{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T21:20:58Z","timestamp":1784928058808,"version":"3.55.0"},"reference-count":82,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100011566","name":"Sidney Kimmel Comprehensive Cancer Center","doi-asserted-by":"publisher","award":["P30 CA006973"],"award-info":[{"award-number":["P30 CA006973"]}],"id":[{"id":"10.13039\/100011566","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["P41 EB024495"],"award-info":[{"award-number":["P41 EB024495"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014039","name":"DOD Prostate Cancer Research Program","doi-asserted-by":"publisher","award":["W81XWH-18-2-0015"],"award-info":[{"award-number":["W81XWH-18-2-0015"]}],"id":[{"id":"10.13039\/100014039","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA255259-04"],"award-info":[{"award-number":["R01 CA255259-04"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U01 CA196390"],"award-info":[{"award-number":["U01 CA196390"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P50CA58236"],"award-info":[{"award-number":["P50CA58236"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA279993-01A1"],"award-info":[{"award-number":["R01 CA279993-01A1"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U54 CA274370"],"award-info":[{"award-number":["U54 CA274370"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016737","name":"Patrick C. Walsh Prostate Cancer Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","pathologyjournal.rcpa.edu.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.pathol.2024.12.637","type":"journal-article","created":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T02:43:27Z","timestamp":1740797007000},"page":"592-604","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Overexpression of fibroblast activation protein (FAP) in the stroma of proliferative inflammatory atrophy (PIA) and primary adenocarcinoma of the prostate"],"prefix":"10.1016","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4087-3186","authenticated-orcid":false,"given":"Fernanda","family":"Caramella-Pereira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7885-3319","authenticated-orcid":false,"given":"Jessica L.","family":"Hicks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0668-0337","authenticated-orcid":false,"given":"Sujayita","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Pomper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizamma","family":"Antony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4601-6481","authenticated-orcid":false,"given":"Alan K.","family":"Meeker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0744-6606","authenticated-orcid":false,"given":"Srinivasan","family":"Yegnasubramanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4847-5307","authenticated-orcid":false,"given":"Angelo M.","family":"De Marzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9807-7433","authenticated-orcid":false,"given":"W. Nathaniel","family":"Brennen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5\u20136","key":"10.1016\/j.pathol.2024.12.637_bib1","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/prca.201300095","article-title":"Understanding fibroblast activation protein (FAP): substrates, activities, expression and targeting for cancer therapy","volume":"8","author":"Hamson","year":"2014","journal-title":"Proteomics Clin Appl"},{"issue":"32","key":"10.1016\/j.pathol.2024.12.637_bib2","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1038\/s41388-018-0275-3","article-title":"Pro-tumorigenic roles of fibroblast activation protein in cancer: back to the basics","volume":"37","author":"Pur\u00e9","year":"2018","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.pathol.2024.12.637_bib3","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s10555-020-09909-3","article-title":"The role of fibroblast activation protein in health and malignancy","volume":"39","author":"Fitzgerald","year":"2020","journal-title":"Cancer Metastasis Rev"},{"issue":"9","key":"10.1016\/j.pathol.2024.12.637_bib4","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1073\/pnas.85.9.3110","article-title":"Cell-surface glycoproteins of human sarcomas: differential expression in normal and malignant tissues and cultured