{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:37:25Z","timestamp":1785875845285,"version":"3.56.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","pathologyjournal.rcpa.edu.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.pathol.2024.09.009","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T16:11:28Z","timestamp":1731773488000},"page":"340-347","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Next-generation sequencing RNA fusion panel for the diagnosis of haematological malignancies"],"prefix":"10.1016","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9124-8981","authenticated-orcid":false,"given":"Trung Quang","family":"Ngo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Fong Na","family":"Goh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7755-8745","authenticated-orcid":false,"given":"Pranav","family":"Dorwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9612-5435","authenticated-orcid":false,"given":"Emmanuel","family":"Leong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3185-6488","authenticated-orcid":false,"given":"Jake","family":"Shortt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale L.","family":"Fedele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5275-374X","authenticated-orcid":false,"given":"Michael","family":"Gilbertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5773-103X","authenticated-orcid":false,"given":"Chun Yew","family":"Fong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naranie","family":"Shanmuganathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beena","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4172-3614","authenticated-orcid":false,"given":"Paul","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.pathol.2024.09.009_bib1","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1038\/s41375-022-01613-1","article-title":"The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: myeloid and histiocytic\/dendritic neoplasms","volume":"36","author":"Khoury","year":"2022","journal-title":"Leukemia"},{"issue":"7","key":"10.1016\/j.pathol.2024.09.009_bib2","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","article-title":"The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: lymphoid neoplasms","volume":"36","author":"Alaggio","year":"2022","journal-title":"Leukemia"},{"issue":"12","key":"10.1016\/j.pathol.2024.09.009_bib3","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1182\/blood.2022016867","article-title":"Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN","volume":"140","author":"D\u00f6hner","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.pathol.2024.09.009_bib4","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.2147\/CMAR.S242479","article-title":"Genetic characterization and risk stratification of acute myeloid leukemia","volume":"12","author":"Pourrajab","year":"2020","journal-title":"Cancer Manag Res"},{"issue":"16","key":"10.1016\/j.pathol.2024.09.009_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13164068","article-title":"Genetic alterations in childhood acute lymphoblastic leukemia: interactions with clinical features and treatment response","volume":"13","author":"Lee","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.pathol.2024.09.009_bib6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s12288-022-01541-1","article-title":"Cytogenetic risk stratification of B-acute lymphoblastic leukemia and its correlation with other prognostic factors","volume":"39","author":"Chadha","year":"2023","journal-title":"Indian J Hematol Blood Transfus"},{"issue":"15","key":"10.1016\/j.pathol.2024.09.009_bib7","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1182\/blood.2021014309","article-title":"Guiding the global evolution of cytogenetic testing for hematologic malignancies","volume":"139","author":"Akkari","year":"2022","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.pathol.2024.09.009_bib8","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/j.jmoldx.2021.08.009","article-title":"Clinical implications of a targeted RNA-sequencing panel in the detection of gene fusions in solid tumors","volume":"23","author":"Sun","year":"2021","journal-title":"J\u00a0Mol Diagn"},{"issue":"Suppl 1","key":"10.1016\/j.pathol.2024.09.009_bib9","doi-asserted-by":"crossref","first-page":"8957","DOI":"10.4081\/hr.2020.8957","article-title":"Advancing leukemia diagnostics: role of next generation sequencing (NGS) in acute myeloid leukemia","volume":"12","author":"Haferlach","year":"2020","journal-title":"Hematol Rep"},{"issue":"5","key":"10.1016\/j.pathol.2024.09.009_bib10","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/s41375-023-01877-1","article-title":"The KMT2A recombinome of acute leukemias in 2023","volume":"37","author":"Meyer","year":"2023","journal-title":"Leukemia"},{"issue":"7954","key":"10.1016\/j.pathol.2024.09.009_bib11","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/s41586-023-05812-3","article-title":"The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia","volume":"615","author":"Issa","year":"2023","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.pathol.2024.09.009_bib12","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1182\/blood.2022015850","article-title":"International Consensus classification of myeloid neoplasms and acute leukemias: integrating morphologic, clinical, and genomic data","volume":"140","author":"Arber","year":"2022","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.pathol.2024.09.009_bib13","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/leu.2008.388","article-title":"AML with translocation t(8;16)(p11;p13) demonstrates