologyjournal.rcpa.edu.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.pathol.2024.04.001","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T15:13:51Z","timestamp":1716218031000},"page":"671-680","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Multicolour and lineage-specific interphase chromosome Flow-FISH: method development and clinical validation"],"prefix":"10.1016","volume":"56","author":[{"given":"Huey-En","family":"Tzeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9109-7199","authenticated-orcid":false,"given":"Yi-Wei","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Ting","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3971-525X","authenticated-orcid":false,"given":"Shih-Sung","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Cheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Hui","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-An","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwei-Fang","family":"Tien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang-Ju","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pathol.2024.04.001_bib1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3109\/10520290009064150","article-title":"A\u00a0review of fluorescence in situ hybridization (FISH): current status and future prospects","volume":"75","author":"Nath","year":"2000","journal-title":"Biotech Histochem"},{"key":"10.1016\/j.pathol.2024.04.001_bib2","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1517\/17530050802558899","article-title":"Fluorescence in situ hybridization techniques in medical diagnostics","volume":"2","author":"Stumm","year":"2008","journal-title":"Expert Opin Med Diagn"},{"key":"10.1016\/j.pathol.2024.04.001_bib3","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S1471-4914(02)02335-3","article-title":"Modern molecular cytogenetic techniques in genetic diagnostics","volume":"8","author":"Tonnies","year":"2002","journal-title":"Trends Mol Med"},{"issue":"Suppl 2","key":"10.1016\/j.pathol.2024.04.001_bib4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF03165090","article-title":"Cytogenetic and FISH studies in myelodysplasia, acute myeloid leukemia, chronic lymphocytic leukemia and lymphoma","volume":"76","author":"Dewald","year":"2002","journal-title":"Int J Hematol"},{"key":"10.1016\/j.pathol.2024.04.001_bib5","first-page":"801","article-title":"Chimerism status is a useful predictor of relapse after allogeneic stem cell transplantation for acute leukemia","volume":"88","author":"Barrios","year":"2003","journal-title":"Haematologica"},{"key":"10.1016\/j.pathol.2024.04.001_bib6","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cancergencyto.2004.08.012","article-title":"The value of fluorescence in situ hybridization in the diagnosis and prognosis of chronic lymphocytic leukemia","volume":"158","author":"Glassman","year":"2005","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.pathol.2024.04.001_bib7","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S0145-2126(03)00104-8","article-title":"Comparison of interphase FISH and metaphase cytogenetics to study myelodysplastic syndrome: an Eastern Cooperative Oncology Group (ECOG) study","volume":"27","author":"Cherry","year":"2003","journal-title":"Leuk Res"},{"key":"10.1016\/j.pathol.2024.04.001_bib8","first-page":"171","article-title":"Reliability evaluation of fluorescence in situ hybridization (FISH) and G-banding on bone marrow and peripheral blood cells in chronic myelogenous leukemia patients","volume":"17","author":"Manaflouyan","year":"2015","journal-title":"Cell J"},{"key":"10.1016\/j.pathol.2024.04.001_bib9","doi-asserted-by":"crossref","first-page":"4939","DOI":"10.1182\/blood-2009-07-229864","article-title":"Chronic myeloid leukemia: a prospective comparison of interphase fluorescence in situ hybridization and chromosome banding analysis for the definition of complete cytogenetic response: a study of the GIMEMA CML WP","volume":"114","author":"Testoni","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.pathol.2024.04.001_bib10","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1182\/blood.V92.7.2322","article-title":"The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties","volume":"92","author":"Grimwade","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.pathol.2024.04.001_bib11","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1182\/asheducation-2016.1.348","article-title":"Mutations in AML: prognostic and therapeutic implications","volume":"2016","author":"DiNardo","year":"2016","journal-title":"Hematol Am Soc Hematol Educ Program"},{"key":"10.1016\/j.pathol.2024.04.001_bib12","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1182\/blood-2017-09-806398","article-title":"iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL","volume":"131","author":"Hallek","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.pathol.2024.04.001_bib13","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S0145-2126(03)00077-8","article-title":"Monitoring of hematopoietic chimerism after sex-mismatched allogeneic stem cell transplantation (alloSCT) by dual-color FISH analysis of X and Y chromosomes","volume":"27","author":"Turkiewicz","year":"2003","journal-title":"Leuk Res"},{"key":"10.1016\/j.pathol.2024.04.001_bib14","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000077555","article-title":"Strategies and clinical implications of chimerism diagnostics after allogeneic hematopoietic stem cell transplantation","volume":"112","author":"Thiede","year":"2004","journal-title":"Acta Haematol"},{"key":"10.1016\/j.pathol.2024.04.001_bib15","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1177\/44.11.8918909","article-title":"Reconstructed three-dimensional images of flow-sorted nuclei hybridized with chromosome-specific probes","volume":"44","author":"Matsuta","year":"1996","journal-title":"J\u00a0Histochem Cytochem"},{"key":"10.1016\/j.pathol.2024.04.001_bib16","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jim.2009.02.004","article-title":"Quantum dots thermal stability improves simultaneous phenotype-specific telomere length measurement by FISH-flow cytometry","volume":"344","author":"Kapoor","year":"2009","journal-title":"J\u00a0Immunol