cells","volume":"85","author":"Rettig","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"issue":"32","key":"10.1016\/j.pathol.2024.12.637_bib5","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1038\/sj.onc.1207730","article-title":"FAPalpha, a surface peptidase expressed during wound healing, is a tumor suppressor","volume":"23","author":"Ramirez-Montagut","year":"2004","journal-title":"Oncogene"},{"issue":"14","key":"10.1016\/j.pathol.2024.12.637_bib6","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1158\/0008-5472.CAN-15-2973","article-title":"FAP promotes immunosuppression by cancer-associated fibroblasts in the tumor microenvironment via STAT3-CCL2 signaling","volume":"76","author":"Yang","year":"2016","journal-title":"Cancer Res"},{"issue":"6","key":"10.1016\/j.pathol.2024.12.637_bib7","doi-asserted-by":"crossref","first-page":"801","DOI":"10.2967\/jnumed.119.227967","article-title":"68Ga-FAPI PET\/CT: tracer uptake in 28 different kinds of cancer","volume":"60","author":"Kratochwil","year":"2019","journal-title":"J Nucl Med"},{"issue":"7","key":"10.1016\/j.pathol.2024.12.637_bib8","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1021\/acs.jmedchem.0c02171","article-title":"Imaging of fibroblast activation protein in cancer xenografts using novel (4-quinolinoyl)-glycyl-2-cyanopyrrolidine-based small molecules","volume":"64","author":"Slania","year":"2021","journal-title":"J Med Chem"},{"issue":"3","key":"10.1016\/j.pathol.2024.12.637_bib9","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s12149-021-01702-8","article-title":"Prostate-specific membrane antigen and fibroblast activation protein distribution in prostate cancer: preliminary data on immunohistochemistry and PET imaging","volume":"36","author":"Kessel","year":"2022","journal-title":"Ann Nucl Med"},{"issue":"2","key":"10.1016\/j.pathol.2024.12.637_bib10","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1158\/1535-7163.MCT-11-0340","article-title":"Rationale behind targeting fibroblast activation protein\u2013expressing carcinoma-associated fibroblasts as a novel chemotherapeutic strategy","volume":"11","author":"Nathaniel","year":"2012","journal-title":"Mol Cancer Ther"},{"issue":"17","key":"10.1016\/j.pathol.2024.12.637_bib11","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1093\/jnci\/djs336","article-title":"Targeting carcinoma-associated fibroblasts within the tumor stroma with a fibroblast activation protein-activated prodrug","volume":"104","author":"Brennen","year":"2012","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"10.1016\/j.pathol.2024.12.637_bib12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2217\/imt-2020-0066","article-title":"Overcoming stromal barriers to immuno-oncological responses via fibroblast activation protein-targeted therapy","volume":"13","author":"Brennen","year":"2021","journal-title":"Immunotherapy"},{"issue":"18","key":"10.1016\/j.pathol.2024.12.637_bib13","doi-asserted-by":"crossref","first-page":"4882","DOI":"10.1158\/1078-0432.CCR-20-1358","article-title":"Imaging fibroblast activation protein alpha improves diagnosis of metastatic prostate cancer with positron emission tomography","volume":"26","author":"Hintz","year":"2020","journal-title":"Clin Cancer Res"},{"issue":"1","key":"10.1016\/j.pathol.2024.12.637_bib14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00259-021-05423-y","article-title":"High fibroblast-activation-protein expression in castration-resistant prostate cancer supports the use of FAPI-molecular theranostics","volume":"49","author":"Kesch","year":"2021","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"3","key":"10.1016\/j.pathol.2024.12.637_bib15","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/cjp2.205","article-title":"A distinct repertoire of cancer-associated fibroblasts is enriched in cribriform prostate cancer","volume":"7","author":"Hesterberg","year":"2021","journal-title":"J Pathol Clin Res"},{"issue":"3","key":"10.1016\/j.pathol.2024.12.637_bib16","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1158\/2767-9764.CRC-21-0183","article-title":"Stromal FAP expression is associated with MRI visibility and patient survival in prostate cancer","volume":"2","author":"Pellinen","year":"2022","journal-title":"Cancer Res Commun"},{"issue":"1","key":"10.1016\/j.pathol.2024.12.637_bib17","doi-asserted-by":"crossref","first-page":"6036","DOI":"10.1038\/s41467-022-33780-1","article-title":"Single cell analysis