unique cytomorphological, cytogenetic, molecular and prognostic features","volume":"23","author":"Haferlach","year":"2009","journal-title":"Leukemia"},{"issue":"5","key":"10.1016\/j.pathol.2024.09.009_bib14","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1111\/bjh.17336","article-title":"Characteristics and outcome of patients with acute myeloid leukaemia and t(8;16)(p11;p13): results from an International Collaborative Study","volume":"192","author":"Kayser","year":"2021","journal-title":"Br J Haematol"},{"issue":"4","key":"10.1016\/j.pathol.2024.09.009_bib15","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/gcc.21918","article-title":"ETV6 rearrangements are recurrent in myeloid malignancies and are frequently associated with other genetic events","volume":"51","author":"Haferlach","year":"2012","journal-title":"Genes Chromosomes Cancer"},{"issue":"13","key":"10.1016\/j.pathol.2024.09.009_bib16","doi-asserted-by":"crossref","first-page":"10987","DOI":"10.18632\/oncotarget.23743","article-title":"Acute myeloid leukemia with t(4;12)(q12;p13): an aggressive disease with frequent involvement of PDGFRA and ETV6","volume":"9","author":"Li","year":"2018","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.pathol.2024.09.009_bib17","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1182\/bloodadvances.2021005280","article-title":"t(4;12)(q12;p13) ETV6-rearranged AML without eosinophilia does not involve PDGFRA: relevance for imatinib insensitivity","volume":"6","author":"Mueller","year":"2022","journal-title":"Blood Adv"},{"issue":"5","key":"10.1016\/j.pathol.2024.09.009_bib18","first-page":"1173","article-title":"The proportion of different BCR-ABL1\u00a0transcript types in chronic myeloid leukemia","volume":"33","author":"Baccarani","year":"2019","journal-title":"Int Overview Leuk"},{"issue":"2","key":"10.1016\/j.pathol.2024.09.009_bib19","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1111\/ijlh.13714","article-title":"Quantification of atypical BCR-ABL1 fusion transcripts in patients with chronic myeloid leukemia: which approach for harmonization?","volume":"44","author":"Bhreathnach","year":"2022","journal-title":"Int J Lab Hematol"},{"issue":"10","key":"10.1016\/j.pathol.2024.09.009_bib20","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1007\/s00432-021-03569-8","article-title":"Assessment of individual molecular response in chronic myeloid leukemia patients with atypical BCR-ABL1 fusion transcripts: recommendations by the EUTOS cooperative network","volume":"147","author":"Sch\u00e4fer","year":"2021","journal-title":"J\u00a0Cancer Res Clin Oncol"},{"issue":"1","key":"10.1016\/j.pathol.2024.09.009_bib21","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jmoldx.2018.09.002","article-title":"Clinical evaluation of massively parallel RNA sequencing for detecting recurrent gene fusions in hematologic malignancies","volume":"21","author":"Kim","year":"2019","journal-title":"J\u00a0Mol Diagn"},{"issue":"5","key":"10.1016\/j.pathol.2024.09.009_bib22","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1182\/bloodadvances.2019001008","article-title":"The application of RNA sequencing for the diagnosis and genomic classification of pediatric acute lymphoblastic leukemia","volume":"4","author":"Brown","year":"2020","journal-title":"Blood Adv"},{"issue":"3","key":"10.1016\/j.pathol.2024.09.009_bib23","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41408-021-00457-9","article-title":"EVI1 dysregulation: impact on biology and therapy of myeloid malignancies","volume":"11","author":"Birdwell","year":"2021","journal-title":"Blood Cancer J"},{"issue":"5","key":"10.1016\/j.pathol.2024.09.009_bib24","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1182\/blood-2016-07-726588","article-title":"Ph-like acute lymphoblastic leukemia: a high-risk subtype in adults","volume":"129","author":"Jain","year":"2017","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.pathol.2024.09.009_bib25","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1038\/s41375-023-01958-1","article-title":"Myeloid\/lymphoid neoplasms with\u00a0eosinophilia and tyrosine kinase gene fusions: reevaluation of\u00a0the\u00a0defining\u00a0characteristics in a registry-based cohort","volume":"37","author":"Metzgeroth","year":"2023","journal-title":"Leukemia"},{"issue":"16","key":"10.1016\/j.pathol.2024.09.009_bib26","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1182\/blood.2019001244","article-title":"Efficacy of tyrosine kinase inhibitors in Ph-like acute lymphoblastic leukemia harboring ABL-class rearrangements","volume":"134","author":"Tanasi","year":"2019","journal-title":"Blood"}],"container-title":["Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302524002988?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302524002988?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T21:07:05Z","timestamp":1741208825000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031302524002988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0031302524002988"],"URL":"https:\/\/doi.org\/10.1016\/j.pathol.2024.09.009","relation":{},"ISSN":["0031-3025"],"issn-type":[{"value":"0031-3025","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Next-generation sequencing RNA fusion panel for the diagnosis of haematological malignancies","name":"articletitle","label":"Article Title"},{"value":"Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pathol.2024.09.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2024 Published by Elsevier B.V. on behalf of Royal College of Pathologists of Australasia. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}