Methods"},{"key":"10.1016\/j.pathol.2024.04.001_bib17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/cyto.10053","article-title":"Telomere length measurement by fluorescence in situ hybridization and flow cytometry: tips and pitfalls","volume":"47","author":"Baerlocher","year":"2002","journal-title":"Cytometry"},{"key":"10.1016\/j.pathol.2024.04.001_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cyto.a.10064","article-title":"Telomere length measurements in leukocyte subsets by automated multicolor flow-FISH","volume":"55","author":"Baerlocher","year":"2003","journal-title":"Cytometry A"},{"key":"10.1016\/j.pathol.2024.04.001_bib19","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1038\/nprot.2006.263","article-title":"Flow cytometry and FISH to measure the average length of telomeres (flow FISH)","volume":"1","author":"Baerlocher","year":"2006","journal-title":"Nat Protoc"},{"key":"10.1016\/j.pathol.2024.04.001_bib20","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1182\/blood-2012-05-434266","article-title":"Interphase chromosome Flow-FISH","volume":"120","author":"Keyvanfar","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.pathol.2024.04.001_bib21","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jim.2018.10.002","article-title":"An optimized protocol to quantify signaling in human transitional B cells by phospho flow cytometry","volume":"463","author":"Zwang","year":"2018","journal-title":"J\u00a0Immunol Methods"},{"key":"10.1016\/j.pathol.2024.04.001_bib22","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/(SICI)1097-0320(19981015)34:5<216::AID-CYTO2>3.0.CO;2-E","article-title":"Fluorescent in situ hybridization on flow-sorted cells as a tool for evaluating minimal residual disease or chimerism after allogenic bone marrow transplantation","volume":"34","author":"Cotteret","year":"1998","journal-title":"Cytometry"},{"key":"10.1016\/j.pathol.2024.04.001_bib23","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1002\/eji.201646632","article-title":"Guidelines for the use of flow cytometry and cell sorting in immunological studies","volume":"47","author":"Cossarizza","year":"2017","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.pathol.2024.04.001_bib24","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bbmt.2008.11.009","article-title":"Allogeneic transplantation for pediatric acute lymphoblastic leukemia: the emerging role of peritransplantation minimal residual disease\/chimerism monitoring and novel chemotherapeutic, molecular, and immune approaches aimed at preventing relapse","volume":"15","author":"Pulsipher","year":"2009","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.pathol.2024.04.001_bib25","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.bbmt.2014.05.026","article-title":"Comparison of chimerism and minimal residual disease monitoring for relapse prediction after allogeneic stem cell transplantation for adult acute lymphoblastic leukemia","volume":"20","author":"Terwey","year":"2014","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.pathol.2024.04.001_bib26","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1002\/cam4.3853","article-title":"Interphase fluorescence in situ hybridization analysis of CD19-selected cells: utility in detecting disease in post-therapy samples of B-cell neoplasms","volume":"10","author":"Parrott","year":"2021","journal-title":"Cancer Med"},{"key":"10.1016\/j.pathol.2024.04.001_bib27","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1016\/j.jcyt.2020.03.034","article-title":"Applying uncertainty analysis to assess the variation of operator performance when manually gating flow cytometry data","volume":"22","author":"Grant","year":"2020","journal-title":"Cytotherapy"},{"key":"10.1016\/j.pathol.2024.04.001_bib28","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1034\/j.1399-0004.2000.580409.x","article-title":"Optimization of the fluorescence in situ hybridization (FISH) technique for high detection efficiency of very small proportions of target interphase nuclei","volume":"58","author":"Yan","year":"2000","journal-title":"Clin Genet"},{"key":"10.1016\/j.pathol.2024.04.001_bib29","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/cyto.a.23769","article-title":"\"Immuno-flowFISH\" for the assessment of cytogenetic abnormalities in chronic lymphocytic leukemia","volume":"95","author":"Hui","year":"2019","journal-title":"Cytometry A"},{"key":"10.1016\/j.pathol.2024.04.001_bib30","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ymeth.2017.11.003","article-title":"Imaging flow cytometry to assess chromosomal abnormalities in chronic lymphocytic leukaemia","volume":"134\u20135","author":"Hui","year":"2018","journal-title":"Methods"},{"key":"10.1016\/j.pathol.2024.04.001_bib31","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/nprot.2017.039","article-title":"FISH-Flow, a protocol for the concurrent detection of mRNA and protein in single cells using fluorescence in situ hybridization and flow cytometry","volume":"12","author":"Arrigucci","year":"2017","journal-title":"Nat Protoc"},{"key":"10.1016\/j.pathol.2024.04.001_bib32","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00876-17","article-title":"A\u00a0novel single-cell FISH-Flow assay identifies effector memory CD4(+) T cells as a major niche for HIV-1 transcription in HIV-infected patients","volume":"8","author":"Grau-Exposito","year":"2017","journal-title":"MBio"}],"container-title":["Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302524001296?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302524001296?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T20:52:39Z","timestamp":1720126359000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031302524001296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S0031302524001296"],"URL":"https:\/\/doi.org\/10.1016\/j.pathol.2024.04.001","relation":{},"ISSN":["0031-3025"],"issn-type":[{"value":"0031-3025","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multicolour and lineage-specific interphase chromosome Flow-FISH: method development and clinical validation","name":"articletitle","label":"Article Title"},{"value":"Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pathol.2024.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}