of cribriform prostate cancer reveals cell intrinsic and tumor microenvironmental pathways of aggressive disease","volume":"13","author":"Wong","year":"2022","journal-title":"Nat Commun"},{"issue":"4","key":"10.1016\/j.pathol.2024.12.637_bib18","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nrc2090","article-title":"Inflammation in prostate carcinogenesis","volume":"7","author":"De Marzo","year":"2007","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"10.1016\/j.pathol.2024.12.637_bib19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrurol.2017.167","article-title":"The inflammatory microenvironment and microbiome in prostate cancer development","volume":"15","author":"Sfanos","year":"2017","journal-title":"Nat Rev Urol"},{"issue":"3","key":"10.1016\/j.pathol.2024.12.637_bib20","doi-asserted-by":"crossref","DOI":"10.1172\/JCI155031","article-title":"Health inequity drives disease biology to create disparities in prostate cancer outcomes","volume":"132","author":"Nelson","year":"2022","journal-title":"J Clin Invest"},{"issue":"6","key":"10.1016\/j.pathol.2024.12.637_bib21","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1016\/S0002-9440(10)65517-4","article-title":"Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesis","volume":"155","author":"De Marzo","year":"1999","journal-title":"Am J Pathol"},{"issue":"1","key":"10.1016\/j.pathol.2024.12.637_bib22","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/pros.1115","article-title":"GSTA1 expression in normal, preneoplastic, and neoplastic human prostate tissue","volume":"49","author":"Parsons","year":"2001","journal-title":"Prostate"},{"issue":"5","key":"10.1016\/j.pathol.2024.12.637_bib23","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/S0002-9440(10)64286-1","article-title":"Intermediate cells in human prostate epithelium are enriched in proliferative inflammatory atrophy","volume":"162","author":"van Leenders","year":"2003","journal-title":"Am J Pathol"},{"issue":"24","key":"10.1016\/j.pathol.2024.12.637_bib24","first-page":"8617","article-title":"Cyclooxygenase-2 is up-regulated in proliferative inflammatory atrophy of the prostate, but not in prostate carcinoma","volume":"61","author":"Zha","year":"2001","journal-title":"Cancer Res"},{"issue":"11","key":"10.1016\/j.pathol.2024.12.637_bib25","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1002\/pros.20595","article-title":"Increased expression of CCAAT\/enhancer-binding protein beta in proliferative inflammatory atrophy of the prostate: relation with the expression of COX-2, the androgen receptor, and presence of focal chronic inflammation","volume":"67","author":"Wang","year":"2007","journal-title":"Prostate"},{"issue":"9","key":"10.1016\/j.pathol.2024.12.637_bib26","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1073\/pnas.0810473106","article-title":"Acute inflammatory proteins constitute the organic matrix of prostatic corpora amylacea and calculi in men with prostate cancer","volume":"106","author":"Sfanos","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"issue":"10","key":"10.1016\/j.pathol.2024.12.637_bib27","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1016\/j.celrep.2016.11.010","article-title":"Low CD38 identifies progenitor-like inflammation-associated luminal cells that can initiate human prostate cancer and predict poor outcome","volume":"17","author":"Liu","year":"2016","journal-title":"Cell Rep"},{"issue":"3","key":"10.1016\/j.pathol.2024.12.637_bib28","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/S0002-9440(10)63452-9","volume":"163","author":"Nakayama","year":"2003","journal-title":"Am J Pathol"},{"issue":"8","key":"10.1016\/j.pathol.2024.12.637_bib29","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1158\/1940-6207.CAPR-22-0485","article-title":"Progressive spreading of DNA methylation in the GSTP1 promoter CpG island across transitions from precursors to invasive prostate cancer","volume":"16","author":"Gupta","year":"2023","journal-title":"Cancer Prev Res"},{"issue":"32","key":"10.1016\/j.pathol.2024.12.637_bib30","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2018976118","article-title":"Oncogenic gene fusions in nonneoplastic precursors as evidence that bacterial infection can initiate prostate cancer","volume":"118","author":"Shrestha","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/j.pathol.2024.12.637_bib31","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/path.6149","article-title":"Club-like cells in proliferative inflammatory atrophy of the prostate","volume":"261","author":"Huang","year":"2023","journal-title":"J Pathol"},{"issue":"1","key":"10.1016\/j.pathol.2024.12.637_bib32","doi-asserted-by":"crossref","first-page":"7414","DOI":"10.1038\/s41467-024-51450-2","article-title":"Convergent alterations in the tumor microenvironment of MYC-driven human and murine prostate cancer","volume":"15","author":"Graham","year":"2024","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.pathol.2024.12.637_bib33","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/pros.24315","article-title":"Multiplex immunohistochemical phenotyping of T cells in primary prostate cancer","volume":"82","author":"Ozbek","year":"2022","journal-title":"Prostate"},{"issue":"1","key":"10.1016\/j.pathol.2024.12.637_bib34","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ajur.2018.11.006","article-title":"If this is true, what does it imply? How end-user antibody validation facilitates insights into biology and disease","volume":"6","author":"Sfanos","year":"2019","journal-title":"Asian J Urol"},{"issue":"29","key":"10.1016\/j.pathol.2024.12.637_bib35","doi-asserted-by":"crossref","first-page":"46710","DOI":"10.18632\/oncotarget.17362","article-title":"Mesenchymal stem cell infiltration during neoplastic transformation of the human prostate","volume":"8","author":"Brennen","year":"2017","journal-title":"Oncotarget"},{"issue":"18","key":"10.1016\/j.pathol.2024.12.637_bib36","doi-asserted-by":"crossref","first-page":"26259","DOI":"10.18632\/oncotarget.8456","article-title":"Acquired resistance to the second-generation androgen receptor antagonist enzalutamide in castration-resistant prostate cancer","volume":"7","author":"Kregel","year":"2016","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.pathol.2024.12.637_bib37","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1021\/acs.bioconjchem.9b00206","article-title":"Development of a cross-reactive monoclonal antibody for detecting the tumor stroma","volume":"30","author":"Hintz","year":"2019","journal-title":"Bioconjug Chem"},{"issue":"1","key":"10.1016\/j.pathol.2024.12.637_bib38","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.celrep.2017.03.037","article-title":"Quantitative multiplex immunohistochemistry reveals myeloid-inflamed tumor-immune complexity associated with poor prognosis","volume":"19","author":"Tsujikawa","year":"2017","journal-title":"Cell Rep"},{"issue":"4","key":"10.1016\/j.pathol.2024.12.637_bib39","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.euo.2018.09.014","article-title":"Mannose receptor-positive macrophage infiltration correlates with prostate cancer onset and metastatic castration-resistant disease","volume":"2","author":"Zarif","year":"2019","journal-title":"Eur Urol Oncol"},{"issue":"10","key":"10.1016\/j.pathol.2024.12.637_bib40","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1097\/01.pas.0000213289.50660.be","article-title":"A working group classification of focal prostate atrophy lesions","volume":"30","author":"De Marzo","year":"2006","journal-title":"Am J Surg Pathol"},{"issue":"9","key":"10.1016\/j.pathol.2024.12.637_bib41","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1038\/modpathol.2008.111","article-title":"Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis","volume":"21","author":"Gurel","year":"2008","journal-title":"Mod Pathol"},{"issue":"1","key":"10.1016\/j.pathol.2024.12.637_bib42","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/path.4980","article-title":"MYC drives overexpression of telomerase RNA (hTR\/TERC) in prostate cancer","volume":"244","author":"Baena-Del Valle","year":"2018","journal-title":"J Pathol"},{"issue":"2","key":"10.1016\/j.pathol.2024.12.637_bib43","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/pros.24633","article-title":"Chromogenic detection of telomere lengths in situ aids the identification of precancerous lesions in the prostate","volume":"84","author":"Ertunc","year":"2024","journal-title":"Prostate"},{"issue":"22","key":"10.1016\/j.pathol.2024.12.637_bib44","first-page":"6405","article-title":"Telomere shortening is an early somatic DNA alteration in human prostate tumorigenesis","volume":"62","author":"Meeker","year":"2002","journal-title":"Cancer Res"},{"issue":"24","key":"10.1016\/j.pathol.2024.12.637_bib45","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.169868","article-title":"MYC-driven increases in mitochondrial DNA copy number occur early and persist throughout prostatic cancer progression","volume":"8","author":"Chen","year":"2023","journal-title":"JCI Insight"},{"issue":"3","key":"10.1016\/j.pathol.2024.12.637_bib46","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/pros.2990240303","article-title":"The proliferative function of basal cells in the normal and hyperplastic human prostate","volume":"24","author":"Bonkhoff","year":"1994","journal-title":"Prostate"},{"issue":"5","key":"10.1016\/j.pathol.2024.12.637_bib47","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/pros.2990270505","article-title":"Cell proliferation in dysplasia of the prostate: analysis by PCNA immunostaining","volume":"27","author":"McNeal","year":"1995","journal-title":"Prostate"},{"issue":"9","key":"10.1016\/j.pathol.2024.12.637_bib48","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1097\/00000478-199809000-00005","article-title":"Histology and cellular kinetics of prostatic atrophy","volume":"22","author":"Ruska","year":"1998","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"10.1016\/j.pathol.2024.12.637_bib49","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/S0002-9440(10)64132-6","article-title":"Postatrophic hyperplasia of the prostate gland: neoplastic precursor or innocent bystander?","volume":"158","author":"Shah","year":"2001","journal-title":"Am J Pathol"},{"issue":"1","key":"10.1016\/j.pathol.2024.12.637_bib50","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/pros.20061","article-title":"Chronic inflammation in benign prostate hyperplasia is associated with focal upregulation of cyclooxygenase-2, Bcl-2, and cell proliferation in the glandular epithelium","volume":"61","author":"Wang","year":"2004","journal-title":"Prostate"},{"issue":"13","key":"10.1016\/j.pathol.2024.12.637_bib51","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1002\/pros.20992","article-title":"Morphological transition of proliferative inflammatory atrophy to high-grade intraepithelial neoplasia and cancer in human prostate","volume":"69","author":"Wang","year":"2009","journal-title":"Prostate"},{"issue":"5","key":"10.1016\/j.pathol.2024.12.637_bib52","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/S0090-4295(00)00776-7","article-title":"Morphologic transitions between proliferative inflammatory atrophy and high-grade prostatic intraepithelial neoplasia","volume":"56","author":"Putzi","year":"2000","journal-title":"Urology"},{"issue":"22","key":"10.1016\/j.pathol.2024.12.637_bib53","doi-asserted-by":"crossref","first-page":"10683","DOI":"10.1158\/0008-5472.CAN-06-0963","article-title":"Decreased NKX3.1 protein expression in focal prostatic atrophy, prostatic intraepithelial neoplasia, and adenocarcinoma: association with gleason score and chromosome 8p deletion","volume":"66","author":"Bethel","year":"2006","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.pathol.2024.12.637_bib54","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/PAS.0b013e318093e3f6","article-title":"Partial atrophy in prostate needle biopsies: a detailed analysis of its morphology, immunophenotype, and cellular kinetics","volume":"32","author":"Przybycin","year":"2008","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"10.1016\/j.pathol.2024.12.637_bib55","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1093\/ajcp\/aqx094","article-title":"Rapid loss of RNA detection by in situ hybridization in stored tissue blocks and preservation by cold storage of unstained slides","volume":"148","author":"Baena-Del Valle","year":"2017","journal-title":"Am J Clin Pathol"},{"issue":"4","key":"10.1016\/j.pathol.2024.12.637_bib56","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1006\/mthe.2000.0141","article-title":"Reversible immortalization of human primary cells by lentivector-mediated transfer of specific genes","volume":"2","author":"Salmon","year":"2000","journal-title":"Mol Ther"},{"issue":"4","key":"10.1016\/j.pathol.2024.12.637_bib57","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/pros.23276","article-title":"Low p16INK4a expression in early passage human prostate basal epithelial cells enables immortalization by telomerase expression alone","volume":"77","author":"Graham","year":"2017","journal-title":"Prostate"},{"key":"10.1016\/j.pathol.2024.12.637_bib58","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1183440","article-title":"A multifactorial analysis of FAP to regulate gastrointestinal cancers progression","volume":"14","author":"Cai","year":"2023","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.pathol.2024.12.637_bib59","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ccr.2010.05.026","article-title":"Integrative genomic profiling of human prostate cancer","volume":"18","author":"Taylor","year":"2010","journal-title":"Cancer Cell"},{"issue":"6917","key":"10.1016\/j.pathol.2024.12.637_bib60","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.pathol.2024.12.637_bib61","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nri.2017.142","article-title":"NF-\u03baB, inflammation, immunity and cancer: coming of age","volume":"18","author":"Taniguchi","year":"2018","journal-title":"Nat Rev Immunol"},{"issue":"12","key":"10.1016\/j.pathol.2024.12.637_bib62","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1172\/JCI38988","article-title":"Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice","volume":"119","author":"Santos","year":"2009","journal-title":"J Clin Invest"},{"issue":"6005","key":"10.1016\/j.pathol.2024.12.637_bib63","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1126\/science.1195300","article-title":"Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha","volume":"330","author":"Kraman","year":"2010","journal-title":"Science"},{"issue":"6230","key":"10.1016\/j.pathol.2024.12.637_bib64","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1126\/science.aaa6204","article-title":"T cell exclusion, immune privilege, and the tumor microenvironment","volume":"348","author":"Joyce","year":"2015","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.pathol.2024.12.637_bib65","doi-asserted-by":"crossref","first-page":"5110","DOI":"10.1038\/s41467-023-40850-5","article-title":"Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors","volume":"14","author":"Xiao","year":"2023","journal-title":"Nat Commun"},{"issue":"9","key":"10.1016\/j.pathol.2024.12.637_bib66","first-page":"2912","article-title":"Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling","volume":"8","author":"Tuxhorn","year":"2002","journal-title":"Clin Cancer Res"},{"issue":"5","key":"10.1016\/j.pathol.2024.12.637_bib67","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/j.1365-2141.2008.07241.x","article-title":"Fibroblast activation protein alpha identifies mesenchymal stromal cells from human bone marrow","volume":"142","author":"Bae","year":"2008","journal-title":"Br J Haematol"},{"issue":"6","key":"10.1016\/j.pathol.2024.12.637_bib68","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1084\/jem.20122344","article-title":"Depletion of stromal cells expressing fibroblast activation protein-\u03b1 from skeletal muscle and bone marrow results in cachexia and anemia","volume":"210","author":"Roberts","year":"2013","journal-title":"J Exp Med"},{"issue":"1","key":"10.1016\/j.pathol.2024.12.637_bib69","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ajpath.2010.09.042","article-title":"Determining prostate cancer-specific death through quantification of stromogenic carcinoma area in prostatectomy specimens","volume":"178","author":"Ayala","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.pathol.2024.12.637_bib70","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.humpath.2017.02.019","article-title":"Histologic features of stromogenic carcinoma of the prostate (carcinomas with reactive stroma grade 3)","volume":"63","author":"De Vivar","year":"2017","journal-title":"Hum Pathol"},{"issue":"13","key":"10.1016\/j.pathol.2024.12.637_bib71","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1002\/pros.23867","article-title":"Fibroblast as a critical stromal cell type determining prognosis in prostate cancer","volume":"79","author":"Blom","year":"2019","journal-title":"Prostate"},{"key":"10.1016\/j.pathol.2024.12.637_bib72","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.humpath.2022.01.009","article-title":"Development and validation of a quantitative reactive stroma biomarker (qRS) for prostate cancer prognosis","volume":"122","author":"Ruder","year":"2022","journal-title":"Hum Pathol"},{"issue":"24","key":"10.1016\/j.pathol.2024.12.637_bib73","doi-asserted-by":"crossref","first-page":"4635","DOI":"10.7150\/jca.28583","article-title":"Cancer-associated fibroblasts correlate with tumor-associated macrophages infiltration and lymphatic metastasis in triple negative breast cancer patients","volume":"9","author":"Zhou","year":"2018","journal-title":"J Cancer"},{"issue":"6","key":"10.1016\/j.pathol.2024.12.637_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106600","article-title":"FAP promotes metastasis and chemoresistance via regulating YAP1 and macrophages in mucinous colorectal adenocarcinoma","volume":"26","author":"Ji","year":"2023","journal-title":"iScience"},{"issue":"4","key":"10.1016\/j.pathol.2024.12.637_bib75","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.jcmgh.2022.12.005","article-title":"Fibroblast activation protein activates macrophages and promotes parenchymal liver inflammation and fibrosis","volume":"15","author":"Yang","year":"2023","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.pathol.2024.12.637_bib76","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/pros.23738","article-title":"Tumor-infiltrating mesenchymal stem cells: drivers of the immunosuppressive tumor microenvironment in prostate cancer?","volume":"79","author":"Krueger","year":"2019","journal-title":"Prostate"},{"issue":"5","key":"10.1016\/j.pathol.2024.12.637_bib77","doi-asserted-by":"crossref","first-page":"R269","DOI":"10.1530\/ERC-13-0151","article-title":"Mesenchymal stem cells as a vector for the inflammatory prostate microenvironment","volume":"20","author":"Brennen","year":"2013","journal-title":"Endocr Relat Cancer"},{"issue":"3","key":"10.1016\/j.pathol.2024.12.637_bib78","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.3390\/ijms22031046","article-title":"Regulation of fibroblast activation protein by transforming growth factor beta-1 in glioblastoma microenvironment","volume":"22","author":"Krepela","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.pathol.2024.12.637_bib79","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41392-021-00641-0","article-title":"Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer","volume":"6","author":"Wu","year":"2021","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"10.1016\/j.pathol.2024.12.637_bib80","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1152\/physrev.00048.2019","article-title":"Diversity and biology of cancer-associated fibroblasts","volume":"101","author":"Biffi","year":"2021","journal-title":"Physiol Rev"},{"issue":"1","key":"10.1016\/j.pathol.2024.12.637_bib81","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3390\/biom13010067","article-title":"Cancer-associated fibroblast heterogeneity, activation and function: implications for prostate cancer","volume":"13","author":"Owen","year":"2022","journal-title":"Biomolecules"},{"issue":"12","key":"10.1016\/j.pathol.2024.12.637_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2018.11.086","article-title":"A cellular anatomy of the normal adult human prostate and prostatic urethra","volume":"25","author":"Henry","year":"2018","journal-title":"Cell Rep"}],"container-title":["Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302525000935?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302525000935?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:37:08Z","timestamp":1762216628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031302525000935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":82,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S0031302525000935"],"URL":"https:\/\/doi.org\/10.1016\/j.pathol.2024.12.637","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.04.04.24305338","asserted-by":"object"}]},"ISSN":["0031-3025"],"issn-type":[{"value":"0031-3025","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Overexpression of fibroblast activation protein (FAP) in the stroma of proliferative inflammatory atrophy (PIA) and primary adenocarcinoma of the prostate","name":"articletitle","label":"Article Title"},{"value":"Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pathol.2024.12.637","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V. on behalf of Royal College of Pathologists of Australasia.","name":"copyright","label":"Copyright"}]}}